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28 results on '"Zeng, Melody Y."'

2. Contributors

Author

Agrawala, Paban K., primary, Alvarado, Christopher, additional, Amir, Mohammed, additional, Bernau, Ksenija, additional, Bhattacharya, Aditi, additional, Biswas, Biswajit, additional, Block, Megan, additional, Boosani, Anvitha, additional, Boosani, Chandra S., additional, Brasier, Allan R., additional, Brown, Julia A., additional, Chakraborty, Rajasree, additional, Das, Abhijit, additional, Dasari, Nikhitha, additional, DiStefano, Johanna K., additional, Dwarakanath, B.S., additional, Fukai, Tohru, additional, Gaikwad, Anil Bhanudas, additional, Gong, Fangyan, additional, Gornati, Rosalba, additional, Goswami, Ritobrata, additional, Gunasekar, Palanikumar, additional, Gupta, Noopur, additional, Hassan, Ebrahim Bani, additional, Jadhav, Gopal P., additional, Jain, Natasha Victoria, additional, Jiang, Fang, additional, Jiang, Wanlin, additional, Kreger, Jonathan, additional, Kulkarni, Yogesh A., additional, Le, Patricia N., additional, Liu, Lei, additional, Maini, Jayant, additional, Mondal, Papiya, additional, Nakai, Kenta, additional, Natarajan, Umamaheswari, additional, Olson, Michael T., additional, Pagiatakis, Christina, additional, Pandkar, Madhura R., additional, Pant, Amit M., additional, Papait, Roberto, additional, Patnaik, Srinivas, additional, Pelham, Christopher J., additional, Prakash, Anu, additional, Rathinavelu, Appu, additional, Sandbo, Nathan, additional, Sarkar, Subhajit, additional, Sharma, Ajay, additional, Sharma, Nisha, additional, Sharma, Vineeta, additional, Shiva, Niharika, additional, Shukla, Sanjeev, additional, Singh, Lakshman, additional, Singh, Sukhveer, additional, Singhal, Saurabh, additional, Srivastava, Vikas, additional, Sudhahar, Varadarajan, additional, Tiffon, Céline, additional, Ushio-Fukai, Masuko, additional, Vandenbon, Alexis, additional, Weng, Judy, additional, Woo, Jesse, additional, Wu, Xiumei, additional, Yadav, Pooja, additional, and Zeng, Melody Y., additional

Published
2023
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4. Gut bacteria–derived serotonin promotes immune tolerance in early life

Author

Sanidad, Katherine Z., primary, Rager, Stephanie L., additional, Carrow, Hannah C., additional, Ananthanarayanan, Aparna, additional, Callaghan, Ryann, additional, Hart, Lucy R., additional, Li, Tingting, additional, Ravisankar, Purnima, additional, Brown, Julia A., additional, Amir, Mohammed, additional, Jin, Jenny C., additional, Savage, Alexandria Rose, additional, Luo, Ryan, additional, Rowdo, Florencia Mardorsky, additional, Martin, M. Laura, additional, Silver, Randi B., additional, Guo, Chun-Jun, additional, Krumsiek, Jan, additional, Inohara, Naohiro, additional, and Zeng, Melody Y., additional

Published
2024
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6. Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens

Author

Zeng, Melody Y, Cisalpino, Daniel, Varadarajan, Saranyaraajan, Hellman, Judith, Warren, H Shaw, Cascalho, Marilia, Inohara, Naohiro, and Núñez, Gabriel

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Biodefense, Infectious Diseases, Prevention, Emerging Infectious Diseases, Digestive Diseases, Vaccine Related, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Aetiology, 2.2 Factors relating to the physical environment, Inflammatory and immune system, Infection, Animals, Bacterial Load, Gram-Negative Bacteria, Gram-Negative Bacterial Infections, Homeostasis, Host-Pathogen Interactions, Immunoglobulin G, Intestines, Mice, Mice, Inbred C57BL, Mice, Knockout, Microbiota, Peptidoglycan, Toll-Like Receptor 2, Toll-Like Receptor 4
Abstract

The gut microbiota is compartmentalized in the intestinal lumen and induces local immune responses, but it remains unknown whether the gut microbiota can induce systemic response and contribute to systemic immunity. We report that selective gut symbiotic gram-negative bacteria were able to disseminate systemically to induce immunoglobulin G (IgG) response, which primarily targeted gram-negative bacterial antigens and conferred protection against systemic infections by E. coli and Salmonella by directly coating bacteria to promote killing by phagocytes. T cells and Toll-like receptor 4 on B cells were important in the generation of microbiota-specific IgG. We identified murein lipoprotein (MLP), a highly conserved gram-negative outer membrane protein, as a major antigen that induced systemic IgG homeostatically in both mice and humans. Administration of anti-MLP IgG conferred crucial protection against systemic Salmonella infection. Thus, our findings reveal an important function for the gut microbiota in combating systemic infection through the induction of protective IgG.

Published
2016

10. Gut bacteria-derived serotonin promotes immune tolerance in early life

Author

Sanidad, Katherine Z., primary, Rager, Stephanie L., additional, Ananthanarayanan, Aparna, additional, Callaghan, Ryann, additional, Li, Tingting, additional, Brown, Julia A., additional, Amir, Mohammed, additional, Jin, Jenny L., additional, Savage, Alexandria Rose, additional, Luo, Ryan, additional, Rowdo, Florencia Mardorsky, additional, Martin, M. Laura, additional, Silver, Randi B., additional, Artis, David, additional, Guo, Chun-Jun, additional, Krumsiek, Jan, additional, Inohara, Naohiro, additional, and Zeng, Melody Y., additional

Published
2022
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11. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

Author

He, Yuan, Zeng, Melody Y., Yang, Dahai, Motro, Benny, and Nunez, Gabriel

Subjects
Gene mutations -- Analysis, Potassium acetate -- Research -- Influence, Interleukins -- Research -- Influence, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases (1). So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common [...]

Published
2016

12. SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy

Author

Jin, Jenny C., primary, Ananthanarayanan, Aparna, additional, Brown, Julia A., additional, Rager, Stephanie L., additional, Bram, Yaron, additional, Sanidad, Katherine Z., additional, Amir, Mohammed, additional, Baergen, Rebecca N., additional, Stuhlmann, Heidi, additional, Schwartz, Robert E., additional, Perlman, Jeffrey M., additional, and Zeng, Melody Y., additional

Published
2022
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13. Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection

Author

Brown, Julia A., primary, Sanidad, Katherine Z., additional, Lucotti, Serena, additional, Lieber, Carolin M., additional, Cox, Robert M., additional, Ananthanarayanan, Aparna, additional, Basu, Srijani, additional, Chen, Justin, additional, Shan, Mengrou, additional, Amir, Mohammed, additional, Schmidt, Fabian, additional, Weisblum, Yiska, additional, Cioffi, Michele, additional, Li, Tingting, additional, Rowdo, Florencia Madorsky, additional, Martin, M. Laura, additional, Guo, Chun-Jun, additional, Lyssiotis, Costas A., additional, Layden, Brian T., additional, Dannenberg, Andrew J., additional, Bieniasz, Paul D., additional, Lee, Benhur, additional, Inohara, Naohiro, additional, Matei, Irina, additional, Plemper, Richard K., additional, and Zeng, Melody Y., additional

Published
2022
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17. Gut microbiome regulates serotonin production in the neonatal intestine to promote immune tolerance in early life

Author

Sanidad, Katherine Z, primary, Rager, Stephanie L, additional, Ananthanarayanan, Aparna, additional, Callaghan, Ryann, additional, Li, Tingting, additional, Jin, Jenny C, additional, Amir, Mohammed, additional, Luo, Ryan, additional, Silver, Randi, additional, Artis, David, additional, Guo, Chun-Jun, additional, Krumsiek, Jan, additional, Inohara, Naohiro, additional, and Zeng, Melody Y, additional

Published
2022
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27. Oxidized polyunsaturated fatty acid promotes colitis and colitis-associated tumorigenesis in mice.

Author

Wang W, Wang Y, Sanidad KZ, Wang Y, Zhang J, Yang W, Sun Q, Bayram I, Song R, Yang H, Johnson D, Sherman HL, Kim D, Minter LM, Wong JJ, Zeng MY, Decker EA, and Zhang G

Abstract

Background and Aims: Human studies suggest that a high intake of polyunsaturated fatty acid (PUFA) is associated with an increased risk of inflammatory bowel disease (IBD). PUFA is highly prone to oxidation. To date, it is unclear whether unoxidized or oxidized PUFA is involved in the development of IBD. Here, we aim to compare the effects of unoxidized PUFA vs. oxidized PUFA on the development of IBD and associated colorectal cancer., Methods: We evaluated the effects of unoxidized and oxidized PUFA on dextran sodium sulfate (DSS)- and IL-10 knockout-induced colitis, and azoxymethane (AOM)/DSS-induced colon tumorigenesis in mice. Additionally, we studied the roles of gut microbiota and Toll-like receptor 4 (TLR4) signaling involved., Results: Administration of a diet containing oxidized PUFA, at human consumption-relevant levels, increases the severity of colitis and exacerbates the development of colitis-associated colon tumorigenesis in mice. Conversely, a diet rich in unoxidized PUFA doesn't promote colitis. Furthermore, oxidized PUFA worsens colitis-associated intestinal barrier dysfunction and leads to increased bacterial translocation, and it fails to promote colitis in Toll-like receptor 4 (TLR4) knockout mice. Finally, oxidized PUFA alters the diversity and composition of gut microbiota, and it fails to promote colitis in mice lacking the microbiota., Conclusions: These results support that oxidized PUFA promotes the development of colitis and associated tumorigenesis in mouse models via TLR4- and gut microbiota-dependent mechanisms. Our findings highlight the potential need to update regulation policies and industrial standards for oxidized PUFA levels in food., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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28. Early life high fructose exposure disrupts microglia function and impedes neurodevelopment.

Author

Wang Z, Lipshutz A, Liu ZL, Trzeciak AJ, Miranda IC, Martínez de la Torre C, Schild T, Lazarov T, Rojas WS, Saavedra PHV, Romero-Pichardo JE, Baako A, Geissmann F, Faraco G, Gan L, Etchegaray JI, Lucas CD, Parkhurst CN, Zeng MY, Keshari KR, and Perry JSA

Abstract

Despite the success of fructose as a low-cost food additive, recent epidemiological evidence suggests that high fructose consumption by pregnant mothers or during adolescence is associated with disrupted neurodevelopment 1-7 . An essential step in appropriate mammalian neurodevelopment is the synaptic pruning and elimination of newly-formed neurons by microglia, the central nervous system's (CNS) resident professional phagocyte 8-10 . Whether early life high fructose consumption affects microglia function and if this directly impacts neurodevelopment remains unknown. Here, we show that both offspring born to dams fed a high fructose diet and neonates exposed to high fructose exhibit decreased microglial density, increased uncleared apoptotic cells, and decreased synaptic pruning in vivo . Importantly, deletion of the high affinity fructose transporter SLC2A5 (GLUT5) in neonates completely reversed microglia dysfunction, suggesting that high fructose directly affects neonatal development. Mechanistically, we found that high fructose treatment of both mouse and human microglia suppresses synaptic pruning and phagocytosis capacity which is fully reversed in GLUT5-deficient microglia. Using a combination of in vivo and in vitro nuclear magnetic resonance- and mass spectrometry-based fructose tracing, we found that high fructose drives significant GLUT5-dependent fructose uptake and catabolism, rewiring microglia metabolism towards a hypo-phagocytic state. Importantly, mice exposed to high fructose as neonates exhibited cognitive defects and developed anxiety-like behavior which were rescued in GLUT5-deficient animals. Our findings provide a mechanistic explanation for the epidemiological observation that early life high fructose exposure is associated with increased prevalence of adolescent anxiety disorders.

Published
2023
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