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19 results on '"Zeng, Johnathan"'

5. Primary Total Laryngectomy versus Organ Preservation for Locally Advanced T3/T4a Laryngeal Cancer.

Author

Lee, Maxwell Y., Belfiglio, Mario, Zeng, Johnathan, Fleming, Christopher W., Koyfman, Shlomo, Joshi, Nikhil P., Lamarre, Eric, Prendes, Brandon, Scharpf, Joseph, Lorenz, Robert R., Woody, Neil M., Adelstein, David J., Geiger, Jessica L., Chute, Deborah J., and Ku, Jamie A.

Abstract

Objective: Organ preservation (OP) treatment for advanced laryngeal cancer has increased compared to primary total laryngectomy. Our study compares oncologic and functional outcomes between these approaches. Study Design: Retrospective cohort study. Setting: Single tertiary care institution. Methods: Retrospective review of patients receiving primary total laryngectomy or OP for laryngeal cancer between 1/1/2000 and 12/31/2018. Results: A total of 118 patients received primary total laryngectomy and 119 received OP. Overall survival was similar between total laryngectomy and OP. When stratified by T stage, disease‐free survival was worse among T3 patients receiving OP versus total laryngectomy. In T3 patients, 28 OP patients experienced local recurrence (28.9%) compared to 3 total laryngectomy patients (7.1%; p < 0.01). In total, 20 OP patients with local recurrence received salvage surgery. These patients had similar overall survival to patients who underwent initial total laryngectomy (TL). About 14 OP patients with local recurrence did not receive salvage surgery. About 89 (75.4%) TL patients achieved normal diet as compared to 64 (53.8%) OP patients (p < 0.001). In TL patients, 106 (89.8%) received primary or secondary tracheoesophageal‐prosthesis, 82 (77.4%) of whom achieved completely understandable speech. Conclusions: There was no difference in survival by treatment in T4 patients, possibly because of strict patient selection. However, disease‐free survival was worse in T3 patients receiving OP, likely due to a high local recurrence rate. Approximately 40% of patients with local recurrence were not eligible for salvage laryngectomy. TL patients had comparable swallowing and speech outcomes with OP patients. Level of Evidence: 3 Laryngoscope, 133:1122–1131, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
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6. Primary Total Laryngectomy versus Organ Preservation for Locally Advanced T3/T4a Laryngeal Cancer

Author

Lee, Maxwell Y., primary, Belfiglio, Mario, additional, Zeng, Johnathan, additional, Fleming, Christopher W., additional, Koyfman, Shlomo, additional, Joshi, Nikhil P., additional, Lamarre, Eric, additional, Prendes, Brandon, additional, Scharpf, Joseph, additional, Lorenz, Robert R., additional, Woody, Neil M., additional, Adelstein, David J., additional, Geiger, Jessica L., additional, Chute, Deborah J., additional, and Ku, Jamie A., additional

Published
2022
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7. Magnetic Resonance Imaging-Targeted and Systematic Biopsy for Detection of Grade Progression in Patients on Active Surveillance for Prostate Cancer

Author

Yerram, Nitin K., primary, Long, Lori, additional, O’Connor, Luke P., additional, Wang, Alex Z., additional, Ahdoot, Michael, additional, Lebastchi, Amir H., additional, Gurram, Sandeep, additional, Zeng, Johnathan, additional, Chalfin, Heather, additional, Harmon, Stephanie A., additional, Mehralivand, Sherif, additional, Merino, Maria J., additional, Parnes, Howard L., additional, Choyke, Peter L., additional, Shih, Joanna, additional, Wood, Bradford J., additional, Turkbey, Baris, additional, and Pinto, Peter A., additional

Published
2021
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8. Reply by Authors

Author

Yerram, Nitin K., primary, Long, Lori, additional, O’Connor, Luke P., additional, Wang, Alex Z., additional, Ahdoot, Michael, additional, Lebastchi, Amir H., additional, Gurram, Sandeep, additional, Zeng, Johnathan, additional, Chalfin, Heather, additional, Harmon, Stephanie A., additional, Mehralivand, Sherif, additional, Merino, Maria J., additional, Parnes, Howard L., additional, Choyke, Peter L., additional, Shih, Joanna, additional, Wood, Bradford J., additional, Turkbey, Baris, additional, and Pinto, Peter A., additional

Published
2021
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9. Changes in Magnetic Resonance Imaging Using the Prostate Cancer Radiologic Estimation of Change in Sequential Evaluation Criteria to Detect Prostate Cancer Progression for Men on Active Surveillance

Author

O’Connor, Luke P., primary, Wang, Alex Z., additional, Yerram, Nitin K., additional, Long, Lori, additional, Ahdoot, Michael, additional, Lebastchi, Amir H., additional, Gurram, Sandeep, additional, Zeng, Johnathan, additional, Harmon, Stephanie A., additional, Mehralivand, Sherif, additional, Merino, Maria J., additional, Parnes, Howard L., additional, Choyke, Peter L., additional, Shih, Joanna H., additional, Wood, Bradford J., additional, Turkbey, Baris, additional, and Pinto, Peter A., additional

Published
2021
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10. PI-RADS® Category as a Predictor of Progression to Unfavorable Risk Prostate Cancer in Men on Active Surveillance

Author

Wang, Alex Z., primary, Oonnor, Luke P., additional, Yerram, Nitin K., additional, Long, Lori, additional, Zeng, Johnathan, additional, Mehralivand, Sherif, additional, Harmon, Stephanie A., additional, Lebastchi, Amir H., additional, Ahdoot, Michael, additional, Gomella, Patrick T., additional, Gurram, Sandeep, additional, Choyke, Peter L., additional, Merino, Maria J., additional, Shih, Joanna H., additional, Wood, Bradford J., additional, Turkbey, Baris, additional, and Pinto, Peter A., additional

Published
2020
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11. Selection of patients for surveillance imaging after radiotherapy for squamous cell carcinoma of oral cavity and oropharynx.

Author

Zeng, Johnathan, primary, Fleming, Christopher W, additional, Lee, Maxwell, additional, Parikh, Rujul H, additional, Rybicki, Lisa A., additional, Joshi, Nikhil, additional, Woody, Neil McIver, additional, Ku, Jamie, additional, Prendes, Brandon, additional, Lamarre, Eric, additional, Lorenz, Robert R, additional, Scharpf, Joseph, additional, Burkey, Brian B., additional, Chute, Deborah, additional, Schwartzman, Larisa, additional, Geiger, Jessica Lyn, additional, Adelstein, David J., additional, and Koyfman, Shlomo A., additional

Published
2020
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13. Association of PI-RADS categories and PSA density with active surveillance progression in patients with prostate cancer.

Author

Wang, Alex Z., primary, O'Connor, Luke P., additional, Yerram, Nitin, additional, Zeng, Johnathan, additional, Mehralivand, Sherif, additional, Harmon, Stephanie, additional, Gurram, Sandeep, additional, Chalfin, Heather, additional, Telfer, Siobhan, additional, Lebastchi, Amir H., additional, Ahdoot, Michael, additional, Gomella, Patrick H., additional, Merino, Maria J., additional, Turkbey, Baris, additional, Wood, Bradford J., additional, Choyke, Peter L., additional, and Pinto, Peter A., additional

Published
2020
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16. Visualizing the Propagation of Acute Lung Injury

Author

Cereda, Maurizio, primary, Xin, Yi, additional, Meeder, Natalie, additional, Zeng, Johnathan, additional, Jiang, YunQing, additional, Hamedani, Hooman, additional, Profka, Harrilla, additional, Kadlecek, Stephen, additional, Clapp, Justin, additional, Deshpande, Charuhas G., additional, Wu, Jue, additional, Gee, James C., additional, Kavanagh, Brian P., additional, and Rizi, Rahim R., additional

Published
2016
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19. Changes in Magnetic Resonance Imaging Using the Prostate Cancer Radiologic Estimation of Change in Sequential Evaluation Criteria to Detect Prostate Cancer Progression for Men on Active Surveillance.

Author

O'Connor LP, Wang AZ, Yerram NK, Long L, Ahdoot M, Lebastchi AH, Gurram S, Zeng J, Harmon SA, Mehralivand S, Merino MJ, Parnes HL, Choyke PL, Shih JH, Wood BJ, Turkbey B, and Pinto PA

Subjects
Humans, Magnetic Resonance Imaging, Male, Neoplasm Grading, Prostatic Neoplasms diagnostic imaging, Watchful Waiting
Abstract

Background: The ability of serial magnetic resonance imaging (MRI) to capture pathologic progression during active surveillance (AS) remains in question., Objective: To determine whether changes in MRI are associated with pathologic progression for patients on AS., Design, Setting, and Participants: From July 2007 through January 2020, we identified all patients evaluated for AS at our institution. Following confirmatory biopsy, a total of 391 patients who underwent surveillance MRI and biopsy at least once were identified (median follow-up of 35.6 mo, interquartile range 19.7-60.6)., Outcome Measurements and Statistical Analysis: All MRI intervals were scored using the "Prostate Cancer Radiologic Estimation of Change in Sequential Evaluation" (PRECISE) criteria, with PRECISE scores =4 considered a positive change in MRI. A generalized estimating equation-based logistic regression analysis was conducted for all intervals with a PRECISE score of <4 to determine the predictors of Gleason grade group (GG) progression despite stable MRI., Results and Limitations: A total of 621 MRI intervals were scored by PRECISE and validated by biopsy. The negative predictive value of stable MRI (PRECISE score <4) was greatest for detecting GG1 to?=?GG3 disease (0.94 [0.91-0.97]). If 2-yr surveillance biopsy were performed exclusively for a positive change in MRI, 3.7% (4/109) of avoided biopsies would have resulted in missed progression from GG1 to?=?GG3 disease. Prostate-specific antigen (PSA) density (odds ratio 1.95 [1.17-3.25], p?=? 0.01) was a risk factor for progression from GG1 to =GG3 disease despite stable MRI., Conclusions: In patients with GG1 disease and stable MRI (PRECISE score <4) on surveillance, grade progression to?=?GG3 disease is not common. In patients with grade progression detected on biopsy despite stable MRI, elevated PSA density appeared to be a risk factor for progression to?=?GG3 disease., Patient Summary: For patients with low-risk prostate cancer on active surveillance, the risk of progressing to grade group 3 disease is low with a stable magnetic resonance image (MRI) after 2?yr. Having higher prostate-specific antigen density increases the risk of progression, despite having a stable MRI., (Copyright © 2020. Published by Elsevier B.V.)

Published
2021
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