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3. Early neonatal outcomes of very-low-birth-weight infants in Turkey: a prospective multicenter study of the Turkish Neonatal Society

Author

Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin; Demirel, Nihal; Baş, Ahmet Yağmur; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunc, Turan; Sarı, Fatma Nur; Karatekin, Güner; Özdemir, Ramazan; Altunhan, Hüseyin; Çetinkaya, Merih; Özcan, Beyza; Özkiraz, Servet; Çalkavur, Sebnem; Tekgündüz, Kadir Şerafettin; Taştekin, Ayhan; Özlü, Ferda; Özyurt, Banu Mutlu; Özdemir, Ahmet; Çetinkaya, Bilin; Demirelli, Yaşar; Köklü, Esad; Çelik, Ülker; Tarakçı, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bülbül, Ali; Asker, Hüseyin Selim; Uygur, ÖzgÜn; Uslu, İlker Sait; Ertuğrul, Sabahattin; Aydemir, Cumhur; Çelik, Hasan Tolga; Küçüktaşçı, Kazım; Arslan, Selda; Ergin, Hacer; Zenciroğlu, Aysegül; Yurttutan, Sadık; Orman, Ayşen; Tuncer, Oğuz; Yaşa, Beril; Acunas, Betül; Takci, Şahin; Gökmen, Zeynel; Özkan, Hilal; Cömert, Serdar; Üstün, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Özge; Akdağ, Arzu; Memisoğlu, Aslı; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Özden; Güzoğlu, Nilüfer; Örs, Rahmi; Kale, Yusuf; Hekimoğlu, Berna; Aylanc, Hakan; Eroğlu, Funda; Şahin, Suzan; Konak, Murat; Sarıcı, Dilek; Kılıç, İlknur; Hakan, Nilay, School of Medicine, Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin; Demirel, Nihal; Baş, Ahmet Yağmur; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunc, Turan; Sarı, Fatma Nur; Karatekin, Güner; Özdemir, Ramazan; Altunhan, Hüseyin; Çetinkaya, Merih; Özcan, Beyza; Özkiraz, Servet; Çalkavur, Sebnem; Tekgündüz, Kadir Şerafettin; Taştekin, Ayhan; Özlü, Ferda; Özyurt, Banu Mutlu; Özdemir, Ahmet; Çetinkaya, Bilin; Demirelli, Yaşar; Köklü, Esad; Çelik, Ülker; Tarakçı, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bülbül, Ali; Asker, Hüseyin Selim; Uygur, ÖzgÜn; Uslu, İlker Sait; Ertuğrul, Sabahattin; Aydemir, Cumhur; Çelik, Hasan Tolga; Küçüktaşçı, Kazım; Arslan, Selda; Ergin, Hacer; Zenciroğlu, Aysegül; Yurttutan, Sadık; Orman, Ayşen; Tuncer, Oğuz; Yaşa, Beril; Acunas, Betül; Takci, Şahin; Gökmen, Zeynel; Özkan, Hilal; Cömert, Serdar; Üstün, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Özge; Akdağ, Arzu; Memisoğlu, Aslı; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Özden; Güzoğlu, Nilüfer; Örs, Rahmi; Kale, Yusuf; Hekimoğlu, Berna; Aylanc, Hakan; Eroğlu, Funda; Şahin, Suzan; Konak, Murat; Sarıcı, Dilek; Kılıç, İlknur; Hakan, Nilay, and School of Medicine

Abstract

Objective: to investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods: a prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of.1500 g were collected for infants who survived. Results: data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137 +/- 245 g and 29 +/- 2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers. Conclusion: the present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs., Turkish Neonatal Society

Published
2019

4. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Author

Uludağ, Günay (ORCID & YÖK ID 175586); Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur; Demirel, Nihal; Koç, Esin; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunç, Turan; Sarı, Fatma Nur; Karatekin, Güner; Köklü, Esad; Altunhan, Hüseyin; Turgut, Hatice; Narter, Fatma; Tarakçı, Nuriye; Tekgündüz, Kadir Şerafettin; Özkiraz, Servet; Aydemir, Cumhur; Özdemir, Ahmet; Çetinkaya, Bilin; Kazancı, Ebru; Taştekin, Ayhan; Calkavur, Şebnem; Özyurt, Banu Mutlu; Demirelli, Yaşar; Asker, Hüseyin Selim; Mutlu, Birgul; Uygur, Özgün; Özkan, Hilal; Armangil, Didem; Özlü, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Özcan, Beyza; Baş, Evrim Kıray; Okulu, Emel; Acunas, Betül; Çelik, Ülker; Uslu, Sait İlker; Mutlu, Mehmet; Demir, Nihat; Eroğlu, Funda; Gökmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Küçüktaşçı, Kazım; Orman, Ayşen; Cömert, Serdar; Ertuğrul, Sabahattin; Üstün, Nuran; Şahin, Özlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadık; Aydemir, Özge; Zenciroğlu, Aysegül; Sarıcı, Dilek; Güzoğlu, Nilüfer; Hamilçıkan, Şahin; Tüzün, Funda; Örs, Rahmi; Arslan, Selda; Akdağ, Arzu; Memişoğlu, Aslı; Yasa, Beril; Hekimoğlu, Berna; Turan, Özden; Aylanc, Hakan; Takçı, Şahin; Çelik, Tolga; Şahin, Suzan; Kılıç, İlknur; Kara, Caner; Tunay, Zuhal Özen; Çelik, Gökhan; Gözen, İbrahim; Satırtav, Günhal; Polat, Nihat; Oral, Ayşe Yeşim; Tokgöz, Mine; Keleş, Sadullah; Bilgin, Burak; Uğurbaş, Silay Cantürk; Karaca, Çağatay; Keşkek, Nedime Şahinoğlu; Ekinci, Dilbade Yıldız; Balcı, Özlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamaç, Günay; Türe, Gamze; Yıldız, Meral; Çalış, Feyza; Sızmaz, Selçuk; Sukgen, Emine; Çetin, Ebru Nevin; Özçimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Özal, Altan; Tufaner, Gökhan; Yücel, Özlem Eski; Kola, Mehmet; Seven, Erbil; Özdek, Şengül; Durukan, Ali Hakan; Kal, Ali; Çelebi, Ali Riza Cenk; Koytak, İbrahim Arif; Alaçamlı, Göksu; Esme, Arif; Çatak, Onur; Perente, İrfan; Şahin, Alparslan; Akçakaya, Aylin Ardagil; Kıray, Gülünay; Nalçacı, Serhat; Aksoy, Ümit; Bakbak, Ber, School of Medicine, Department of Internal Medicine, Uludağ, Günay (ORCID & YÖK ID 175586); Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur; Demirel, Nihal; Koç, Esin; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunç, Turan; Sarı, Fatma Nur; Karatekin, Güner; Köklü, Esad; Altunhan, Hüseyin; Turgut, Hatice; Narter, Fatma; Tarakçı, Nuriye; Tekgündüz, Kadir Şerafettin; Özkiraz, Servet; Aydemir, Cumhur; Özdemir, Ahmet; Çetinkaya, Bilin; Kazancı, Ebru; Taştekin, Ayhan; Calkavur, Şebnem; Özyurt, Banu Mutlu; Demirelli, Yaşar; Asker, Hüseyin Selim; Mutlu, Birgul; Uygur, Özgün; Özkan, Hilal; Armangil, Didem; Özlü, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Özcan, Beyza; Baş, Evrim Kıray; Okulu, Emel; Acunas, Betül; Çelik, Ülker; Uslu, Sait İlker; Mutlu, Mehmet; Demir, Nihat; Eroğlu, Funda; Gökmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Küçüktaşçı, Kazım; Orman, Ayşen; Cömert, Serdar; Ertuğrul, Sabahattin; Üstün, Nuran; Şahin, Özlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadık; Aydemir, Özge; Zenciroğlu, Aysegül; Sarıcı, Dilek; Güzoğlu, Nilüfer; Hamilçıkan, Şahin; Tüzün, Funda; Örs, Rahmi; Arslan, Selda; Akdağ, Arzu; Memişoğlu, Aslı; Yasa, Beril; Hekimoğlu, Berna; Turan, Özden; Aylanc, Hakan; Takçı, Şahin; Çelik, Tolga; Şahin, Suzan; Kılıç, İlknur; Kara, Caner; Tunay, Zuhal Özen; Çelik, Gökhan; Gözen, İbrahim; Satırtav, Günhal; Polat, Nihat; Oral, Ayşe Yeşim; Tokgöz, Mine; Keleş, Sadullah; Bilgin, Burak; Uğurbaş, Silay Cantürk; Karaca, Çağatay; Keşkek, Nedime Şahinoğlu; Ekinci, Dilbade Yıldız; Balcı, Özlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamaç, Günay; Türe, Gamze; Yıldız, Meral; Çalış, Feyza; Sızmaz, Selçuk; Sukgen, Emine; Çetin, Ebru Nevin; Özçimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Özal, Altan; Tufaner, Gökhan; Yücel, Özlem Eski; Kola, Mehmet; Seven, Erbil; Özdek, Şengül; Durukan, Ali Hakan; Kal, Ali; Çelebi, Ali Riza Cenk; Koytak, İbrahim Arif; Alaçamlı, Göksu; Esme, Arif; Çatak, Onur; Perente, İrfan; Şahin, Alparslan; Akçakaya, Aylin Ardagil; Kıray, Gülünay; Nalçacı, Serhat; Aksoy, Ümit; Bakbak, Ber, School of Medicine, and Department of Internal Medicine

Abstract

Background to evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. Methods: a prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA)<= 32 weeks and those with a BW> 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses. Results: the TR-ROP study included 6115 infants: 4964 (81%) with a GA <= 32 weeks and 1151 (19%) with a GA>32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW <= 1500 g. Sixty-six (16%) of the treated infants did not fulfil the Early Treatment for Retinopathy of Prematurity requirements for treatment. Conclusions: screening of infants with a GA <= 34 weeks or a BW<1700 g appears to be appropriate in Turkey. Monitoring standards of neonatal care and conducting quality improvement projects across the country are recommended to improve neonatal outcomes in Turkish NICUs., NA

Published
2018

5. Intussusception in a term newborn with duct-dependent congenital heart disease

Author

AYDIN, Banu, DİLLİ, Dilek, ZENCİROĞLU, Aysegül, ERDOĞAN, Derya, KARAMAN, İbrahim, İPEK, Mehmet Şah, and OKUMUŞ, Nurullah

Subjects
Prostaglandin E1,yenidoğan,gast­rointestinal, Prostaglandin E1,newborn,gastrointestinal
Abstract

Prostaglandin E1 infüzyonu, duktus bağımlı konjenital kalp hastalığı olan yenidoğanlarda ameliyat edilinceye kadar duktusu açık tutmak amacıyla yaygın olarak kul­lanılmaktadır. Prostaglandin E1 yaşam kurtarıcı bir ilactır ancak ateş, apne, bradikardi, hipotansiyon, konvülziyon, ödem ve kortikal hiperostoz gibi birçok yan etkiye de yol açabilir. İlacın doz azaltmasına yanıt veren ishal dışın­da gastrointestinal sistemle ilgili önemli yan etkisi rapor edilmemektedir. Bu yazıda duktus bağımlı konjenital kalp hastalığı olan ve olasılıkla prostaglandin tedavisi ile te­tiklenen intestinal invajinasyon gelişen bir olgu sunuldu., Prostaglandin E1 infusion is widely used to maintain pa­tency of ductus arteriosus in newborns with duct-depen­dent congenital heart disease until surgery. Prostaglandin E1 is a lifesaving drug, but it has many side effects includ­ing fever, apnea, bradycardia, hypotension, convulsion, edema, and cortical hyperostosis. The gastrointestinal tract has not been recognized as a major site of serious adverse effects of prostaglandin E1 infusion, although diarrhea is a well-recognized side effect that usually re­sponds to dose reduction. In this report, we present a case of intestinal intussusception presumably induced by prostaglandin therapy in a newborn with duct-dependent congenital heart disease.

Published
2015

6. Main Risk Factors for Mortality After Cardiovascular Interventions in Newborns with Critical Congenital Heart Diseases

Author

ÜSTÜN, Nuran, DİLLİ, Dilek, ÖZGÜR, Senem, KOÇ, Murat, ZENCİROĞLU, Aysegül, BEKEN, Serdar, and OKUMUŞ, Nurullah

Subjects
Konjenital kalp hastalığı,Yenidoğan,Prematürite, Congenital heart disease,Newborn,Prematurity
Abstract

Amaç: Kritik konjenital kalp hastalıklı (KKH) yenidoğanlarda girişim sonrası mortaliteyi etkileyen risk faktörlerinin belirlenmesi amaçlandı.Gereç ve Yöntemler: Üçüncü düzey bir yenidoğan yoğun bakım ünitesinde (YYBÜ) Eylül 2010–Ocak 2012 tarihleri arasında izlenen ve girişim uygulanan kritik KKH tanılı 105 yenidoğan incelendi. Hastaların demografik verileri, girişim öncesi ve sonrası klinik bulguları, girişim tipi, Doğuştan Kalp Cerrahisi için Risk Ayarlanması sınıflamasına göre girişimsel risk skoru (Risk Adjustment in Congenital Heart Surgery; RACHS-1) ile ilgili veriler kaydedildi.Bulgular: Kardiyak girişim sırasında ortalama yaş 15.2±11.8 gündü. Transkateter girişim 29 (%27.6) hastada uygulandı. Toplam 76 hastaya (%72.4) kardiyak cerrahi girişim yapıldı. Girişim sonrası dönemde düşük kardiyak debi, pnömoni ve sepsis görülme sıklığı cerrahi girişim yapılan olgularda daha yüksekti. Bu hastalarda YYBÜ kalış süresi de daha uzundu. Mortalite oranı %35.2 (n=37) olarak bulundu. Transkateter girişim yapılan hastalarda mortalite daha düşüktü. Univaryant analizde ölen hastalarda gebelik haftasının daha düşük, prematürite oranının daha fazla, eşlik eden hastalık sıklığının daha yüksek, girişim öncesi mekanik ventilatörde kalma oranı, inotrop desteği, pulmoner hipertansiyon ve sepsis oranının daha fazla, cerrahi girişim gereksiniminin daha çok, girişim sırasındaki yaş ve RACHS-1 skorunun daha yüksek olduğu saptandı. Çoklu regresyon analizinde RACHS-1 skorunun yüksek olmasının mortalite ile ilişkili olduğu (Odds oranı: 4.5, %95 GA (1.5-13.1), p=0.005), gebelik yaşının büyük olmasının ise koruyucu bir faktör olduğu dikkati çekti (Odds oranı: 0.6, GA( %95) (0.5-0.9), p = 0.01).Sonuç: Bu çalışmada cerrahi girişim gereken kritik KKH’lı yenidoğanlar arasında mortalitenin yüksek olduğu, özellikle gebelik haftasının düşük, RACHS-1 skorunun ise yüksek olmasının mortalite riskini artırdığı sonucuna varıldı., Objective: It was aimed to define the main risk factors that affect mortality in infants with critical congenital heart disease (CHD).Material and Methods: We analyzed data from 105 infants with critical CHD underwent cardiovascular intervention at a tertiary neonatal intensive care unit (NICU) between September 2010 and January 2012. Demographic data, clinical findings (before and after intervention), type of intervention, and intervention risk score according to Risk Adjustment in Congenital Heart Surgery (RACHS-1) classification were evaluated. Results: The mean age at cardiovascular intervention was 15.2±11.8 days. Transcatheter interventions were performed in 29 patients (27.6%). Seventy-six patients (72.4%) underwent cardiovascular surgery. At post-interventional period, the rates of low cardiac output, pneumonia, and sepsis were significantly higher among patients underwent surgical intervention. Length of NICU stay was also longer among them. Overall mortality rate was 35.2% (n=37). Mortality was significantly lower in infants underwent transcatheter intervention. Univariate analyses showed that nonsurvivors differed from survivors in terms of gestational age, prematurity, the presence of associated disorder, pre-interventional need of mechanical ventilation, need of inotropic support, the presence of pulmonary hypertension and sepsis, requirement of cardiovascular surgery, age at intervention, and RACHS-1 score. Multivariate analysis showed that higher RACHS-1 score was associated with mortality (OR: 4.5, 95% CI (1.5-13.1), p=0.005) while higher gestational age was a preventive factor (OR: 0.6, 95% CI (0.5-0.9), p=0.01).Conclusion: Our study indicates that lower gestational age and severity of the disease seem to be most possible risk factors for mortality among infants with critical CHD

Published
2014

9. Early neonatal outcomes of very-low-birthweight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society

Author

Hüseyin Selim Asker, Emrah Can, Cumhur Aydemir, Betül Acunaş, Ali Bulbul, Turan Tunc, Kadir Şerafettin Tekgündüz, Hasan Tolga Çelik, Şahin Takcı, Ramazan Ozdemir, Ahmet Ozdemir, Mehmet Mutlu, Ferda Özlü, Yasar Demirelli, Beyza Ozcan, Rahmi Ors, Fatma Nur Sari, Ilknur Kilic, Guner Karatekin, Dilek Ulubas Isik, Banu Mutlu Özyurt, Berna Hekimoğlu, Sabahattin Ertuğrul, Murat Konak, Selda Arslan, Nuriye Tarakci, Ozgun Uygur, Serdar Cömert, Sadık Yurttutan, Kazim Kucuktasci, Emel Okulu, Arzu Akdag, Nilay Hakan, Nilüfer Güzoğlu, Tugba Gursoy, Hakan Aylanç, Şebnem Çalkavur, Asli Memisoglu, Ayşegül Zenciroğlu, Bilin Cetinkaya, Serdar Beken, Ozge Aydemir, Hacer Ergin, Ibrahim Murat Hirfanoglu, Yusuf Kale, Didem Armangil, Suzan Sahin, Bilge Tanyeri Bayraktar, Özden Turan, Huseyin Altunhan, Servet Ozkiraz, İlker Uslu, Nihal Demirel, Funda Eroglu, Zeynel Gokmen, Aysen Orman, Leyla Bilgin, Esin Koç, Beril Yasa, Demet Terek, Funda Tuzun, Esad Koklu, Nuran Üstün, Birgul Mutlu, Ahmet Yagmur Bas, Merih Cetinkaya, Hilal Özkan, Fatma Narter, Mustafa Kurthan Mert, Ayhan Tastekin, Ulker Celik, Dilek Sarici, Oğuz Tuncer, KOÇ E., DEMİREL N., BAŞ A. Y., Isik D. U., HIRFANOĞLU İ. M., Tunc T., Sari F. N., Karatekin G., ÖZDEMİR R., Altunhan H., et al., Ege Üniversitesi, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Hakan, Nilay, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı, Ertuǧrul, Sabahattin, Selçuk Üniversitesi, OMÜ, Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin, Demirel, Nihal, Baş, Ahmet Yağmur, Işık, Dilek Ulubaş, Hirfanoğlu, İbrahim Murat, Tunc, Turan, Sarı, Fatma Nur, Karatekin, Güner, Özdemir, Ramazan, Altunhan, Hüseyin, Çetinkaya, Merih, Özcan, Beyza, Özkiraz, Servet, Çalkavur, Sebnem, Tekgündüz, Kadir Şerafettin, Taştekin, Ayhan, Özlü, Ferda, Özyurt, Banu Mutlu, Özdemir, Ahmet, Çetinkaya, Bilin, Demirelli, Yaşar, Köklü, Esad, Çelik, Ülker, Tarakçı, Nuriye, Armangil, Didem, Okulu, Emel, Narter, Fatma, Mutlu, Birgul, Mert, Mustafa Kurthan, Bülbül, Ali, Asker, Hüseyin Selim, Uygur, ÖzgÜn, Uslu, İlker Sait, Ertuğrul, Sabahattin, Aydemir, Cumhur, Çelik, Hasan Tolga, Küçüktaşçı, Kazım, Arslan, Selda, Ergin, Hacer, Zenciroğlu, Aysegül, Yurttutan, Sadık, Orman, Ayşen, Tuncer, Oğuz, Yaşa, Beril, Acunas, Betül, Takci, Şahin, Gökmen, Zeynel, Özkan, Hilal, Cömert, Serdar, Üstün, Nuran, Mutlu, Mehmet, Bayraktar, Bilge Tanyeri, Bilgin, Leyla, Tuzun, Funda, Aydemir, Özge, Akdağ, Arzu, Memisoğlu, Aslı, Can, Emrah, Terek, Demet, Beken, Serdar, Turan, Özden, Güzoğlu, Nilüfer, Örs, Rahmi, Kale, Yusuf, Hekimoğlu, Berna, Aylanc, Hakan, Eroğlu, Funda, Şahin, Suzan, Konak, Murat, Sarıcı, Dilek, Kılıç, İlknur, School of Medicine, Acibadem University Dspace, KKÜ, and Kırıkkale Üniversitesi

Subjects
Male, Turkey, Temel Bilimler (SCI), very low birth weight, ÇOK DİSİPLİNLİ BİLİMLER, Pathology and Laboratory Medicine, blood culture, Pediatrics, Infant, Newborn, Diseases, lung dysplasia, sepsis, Families, 0302 clinical medicine, newborn, Pregnancy, Birth Weight, Medicine, Prospective Studies, Children, [Anahtar Kelime Yok], Organic Compounds, adult, steroid, Pregnancy Outcome, clinical trial, Retinopathy of prematurity, cohort analysis, Bronchopulmonary dysplasia, Necrotizing enterocolitis, Morbidity, Mortality, Health, Prematurity, Infections, Countries, Distress, Sepsis, Physical Sciences, disease severity, prospective study, survival rate, medicine.medical_specialty, Science, Article, patent ductus arteriosus, 03 medical and health sciences, Signs and Symptoms, turkey (bird), Intensive Care Units, Neonatal, Intensive care, Humans, Retinopathy of Prematurity, human, Retinopathy, necrotizing enterocolitis, MULTIDISCIPLINARY SCIENCES, Chemical Compounds, Biology and Life Sciences, Neonates, Doğa Bilimleri Genel, medicine.disease, major clinical study, neonatal intensive care unit, Health Care, hospital discharge, Ophthalmology, Low birth weight, multicenter study, NATURAL SCIENCES, GENERAL, Population Groupings, Health Statistics, Neonatology, Developmental Biology, genetic structures, morbidity, hemodynamics, Neonatal Care, Turkey (republic), Medicine and Health Sciences, Infant, Very Low Birth Weight, 030212 general & internal medicine, gestational age, Prospective cohort study, Science and technology, Multidisciplinary, Temel Bilimler, Gestational age, newborn disease, Chemistry, female, Natural Sciences (SCI), brain hemorrhage, Retinal Disorders, Steroids, Female, Neonatal Sepsis, newborn morbidity, medicine.symptom, Natural Sciences, Infants, Research Article, Adult, Birth weight, Gestational Age, Turkish Neonatal Society, Diagnostic Medicine, 030225 pediatrics, retinopathy, controlled study, outcome assessment, perinatal period, Multidisipliner, business.industry, Organic Chemistry, prematurity, Infant, Newborn, infant, Age Groups, People and Places, Study, business, Early Neonatal Outcomes
Abstract

Beken, Serdar/0000-0002-8609-2684; BAS, AHMET YAGMUR/0000-0002-1329-2167; Bulbul, Ali/0000-0002-3510-3056; Karatekin, Guner/0000-0001-7112-0323, WOS: 000534242500056, PubMed: 31851725, Objective To investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods A prospective cohort study was performed between April 1, 2016 and April 30, 2017. the study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of.1500 g were collected for infants who survived. Results Data from 69 NICUs were obtained. the mean birth weight and gestational age were 1137 +/- 245 g and 29 +/- 2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers. Conclusion the present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs., Turkish Neonatal Society [2-2016]; Turkish Neonatal Society, This study was supported by the Turkish Neonatal Society, http://www.neonatology.org.tr, number 2-2016, received by AYB. Turkish Neonatal Society funded the study's online registry system. the funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Published
2019

10. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Author

Bas, Ahmet Yagmur, Demirel, Nihal, Koc, Esin, Isik, Dilek Ulubas, Hirfanoglu, Ibrahim Murat, Tunc, Turan, Sari, Fatma Nur, Karatekin, Guner, Koklu, Esad, Altunhan, Huseyin, Turgut, Hatice, Narter, Fatma, Tarakci, Nuriye, Tekgunduz, Kadir Serafettin, Ozkiraz, Servet, Aydemir, Cumhur, Ozdemir, Ahmet, Cetinkaya, Bilin, Kazanci, Ebru, Tastekin, Ayhan, Calkavur, Sebnem, Ozyurt, Banu Mutlu, Demirelli, Yasar, Asker, Huseyin Selim, Mutlu, Birgul, Uygur, Ozgun, Ozkan, Hilal, Armangil, Didem, Ozlu, Ferda, Mert, Mustafa Kurthan, Ergin, Hacer, Ozcan, Beyza, Bas, Evrim Kiray, Okulu, Emel, Acunas, Betul, Celik, Ulker, Uslu, Sait Ilker, Mutlu, Mehmet, Demir, Nihat, Eroglu, Funda, Gokmen, Zeynel, Beken, Serdar, Bayraktar, Bilge Tanyeri, Hakan, Nilay, Kucuktasci, Kazim, Orman, Aysen, Comert, Serdar, Ertugrul, Sabahattin, Ustun, Nuran, Sahin, Ozlem, Terek, Demet, Kale, Yusuf, Konak, Murat, Yurttutan, Sadik, Aydemir, Ozge, Zenciroglu, Aysegul, Sarici, Dilek, Guzoglu, Nilufer, Hamilcikan, Sahin, Gursoy, Tugba, Tuzun, Funda, Ors, Rahmi, Arslan, Selda, Akdag, Arzu, Memisoglu, Asli, Yasa, Beril, Hekimoglu, Berna, Turan, Ozden, Aylanc, Hakan, Takci, Sahin, Celik, Tolga, Sahin, Suzan, Kilic, Ilknur, Kara, Caner, Tunay, Zuhal Ozen, Celik, Gokhan, Gozen, Ibrahim, Satirtav, Gunhal, Polat, Nihat, Oral, Ayse Yesim, Tokgoz, Mine, Keles, Sadullah, Bilgin, Burak, Ugurbas, Silay Canturk, Karaca, Cagatay, Keskek, Nedime Sahinoglu, Ekinci, Dilbade Yildiz, Balci, Ozlem, Altan, Emir Volkan, Bakbak, Sevda, Ceylan, Nihan Aksu, Kimyon, Sabit, Alyamac, Gunay, Ture, Gamze, Yildiz, Meral, Calis, Feyza, Sizmaz, Selcuk, Sukgen, Emine, Cetin, Ebru Nevin, Ozcimen, Muammer, Demir, Semra Tiryaki, Atila, Huban, Ozal, Altan, Tufaner, Gokhan, Yucel, Ozlem Eski, Kola, Mehmet, Seven, Erbil, Ozdek, Sengul, Durukan, Ali Hakan, Kal, Ali, Celebi, Ali Riza Cenk, Koytak, Ibrahim Arif, Alacamli, Goksu, Esme, Arif, Catak, Onur, Perente, Irfan, Sahin, Alparslan, Akcakaya, Aylin Ardagil, Kiray, Gulunay, Nalcaci, Serhat, Aksoy, Umit, Bakbak, Berker, Comez, Aysegul, Gursoy, Huseyin, Kabatas, Emrah Utku, Petricli, Ikbal Seza, Yumusak, Mehmet Erhan, Kirgiz, Ahmet, Uludag, Gunay, Yaman, Aylin, Dadaci, Zeynep, Karatas, Ali, Celiker, Hande, Cebeci, Zafer, Esenulku, Mahmut Cenap, Akkoyun, Imren, Ersan, Ismail, Demir, Selim, Kadayifcilar, Sibel, Unsal, Ayse Ipek Akyuz, Hocaoglu, Mumin, Grp, T. R.-R.O.P. Study, Ege Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, Çukurova Üniversitesi, Çocuk Sağlığı ve Hastalıkları, KOYTAK, İBRAHİM ARİF, Uludağ, Günay (ORCID & YÖK ID 175586), Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur, Demirel, Nihal, Koç, Esin, Işık, Dilek Ulubaş, Hirfanoğlu, İbrahim Murat, Tunç, Turan, Sarı, Fatma Nur, Karatekin, Güner, Köklü, Esad, Altunhan, Hüseyin, Turgut, Hatice, Narter, Fatma, Tarakçı, Nuriye, Tekgündüz, Kadir Şerafettin, Özkiraz, Servet, Aydemir, Cumhur, Özdemir, Ahmet, Çetinkaya, Bilin, Kazancı, Ebru, Taştekin, Ayhan, Calkavur, Şebnem, Özyurt, Banu Mutlu, Demirelli, Yaşar, Asker, Hüseyin Selim, Mutlu, Birgul, Uygur, Özgün, Özkan, Hilal, Armangil, Didem, Özlü, Ferda, Mert, Mustafa Kurthan, Ergin, Hacer, Özcan, Beyza, Baş, Evrim Kıray, Okulu, Emel, Acunas, Betül, Çelik, Ülker, Uslu, Sait İlker, Mutlu, Mehmet, Demir, Nihat, Eroğlu, Funda, Gökmen, Zeynel, Beken, Serdar, Bayraktar, Bilge Tanyeri, Hakan, Nilay, Küçüktaşçı, Kazım, Orman, Ayşen, Cömert, Serdar, Ertuğrul, Sabahattin, Üstün, Nuran, Şahin, Özlem, Terek, Demet, Kale, Yusuf, Konak, Murat, Yurttutan, Sadık, Aydemir, Özge, Zenciroğlu, Aysegül, Sarıcı, Dilek, Güzoğlu, Nilüfer, Hamilçıkan, Şahin, Tüzün, Funda, Örs, Rahmi, Arslan, Selda, Akdağ, Arzu, Memişoğlu, Aslı, Yasa, Beril, Hekimoğlu, Berna, Turan, Özden, Aylanc, Hakan, Takçı, Şahin, Çelik, Tolga, Şahin, Suzan, Kılıç, İlknur, Kara, Caner, Tunay, Zuhal Özen, Çelik, Gökhan, Gözen, İbrahim, Satırtav, Günhal, Polat, Nihat, Oral, Ayşe Yeşim, Tokgöz, Mine, Keleş, Sadullah, Bilgin, Burak, Uğurbaş, Silay Cantürk, Karaca, Çağatay, Keşkek, Nedime Şahinoğlu, Ekinci, Dilbade Yıldız, Balcı, Özlem, Altan, Emir Volkan, Bakbak, Sevda, Ceylan, Nihan Aksu, Kimyon, Sabit, Alyamaç, Günay, Türe, Gamze, Yıldız, Meral, Çalış, Feyza, Sızmaz, Selçuk, Sukgen, Emine, Çetin, Ebru Nevin, Özçimen, Muammer, Demir, Semra Tiryaki, Atila, Huban, Özal, Altan, Tufaner, Gökhan, Yücel, Özlem Eski, Kola, Mehmet, Seven, Erbil, Özdek, Şengül, Durukan, Ali Hakan, Kal, Ali, Çelebi, Ali Riza Cenk, Koytak, İbrahim Arif, Alaçamlı, Göksu, Esme, Arif, Çatak, Onur, Perente, İrfan, Şahin, Alparslan, Akçakaya, Aylin Ardagil, Kıray, Gülünay, Nalçacı, Serhat, Aksoy, Ümit, Bakbak, Berker, Çömez, Ayşegül, Gürsoy, Hüseyin, Kabataş, Emrah Utku, Petricli, İkbal Seza, Yumuşak, Mehmet Erhan, Kırgız, Ahmet, Yaman, Aylin, Dadacı, Zeynep, Karataş, Ali, Çeliker, Hande, Cebeci, Zafer, Esenülkü, Mahmut Cenap, Akkoyun, İmren, Ersan, İsmail, Demir, Selim, Kadayıfçılar, Sibel, Ünsal, Ayşe İpek Akyüz, Hocaoğlu, Mümin, School of Medicine, Department of Internal Medicine, MÜ, Kırıkkale Üniversitesi, Selçuk Üniversitesi, Bas, Ahmet Yagmur, Koc, Esin, Isik, Dilek Ulubas, Hirfanoglu, Ibrahim Murat, Tunc, Turan, Sari, Fatma Nur, Karatekin, Guner, Koklu, Esad, Altunhan, Huseyin, Tarakci, Nuriye, Tekgunduz, Kadir Serafettin, Ozkiraz, Servet, Ozdemir, Ahmet, Cetinkaya, Bilin, Kazanci, Ebru, Tastekin, Ayhan, Calkavur, Sebnem, Ozyurt, Banu Mutlu, Demirelli, Yasar, Asker, Huseyin Selim, Uygur, Ozgun, Ozkan, Hilal, Ozlu, Ferda, Ozcan, Beyza, Bas, Evrim Kiray, Acunas, Betul, Celik, Ulker, Uslu, Sait Ilker, Eroglu, Funda, Gokmen, Zeynel, Kucuktasci, Kazim, Orman, Aysen, Comert, Serdar, Ertugrul, Sabahattin, Ustun, Nuran, Sahin, Ozlem, Yurttutan, Sadik, Aydemir, Ozge, Zenciroglu, Aysegul, Sarici, Dilek, Guzoglu, Nilufer, Hamilcikan, Sahin, Gursoy, Tugba, Tuzun, Funda, Ors, Rahmi, Akdag, Arzu, Memisoglu, Asli, Hekimoglu, Berna, Turan, Ozden, Takci, Sahin, Celik, Tolga, Sahin, Suzan, Kilic, Ilknur, Tunay, Zuhal Ozen, Celik, Gokhan, Gozen, Ibrahim, Satirtav, Gunhal, Oral, Ayse Yesim, Tokgoz, Mine, Keles, Sadullah, Ugurbas, Silay Canturk, Karaca, Cagatay, Keskek, Nedime Sahinoglu, Ekinci, Dilbade Yildiz, Balci, Ozlem, Alyamac, Gunay, Ture, Gamze, Yildiz, Meral, Calis, Feyza, Sizmaz, Selcuk, Cetin, Ebru Nevin, Ozcimen, Muammer, Ozal, Altan, Tufaner, Gokhan, Yucel, Ozlem Eski, Ozdek, Sengul, Celebi, Ali Riza Cenk, Koytak, Ibrahim Arif, Alacamli, Goksu, Catak, Onur, Perente, Irfan, Sahin, Alparslan, Akcakaya, Aylin Ardagil, Kiray, Gulunay, Nalcaci, Serhat, Aksoy, Umit, Comez, Aysegul, Gursoy, Huseyin, Kabatas, Emrah Utku, Petricli, Ikbal Seza, Yumusak, Mehmet Erhan, Kirgiz, Ahmet, Uludag, Gunay, Dadaci, Zeynep, Karatas, Ali, Celiker, Hande, Esenulku, Mahmut Cenap, Akkoyun, Imren, Ersan, Ismail, Kadayifcilar, Sibel, Unsal, Ayse Ipek Akyuz, Hocaoglu, Mumin, OMÜ, Tıp Fakültesi, and Acibadem University Dspace

Subjects
Male, BLOOD-TRANSFUSION, Pediatrics, Turkey, INFANTS, Logistic regression, 0302 clinical medicine, Risk Factors, FOR-GESTATIONAL-AGE, Prevalence, Birth Weight, Infant, Very Low Birth Weight, Prospective Studies, Prospective cohort study, [Anahtar Kelime Yok], Neovascularisation, Incidence, Incidence (epidemiology), Gestational age, Retinopathy of prematurity, Clinical Science, Sensory Systems, Female, Infant, Premature, Child health (paediatrics), Retina, Treatment medical, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Birth weight, Gestational Age, Sepsis, 03 medical and health sciences, Cellular and Molecular Neuroscience, Neonatal Screening, Intensive Care Units, Neonatal, 030225 pediatrics, Intensive care, medicine, Humans, Retinopathy of Prematurity, business.industry, Child Health (paediatrics), Infant, Newborn, [No Keywords], Infant, medicine.disease, eye diseases, Ophthalmology, For-Gestational-Age, TR-ROP Study, 030221 ophthalmology & optometry, Treatment Medical, Blood-Transfusion, WEIGHT, Weight, Infants, Severity of Retinopathy, business, Medicine
Abstract

Background To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition., Methods A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA) 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses., Results The TR-ROP study included 6115 infants: 4964 (81%) with a GA 32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW, Conclusions Screening of infants with a GA

Published
2018

11. National guidelines for delivery room management.

Author

Oygür N, Önal EE, and Zenciroğlu A

Abstract

The following guideline is designed to give recommendations for the routine care of all neonates immediately after delivery, and the resuscitation and delivery room approach of all high-risk infants in light of recent literature. The guideline has been prepared as three different parts. The first part is about routine procedures that have to be performed to all healthy term and preterm infants in delivery room care. The second part summaries the basic principles of resusucitation including the latest changes that were mentioned in the International Liaison Committee on Resuscitation (ILCOR)-2015 guideline. Recommendations about the delivery room management of rare clinical conditions have been discussed in the last part. The social, medical conditions, and the resourses of Turkey have also been taken into consideration in its preparation. We hope it will be useful for all pediatricians and neonatologists for use as a essential guideline in delivery room care., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.

Published
2018
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12. Seizure due to somatostatin analog discontinuation in a case diagnosed as congenital hyperinsulinism novel mutation.

Author

Baş VN, Ozkan M, Zenciroğlu A, Cavuşoğlu YH, Cetinkaya S, and Aycan Z

Subjects
Congenital Hyperinsulinism drug therapy, Congenital Hyperinsulinism surgery, Female, Gastrointestinal Agents adverse effects, Humans, Hypoglycemia drug therapy, Hypoglycemia genetics, Hypoglycemia surgery, Infant, Infant, Newborn, Sulfonylurea Receptors, ATP-Binding Cassette Transporters genetics, Congenital Hyperinsulinism genetics, Octreotide adverse effects, Potassium Channels, Inwardly Rectifying genetics, Receptors, Drug genetics, Seizures chemically induced, Seizures genetics, Substance Withdrawal Syndrome diagnosis
Abstract

The most common reason for refractory hypoglycemia in newborns is congenital hyperinsulinism. We report a girl with congenital hyperinsulinism due to novel homozygous mutation (c.2041-25 G>A; aberrant splicing mutation) in the ABCC8 gene encoding SUR1 and during somatostatin analog (octreotide) discontinuation developed by nonhypoglycemic seizures. The newborn (birth weight of 3,750 g) was referred to our clinic because of hypoglycemic seizures at 4 h postnatal. On admission, blood glucose was 24 mg/dL and intravenous glucose infusion was started. The patient's insulin level was 27 mIU/mL during the hypoglycemic period. Phenobarbital (5 mg/ kg/day) was added because of short-acting generalized clonic seizures. Although the patient received high doses of diazoxide, esidrex, and octreotide approximately for 2 months, hypoglycemic episodes continued. Then the patient had near-total pancreatectomy, and pathology confirmed a diffuse form of congenital hyperinsulinism. There was homozygous mutation in the ABCC8 gene encoding SUR1, which confirmed the diagnosis of autosomal recessive congenital hyperinsulinism. During octreotide discontinuation, the patient developed non-hypoglycemic seizures, which were controlled by restarting the previous doses. In the light of in vitro and in vivo studies on antiepileptic effects of somatostatin, we believe that seizures in our case have developed secondary octreotide discontinuity.

Published
2012

13. Neonatal jaundice and splenic hematoma.

Author

Zenciroğlu A, Tayman C, Bas AY, and Demirel N

Subjects
Female, Follow-Up Studies, Hematoma complications, Hematoma therapy, Humans, Infant, Newborn, Jaundice, Neonatal complications, Jaundice, Neonatal therapy, Risk Assessment, Severity of Illness Index, Splenic Diseases complications, Splenic Diseases therapy, Tomography, X-Ray Computed, Treatment Outcome, Exchange Transfusion, Whole Blood methods, Hematoma diagnosis, Jaundice, Neonatal diagnosis, Splenic Diseases diagnosis
Abstract

In the newborn period, unconjugated hyperbilirubinemia (UHB) is common, multifactoral, and associated with a variety of physiologic and pathologic conditions. The most commonly identified pathologic cause leading to hyperbilirubinemia is hemolytic disease of the newborn. We report a five-days-old female infant with neonatal jaundice secondary to splenic hematoma.

Published
2006

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