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20 results on '"Zelst, B. van"'

2. Onderschat de bever niet

Author

Bos, D., Zelst, B. van, Dijkstra, V., Bos, D., Zelst, B. van, and Dijkstra, V.

Abstract

Vanwege de problemen die bevers kunnen veroorzaken, is het niet verstandig om de ontwikkeling van de populatie overal op zijn beloop te laten. Door een slimme inrichting van ons landschap en een adequaat beheer kunnen we de populatieontwikkeling richting geven.

Published
2023

3. Hoe krijgen we grote gravers op het juiste spoor?

Author

Zelst, B. van, Dijkstra, V., Teurlincx, S., Zelst, B. van, Dijkstra, V., and Teurlincx, S.

Abstract

Dassen hebben met hun gegraaf een hoop teweeggebracht de afgelopen weken. Treinverkeer in delen van Brabant en Friesland werd stilgelegd, en onder de A50 zijn dassenburchten ontdekt. Net als de das, graaft ook de bever zich een weg onder het spoor door. Hoe kunnen we het landschap zodanig inrichten dat zowel mens als natuur hier een plek hebben?

Published
2023

7. Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters

Author

Caetano-Pinto, P., Jamalpoor, A., Ham, J.C., Goumenou, A., Mommersteeg, M., Pijnenburg, D., Ruijtenbeek, R., Sanchez-Romero, N., Zelst, B. van, Heil, S.G., Jansen, J., Wilmer, M.J.G., Herpen, C.M.L. van, Masereeuw, R., Caetano-Pinto, P., Jamalpoor, A., Ham, J.C., Goumenou, A., Mommersteeg, M., Pijnenburg, D., Ruijtenbeek, R., Sanchez-Romero, N., Zelst, B. van, Heil, S.G., Jansen, J., Wilmer, M.J.G., Herpen, C.M.L. van, and Masereeuw, R.

Abstract

Contains fulltext : 174845.pdf (publisher's version ) (Open Access), The combination of methotrexate with epidermal growth factor receptor (EGFR) recombinant antibody, cetuximab, is currently being investigated in treatment of head and neck carcinoma. As methotrexate is cleared by renal excretion, we studied the effect of cetuximab on renal methotrexate handling. We used human conditionally immortalized proximal tubule epithelial cells overexpressing either organic anion transporter 1 or 3 (ciPTEC-OAT1/ciPTEC-OAT3) to examine OAT1 and OAT3, and the efflux pumps breast cancer resistance protein (BCRP), multidrug resistance protein 4 (MRP4), and P-glycoprotein (P-gp) in methotrexate handling upon EGF or cetuximab treatment. Protein kinase microarrays and knowledge-based pathway analysis were used to predict EGFR-mediated transporter regulation. Cytotoxic effects of methotrexate were evaluated using the dimethylthiazol bromide (MTT) viability assay. Methotrexate inhibited OAT-mediated fluorescein uptake and decreased efflux of Hoechst33342 and glutathione-methylfluorescein (GS-MF), which suggested involvement of OAT1/3, BCRP, and MRP4 in transepithelial transport, respectively. Cetuximab reversed the EGF-increased expression of OAT1 and BCRP as well as their membrane expressions and transport activities, while MRP4 and P-gp were increased. Pathway analysis predicted cetuximab-induced modulation of PKC and PI3K pathways downstream EGFR/ERBB2/PLCg. Pharmacological inhibition of ERK decreased expression of OAT1 and BCRP, while P-gp and MRP4 were increased. AKT inhibition reduced all transporters. Exposure to methotrexate for 24 h led to a decreased viability, an effect that was reversed by cetuximab. In conclusion, cetuximab downregulates OAT1 and BCRP while upregulating P-gp and MRP4 through an EGFR-mediated regulation of PI3K-AKT and MAPKK-ERK pathways. Consequently, cetuximab attenuates methotrexate-induced cytotoxicity, which opens possibilities for further research into nephroprotective comedication therapies.

Published
2017

9. Over de moeizame relatie tussen het Unierecht en arbitrage

Author

Zelst, B. van

Subjects
Business Law (Commercial Law), Onderneming en Algemeen Vermogensrecht, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 145499.pdf (Publisher’s version ) (Open Access) 5 p.

Published
2015

10. Dissenting opinions in arbitrage

Author

Zelst, B. van

Subjects
Business Law (Commercial Law), Onderneming en Algemeen Vermogensrecht
Abstract

Item does not contain fulltext 6 p.

Published
2015

11. Contracteren met arbiters

Author

Zelst, B. van

Subjects
Business Law (Commercial Law), Onderneming en Algemeen Vermogensrecht
Abstract

Item does not contain fulltext 8 p.

Published
2014

13. Arbitrage in de verzekeringspraktijk

Author

Kalff, M.L.S., Zelst, B. van, Klaassen, C.J.M., Tiggele-van der Velde, N. van, Ernste, P.E., Franken, A.Ch.H., Klaassen, C.J.M., Tiggele-van der Velde, N. van, Ernste, P.E., and Franken, A.Ch.H.

Subjects
Serie onderneming en recht, Business Law (Commercial Law), Onderneming en Algemeen Vermogensrecht
Abstract

Item does not contain fulltext

Published
2014

14. The Netherlands

Author

Zelst, B. van, Finizio, S., Miles, W., and Caher, C.

Subjects
Business Law (Commercial Law), Onderneming en Algemeen Vermogensrecht
Abstract

Item does not contain fulltext

Published
2014

16. Arbitrage in de verzekeringspraktijk

Author

Klaassen, C.J.M., Tiggele-van der Velde, N. van, Ernste, P.E., Franken, A.Ch.H., Kalff, M.L.S., Zelst, B. van, Klaassen, C.J.M., Tiggele-van der Velde, N. van, Ernste, P.E., Franken, A.Ch.H., Kalff, M.L.S., and Zelst, B. van

Abstract

Item does not contain fulltext

Published
2014

18. The Netherlands

Author

Finizio, S., Miles, W., Caher, C., Zelst, B. van, Finizio, S., Miles, W., Caher, C., and Zelst, B. van

Abstract

Item does not contain fulltext

Published
2014

19. De bevoor(oor)deelde arbiter: een onderzoek naar de verplichting tot arbitrale onafhankelijkheid en onpartijdigheid

Author

Ribbers, P.L.F., Snijders, H.J., Krans, H.B., Koppenol-Laforce, M.E., Haersolte-van Hof, J.J. van, Meijer, G.J., Zelst, B. van, and Leiden University

Subjects
Impartiality, Annulment, Arbitration, Arbitrator, Waiver, Disclosure, Challenge, Independence
Abstract

This thesis focuses on the duty of independence and impartiality for arbitrators. The starting point is unambiguous: an arbitrator should be independent and impartial. Less unambiguous is the answer to the question of what this duty of arbitral independence and impartiality entails. This thesis aimed to shed light on this (general) research question.The objective of this doctoral research was twofold. On the one hand, the objective was to gain insight into the way in which the duty of arbitral independence and impartiality is interpreted judicially. To this end, it was examined how the duty is interpreted in arbitration legislation, institutional rules, and (arbitral) court rulings. On the other hand, the objective was to shed light on a number of (open) questions related to the scope of the duty. In this respect, it was examined, among other things, who exactly is subject to the duty, how the duty emerges in arbitration legislation and institutional rules, what the duty aims to achieve, the question from when and to when arbitrators must be independent and impartial, and whether the parties can waive the right to an independent and impartial arbitrator.

Published
2022

20. [Untitled]

Author

Snijders, H.J., Krans, H.B., Koppenol-Laforce, M.E., Haersolte-van Hof, J.J. van, Meijer, G.J., Zelst, B. van, and Leiden University

Subjects
Impartiality, Annulment, Arbitration, Arbitrator, Waiver, Disclosure, Challenge, Independence
Abstract

This thesis focuses on the duty of independence and impartiality for arbitrators. The starting point is unambiguous: an arbitrator should be independent and impartial. Less unambiguous is the answer to the question of what this duty of arbitral independence and impartiality entails. This thesis aimed to shed light on this (general) research question.The objective of this doctoral research was twofold. On the one hand, the objective was to gain insight into the way in which the duty of arbitral independence and impartiality is interpreted judicially. To this end, it was examined how the duty is interpreted in arbitration legislation, institutional rules, and (arbitral) court rulings. On the other hand, the objective was to shed light on a number of (open) questions related to the scope of the duty. In this respect, it was examined, among other things, who exactly is subject to the duty, how the duty emerges in arbitration legislation and institutional rules, what the duty aims to achieve, the question from when and to when arbitrators must be independent and impartial, and whether the parties can waive the right to an independent and impartial arbitrator.

Published
2022

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