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2. Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D

Author

Weiss Thomas, Hergeth Sonja, Zeissler Ulrike, Izzo Annalisa, Tropberger Philipp, Zee Barry M, Dundr Miroslav, Garcia Benjamin A, Daujat Sylvain, and Schneider Robert

Subjects
Genetics, QH426-470
Abstract

Abstract Background The linker histone H1 has a key role in establishing and maintaining higher order chromatin structure and in regulating gene expression. Mammals express up to 11 different H1 variants, with H1.2 and H1.4 being the predominant ones in most somatic cells. Like core histones, H1 has high levels of covalent modifications; however, the full set of modifications and their biological role are largely unknown. Results In this study, we used a candidate screen to identify enzymes that methylate H1 and to map their corresponding methylation sites. We found that the histone lysine methyltransferases G9a/KMT1C and Glp1/KMT1D methylate H1.2 in vitro and in vivo, and we mapped this novel site to lysine 187 (H1.2K187) in the C-terminus of H1. This H1.2K187 methylation is variant-specific. The main target for methylation by G9a in H1.2, H1.3, H1.5 and H1.0 is in the C-terminus, whereas H1.4 is preferentially methylated at K26 (H1.4K26me) in the N-terminus. We found that the readout of these marks is different; H1.4K26me can recruit HP1, but H1.2K187me cannot. Likewise, JMJD2D/KDM4 only reverses H1.4K26 methylation, clearly distinguishing these two methylation sites. Further, in contrast to C-terminal H1 phosphorylation, H1.2K187 methylation level is steady throughout the cell cycle. Conclusions We have characterised a novel methylation site in the C-terminus of H1 that is the target of G9a/Glp1 both in vitro and in vivo. To our knowledge, this is the first demonstration of variant-specific histone methylation by the same methyltransferases, but with differing downstream readers, thereby supporting the hypothesis of H1 variants having specific functions.

Published
2010
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13. Syphilis

Author

Horovitz, v. Zeissl, Finger, Hochsinger, Freud, Auspitz, and Banze

Published
1885
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16. Hautkrankheiten

Author

Kaposi, Dornig, Ortmann, Horovitz, Rosenthal, Stern, H., Finger, v. Zeissl, Bildungsanomalien, and Hiorth

Published
1888
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17. Hautkrankheiten

Author

Riehl, Rosenthal, O., Szadek, Jarisch, Horovitz, v. Zeissl, Boeck, Minkowski, Breda, Finger, and Tavernier

Published
1886
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34. Hautkrankheiten.

Author

Riehl, Rosenthal, O., Szadek, Jarisch, Horovitz, Zeissl, Boeck, Minkowski, Breda, Finger, and Tavernier

Published
1888
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36. Syphilis.

Author

Horovitz, v. Zeissl, Finger, Hochsinger, Freud, Auspitz, and Banze

Published
1888
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42. Ueber extragenitale Syphilisinfection

Author

A. Pospelow, null K., null Horovitz, null Szadek, null Dornig, null Zeissl, null Finger, and O. Rosenthal

Subjects
Dermatology, General Medicine
Published
1889

43. Hautkrankheiten

Author

null Hochsinger, null Horovitz, null Riehl, null Caspary, null Finger, and null Zeissl

Subjects
Dermatology, General Medicine
Published
1886

44. Ueber 'Skerljevo'

Author

Maximilian Zeissl

Subjects
Dermatology, General Medicine
Published
1887

45. Syphilis

Author

null Horovitz, null v. Zeissl, null Finger, null Hochsinger, null Freud, null Auspitz, and null Banze

Subjects
Dermatology, General Medicine
Published
1885

46. Hautkrankheiten

Author

null Kaposi, null Dornig, null Ortmann, null Horovitz, null Rosenthal, H. Stern, null Finger, null v. Zeissl, null Bildungsanomalien, and null Hiorth

Subjects
Dermatology, General Medicine
Published
1888

47. Das sogenannte subcutane Kondylom

Author

H. Zeissl

Subjects
medicine.medical_specialty, business.industry, Medicine, Dermatology, General Medicine, business
Abstract

n/a

Published
1869

49. Pathology and Therapeutics of Acute Catarrh of the Bladder

Author

Herman Zeissl

Subjects
Pathology, medicine.medical_specialty, Fuel Technology, business.industry, medicine, Energy Engineering and Power Technology, Catarrh, General Medicine, business, medicine.disease
Abstract

n/a

Published
1865

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