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653 results on '"Zehnder M"'

7. European Society of Endodontology position statement: Management of deep caries and the exposed pulp

Author

Duncan, H F, Galler, K M, Tomson, P L, Simon, S, El-Karim, I, Kundzina, R, Krastl, G, Dammaschke, T, Fransson, H, Markvart, M, Zehnder, M, Bjørndal, L, Dummer, P M H, and University of Zurich

Subjects
Position statement, medicine.medical_specialty, VDP::Medical disciplines: 700::Clinical dentistry disciplines: 830::Preservative dental care: 831, education, 0206 medical engineering, tertiary dentinogenesis, Pulpotomy, 610 Medicine & health, 02 engineering and technology, Dental Caries, Odontologi, Dental Pulp Capping, Endodontics, 03 medical and health sciences, 0302 clinical medicine, General Dentistry, 10066 Clinic of Conservative and Preventive Dentistry, medicine, Humans, Pulpitis, pulpotomy, VDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830::Konserverende tannpleie: 831, Dental Pulp, caries, business.industry, pulp capping, vital pulp treatment, 030206 dentistry, medicine.disease, 3500 General Dentistry, 020601 biomedical engineering, Review article, Pulp capping, pulpitis, Dentistry, Family medicine, stepwise excavation, Pulp (tooth), dental pulp, business, Periapical Periodontitis
Abstract

This position statement on the management of deep caries and the exposed pulp represents the consensus of an expert committee, convened by the European Society of Endodontology (ESE). Preserving the pulp in a healthy state with sustained vitality, preventing apical periodontitis and developing minimally invasive biologically based therapies are key themes within contemporary clinical endodontics. The aim of this statement was to summarize current best evidence on the diagnosis and classification of deep caries and caries‐induced pulpal disease, as well as indicating appropriate clinical management strategies for avoiding and treating pulp exposure in permanent teeth with deep or extremely deep caries. In presenting these findings, areas of controversy, low‐quality evidence and uncertainties are highlighted, prior to recommendations for each area of interest. A recently published review article provides more detailed information and was the basis for this position statement (Bjørndal et al. 2019, International Endodontic Journal, doi:10.1111/iej.13128). The intention of this position statement is to provide the practitioner with relevant clinical guidance in this rapidly developing area. An update will be provided within 5 years as further evidence emerges.

Published
2019

9. Contrast-enhanced micro-CT to assess dental pulp tissue debridement in root canals of extracted teeth: a series of cascading experiments towards method validation

Author

De-Deus, G, Belladonna, F G, Cavalcante, D M, Simões-Carvalho, M, Silva, E J N L, Carvalhal, J C A, Zamolyi, R Q, Lopes, R T, Versiani, M A, Dummer, P M H, Zehnder, M, University of Zurich, and De-Deus, G

Subjects
10066 Clinic of Conservative and Preventive Dentistry, 610 Medicine & health, 3500 General Dentistry
Published
2021
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14. MMP-9 Levels and NaOCl Lavage in Randomized Trial on Direct Pulp Capping.

Author

Ballal, N.V., Duncan, H.F., Wiedemeier, D.B., Rai, N., Jalan, P., Bhat, V., Belle, V.S., and Zehnder, M.

Abstract

Outcome expectations of direct pulp capping in carious teeth are obscured by a clinically unknown infiltration and breakdown of the dental pulp tissue. Histologic studies showed that this soft tissue breakdown is related to the innate immune system. We hypothesized 1) that a neutrophil biomarker could predict the outcome of direct pulp capping and 2) that using sodium hypochlorite (NaOCl) as a lavage solution to remove necrotized infected pulp tissue could improve it. In this randomized trial in mature posterior teeth causing no or mild discomfort with carious pulpal exposures, pulpal fluid was collected to assess neutrophil gelatinase (matrix metalloproteinase 9 [MMP-9]) per total protein (TP) levels as a predictive local biomarker. Subsequently, the dentin-pulp wound was randomly washed with a 2.5% NaOCl or a physiologic saline solution (1:1 allocation), capped with mineral trioxide aggregate, and the tooth was immediately restored with a resin-based composite restoration. Ninety-six patients were included, and 84 individuals could be followed up to treatment failure or clinically confirmed pulp survival after a minimum of 1 y. The entire data were fitted to a Cox proportional hazards model to assess the influence of the observational variables MMP-9/TP and discomfort with the randomized lavage treatment on pulp survival. The Kaplan-Meier pulp survival rates after 1 y were 55% for saline and 89% for NaOCl lavage. The inflammatory state of the pulp tissue as reflected by MMP-9/TP levels and NaOCl lavage had a highly significant (P < 0.001 and P = 0.004, respectively) impact on pulp survival, while mild preoperative discomfort did not. In conclusion, MMP-9/TP showed great promise as a predictive local biomarker, and NaOCl lavage considerably improved the survival time of cariously exposed and directly capped pulps. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Contrast‐enhanced micro‐CT to assess dental pulp tissue debridement in root canals of extracted teeth: a series of cascading experiments towards method validation

Author

De‐Deus, G., primary, Belladonna, F. G., additional, Cavalcante, D. M., additional, Simões‐Carvalho, M., additional, Silva, E. J. N. L., additional, Carvalhal, J. C. A., additional, Zamolyi, R. Q., additional, Lopes, R. T., additional, Versiani, M. A., additional, Dummer, P. M. H., additional, and Zehnder, M., additional

Published
2020
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42. Steric control of directional isomerism in dicopper(I) helicates of asymmetrically substituted 2,2':6',2':2',6'''-quaterpyridine derivatives

Author

Constable, E.C., Heirtzler, F., Neuburger, M., and Zehnder, M.

Subjects
Isomerization -- Research, Ligand binding (Biochemistry) -- Research, Chemistry
Abstract

1H and 13C nuclear magnetic resonance spectroscopy investigations on the dicopper(I) double helicates of 2,2':6'2\2:2',6'-quaterpyridine derivatives prepared with asymmetrically substituted alkyl groups shows that helical isomer development depends upon intramolecular interaction between the constituent helicands of the double helicate. The techniques to create quaterpyridine ligands and dicopper(I) helicates are given.

Published
1997

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