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25 results on '"Zeglen, Slawomir"'

7. Routine Coronary Angiography is Still the Key Test for Patients Eligible for Lung Transplantation Also for Those With No Symptoms and With High Risk of Coronary Artery Disease

Author

Karolak, Wojtek, Pastwa, Krystyna, Addo, Salma Ali, Khan, Salin, Shinde, Reema, Nuur, Ikram Mukhtar, Kumaravel, Adith, Reta, Feven Kifle, Wojarski, Jacek, Maruszewski, Marcin, Woźniak-Grygiel, Elżbieta, Chmielecki, Michał, Frankiewicz, Anna, Nagajewski, Adam, Abba, Mary Ene, Łącka, Monika, and Żeglen, Sławomir

Published
2022
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10. Novel polymeric inhibitors of HCoV-NL63

Author

Milewska, Aleksandra, Ciejka, Justyna, Kaminski, Kamil, Karewicz, Anna, Bielska, Dorota, Zeglen, Slawomir, Karolak, Wojciech, Nowakowska, Maria, Potempa, Jan, Bosch, Berend Jan, Pyrc, Krzysztof, and Szczubialka, Krzysztof

Published
2013
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18. Entry of Human Coronavirus NL63 into the Cell

Author

Milewska, Aleksandra, primary, Nowak, Paulina, additional, Owczarek, Katarzyna, additional, Szczepanski, Artur, additional, Zarebski, Miroslaw, additional, Hoang, Agnieszka, additional, Berniak, Krzysztof, additional, Wojarski, Jacek, additional, Zeglen, Slawomir, additional, Baster, Zbigniew, additional, Rajfur, Zenon, additional, and Pyrc, Krzysztof, additional

Published
2018
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19. HTCC: Broad Range Inhibitor of Coronavirus Entry

Author

Milewska, Aleksandra, primary, Kaminski, Kamil, additional, Ciejka, Justyna, additional, Kosowicz, Katarzyna, additional, Zeglen, Slawomir, additional, Wojarski, Jacek, additional, Nowakowska, Maria, additional, Szczubiałka, Krzysztof, additional, and Pyrc, Krzysztof, additional

Published
2016
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20. Staphylococcus aureus proteases degrade lung surfactant protein a potentially impairing innate immunity of the lung

Author

Kantyka, Tomasz, Pyrc, Krzysztof, Gruca, Milosz, Smagur, Jan, Plaza, Karolina, Guzik, Krzysztof, Zeglen, Slawomir, Ochman, Marek, and Potempa, Jan

Subjects
Staphylococcus aureus, Pulmonary Surfactant-Associated Protein A, Neutrophils, biochemical phenomena, metabolism, and nutrition, Article, Immunity, Innate, Cysteine Endopeptidases, proteinases, Phagocytosis, host defense, Pneumonia, Staphylococcal, Humans, bacteriology, Lung
Abstract

The pulmonary surfactant is a complex mixture of lipids and proteins that is important for respiratory lung functions, which also provides the first line of innate immune defense. Pulmonary surfactant protein-A (SP-A) is a major surfactant component with immune functions with importance during Staphylococcus aureus infections that has been demonstrated in numerous studies. The current study showed that S. aureus can efficiently cleave the SP-A protein using its arsenal of proteolytic enzymes. This degradation appears to be mediated by cysteine proteases, in particular staphopain A (ScpA). The staphopain-mediated proteolysis of SP-A resulted in a decrease or complete abolishment of SP-A biological activity, including the promotion of S. aureus phagocytosis by neutrophils, aggregation of Gram-negative bacteria and bacterial cell adherence to epithelium. Significantly, ScpA has also efficiently degraded SP-A in complete bronchi-alveolar lavage fluid from human lungs. This indicates that staphopain activity in the lungs is resistant to protease inhibitors, thus suggesting that SP-A can be cleaved in vivo. Collectively, this study showed that the S. aureus protease ScpA is an important virulence factor that may impair innate immunity of the lungs.

Published
2013

21. Novel polymeric inhibitors of HCoV-NL63

Author

LS Virologie, Milewska, Aleksandra, Ciejka, Justyna, Kaminski, Kamil, Karewicz, Anna, Bielska, Dorota, Zeglen, Slawomir, Karolak, Wojciech, Nowakowska, Maria, Potempa, Jan, Bosch, Berend Jan, Pyrc, Krzysztof, Szczubialka, Krzysztof, LS Virologie, Milewska, Aleksandra, Ciejka, Justyna, Kaminski, Kamil, Karewicz, Anna, Bielska, Dorota, Zeglen, Slawomir, Karolak, Wojciech, Nowakowska, Maria, Potempa, Jan, Bosch, Berend Jan, Pyrc, Krzysztof, and Szczubialka, Krzysztof

Published
2013

23. Use of Sensitive, Broad-Spectrum Molecular Assays and Human Airway Epithelium Cultures for Detection of Respiratory Pathogens

Author

Pyrc, Krzysztof, primary, Stożek, Karol, additional, Wojcik, Krzysztof, additional, Gawron, Katarzyna, additional, Zeglen, Slawomir, additional, Karolak, Wojciech, additional, Wojarski, Jacek, additional, Ochman, Marek, additional, Hubalewska-Mazgaj, Magdalena, additional, Bochenek, Grazyna, additional, Sanak, Marek, additional, Zembala, Marian, additional, Szczeklik, Andrzej, additional, and Potempa, Jan, additional

Published
2012
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25. Staphylococcus aureusProteases Degrade Lung Surfactant Protein A Potentially Impairing Innate Immunity of the Lung

Author

Kantyka, Tomasz, Pyrc, Krzysztof, Gruca, Milosz, Smagur, Jan, Plaza, Karolina, Guzik, Krzysztof, Zeglen, Slawomir, Ochman, Marek, and Potempa, Jan

Abstract

AbstractThe pulmonary surfactant is a complex mixture of lipids and proteins that is important for respiratory lung functions, which also provides the first line of innate immune defense. Pulmonary surfactant protein-A (SP-A) is a major surfactant component with immune functions with importance during Staphylococcus aureusinfections that has been demonstrated in numerous studies. The current study showed that S. aureuscan efficiently cleave the SP-A protein using its arsenal of proteolytic enzymes. This degradation appears to be mediated by cysteine proteases, in particular staphopain A (ScpA). The staphopain-mediated proteolysis of SP-A resulted in a decrease or complete abolishment of SP-A biological activity, including the promotion of S. aureusphagocytosis by neutrophils, aggregation of Gram-negative bacteria and bacterial cell adherence to epithelium. Significantly, ScpA has also efficiently degraded SP-A in complete bronchi-alveolar lavage fluid from human lungs. This indicates that staphopain activity in the lungs is resistant to protease inhibitors, thus suggesting that SP-A can be cleaved in vivo. Collectively, this study showed that the S. aureusprotease ScpA is an important virulence factor that may impair innate immunity of the lungs.Copyright © 2012 S. Karger AG, Basel

Published
2013
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