1. Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes
- Author
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de Jong, Simone, van Eijk, Kristel R, Zeegers, Dave W L H, Strengman, Eric, Janson, Esther, Veldink, Jan H, van den Berg, Leonard H, Cahn, Wiepke, Kahn, René S, Boks, Marco P M, Ophoff, Roel A, Werge, Thomas Mears, Hansen, Thomas, Ingason, Andrés, Olsen, Line, Thygesen, Johan Hilge, de Jong, Simone, van Eijk, Kristel R, Zeegers, Dave W L H, Strengman, Eric, Janson, Esther, Veldink, Jan H, van den Berg, Leonard H, Cahn, Wiepke, Kahn, René S, Boks, Marco P M, Ophoff, Roel A, Werge, Thomas Mears, Hansen, Thomas, Ingason, Andrés, Olsen, Line, and Thygesen, Johan Hilge
- Abstract
There is genetic evidence that schizophrenia is a polygenic disorder with a large number of loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of schizophrenia have had limited success, with the best finding at the MHC locus at chromosome 6p. A recent effort of the Psychiatric GWAS consortium (PGC) yielded five novel loci for schizophrenia. In this study, we aim to highlight additional schizophrenia susceptibility loci from the PGC study by combining the top association findings from the discovery stage (9394 schizophrenia cases and 12 462 controls) with expression QTLs (eQTLs) and differential gene expression in whole blood of schizophrenia patients and controls. We examined the 6192 single-nucleotide polymorphisms (SNPs) with significance threshold at P
- Published
- 2012