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164 results on '"Zebekakis, Pantelis E."'

7. Gender-Related Differences in the Levels of Ambulatory BP and Intensity of Antihypertensive Treatment in Patients Undergoing Peritoneal Dialysis

Author

Kontogiorgos, Ioannis, primary, Georgianos, Panagiotis I., additional, Vaios, Vasilios, additional, Vareta, Georgia, additional, Georgianou, Eleni, additional, Karligkiotis, Apostolos, additional, Sgouropoulou, Vasiliki, additional, Kantartzi, Konstantia, additional, Zebekakis, Pantelis E., additional, and Liakopoulos, Vassilios, additional

Published
2023
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14. Prevalence of Apparent Treatment–Resistant Hypertension in ESKD Patients Receiving Peritoneal Dialysis

Author

Vareta, Georgia, primary, Georgianos, Panagiotis I, additional, Vaios, Vasilios, additional, Sgouropoulou, Vasiliki, additional, Georgianou, Eleni I, additional, Leivaditis, Konstantinos, additional, Mavromatidis, Konstantinos, additional, Dounousi, Evangelia, additional, Papagianni, Aikaterini, additional, Balaskas, Elias V, additional, Zebekakis, Pantelis E, additional, and Liakopoulos, Vassilios, additional

Published
2022
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16. Feeding during Dialysis Increases Intradialytic Blood Pressure Variability and Reduces Dialysis Adequacy

Author

Fotiadou, Elena, primary, Georgianos, Panagiotis I., additional, Vaios, Vasilios, additional, Sgouropoulou, Vasiliki, additional, Divanis, Dimitrios, additional, Karligkiotis, Apostolos, additional, Leivaditis, Konstantinos, additional, Chourdakis, Michail, additional, Zebekakis, Pantelis E., additional, and Liakopoulos, Vassilios, additional

Published
2022
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17. Epidemiology of Hypertension among Patients on Peritoneal Dialysis Using Standardized Office and Ambulatory Blood Pressure Recordings

Author

Vareta, Georgia, primary, Georgianos, Panagiotis I., additional, Vaios, Vasilios, additional, Sgouropoulou, Vasiliki, additional, Roumeliotis, Stefanos, additional, Georgoulidou, Anastasia, additional, Dounousi, Evangelia, additional, Eleftheriadis, Theodoros, additional, Papagianni, Aikaterini, additional, Balaskas, Elias V., additional, Zebekakis, Pantelis E., additional, and Liakopoulos, Vassilios, additional

Published
2022
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20. Supplemental Material, sj-doc-1-ptd-10.1177_0896860821996927 - Age dependence of brachial cuff-based ambulatory PWV in end-stage kidney disease patients undergoing long-term peritoneal dialysis

Author

Vaios, Vasilios, Georgianos, Panagiotis I, Vareta, Georgia, Divanis, Dimitrios, Dounousi, Evangelia, Eleftheriadis, Theodoros, Papagianni, Aikaterini, Zebekakis, Pantelis E, and Liakopoulos, Vassilios

Subjects
Medicine
Abstract

Supplemental Material, sj-doc-1-ptd-10.1177_0896860821996927 for Age dependence of brachial cuff-based ambulatory PWV in end-stage kidney disease patients undergoing long-term peritoneal dialysis by Vasilios Vaios, Panagiotis I Georgianos, Georgia Vareta, Dimitrios Divanis, Evangelia Dounousi, Theodoros Eleftheriadis, Aikaterini Papagianni, Pantelis E Zebekakis and Vassilios Liakopoulos in Peritoneal Dialysis International

Published
2021
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22. Physical examination for the detection of hypervolemia among patients on chronic dialysis: A diagnostic‐test study

Author

Tsikliras, Nikolaos C., primary, Georgianos, Panagiotis I., additional, Vaios, Vasilios, additional, Kousoula, Varvara, additional, Kirgialanis, Apostolos, additional, Chatzidimitriou, Christos, additional, Mavromatidis, Kostantinos, additional, Liakopoulos, Vassilios, additional, Zebekakis, Pantelis E., additional, and Balaskas, Elias V., additional

Published
2021
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26. Prevalence and control of hypertension among patients on haemodialysis

Author

Tsikliras, Nikolaos, primary, Georgianos, Panagiotis I., additional, Vaios, Vasilios, additional, Minasidis, Elias, additional, Anagnostara, Aggelina, additional, Chatzidimitriou, Christos, additional, Syrganis, Christos, additional, Liakopoulos, Vassilios, additional, Zebekakis, Pantelis E., additional, and Balaskas, Elias V., additional

Published
2020
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30. Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab

Author

Georgianos, Panagiotis I., Vaios, Vasilios, Leontaridou, Eleni, Karayannopoulou, Georgia, Koletsa, Triantafyllia, Sioulis, Athanasios, Balaskas, Elias V., and Zebekakis, Pantelis E.

Subjects
Article Subject, urologic and male genital diseases
Abstract

Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several “immune-mediated” adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3.5 months after initiation of immunotherapy with nivolumab. Urinalysis revealed sterile pyuria, without microscopic hematuria or proteinuria. Immunological examination was negative. A renal biopsy showed severe interstitial inflammatory infiltration of T-cells, monocytes, and eosinophils without interstitial granulomas and normal appearance of glomeruli, indicating acute interstitial nephritis (AIN) as the cause of AKI. After a short-term course of corticosteroids and permanent nivolumab discontinuation, partial recovery of renal function was noted. AIN is a rare adverse effect of ICPIs that mandates the close monitoring of renal function in patients under immunotherapy with these agents.

Published
2019
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34. Changes in kidney function in a population with essential hypertension in real life settings

Author

Ptinopoulou, Anastasia G., Pikilidou, Maria I., Tziolas, Ioannis M., Haidich, Anna-Bettina, Mark, Patrick B., Zebekakis, Pantelis E., and Lasaridis, Anastasios N.

Subjects
RC
Abstract

Introduction. Hypertension has been identified as one of the\ud commonest modifiable determinants for chronic kidney disease\ud progression. A variety of antihypertensive drugs are available and\ud their effect on kidney function has been investigated by a large\ud number of randomized controlled trials. Observational studies,\ud although scarcely been used, outpatient can reflect everyday\ud practice, where drug exposures vary over time, and may provide\ud an alternative for detecting longitudinal changes in kidney function.\ud Materials and Methods. We applied mixed model repeated measures\ud analysis to investigate the effect of antihypertensive drug categories\ud and their combinations on kidney function change over time in a\ud cohort of 779 patients with essential hypertension, using the data\ud from a Greek hypertension outpatient clinic. Antihypertensive\ud drugs were grouped in 5 categories. Their effect was evaluated\ud and their combinations with and without renin-angiotensin-system\ud inhibitors (RASI) to each other. In addition, the combination of\ud RASI with calcium channel blockers (CCBs) was studied.\ud Results. Diuretics, RASI, CCBs, and beta-blockers had a significant\ud renoprotective and blood pressure lowering effect. Combinations\ud with RASI had a smaller beneficial effect on kidney function\ud compared to CCBs (0.75 mL/min/1.73 m2\ud per year of drug use\ud versus 0.97 mL/min/1.73 m2). There was no additional effect\ud when combining RASI with CCBs. However, the lowering effect\ud on systolic blood pressure was greater (-0.83 mm Hg per year of\ud drug use, P < .001).\ud Conclusions. RASI were found to have a smaller, although\ud significant, renoprotective effect. There was no additional effect\ud on kidney function when combining RASI with CCBs.

Published
2017

38. Pulse Wave Velocity Assessment for Cardiovascular Risk Prognostication in ESKD: Weighting Recent Evidence

Author

Georgianos, Panagiotis I., Vaios, Vasilios, Eleftheriadis, Theodoros, Zebekakis, Pantelis E., and Liakopoulos, Vassilios

Abstract

Background: Among patients with end-stage kidney disease (ESKD), arterial stiffness is considered as a powerful predictor of cardiovascular (CV) morbidity and mortality. However, the relevance of aortic pulse wave velocity (PWV) as a prognostic biomarker for CV risk estimation is not yet fully clear. Methods: We performed a systematic search of Medline/PubMed database from inception through August 21, 2019 to identify observational cohort studies conducted in ESKD patients and exploring the association of PWV with CV events and mortality. Results: Whereas “historical” cohort studies showed aortic PWV to be associated with higher risk of CV and all-cause mortality, recent studies failed to reproduce the independent predictive value of aortic PWV in older ESKD patients. Studies using state-of-the-art prognostic tests showed that the addition of aortic PWV to standard clinical risk scores could only modestly improve CV risk reclassification. Studies associating improvement in PWV in response to blood pressure (BP)-lowering with improvement in survival cannot demonstrate direct cause-and-effect associations due to their observational design and absence of accurate methodology to assess the BP burden. Conclusion: Despite the strong pathophysiological relevance of arterial stiffness as a mediator of CV disease in ESKD, the assessment of aortic PWV for CV risk stratification in this population appears to be of limited value. Whether aortic PWV assessment is valuable in guiding CV risk factor management and whether such a therapeutic approach is translated into improvement in clinical outcomes, is an issue of clinical relevance that warrants investigation in properly-designed randomized trials.

Published
2021
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39. Comparative Epidemiology of Resistant Hypertension in Chronic Kidney Disease and the General Hypertensive Population

Author

Sarafidis, Pantelis A., Georgianos, Panagiotis I., and Zebekakis, Pantelis E.

Abstract

Until a few years ago, information regarding the epidemiology of resistant hypertension was obtained from indirect sources, such as cross-sectional studies on hypertension control in large cohorts from tertiary hypertension centers and outcome trials in hypertension. During the past 3 years, however, large population-based studies have provided direct epidemiologic data on resistant hypertension and estimated its prevalence at 8% to 12% of adult patients with hypertension. Chronic kidney disease (CKD), in particular, has been long considered a frequent underlying cause of resistant hypertension, however, recently, direct epidemiologic data for this entity in patients with CKD were brought to light again, suggesting an even higher prevalence of resistant hypertension (approximately 20%-35%) among such individuals. Furthermore, recent prospective cohort studies have suggested incident resistant hypertension to be associated with increased cardiovascular and renal risk in both the general hypertensive population and patients with CKD. This article discusses currently available data on epidemiology of resistant hypertension, providing a comparative overview of its prevalence, incidence, and prognosis in these two populations.

Published
2024
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44. Hemodiafiltration Does Not Have Additional Benefits over Hemodialysis on Arterial Stiffness, Wave Reflections and Central Aortic Pressures

Author

Georgianos, Panagiotis I., primary, Sarafidis, Pantelis A., additional, Karpetas, Antonios, additional, Kosmidis, Dimitrios, additional, Sioulis, Athanasios, additional, Liakopoulos, Vassilios, additional, Stamatiadis, Dimitrios N., additional, Papagianni, Aikaterini, additional, Zebekakis, Pantelis E., additional, Nikolaidis, Pavlos, additional, and Lasaridis, Anastasios N., additional

Published
2014
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45. Evaluation of a Novel Brachial Cuff-Based Oscillometric Method for Estimating Central Systolic Pressure in Hemodialysis Patients

Author

Sarafidis, Pantelis A., primary, Georgianos, Panagiotis I., additional, Karpetas, Antonios, additional, Bikos, Athanasios, additional, Korelidou, Linda, additional, Tersi, Maria, additional, Divanis, Dimitrios, additional, Tzanis, Georgios, additional, Mavromatidis, Konstantinos, additional, Liakopoulos, Vassilios, additional, Zebekakis, Pantelis E., additional, Lasaridis, Anastasios, additional, and Protogerou, Athanase D., additional

Published
2014
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48. Ambulatory blood pressure reduction after rosiglitazone treatment in patients with type 2 diabetes and hypertension correlates with insulin sensitivity increase

Author

Sarafidis, Panteleimon A, primary, Lasaridis, Anastasios N, additional, Nilsson, Peter M, additional, Pagkalos, Emmanuil M, additional, Hitoglou-Makedou, Areti D, additional, Pliakos, Christodoulos I, additional, Kazakos, Kiriakos A, additional, Yovos, John G, additional, Zebekakis, Pantelis E, additional, Tziolas, Ioannis M, additional, and Tourkantonis, Achilleas N, additional

Published
2004
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49. Effects of Low-Dose Atorvastatin on Arterial Stiffness and Central Aortic Pressure Augmentation in Patients With Hypertension and Hypercholesterolemia.

Author

Kanaki, Aggeliki I., Sarafidis, Pantelis A., Georgianos, Panagiotis I., Kanavos, Konstantinos, Tziolas, Ioannis M., Zebekakis, Pantelis E., and Lasaridis, Anastasios N.

Subjects
ARTERIAL diseases, HYPERCHOLESTEREMIA, HYPERTENSION risk factors, GENETIC pleiotropy, PLACEBOS, STATINS (Cardiovascular agents)
Abstract

BACKGROUND Experimental and clinical data suggest that statins exert anti-inflammatory and antiproliferative actions on vasculature beyond their lipid-lowering properties. Whether these pleiotropic effects of statins translate into a beneficial effect on arterial stiffness is not clear. This study aimed to evaluate the potential effects of low-dose atorvastatin treatment on arterial stiffness and central arterial pressure waveforms in patients with mild hypertension and hypercholesterolemia. METHODS In a double-blind, randomized, placebo-controlled fashion, 50 hypertensive and hypercholesterolemic patients were allocated to receive 10mg of atorvastatin or placebo for 26 weeks. Arterial stiffness was assessed by aortic pulse-wave velocity (PWV) using a Sphygmocor device. Central arterial pressure waveform parameters were estimated by radial artery applanation tonometry. Heart rate–adjusted augmentation index (AIx(75)) was used as measure of wave reflections. RESULTS At study end, aortic PWV (9.0±1.5 vs. 10.9±2.6 m/sec; P<0.001) and AIx(75) (24.9% ± 9.7% vs 28.8% ± 11.8%; P < 0.001) were significantly lower in the atorvastatin group than that placebo group. Furthermore, decreases in central aortic systolic blood pressure and pulse pressure were evident at study-end with atorvastatin but not with placebo (130±8 vs. 138±6mm Hg, P < 0.001; 48±7 vs. 53±6mm Hg, P < 0.05, respectively). Atorvastatin-induced reductions in aortic PWV during follow-up showed significant associations with changes in AIx(75) and central aortic systolic blood pressure and pulse pressure. CONCLUSIONS This study shows that low-dose atorvastatin treatment improves arterial stiffness and exerts a reduction on central aortic pressures. These effects may represent a potential mechanism of cardiovascular risk reduction observed with statin use. CLINICAL TRIAL REGISTRATION ClinicalTrials.gov Database Identifier Number: NCT01126684 [ABSTRACT FROM AUTHOR]

Published
2013
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