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Recent advances in immunomics have shown that T-cell receptor (TCR) signatures can accurately predict active or recent infection by leveraging the high specificity of TCR binding to disease antigens. However, the extreme diversity of the adaptive immune repertoire presents challenges in reliably identifying disease-specific TCRs. Population genetics and sequencing depth can also have strong systematic effects on repertoires, which requires careful consideration when developing diagnostic models. We present an Adaptive Immune Repertoire-Invariant Variational Autoencoder (AIRIVA), a generative model that learns a low-dimensional, interpretable, and compositional representation of TCR repertoires to disentangle such systematic effects in repertoires. We apply AIRIVA to two infectious disease case-studies: COVID-19 (natural infection and vaccination) and the Herpes Simplex Virus (HSV-1 and HSV-2), and empirically show that we can disentangle the individual disease signals. We further demonstrate AIRIVA's capability to: learn from unlabelled samples; generate in-silico TCR repertoires by intervening on the latent factors; and identify disease-associated TCRs validated using TCR annotations from external assay data.

We study nonconvex quadratic problems (QPs) with quadratic separable constraints, where these constraints can be defined both as inequalities or equalities. We derive sufficient conditions for these types of problems to present the S-property, which ultimately guarantees strong duality between the primal and dual problems of the QP. We study the existence of solutions and propose a novel distributed algorithm to solve the problem optimally when the S-property is satisfied. Finally, we illustrate our theoretical results proving that the robust least squares problem with multiple constraints has the strong duality property.

We propose Preferential MoE, a novel human-ML mixture-of-experts model that augments human expertise in decision making with a data-based classifier only when necessary for predictive performance. Our model exhibits an interpretable gating function that provides information on when human rules should be followed or avoided. The gating function is maximized for using human-based rules, and classification errors are minimized. We propose solving a coupled multi-objective problem with convex subproblems. We develop approximate algorithms and study their performance and convergence. Finally, we demonstrate the utility of Preferential MoE on two clinical applications for the treatment of Human Immunodeficiency Virus (HIV) and management of Major Depressive Disorder (MDD)., Comment: 10 pages, 5 figures, 4 tables, AMIA 2021 Virtual Informatics Summit

Filter banks are a popular tool for the analysis of piecewise smooth signals such as natural images. Motivated by the empirically observed properties of scale and detail coefficients of images in the wavelet domain, we propose a hierarchical deep generative model of piecewise smooth signals that is a recursion across scales: the low pass scale coefficients at one layer are obtained by filtering the scale coefficients at the next layer, and adding a high pass detail innovation obtained by filtering a sparse vector. This recursion describes a linear dynamic system that is a non-Gaussian Markov process across scales and is closely related to multilayer-convolutional sparse coding (ML-CSC) generative model for deep networks, except that our model allows for deeper architectures, and combines sparse and non-sparse signal representations. We propose an alternating minimization algorithm for learning the filters in this hierarchical model given observations at layer zero, e.g., natural images. The algorithm alternates between a coefficient-estimation step and a filter update step. The coefficient update step performs sparse (detail) and smooth (scale) coding and, when unfolded, leads to a deep neural network. We use MNIST to demonstrate the representation capabilities of the model, and its derived features (coefficients) for classification.

Multiagent systems where agents interact among themselves and with a stochastic environment can be formalized as stochastic games. We study a subclass named Markov potential games (MPGs) that appear often in economic and engineering applications when the agents share a common resource. We consider MPGs with continuous state-action variables, coupled constraints and nonconvex rewards. Previous analysis followed a variational approach that is only valid for very simple cases (convex rewards, invertible dynamics, and no coupled constraints); or considered deterministic dynamics and provided open-loop (OL) analysis, studying strategies that consist in predefined action sequences, which are not optimal for stochastic environments. We present a closed-loop (CL) analysis for MPGs and consider parametric policies that depend on the current state. We provide easily verifiable, sufficient and necessary conditions for a stochastic game to be an MPG, even for complex parametric functions (e.g., deep neural networks); and show that a closed-loop Nash equilibrium (NE) can be found (or at least approximated) by solving a related optimal control problem (OCP). This is useful since solving an OCP--which is a single-objective problem--is usually much simpler than solving the original set of coupled OCPs that form the game--which is a multiobjective control problem. This is a considerable improvement over the previously standard approach for the CL analysis of MPGs, which gives no approximate solution if no NE belongs to the chosen parametric family, and which is practical only for simple parametric forms. We illustrate the theoretical contributions with an example by applying our approach to a noncooperative communications engineering game. We then solve the game with a deep reinforcement learning algorithm that learns policies that closely approximates an exact variational NE of the game., Comment: Presented at ICLR2018

Demand-side management presents significant benefits in reducing the energy load in smart grids by balancing consumption demands or including energy generation and/or storage devices in the user's side. These techniques coordinate the energy load so that users minimize their monetary expenditure. However, these methods require accurate predictions in the energy consumption profiles, which make them inflexible to real demand variations. In this paper we propose a realistic model that accounts for uncertainty in these variations and calculates a robust price for all users in the smart grid. We analyze the existence of solutions for this novel scenario, propose convergent distributed algorithms to find them, and perform simulations considering energy expenditure. We show that this model can effectively reduce the monetary expenses for all users in a real-time market, while at the same time it provides a reliable production cost estimate to the energy supplier., Comment: in IEEE Transactions on Smart Grid, 2016

We analyze the problem of localization algorithms for underwater sensor networks. We first characterize the underwater channel for radio communications and adjust a linear model with measurements of real transmissions. We propose an algorithm where the sensor nodes collaboratively estimate their unknown positions in the network. In this setting, we assume low connectivity of the nodes, low data rates, and nonzero probability of lost packets in the transmission. Finally, we consider the problem of a node estimating it's position in underwater navigation. We also provide simulations illustrating the previous proposals.

We use real measurements of the underwater channel to simulate a whole underwater RF wireless sensor networks, including propagation impairments (e.g., noise, interference), radio hardware (e.g., modulation scheme, bandwidth, transmit power), hardware limitations (e.g., clock drift, transmission buffer) and complete MAC and routing protocols. The results should be useful for designing centralized and distributed algorithms for applications like monitoring, event detection, localization and aid to navigation. We also explain the changes that have to be done to Castalia in order to perform the simulations., Comment: Underwater Communications and Networking 2016

In a noncooperative dynamic game, multiple agents operating in a changing environment aim to optimize their utilities over an infinite time horizon. Time-varying environments allow to model more realistic scenarios (e.g., mobile devices equipped with batteries, wireless communications over a fading channel, etc.). However, solving a dynamic game is a difficult task that requires dealing with multiple coupled optimal control problems. We focus our analysis on a class of problems, named \textit{dynamic potential games}, whose solution can be found through a single multivariate optimal control problem. Our analysis generalizes previous studies by considering that the set of environment's states and the set of players' actions are constrained, as it is required by most of the applications. And the theoretical results are the natural extension of the analysis for static potential games. We apply the analysis and provide numerical methods to solve four key example problems, with different features each: energy demand control in a smart-grid network, network flow optimization in which the relays have bounded link capacity and limited battery life, uplink multiple access communication with users that have to optimize the use of their batteries, and two optimal scheduling games with nonstationary channels.