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4 results on '"Zayago-Angeles, Dulce M."'

1. Implication of myddosome complex genetic variants in outcome severity of COVID-19 patients

Author

Martínez-Gómez, Laura E., Martinez-Armenta, Carlos, Medina-Luna, Daniel, Ordoñez-Sánchez, María Luisa, Tusie-Luna, Tere, Ortega-Peña, Silvestre, Herrera-López, Brígida, Suarez-Ahedo, Carlos, Jimenez-Gutierrez, Guadalupe Elizabeth, Hidalgo-Bravo, Alberto, Vázquez-Cárdenas, Paola, Vidal-Vázquez, Rosa P., Ramírez-Hinojosa, Juan P., Martinez Matsumoto, Pilar Miyoko, Vargas-Alarcón, Gilberto, Posadas-Sánchez, Rosalinda, Fragoso, José-Manuel, Martínez-Ruiz, Felipe de J., Zayago-Angeles, Dulce M., Mata-Miranda, Mónica Maribel, Vázquez-Zapién, Gustavo Jesús, Martínez-Cuazitl, Adriana, Andrade-Alvarado, Javier, Granados, Julio, Ramos-Tavera, Luis, Camacho-Rea, María del Carmen, Segura-Kato, Yayoi, Rodríguez-Pérez, José Manuel, Coronado-Zarco, Roberto, Franco-Cendejas, Rafael, López-Jácome, Luis Esau, Magaña, Jonathan J., Vela-Amieva, Marcela, Pineda, Carlos, Martínez-Nava, Gabriela Angélica, and López-Reyes, Alberto

Published
2023
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2. The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes

Author

Martínez-Gómez, Laura Edith, primary, Martinez-Armenta, Carlos, additional, Tusie-Luna, Teresa, additional, Vázquez-Cárdenas, Paola, additional, Vidal-Vázquez, Rosa P., additional, Ramírez-Hinojosa, Juan P., additional, Gómez-Martín, Diana, additional, Vargas-Alarcón, Gilberto, additional, Posadas-Sánchez, Rosalinda, additional, Fragoso, José Manuel, additional, de la Peña, Aurora, additional, Rodríguez-Pérez, José Manuel, additional, Mata-Miranda, Mónica M., additional, Vázquez-Zapién, Gustavo J., additional, Martínez-Cuazitl, Adriana, additional, Martínez-Ruiz, Felipe de J., additional, Zayago-Angeles, Dulce M., additional, Ramos-Tavera, Luis, additional, Méndez-Aguilera, Alberto, additional, Camacho-Rea, María del C., additional, Ordoñez-Sánchez, María L., additional, Segura-Kato, Yayoi, additional, Suarez-Ahedo, Carlos, additional, Olea-Torres, Jessel, additional, Herrera-López, Brígida, additional, Pineda, Carlos, additional, Martínez-Nava, Gabriela A., additional, and López-Reyes, Alberto, additional

Published
2024
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3. ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men

Author

Martínez-Gómez, Laura E., primary, Herrera-López, Brígida, additional, Martinez-Armenta, Carlos, additional, Ortega-Peña, Silvestre, additional, Camacho-Rea, María del Carmen, additional, Suarez-Ahedo, Carlos, additional, Vázquez-Cárdenas, Paola, additional, Vargas-Alarcón, Gilberto, additional, Rojas-Velasco, Gustavo, additional, Fragoso, José Manuel, additional, Vidal-Vázquez, Patricia, additional, Ramírez-Hinojosa, Juan P., additional, Rodríguez-Sánchez, Yunuen, additional, Barrón-Díaz, David, additional, Moreno, Mariana L., additional, Martínez-Ruiz, Felipe de J., additional, Zayago-Angeles, Dulce M., additional, Mata-Miranda, Mónica Maribel, additional, Vázquez-Zapién, Gustavo Jesús, additional, Martínez-Cuazitl, Adriana, additional, Barajas-Galicia, Edith, additional, Bustamante-Silva, Ludwing, additional, Zazueta-Arroyo, Diana, additional, Rodríguez-Pérez, José Manuel, additional, Hernández-González, Olivia, additional, Coronado-Zarco, Roberto, additional, Lucas-Tenorio, Vania, additional, Franco-Cendejas, Rafael, additional, López-Jácome, Luis Esau, additional, Vázquez-Juárez, Rocío Carmen, additional, Magaña, Jonathan J., additional, Cruz-Ramos, Marlid, additional, Granados, Julio, additional, Hernández-Doño, Susana, additional, Delgado-Saldivar, Diego, additional, Ramos-Tavera, Luis, additional, Coronado-Zarco, Irma, additional, Guajardo-Salinas, Gustavo, additional, Muñoz-Valle, José Francisco, additional, Pineda, Carlos, additional, Martínez-Nava, Gabriela Angélica, additional, and López-Reyes, Alberto, additional

Published
2022
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4. Metabolic Reprogramming in SARS-CoV-2 Infection Impacts the Outcome of COVID-19 Patients.

Author

Martínez-Gómez, Laura E., Ibarra-González, Isabel, Fernández-Lainez, Cynthia, Tusie, Teresa, Moreno-Macías, Hortensia, Martinez-Armenta, Carlos, Jimenez-Gutierrez, Guadalupe Elizabeth, Vázquez-Cárdenas, Paola, Vidal-Vázquez, Patricia, Ramírez-Hinojosa, Juan P., Rodríguez-Zulueta, Ana P., Vargas-Alarcón, Gilberto, Rojas-Velasco, Gustavo, Sánchez-Muñoz, Fausto, Posadas-Sanchez, Rosalinda, Martínez-Ruiz, Felipe de J., Zayago-Angeles, Dulce M., Moreno, Mariana L., Barajas-Galicia, Edith, and Lopez-Cisneros, Gerardo

Subjects
COVID-19, SARS-CoV-2, TANDEM mass spectrometry, TYPE 2 diabetes, CORONAVIRUS diseases, AMINO acids
Abstract

Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) infection triggers inflammatory clinical stages that affect the outcome of patients with coronavirus disease 2019 (COVID-19). Disease severity may be associated with a metabolic imbalance related to amino acids, lipids, and energy-generating pathways. The aim of this study was to characterize the profile of amino acids and acylcarnitines in COVID-19 patients. A multicenter, cross-sectional study was carried out. A total of 453 individuals were classified by disease severity. Levels of 11 amino acids, 31 acylcarnitines, and succinylacetone in serum samples were analyzed by electrospray ionization–triple quadrupole tandem mass spectrometry. Different clusters were observed in partial least squares discriminant analysis, with phenylalanine, alanine, citrulline, proline, and succinylacetone providing the major contribution to the variability in each cluster (variable importance in the projection >1.5). In logistic models adjusted by age, sex, type 2 diabetes mellitus, hypertension, and nutritional status, phenylalanine was associated with critical outcomes (odds ratio=5.3 (95% CI 3.16-9.2) in the severe vs. critical model, with an area under the curve of 0.84 (95% CI 0.77-0.90). In conclusion the metabolic imbalance in COVID-19 patients might affect disease progression. This work shows an association of phenylalanine with critical outcomes in COVID-19 patients, highlighting phenylalanine as a potential metabolic biomarker of disease severity. [ABSTRACT FROM AUTHOR]

Published
2022
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