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Your search keyword '"Zawawi, Ayat"' showing total 27 results
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27 results on '"Zawawi, Ayat"'

3. Livelihood activities, human mobility, and risk of malaria infection in elimination settings: a case–control study

Author

Abdalal, Shaymaa A., Yukich, Joshua, Andrinopoulos, Katherine, Alghanmi, Maimonah, Wakid, Majed H., Zawawi, Ayat, Harakeh, Steve, Altwaim, Sarah A., Gattan, Hattan, Baakdah, Fadi, Gaddoury, Mahmoud A., Niyazi, Hatoon A., Mokhtar, Jawahir A., Alruhaili, Mohammed H., Alsaady, Isra, Alhabbab, Rowa, Alfaleh, Mohamed, Hashem, Anwar M., Alahmadey, Ziab Zakey, and Keating, Joseph

Published
2023
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4. Seroprevalence of Toscana and sandfly fever Sicilian viruses in humans and livestock animals from western Saudi Arabia

Author

Al-numaani, Sarah Ayman, Al-Nemari, Alaa Talat, El-Kafrawy, Sherif A., Hassan, Ahmed M., Tolah, Ahmed M., Alghanmi, Maimonah, Zawawi, Ayat, Masri, Badr Essa, Hindawi, Salwa I., Alandijany, Thamir A., Bajrai, Leena H., Bukhari, Abdullah, Mahmoud, Ahmad Bakur, Al Salem, Waleed S., Algaissi, Abdullah, Charrel, Remi N., Azhar, Esam I., and Hashem, Anwar M.

Published
2023
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5. Towards the development of a novel vaccine for Trichuris trichiura

Author

Zawawi, Ayat, Derrick, Jeremy, Brass, Andrew, and Else, Kathryn

Subjects
615.3, VLP-based vaccine, Trichuris trichiura
Abstract

Trichuris trichiura (whipworm) is a soil-transmitted helminth parasite that affects around 500 million people worldwide, resulting in disability and poor child development, especially in areas of poor hygiene and sanitation. The ideal vaccine to protect against T. trichiura in humans would include protein epitopes that elicit a protective T helper cell type 2 immune response. Herein, we used bioinformatics tools to identify candidate histocompatibility complex class II (MHC-II) molecule T-cell epitopes from known Trichuris muris proteins selected using inclusion and exclusion criteria. T. muris is the murine whipworm that is closely related to the human pathogen making it a relevant model parasite. A number of prediction tools are available for the identification of peptides that bind to MHC-II molecules. The lack of standardised methodology and the difficulty of MHC-II epitope prediction make the selection of an appropriate prediction tool difficult. This study reports a systematic review to choose the most appropriate tools to predict MHC-II epitopes. Subsequently, up to fifteen epitopes were predicted, from the selected T. muris proteins and expressed on Hepatitis B core antigen virus-like particles VLP (HBc-Ag). VLPs expressing Trichuris MHC-II T-cell epitopes were tested in vitro to address whether they could activate and be taken up by antigen-presenting cells (APCs). VLPs expressing T-cell epitopes efficiently stimulated both antigen-presenting cells (dendritic cells and macrophages) to produce a broad range of pro-inflammatory and anti-inflammatory cytokines and were internalised and well co-localized in the lysosomes of both APCs. I also immunised mice with VLPs+ T-cell epitopes prior to infection with T. muris to test the protective immune response in vivo. Notably, upon challenge infection, mice vaccinated with the VLPs+ T-cell epitopes showed a significantly reduced worm burden in the caecum and colon. Immunisation of mice with VLPs+ T-cell epitopes followed by infection induced T. muris-specific IgM and IgG2c antibody responses. High levels of VLPs+ T-cell epitopes-specific IgM and IgG2c, were also induced after challenge infections. The protection of mice by VLPs+ T-cell epitopes was also characterised by the production of mesenteric lymph node (MLN)-derived Th2 cytokines. The predicted epitopes identified using the right combination of immunoinformatics and immunogenicity screening tools have the potential to bring T. trichiura to a vaccine trial.

Published
2019

7. ACE2-Fc and DPP4-Fc decoy receptors against SARS-CoV-2 and MERS-CoV variants: A quick therapeutic option for current and future coronaviruses outbreaks

Author

Alfaleh, Mohamed A, primary, Alsulaiman, Reem M, additional, Almahboub, Sarah A, additional, Nezamuldeen, Leena, additional, Zawawi, Ayat, additional, Aljehani, Najwa D, additional, Yasir, Muhammad, additional, Abdulaal, Rwaa H, additional, Alkhaldi, Rami, additional, Helal, Assala, additional, Alamri, Sawsan S, additional, Malki, Jana, additional, Alhabbab, Rowa Y, additional, Abujamel, Turki S, additional, Alhakamy, Nabil A, additional, Alnami, Aisha, additional, Algaissi, Abdullah, additional, Hassanain, Mazen, additional, and Hashem, Anwar M, additional

Published
2023
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8. Effect of Extraction Methods on the Antioxidant Potential and Cytotoxicity of the Combined Ethanolic Extracts of Daucus carota L., Beta vulgaris L., Phyllanthus emblica L. and Lycopersicon esculentum against Gastric Adenocarcinoma Cells

Author

Chauhan, Mahima, primary, Garg, Vandana, additional, Zia, Ghazala, additional, Dutt, Rohit, additional, Alghamdi, Badrah S., additional, Zawawi, Ayat, additional, Ashraf, Ghulam Md., additional, and Farhana, Aisha, additional

Published
2023
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9. Novel curcumin nanoformulation induces apoptosis, and reduces migration and angiogenesis in liver cancer cells

Author

Harakeh, Steve, primary, Saber, Saber H., additional, Al-Raddadi, Rajaa, additional, Alamri, Turki, additional, Al-Jaouni, Soad, additional, Qari, Mohammed, additional, Qari, Yousef, additional, Haque, Shafiul, additional, Zawawi, Ayat, additional, Ali, Soad S., additional, Elmageed, Zakaria Y. Abd, additional, and Mousa, Shaker, additional

Published
2023
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10. ACE2-Fc and DPP4-Fc decoy receptors against SARS-CoV-2 and MERS-CoV variants: a quick therapeutic option for current and future coronaviruses outbreaks.

Author

Alfaleh, Mohamed A, Alsulaiman, Reem M, Almahboub, Sarah A, Nezamuldeen, Leena, Zawawi, Ayat, Aljehani, Najwa D, Yasir, Muhammad, Abdulal, Rwaa H, Alkhaldi, Rami, Helal, Assala, Alamri, Sawsan S, Malki, Jana, Alhabbab, Rowa Y, Abujamel, Turki S, Alhakamy, Nabil A, Alnami, Aisha, Algaissi, Abdullah, Hassanain, Mazen, and Hashem, Anwar M

Published
2024
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11. The importance of combining serological testing with RT-PCR assays for efficient detection of COVID-19 and higher diagnostic accuracy

Author

Alamri, Sawsan S., primary, Alsaieedi, Ahdab, additional, Khouqeer, Yousef, additional, Afeef, Marwah, additional, Alharbi, Samiyah, additional, Algaissi, Abdullah, additional, Alghanmi, Maimonah, additional, Altorki, Tarfa, additional, Zawawi, Ayat, additional, Alfaleh, Mohamed A., additional, Hashem, Anwar M., additional, and Alhabbab, Rowa, additional

Published
2023
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12. Prevalence of permethrin-resistant kdr mutation in head lice (Pediculus humanus capitis) from elementary school students in Jeddah, Saudi Arabia.

Author

Alsaady, Isra M., Altwaim, Sarah, Gattan, Hattan S., Alghanmi, Maimonah, Zawawi, Ayat, Ahmedah, Hanadi, Wakid, Majed H., and Azhar, Esam I.

Subjects
SCHOOL children, SODIUM channels, RESTRICTION fragment length polymorphisms, LICE, AMINO acid sequence, GENETIC mutation
Abstract

Head lice (Pediculus humanus capitis) are a major global concern, and there is growing evidence of an increase in head lice prevalence among Saudi schoolchildren. The purpose of this study is to investigate the prevalence of an insecticidal resistance mutation in head lice collected from schoolchildren. A polymerase chain reaction (PCR) was used to amplify a segment of the voltage-gated sodium channel gene subunit to assess the prevalence and distribution of the kdr T917I mutation in head lice. Subsequently, the restriction fragment length polymorphism (RFLP) patterns revealed two genotypic forms: homozygous-susceptible (SS) and homozygous-resistant (RR). The results showed that 17 (37.80%) of the 45 samples were SS, whereas 28 (62.2%) were RR and T917I and L920F point mutations were found in the nucleotide and amino acid sequences of RR. Compared to other nations, the frequency of permethrin resistance mutation in the head louse population in Saudi Arabia was low. This study provides the first evidence of permethrin resistance mutation in human head lice in Saudi Arabia. The findings of this study will highlight the rising incidence of the kdr mutation in head lice in Saudi Arabia. [ABSTRACT FROM AUTHOR]

Published
2023
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15. A Description of Malaria–related Knowledge, Perceptions, Practices, and Treatment– Seeking Behaviors of Migrants Workers in Jazan, Saudi Arabia

Author

Abdalal, Shaymaa A., primary, Yukich, Joshua, additional, Andrinoplous, Katherine, additional, Alghanmi, Maimonah, additional, Wakid, Majed H., additional, Zawawi, Ayat, additional, Harakeh, Steve, additional, Altwaim, Sarah, additional, Gattan, Hattan, additional, Niyazi, Hatton, additional, Alruhaili, Mohammed, additional, Keating, Joseph, additional, and Baakdah, Fadi, additional

Published
2022
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16. Livelihood Activities, Human Mobility and Risk of Malaria Infection in Elimination Settings: a Case–control Study

Author

Abdalal, Shaymaa A., primary, Yukich, Joshua, additional, Andrinoplous, Katherine, additional, Alghanmi, Maimonah, additional, Wakid, Majed H., additional, Zawawi, Ayat, additional, Harakeh, Steve, additional, Altwaim, Sarah, additional, Gattan, Hattan, additional, Baakdah, Fadi, additional, Gaddoury, Mahmoud A, additional, Niyazi, Hatton, additional, Mokhtar, Jawaher, additional, Alruhaili, Mohammed, additional, Keating, Joseph, additional, and Alsaady, Isra, additional

Published
2022
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21. Haematological, Biochemical, and Inflammatory Biomarkers of COVID-19 Patients Hospitalized in Critical Unit: A Retrospective Study

Author

Alsafi, Radi T, primary, Minshawi, Faisal, additional, Alshareef, Ahmad, additional, Althobiany, Essa, additional, Alqurashi, Afnan, additional, Zawawi, Ayat, additional, Qasem, Ahmed, additional, Halawani, Amr J, additional, Almatrafi, Mohammed, additional, Alwafi, Hassan, additional, Samannodi, Mohammed, additional, Salawati, Emad, additional, and Assaggaf, Hamza M, additional

Published
2022
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