1. [Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene PROC and genetic predisposition to unfavorable outcomes patients undergoing acute coronary syndrome].
- Author
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Agapkina IuV, Nikitin AG, Brovkin AN, Pushkov AA, Evdokimova MA, Kudriashova OIu, Osmolovskaia VS, Minushkina LO, Kochkina MS, Selezneva ND, Dankovtseva EN, Chumakova OS, Baklanova TN, Talyzin PA, Reznichenko NE, Donetskaia OP, Tereshchenko SN, Krasil'nikova ES, Dzhaiani NA, Akatova EV, Glezer MG, Galiavich AS, Zakirova VB, Kaziolova NA, Timofeeva IV, Iagoda AV, Boeva OI, Katel'nitskaia LI, Khorolets EV, Shlyk SV, Volkova ÉG, Margarian MP, Guz' IO, Konstantinov VO, Timofeeva AN, Sidorenko BA, Zateĭshchikiov DA, and Nosikov VV
- Subjects
- Alleles, Disease-Free Survival, Female, Genotype, Humans, Male, Middle Aged, Russia epidemiology, Survival Rate, Acute Coronary Syndrome genetics, Acute Coronary Syndrome mortality, Fibrinogen genetics, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Protein C genetics
- Abstract
We investigated the association of polymorphisms of genes FGB G(-455)A and PROCC(-1654)T with coronary artery disease (CAD) in the Russian population. A total of 1145 patients with CAD diagnose on the basis of clinical studies in cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol and Rostov-on-Don. Supervision term was 1.14 +/- +/- 0.33 years (the maximum term 3.2 years). The group studied do not differ significantly with respect to the distributions of G(-455)A alleles and genotypes. However in case of gene PROC C(-1654)T polymorphism we determined that patients with CAD diagnose and Talleles of PROC gene had unfavorable outcome more often than patients with homozygous C alleles. Survival time from end point from carrier phenotype TT and CTis 2.19 +/- 0.18 r. years against 2.46 +/- 0.16 from carrier phenotype CCgene PROC. The obtained data allows to assume the important role of the genes which are responsible for functioning of system of a hemostasis, in the accelerated formation of failures at the patients who had a coronary syndrome.
- Published
- 2010