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Objective: There is limited evidence for the early and rapid assessment of earthquake-related soft tissue injuries. This research examined parameters that can be utilized to identify the prognosis of patients with these injuries. Materials and Methods: This retrospective study was conducted at Erciyes University. Patients injured in the Kahramanmaraş-centered earthquake in Türkiye in 2023 were enrolled. The effect of injury types, trauma, and injury severity scores (TRISS), and specific laboratory values of the patients at the time of application on the success of soft tissue reconstruction was investigated. Results: A total of 61 patients were enrolled in the study. The median TRISS scores were 98.35 in Group 1, 88.20 in Group 2, and 57.35 in Group 3. The TRISS scores exhibited statistically significant differences between the groups. The TRISS score of Group 3 was found to be significantly lower than those of Groups 1 and 2 (p<0.001, p<0.011, respectively). Prolongation of the time spent under the wreckage and elevated TRISS scores were correlated with an increase in the number of injury debridements, a decrease in injury closure success, an increase in the frequency of Acinetobacter baumanii reproduction, an increase in the need for amputation, an increase in mortality, and hospitalization costs (p<0.05). Conclusion: In the early and rapid assessment of earthquake-related soft tissue injuries, the time spent under the wreckage and the TRISS score were crucial parameters in determining the prognosis. The parameters mentioned above may guide the management of patients with earthquake-related soft tissue injuries. [ABSTRACT FROM AUTHOR]

This study investigated the intricate interplay between Crimean‐Congo hemorrhagic fever virus (CCHFV) infection and alterations in amino acid metabolism. Our primary aim is to elucidate the impact of Crimean‐Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography‐tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease. [ABSTRACT FROM AUTHOR]

Several studies have shown a high prevalence of dyslipidemia in children. Since childhood lipid concentrations continue into adulthood, recognition of lipid abnormalities in the early period is crucial to prevent the development of future coronary heart disease (CHD). Low density lipoprotein cholesterol (LDL-C) is one of the most used parameters in the initiation and follow-up of treatment in patients with dyslipidemia. It is a well known fact that LDL-C lowering therapy reduces the risk of future CHD. Therefore, accurate determination of the LDL-C levels is so important for the management of lipid abnormalities. This study aimed to validate different LDL-C estimating equations in the Turkish population, composed of children and adolescents. A total of 3,908 children below 18 years old at Sivas Cumhuriyet University Hospital (Sivas, Turkey) were included in this study. LDL-C was directly measured by direct homogeneous assays, i.e., Roche, Beckman, Siemens and estimated by Friedewald's, Martin/Hopkins', extended Martin-Hopkins' and Sampson's formulas. The concordances between the estimations obtained by the formulas and the direct measurements were evaluated both overall and separately for the LDL-C, triglycerides (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) sublevels. Linear regression analysis was performed and residual error plots were generated between each estimation and direct measurement method. Coefficient of determination (R²) and mean absolute deviations were also evaluated. The overall concordance of Friedewald, Sampson, Martin-Hopkins and the extended Martin-Hopkins formula were 64.6%, 69.9%, 69.4%, and 84.3% for the Roche direct assay, 69.8%, 71.6%, 73.6% and 80.4% for the Siemens direct assay, 66.5%, 68.8%, 68.9% and 82.1% for the Beckman direct assay, respectively. The extended Martin-Hopkins formula had the highest concordance coefficient in both overall and all sublevels of LDL-C, non-HDL-C, and TG. When estimating the LDL-C categories, the highest underestimation degrees were obtained with the Friedewald formula. Our analysis, conducted in a large pediatric population, showed that the extended Martin-Hopkins equation gives more reliable results in estimation of LDL-C compared to other equations. [ABSTRACT FROM AUTHOR]

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