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Your search keyword '"Zaragoza, Katrin"' showing total 12 results
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12 results on '"Zaragoza, Katrin"'

3. First-in-human phase I study of the microtubule inhibitor plocabulin in patients with advanced solid tumors

Author

Elez, Elena, primary, Gomez-Roca, Carlos, additional, Soto Matos-Pita, Arturo, additional, Argiles, Guillem, additional, Valentin, Thibaud, additional, Coronado, Cinthya, additional, Iglesias, Jorge, additional, Macarulla, Teresa, additional, Betrian, Sarah, additional, Fudio, Salvador, additional, Zaragoza, Katrin, additional, Tabernero, Josep, additional, and Delord, Jean-Pierre, additional

Published
2018
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5. Anti-tumor activity of PM1183 (lurbinectedin) in combination with capecitabine in metastatic breast cancer patients: Results from a phase I trial.

Author

Awada, Ahmad, primary, Aftimos, Philippe Georges, additional, Calvo, Emiliano, additional, Boni, Valentina, additional, Moreno, Victor, additional, Doger, Bernard, additional, Luepke, Xarles Erik, additional, Zaragoza, Katrin, additional, Siguero, Mariano, additional, Kahatt, Carmen Maria, additional, Soto-Matos, Arturo, additional, Sauri, Tamara, additional, and Tabernero, Josep, additional

Published
2018
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7. CORALLEEN: A phase 2 clinical trial of chemotherapy or letrozole plus ribociclib as neoadjuvant treatment for postmenopausal patients with luminal B/HER2-negative breast cancer.

Author

Gavilá, Joaquín, primary, Saura, Cristina, additional, Oliveira, Mafalda, additional, Ortega, Vanesa, additional, Lopez, Rafael, additional, Ciruelos, Eva M., additional, Gonzalez, Xavier, additional, Zaragoza, Katrin, additional, Pelaez Rivas, Alexandra, additional, de La Pena, Lorena, additional, and Prat, Aleix, additional

Published
2017
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8. A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo

Author

Fellner, Thomas, Lackner, Daniel H., Hombauer, Hans, Piribauer, Patrick, Murdak, Ingrid, Zaragoza, Katrin, Juno, Claudia, and Ogris, Egon

Subjects
Phylogeny -- Genetic aspects, Threonine -- Physiological aspects, Serine -- Physiological aspects, Phosphatases -- Genetic aspects, Proteins -- Genetic aspects, Genetic research -- Analysis, Biological sciences
Abstract

Research has been conducted on protein phosphatase 2A. The authors describe the study of the phylogenetically conserved mechanism generating phospho-serine/threonine-specific protein phosphatase 2A in vivo.

Published
2003

11. Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation

Author

Senese, Silvia, primary, Zaragoza, Katrin, additional, Minardi, Simone, additional, Muradore, Ivan, additional, Ronzoni, Simona, additional, Passafaro, Alfonso, additional, Bernard, Loris, additional, Draetta, Giulio F., additional, Alcalay, Myriam, additional, Seiser, Christian, additional, and Chiocca, Susanna, additional

Published
2007
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12. C/EBPβΔuORF mice--a genetic model for uORF-mediated translational control in mammals.

Author

Wethmar, Klaus, Bégay, Valérie, Smink, Jeske J., Zaragoza, Katrin, Wiesenthal, Volker, Dörken, Bernd, Calkhoven, Cornelis F., and Leutz, Achim

Subjects
*GENETIC models, *LIVER regeneration, *CELL cycle, *CARRIER proteins, *LIVER cells, *OSTEOCLASTS, *LABORATORY rats
Abstract

Upstream ORFs (uORFs) are translational control elements found predominantly in transcripts of key regulatory genes. No mammalian genetic model exists to experimentally validate the physiological relevance of uORF-regulated translation initiation. We report that mice deficient for the CCAAT/enhancer-binding protein β (C/EBPβ) uORF initiation codon fail to initiate translation of the autoantagonistic LIP (liver inhibitory protein) C/EBPβ isoform. C/EBPβΔuORF mice show hyperactivation of acute-phase response genes, persistent repression of E2F-regulated genes, delayed and blunted S-phase entry of hepatocytes after partial hepatectomy, and impaired osteoclast differentiation. These data and the widespread prevalence of uORFs in mammalian transcriptomes suggest a comprehensive role of uORF-regulated translation in (patho)physiology. [ABSTRACT FROM AUTHOR]

Published
2010

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