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4. Self-medication practice in pregnant women from central Mexico

Author

Alonso-Castro, Angel Josabad, Ruiz-Padilla, Alan Joel, Ruiz-Noa, Yeniley, Alba-Betancourt, Clara, Domínguez, Fabiola, Ibarra-Reynoso, Lorena Del Rocío, Maldonado-Miranda, Juan José, Carranza-Álvarez, Candy, Blanco-Sandate, Christian, Ramírez-Morales, Marco Antonio, Zapata-Morales, Juan Ramón, Deveze-Álvarez, Martha Alicia, Mendoza-Macías, Claudia Leticia, Solorio-Alvarado, Cesar Rogelio, and Rangel-Velázquez, Joceline Estefanía

Published
2018
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8. Neuropharmacological Activities of Ceiba aesculifolia (Kunth) Britten & Baker f (Malvaceae)

Author

Bustos-Gómez, Chrystyan Iván, primary, Gasca-Martínez, Deisy, additional, Yáñez-Barrientos, Eunice, additional, Hidalgo-Figueroa, Sergio, additional, Gonzalez-Rivera, Maria L., additional, Barragan-Galvez, Juan Carlos, additional, Zapata-Morales, Juan Ramón, additional, Isiordia-Espinoza, Mario, additional, Corrales-Escobosa, Alma Rosa, additional, and Alonso-Castro, Angel Josabad, additional

Published
2022
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9. Antinociceptive effects of Laelia anceps Lindl. and Cyrtopodium macrobulbon (Lex.) G.A. Romero & Carnevali, and comparative evaluation of their metabolomic profiles

Author

Yáñez-Barrientos, Eunice, primary, González-Ibarra, Alan Alexander, additional, Wrobel, Kazimierz, additional, Wrobel, Katarzyna, additional, Corrales-Escobosa, Alma Rosa, additional, Alonso-Castro, Angel Josabad, additional, Carranza-Álvarez, Candy, additional, Ponce-Hernández, Amauri, additional, Isiordia-Espinoza, Mario Alberto, additional, Ortiz-Andrade, Rolffy, additional, Torres-Gutiérrez, Karen Lizbeth, additional, Luna-Rubio, Sarahí, additional, and Zapata-Morales, Juan Ramón, additional

Published
2022
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11. In vitro and In vivo Synergistic Interactions of the Flavonoid Rutin with Paracetamol and with Non-Steroidal Anti-Inflammatory Drugs

Author

Zapata-Morales, Juan Ramón, primary, Alonso-Castro, Angel Josabad, additional, Muñoz-Martínez, Gloria Sarahí, additional, Martínez-Rodríguez, María Mayela, additional, Nambo-Arcos, Mónica Esther, additional, Brennan-Bourdon, Lorena Michele, additional, Aragón-Martínez, Othoniel Hugo, additional, and Martínez-Morales, Jesús Flavio, additional

Published
2021
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13. ANTINOCICEPTIVE EFFECT OF 4-ALLYL-2-METHOXYPHENOL AND DICLOFENAC CO-ADMINISTRATION IN THE FORMALIN TEST IN RATS.

Author

GONZÁLEZ-LUGO, OLGA EDITH, ZAPATA-MORALES, JUAN RAMÓN, POZOS GUILLÉN, AMAURY DE JESÚS, CAMACHO LUIS, ABELARDO, PONCE PEÑA, PATRICIA, RANGEL LÓPEZ, AZAHEL DE JESÚS, and VÉRTIZ HERNÁNDEZ, ANGEL ANTONIO

Subjects
DICLOFENAC, FORMALDEHYDE, OPIOID analgesics, CLOVE tree, RATS
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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15. Anti-inflammatory and antinociceptive effects of an ethanol extract from Senna septemtrionalis

Author

Arana-Argáez, Víctor Ermilo, primary, Domínguez, Fabiola, additional, Moreno, Diego A., additional, Isiordia-Espinoza, Mario Alberto, additional, Lara-Riegos, Julio Cesar, additional, Ceballos-Góngora, Emanuel, additional, Zapata-Morales, Juan Ramón, additional, Franco-de la Torre, Lorenzo, additional, Sánchez-Enríquez, Sergio, additional, and Alonso-Castro, Angel Josabad, additional

Published
2019
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17. Diuretic activity and neuropharmacological effects of an ethanol extract from Senna septemtrionalis (Viv.) H.S. Irwin & Barneby (Fabaceae)

Author

Alonso-Castro, Angel Josabad, primary, Alba-Betancourt, Clara, additional, Yáñez-Barrientos, Eunice, additional, Luna-Rocha, Cynthia, additional, Páramo-Castillo, Astrid Selene, additional, Aragón-Martínez, Othoniel H., additional, Zapata-Morales, Juan Ramón, additional, Cruz-Jiménez, Gustavo, additional, Gasca-Martínez, Deisy, additional, González-Ibarra, Alan Alexander, additional, Álvarez-Camacho, Daniel Antonio, additional, and Devezé-Álvarez, Martha Alicia, additional

Published
2019
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18. Self-treatment with herbal products for weight-loss among overweight and obese subjects from central Mexico

Author

Alonso-Castro, Angel Josabad, primary, Ruiz-Padilla, Alan Joel, additional, Ramírez-Morales, Marco Antonio, additional, Alcocer-García, Sara Guadalupe, additional, Ruiz-Noa, Yeniley, additional, Ibarra-Reynoso, Lorena Del Rocío, additional, Solorio-Alvarado, Cesar Rogelio, additional, Zapata-Morales, Juan Ramón, additional, Mendoza-Macías, Claudia Leticia, additional, Deveze-Álvarez, Martha Alicia, additional, and Alba-Betancourt, Clara, additional

Published
2019
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19. Antinociception and less gastric injury with the dexketoprofen‐tapentadol combination in mice.

Author

Franco de la‐Torre, Lorenzo, Alonso‐Castro, Ángel Josabad, Zapata‐Morales, Juan Ramón, Rivas‐Carrillo, Jorge David, Vidaurrazaga‐Lugo, José, Partida‐Castellanos, Elsa Maria, Granados‐Soto, Vinicio, and Isiordia‐Espinoza, Mario Alberto

Subjects
VISCERAL pain, MICE, WOUNDS & injuries, STOMACH
Abstract

The purpose of this study was to evaluate the antinociceptive interaction between dexketoprofen and tapentadol in three different dose ratios, as well as the ulcerogenic activity of this combination. Dose–response curves were carried out for dexketoprofen, tapentadol, and dexketoprofen–tapentadol combinations in the acetic acid‐induced writhing test in mice. On the other hand, the gastric damage of all treatments was assessed after the surgical extraction of the stomachs. Intraperitoneal administration of dexketoprofen and tapentadol induced a dose‐dependent antinociceptive effect, reaching a maximal effect of about 58% and 99%, respectively. Isobolographic analysis and the interaction index showed that the three proportions produced an analgesic potentiation (synergistic interaction). Interestingly, the 1:1 and 1:3 ratios of the drugs combination produced minor gastric injury in comparison with the 3:1 proportion. Our data suggest that all proportions of the dexketoprofen–tapentadol combination produced a synergistic interaction in the acetic acid‐induced visceral pain model in mice with a low incidence of gastric injury. [ABSTRACT FROM AUTHOR]

Published
2021
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21. Pharmacological and toxicological study of a chemical-standardized ethanol extract of the branches and leaves from Eysenhardtia polystachya (Ortega) Sarg. (Fabaceae)

Author

Alonso-Castro, Angel Josabad, primary, Zapata-Morales, Juan Ramón, additional, Arana-Argáez, Victor, additional, Torres-Romero, Julio Cesar, additional, Ramírez-Villanueva, Eyra, additional, Pérez-Medina, Sabino Eduardo, additional, Ramírez-Morales, Marco Antonio, additional, Juárez-Méndez, Mario Alberto, additional, Infante-Barrios, Yessica Paola, additional, Martínez-Gutiérrez, Fidel, additional, Carranza-Álvarez, Candy, additional, Isiordia-Espinoza, Mario Alberto, additional, and Flores-Santos, Andrés, additional

Published
2018
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24. Chemical characterization, pharmacological effects, and toxicity of an ethanol extract of Celtis pallida Torr. (Cannabaceae) aerial parts

Author

Rojas-Bedolla, Edgar Isaac, primary, Gutiérrez-Pérez, Jorge Luis, additional, Arenas-López, Mario Iván, additional, González-Chávez, Marco Martin, additional, Zapata-Morales, Juan Ramón, additional, Mendoza-Macías, Claudia Leticia, additional, Carranza-Álvarez, Candy, additional, Maldonado-Miranda, Juan José, additional, Deveze-Álvarez, Martha Alicia, additional, and Alonso-Castro, Angel Josabad, additional

Published
2018
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25. Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Author

Alonso-Castro, Angel Josabad, Domínguez, Fabiola, Ruiz-Padilla, Alan Joel, Campos-Xolalpa, Nimsi, Zapata-Morales, Juan Ramón, Carranza-Alvarez, Candy, and Maldonado-Miranda, Juan Jose

Subjects
Article Subject, fungi, food and beverages
Abstract

The consumption of medicinal plants has notably increased over the past two decades. People consider herbal products as safe because of their natural origin, without taking into consideration whether these plants contain a toxic principle. This represents a serious health problem. A bibliographic search was carried out using published scientific material on native plants from Mexico, Central America, and the Caribbean, which describe the ethnobotanical and toxicological information of medicinal plants empirically considered to be toxic. A total of 216 medicinal plants belonging to 77 families have been reported as toxic. Of these plants, 76 had been studied, and 140 plants lacked studies regarding their toxicological effects. The toxicity of 16 plants species has been reported in clinical cases, particularly in children. From these plants, deaths have been reported with the consumption of Chenopodium ambrosioides, Argemone mexicana, and Thevetia peruviana. In most of the cases, the principle of the plant responsible for the toxicity is unknown. There is limited information about the toxicity of medicinal plants used in Mexico, Central America, and the Caribbean. More toxicological studies are necessary to contribute information about the safe use of the medicinal plants cited in this review.

Published
2017
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26. Antinociceptive Activity of Ent-Dihydrotucumanoic Acid Isolated fromGymnosperma glutinosumSpreng Less

Author

Alonso-Castro, Angel Josabad, primary, González-Chávez, Marco Martin, additional, Zapata-Morales, Juan Ramón, additional, Verdinez-Portales, Alexia Karina, additional, Sánchez-Recillas, Amanda, additional, Ortiz-Andrade, Rolffy, additional, Isiordia-Espinoza, Mario, additional, Martínez-Gutiérrez, Fidel, additional, Ramírez-Morales, Marco Antonio, additional, Domínguez, Fabiola, additional, Juache-Flores, María Elizabeth, additional, and Martínez, Roberto, additional

Published
2017
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29. Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Author

Alonso Castro, Angel Josabad, Domínguez, Fabiola, Ruiz Padilla, Alan Joel, Campos Xolalpa, Nimsi, Zapata Morales, Juan Ramón, Carranza Alvarez, Candy, Maldonado Miranda, Juan Jose, Alonso Castro, Angel Josabad, Domínguez, Fabiola, Ruiz Padilla, Alan Joel, Campos Xolalpa, Nimsi, Zapata Morales, Juan Ramón, Carranza Alvarez, Candy, and Maldonado Miranda, Juan Jose

Published
2017

30. Hydrocortisone release from tablets based on bioresorbable poly(ether-ester-urethane)s

Author

Universidad de Guanajuato, Consejo Nacional de Ciencia y Tecnología (México), Ministerio de Economía y Competitividad (España), Orozco-Castellanos, Luis Manuel, Marcos-Fernández, Ángel, Alonso Castro, Angel Josabad, González-García, Gerardo, Báez-García, José Eduardo, Rivera-Leyva, Julio Cesar, Zapata-Morales, Juan Ramón, Ruiz-Padilla, Alan Joel, Universidad de Guanajuato, Consejo Nacional de Ciencia y Tecnología (México), Ministerio de Economía y Competitividad (España), Orozco-Castellanos, Luis Manuel, Marcos-Fernández, Ángel, Alonso Castro, Angel Josabad, González-García, Gerardo, Báez-García, José Eduardo, Rivera-Leyva, Julio Cesar, Zapata-Morales, Juan Ramón, and Ruiz-Padilla, Alan Joel

Abstract

Bioresorbable linear poly(ether-ester-urethane)s with different hydrophilic characteristics were synthesized from triblock copolymers of poly(¿-caprolactone)-poly(ethylene oxide)-poly(¿-caprolactone) (PCL-PEO) as macrodiols, and L-lysine diisocyanate (LDI) or hexamethylenediisocyanate (HDI) were used as the required diisocyanates. Macrodiols were obtained by ring-opening polymerization (ROP) of ¿-caprolactone (CL). Polyurethanes were synthesized by the reaction of the triblock copolymers with LDI or HDI in solution using stannous 2-ethylhexanoate as catalyst. Polyurethane tablets were fabricated and investigated as prospective drug delivery systems. The effect of the PEO content on the polymers¿ performance as drug carriers was evaluated. It was found that water provoked more swelling and erosion of polymers with higher contents of PEO. The hydrocortisone release profiles were analyzed using the Ritger-Peppas approximation. An anomalous release behaviour (values of n higher than 0.5) was found for most of the analyzed samples

Published
2017

31. Use of medicinal plants by health professionals in Mexico

Author

Alonso-Castro, Angel Josabad, primary, Domínguez, Fabiola, additional, Maldonado-Miranda, Juan José, additional, Castillo-Pérez, Luis Jesús, additional, Carranza-Álvarez, Candy, additional, Solano, Eloy, additional, Isiordia-Espinoza, Mario Alberto, additional, del Carmen Juárez-Vázquez, María, additional, Zapata-Morales, Juan Ramón, additional, Argueta-Fuertes, Marco Antonio, additional, Ruiz-Padilla, Alan Joel, additional, Solorio-Alvarado, César Rogelio, additional, Rangel-Velázquez, Joceline Estefanía, additional, Ortiz-Andrade, Rolffy, additional, González-Sánchez, Ignacio, additional, Cruz-Jiménez, Gustavo, additional, and Orozco-Castellanos, Luis Manuel, additional

Published
2017
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37. Anti‐inflammatory and antinociceptive effects of tilifodiolide, isolated from Salvia tiliifolia Vahl (Lamiaceae).

Author

González‐Chávez, Marco Martin, Alonso‐Castro, Angel Josabad, Zapata‐Morales, Juan Ramón, Arana‐Argáez, Víctor, Torres‐Romero, Julio Cesar, Medina‐Rivera, Yessica Elisa, Sánchez‐Mendoza, Ernesto, and Pérez‐Gutiérrez, Salud

Subjects
ANTI-inflammatory agents, LAMIACEAE, ANALGESICS, PAIN management, DRUG administration, THERAPEUTICS
Abstract

Abstract: Salvia tiliifolia Vahl (Lamiaceae) is used for the empirical treatment of pain and inflammation. The diterpenoid tilifodiolide (TFD) was isolated from Salvia tiliifolia. The in vitro anti‐inflammatory effects of TFD (0.1–200 µM) were assessed using murine macrophages stimulated with LPS and estimating the levels of pro‐inflammatory mediators for 48 h. The in vivo anti‐inflammatory activity of TFD was assessed using the carrageenan‐induced paw edema test for 6 h. The antinociceptive effects of TFD were evaluated using the formalin test and the acetic acid induced‐writhing test. The effects of TFD on locomotor activity were assessed using the open field test and the rotarod test. TFD inhibited the production of TNF‐α (IC50 = 5.66 µM) and IL‐6 (IC50 = 1.21 µM) in macrophages. TFD (200 mg/kg) showed anti‐inflammatory effects with similar activity compared to 10 mg/kg indomethacin. The administration of TFD induced antinociception in the phase 1 (ED50 = 48.2 mg/kg) and the phase 2 (ED50 = 28.9 mg/kg) of the formalin test. In the acetic acid assay, TFD showed antinociceptive effects (ED50 = 32.3 mg/kg) with similar potency compared to naproxen (ED50 = 36.2 mg/kg). In the presence of different inhibitors in the acetic acid assay, only the co‐administration of TFD and naloxone reverted the antinociceptive activity shown by TFD alone. TFD did not affect locomotor activity in mice. TFD exerts in vitro and in vivo anti‐inflammatory activity and in vivo antinociceptive effects. [ABSTRACT FROM AUTHOR]

Published
2018
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41. Antinociceptive Activity of Ent-Dihydrotucumanoic Acid Isolated from Gymnosperma glutinosum Spreng Less.

Author

Alonso ‐ Castro, Angel Josabad, González ‐ Chávez, Marco Martin, Zapata ‐ Morales, Juan Ramón, Verdinez ‐ Portales, Alexia Karina, Sánchez ‐ Recillas, Amanda, Ortiz ‐ Andrade, Rolffy, Isiordia ‐ Espinoza, Mario, Martínez ‐ Gutiérrez, Fidel, Ramírez ‐ Morales, Marco Antonio, Domínguez, Fabiola, Juache ‐ Flores, María Elizabeth, and Martínez, Roberto

Subjects
GYMNOSPERMS, ANALGESICS, ANTI-inflammatory agents, SEDATIVES, ANTINEOPLASTIC agents
Abstract

ABSTRACT [ABSTRACT FROM AUTHOR]

Published
2017
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42. The antinociceptive effects of a standardized ethanol extract of the Bidens odorata Cav (Asteraceae) leaves are mediated by ATP-sensitive K+ channels.

Author

Zapata-Morales, Juan Ramón, Alonso-Castro, Angel Josabad, Domínguez, Fabiola, Carranza-Álvarez, Candy, Isiordia-Espinoza, Mario, Hernández-Morales, Alejandro, and Solorio-Alvarado, Cesar

Subjects
*ADENOSINE triphosphate, *ANTI-inflammatory agents, *BIOLOGICAL models, *DNA, *EAR, *EDEMA, *HYPOGLYCEMIC sulfonylureas, *MICE, *NALOXONE, *PAIN management, *PLANT extracts
Abstract

Ethnopharmacological relevance Bidens odorata Cav (Asteraceae) is used for the empirical treatment of inflammation and pain. Aim of the study This work evaluated the in vitro and in vivo toxicity, antioxidant activity, as well as the anti-inflammatory and antinociceptive effects of an ethanol extract from Bidens odorata leaves (BOE). Materials and methods The in vitro toxicity of BOE (10–1000 µg/ml) was evaluated with the comet assay in PBMC. The in vivo acute toxicity of BOE (500–5000 mg/kg) and the effect of BOE (10–1000 µg/ml) on the level of ROS in PBMC were determined. The in vivo anti-inflammatory activity of BOE was assessed using the TPA-induced ear edema in mice. The antinociceptive activities of BOE (50–200 mg/kg p.o.) were assessed using the acetic acid and formalin tests. The antinociceptive mechanism of BOE was determined using naloxone and glibenclamide. Results BOE lacked DNA damage, and showed low in vivo toxicity (LD 50 > 5000 mg/kg p.o.). BOE inhibited ROS production (IC 50 = 252.13 ± 20.54 µg/ml), and decreased inflammation by 36.1 ± 3.66%. In both antinociceptive test, BOE (200 mg/kg) exerted activity with similar activity than the reference drugs. Conclusion B. odorata exerts low in vitro and in vivo toxicity, antioxidant effects, moderate in vivo anti-inflammatory activity, and antinociceptive effects mediated by ATP-sensitive K + channels. [ABSTRACT FROM AUTHOR]

Published
2017
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43. Antinociceptive Activity of an Ethanol Extract of Justicia spicigera.

Author

Zapata ‐ Morales, Juan Ramón, Alonso ‐ Castro, Angel Josabad, Domínguez, Fabiola, Carranza ‐ Álvarez, Candy, Castellanos, Luis Manuel Orozco, Martínez ‐ Medina, Rosa María, and Pérez ‐ Urizar, José

Subjects
*HERBAL medicine, *JUSTICIA americana, *NONSTEROIDAL anti-inflammatory agents, *ANALGESICS, *PLANT extracts
Abstract

The aim of the present study was to evaluate the antinociceptive and sedative activity of an ethanol extract of Justicia spicigera an evergreen used in Mexican traditional medicine for the relief of pain, wounds, fever and inflammation. At 200 mg/kg po, the maximum dose examined, the ethanol extract of J. spicigera (JSE) had analgesic activity in mice in the acetic acid writhing test, the second phase of the formalin test and the tail flick test that was similar in efficacy to the NSAID, naproxen (150 mg/kg po). JSE was inactive in the hot plate test and and the ketamine-induced sleeping time test; it had no sedative effects. These results show that the ethanol extract from the leaves of J. spicigera has antinociceptive effects in mice without inducing sedation. [ABSTRACT FROM AUTHOR]

Published
2016
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44. Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.

Author

Orozco-Solís, Mariana, García-Ávalos, Yazmín, Pichardo-Ramírez, Celeste, Tobías-Azúa, Francisco, Zapata-Morales, Juan-Ramón, Aragon-Martínez, Othoniel-Hugo, and Isiordia-Espinoza, Mario-Alberto

Subjects
DICLOFENAC, POSTOPERATIVE pain prevention, TRISMUS, THIRD molar surgery, DENTAL extraction, ORAL surgery, LYMPHEDEMA, PREVENTION, SURGICAL complications, THERAPEUTICS
Abstract

Background: Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, with pain peaking between 6 and 8 hours when a conventional local anesthetic is used. Dental pain is largely inflammatory, and evidence-based medicine has shown that nonsteroidal anti-inflammatory drugs are the best analgesics for dental pain. The aim of this study was to compare the analgesic, anti-inflammatory and anti-trismus effect of a single dose of diclofenac and meloxicam after mandibular third molar extraction. Material and Methods: A total of 36 patients were randomized into two treatment groups, each with 18 patients, using a series of random numbers: Group A, was administered 100 mg of diclofenac; and Group B, 15 mg of meloxicam. Drugs were administered orally 1 hour prior to surgery. We evaluated pain intensity, analgesic consumption, swelling, as well as trismus. Results: The results of this study showed that patients receiving 15 mg of meloxicam had less postoperative pain (P=0.04) and better aperture than those receiving 100 mg of diclofenac (P=0.03). The meloxicam group presented less swelling than diclofenac group; however, significant statistical differences were not observed. Conclusions: Data of this double-blind, randomized, parallel-group clinical trial demonstrated that patients receiving 15 mg of preoperative meloxicam had a better postoperative analgesia and anti-trismus effect compared with who were given 100 mg of diclofenac after third molar extractions. [ABSTRACT FROM AUTHOR]

Published
2016
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