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Vincenzo Nobile,1 Eleonora Spartà ,1 Valentina Zanoletti,1 Francesco Sandolo,2 Enza Cestone2 1R&D Department, Complife Italia, San Martino Siccomario, PV, Italy; 2In vivo Testing Department, Complife Italia, San Martino Siccomario, PV, ItalyCorrespondence: Vincenzo Nobile, R&D Department, Complife Italia, San Martino Siccomario, 27028 PV, Italy, Tel + 39 0382 25504, Fax +39 0382 536006, Email vincenzo.nobile@complifegroup.comPurpose: The present study was aimed at evaluating the efficacy of a cosmetic product in improving the appearance of periocular skin.Patients and Methods: An open-label study on 40 female subjects showing clinical signs of skin aging in the periocular area (including bags under the eye and dark circles) was conducted. At day 0 and day 28 the bags under eye volume, dark circles color, skin texture, skin moisturization, skin elasticity, and skin radiance were measured. The instrumental measurements were integrated by clinical analysis carried out by a board-certified dermatologist and by a self-assessment questionnaire carried out by each subject participating in the study.Results: After 28 days of product use the volume of the bags under the eye was decreased by 6.8% (p = 0.005), the dark circle color red and blue component improved by 7.1% (p = 0.001) and 4.0% (p = 0.001), respectively, wrinkle depth and skin roughness decreased by 15.8% (p = 0.001) and 6.3% (p = 0.011), respectively, skin moisturization increased by 11.7% (p = 0.000), the skin distensibility decreased by 8.9% (p = 0.000), the overall skin elasticity increased by 10.4% (p = 0.000), and the skin radiance increased by 16.3% (p = 0.000). The instrumental measured effects were also confirmed by the clinical analysis of the dermatologist and the self-assessment questionnaire output.Conclusion: Conclusions: our results suggest that the test product is effective for periocular skin aesthetics (reduction of imperfections undermining the periocular area) and wellness.Keywords: ba