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1. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Author

Han, L.K.M., Dinga, R., Hahn, T., Ching, C.R., Eyler, L.T., Aftanas, L., Aghajani, M., Aleman, A., Baune, B.T., Berger, K., Brak, I., Filho, G.B., Carballedo, A., Connolly, C.G., Couvy-Duchesne, B., Cullen, K.R., Dannlowski, U., Davey, C.G., Dima, D., Duran, F.L.S., Enneking, V., Filimonova, E., Frenzel, S., Frodl, T., Fu, C.H.Y., Godlewska, B.R., Gotlib, I.H., Grabe, H.J., Groenewold, N.A., Grotegerd, D., Gruber, O., Hall, G.B., Harrison, B.J., Hatton, S.N., Hermesdorf, M., Hickie, I.B., Ho, T.C., Hosten, N., Jansen, Andreas, Kähler, C., Kircher, T., Klimes-Dougan, B., Krämer, B., Krug, A., Lagopoulos, J., Leenings, R., MacMaster, F.P., MacQueen, G., McIntosh, A., McLellan, Q., McMahon, K.L., Medland, S.E., Mueller, B.A., Mwangi, B., Osipov, E., Portella, M.J., Pozzi, E., Reneman, L., Repple, J., Rosa, P.G., Sacchet, M.D., Sämann, P.G., Schnell, K., Schrantee, A., Simulionyte, E., Soares, J.C., Sommer, J., Stein, D.J., Steinsträter, O., Strike, L.T., Thomopoulos, S.I., Tol, M.J.D. van, Veer, I.M., Vermeiren, R., Walter, H., Wee, N.J.A. van der, Werff, S.J.A. van der, Whalley, H., Winter, N.R., Wittfeld, K., Wright, M.J., Wu, M.J., Völzke, H., Yang, T.T., Zannias, V., Zubicaray, G.I. de, Zunta-Soares, G.B., Abé, C., Alda, M., Andreassen, O.A., Bøen, E., Bonnin, C.M., Canales-Rodriguez, E.J., Cannon, D., Caseras, X., Chaim-Avancini, T.M., Elvsåshagen, T., Favre, P., Foley, S.F., Fullerton, J.M., Ruhé, H.G., Schene, A.H., Marquand, A.F., Cole, J., Schmaal, L., Han, L.K.M., Dinga, R., Hahn, T., Ching, C.R., Eyler, L.T., Aftanas, L., Aghajani, M., Aleman, A., Baune, B.T., Berger, K., Brak, I., Filho, G.B., Carballedo, A., Connolly, C.G., Couvy-Duchesne, B., Cullen, K.R., Dannlowski, U., Davey, C.G., Dima, D., Duran, F.L.S., Enneking, V., Filimonova, E., Frenzel, S., Frodl, T., Fu, C.H.Y., Godlewska, B.R., Gotlib, I.H., Grabe, H.J., Groenewold, N.A., Grotegerd, D., Gruber, O., Hall, G.B., Harrison, B.J., Hatton, S.N., Hermesdorf, M., Hickie, I.B., Ho, T.C., Hosten, N., Jansen, Andreas, Kähler, C., Kircher, T., Klimes-Dougan, B., Krämer, B., Krug, A., Lagopoulos, J., Leenings, R., MacMaster, F.P., MacQueen, G., McIntosh, A., McLellan, Q., McMahon, K.L., Medland, S.E., Mueller, B.A., Mwangi, B., Osipov, E., Portella, M.J., Pozzi, E., Reneman, L., Repple, J., Rosa, P.G., Sacchet, M.D., Sämann, P.G., Schnell, K., Schrantee, A., Simulionyte, E., Soares, J.C., Sommer, J., Stein, D.J., Steinsträter, O., Strike, L.T., Thomopoulos, S.I., Tol, M.J.D. van, Veer, I.M., Vermeiren, R., Walter, H., Wee, N.J.A. van der, Werff, S.J.A. van der, Whalley, H., Winter, N.R., Wittfeld, K., Wright, M.J., Wu, M.J., Völzke, H., Yang, T.T., Zannias, V., Zubicaray, G.I. de, Zunta-Soares, G.B., Abé, C., Alda, M., Andreassen, O.A., Bøen, E., Bonnin, C.M., Canales-Rodriguez, E.J., Cannon, D., Caseras, X., Chaim-Avancini, T.M., Elvsåshagen, T., Favre, P., Foley, S.F., Fullerton, J.M., Ruhé, H.G., Schene, A.H., Marquand, A.F., Cole, J., and Schmaal, L.

Abstract

Item does not contain fulltext, Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.

Published
2021

2. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Author

Han, LKM, Dinga, R, Hahn, T, Ching, CRK, Eyler, LT, Aftanas, L, Aghajani, M, Aleman, A, Baune, BT, Berger, K, Brak, I, Busatto Filho, G, Carballedo, A, Connolly, CG, Couvy-Duchesne, B, Cullen, KR, Dannlowski, U, Davey, CG, Dima, D, Duran, FLS, Enneking, V, Filimonova, E, Frenzel, S, Frodl, T, Fu, CHY, Godlewska, BR, Gotlib, IH, Grabe, HJ, Groenewold, NA, Grotegerd, D, Gruber, O, Hall, GB, Harrison, BJ, Hatton, SN, Hermesdorf, M, Hickie, IB, Ho, TC, Hosten, N, Jansen, A, Kaehler, C, Kircher, T, Klimes-Dougan, B, Kraemer, B, Krug, A, Lagopoulos, J, Leenings, R, MacMaster, FP, MacQueen, G, McIntosh, A, McLellan, Q, McMahon, KL, Medland, SE, Mueller, BA, Mwangi, B, Osipov, E, Portella, MJ, Pozzi, E, Reneman, L, Repple, J, Rosa, PGP, Sacchet, MD, Saemann, PG, Schnell, K, Schrantee, A, Simulionyte, E, Soares, JC, Sommer, J, Stein, DJ, Steinstraeter, O, Strike, LT, Thomopoulos, SI, van Tol, M-J, Veer, IM, Vermeiren, RRJM, Walter, H, van der Wee, NJA, van der Werff, SJA, Whalley, H, Winter, NR, Wittfeld, K, Wright, MJ, Wu, M-J, Voelzke, H, Yang, TT, Zannias, V, de Zubicaray, GI, Zunta-Soares, GB, Abe, C, Alda, M, Andreassen, OA, Boen, E, Bonnin, CM, Canales-Rodriguez, EJ, Cannon, D, Caseras, X, Chaim-Avancini, TM, Elvsashagen, T, Favre, P, Foley, SF, Fullerton, JM, Goikolea, JM, Haarman, BCM, Hajek, T, Henry, C, Houenou, J, Howells, FM, Ingvar, M, Kuplicki, R, Lafer, B, Landen, M, Machado-Vieira, R, Malt, UF, McDonald, C, Mitchell, PB, Nabulsi, L, Otaduy, MCG, Overs, BJ, Polosan, M, Pomarol-Clotet, E, Radua, J, Rive, MM, Roberts, G, Ruhe, HG, Salvador, R, Sarro, S, Satterthwaite, TD, Savitz, J, Schene, AH, Schofield, PR, Serpa, MH, Sim, K, Soeiro-de-Souza, MG, Sutherland, AN, Temmingh, HS, Timmons, GM, Uhlmann, A, Vieta, E, Wolf, DH, Zanetti, MV, Jahanshad, N, Thompson, PM, Veltman, DJ, Penninx, BWJH, Marquand, AF, Cole, JH, Schmaal, L, Han, LKM, Dinga, R, Hahn, T, Ching, CRK, Eyler, LT, Aftanas, L, Aghajani, M, Aleman, A, Baune, BT, Berger, K, Brak, I, Busatto Filho, G, Carballedo, A, Connolly, CG, Couvy-Duchesne, B, Cullen, KR, Dannlowski, U, Davey, CG, Dima, D, Duran, FLS, Enneking, V, Filimonova, E, Frenzel, S, Frodl, T, Fu, CHY, Godlewska, BR, Gotlib, IH, Grabe, HJ, Groenewold, NA, Grotegerd, D, Gruber, O, Hall, GB, Harrison, BJ, Hatton, SN, Hermesdorf, M, Hickie, IB, Ho, TC, Hosten, N, Jansen, A, Kaehler, C, Kircher, T, Klimes-Dougan, B, Kraemer, B, Krug, A, Lagopoulos, J, Leenings, R, MacMaster, FP, MacQueen, G, McIntosh, A, McLellan, Q, McMahon, KL, Medland, SE, Mueller, BA, Mwangi, B, Osipov, E, Portella, MJ, Pozzi, E, Reneman, L, Repple, J, Rosa, PGP, Sacchet, MD, Saemann, PG, Schnell, K, Schrantee, A, Simulionyte, E, Soares, JC, Sommer, J, Stein, DJ, Steinstraeter, O, Strike, LT, Thomopoulos, SI, van Tol, M-J, Veer, IM, Vermeiren, RRJM, Walter, H, van der Wee, NJA, van der Werff, SJA, Whalley, H, Winter, NR, Wittfeld, K, Wright, MJ, Wu, M-J, Voelzke, H, Yang, TT, Zannias, V, de Zubicaray, GI, Zunta-Soares, GB, Abe, C, Alda, M, Andreassen, OA, Boen, E, Bonnin, CM, Canales-Rodriguez, EJ, Cannon, D, Caseras, X, Chaim-Avancini, TM, Elvsashagen, T, Favre, P, Foley, SF, Fullerton, JM, Goikolea, JM, Haarman, BCM, Hajek, T, Henry, C, Houenou, J, Howells, FM, Ingvar, M, Kuplicki, R, Lafer, B, Landen, M, Machado-Vieira, R, Malt, UF, McDonald, C, Mitchell, PB, Nabulsi, L, Otaduy, MCG, Overs, BJ, Polosan, M, Pomarol-Clotet, E, Radua, J, Rive, MM, Roberts, G, Ruhe, HG, Salvador, R, Sarro, S, Satterthwaite, TD, Savitz, J, Schene, AH, Schofield, PR, Serpa, MH, Sim, K, Soeiro-de-Souza, MG, Sutherland, AN, Temmingh, HS, Timmons, GM, Uhlmann, A, Vieta, E, Wolf, DH, Zanetti, MV, Jahanshad, N, Thompson, PM, Veltman, DJ, Penninx, BWJH, Marquand, AF, Cole, JH, and Schmaal, L

Abstract

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.

Published
2021

3. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.

Author

Han LKM, Dinga R, Hahn T, Ching CRK, Eyler LT, Aftanas L, Aghajani M, Aleman A, Baune BT, Berger K, Brak I, Filho GB, Carballedo A, Connolly CG, Couvy-Duchesne B, Cullen KR, Dannlowski U, Davey CG, Dima D, Duran FLS, Enneking V, Filimonova E, Frenzel S, Frodl T, Fu CHY, Godlewska BR, Gotlib IH, Grabe HJ, Groenewold NA, Grotegerd D, Gruber O, Hall GB, Harrison BJ, Hatton SN, Hermesdorf M, Hickie IB, Ho TC, Hosten N, Jansen A, Kähler C, Kircher T, Klimes-Dougan B, Krämer B, Krug A, Lagopoulos J, Leenings R, MacMaster FP, MacQueen G, McIntosh A, McLellan Q, McMahon KL, Medland SE, Mueller BA, Mwangi B, Osipov E, Portella MJ, Pozzi E, Reneman L, Repple J, Rosa PGP, Sacchet MD, Sämann PG, Schnell K, Schrantee A, Simulionyte E, Soares JC, Sommer J, Stein DJ, Steinsträter O, Strike LT, Thomopoulos SI, van Tol MJ, Veer IM, Vermeiren RRJM, Walter H, van der Wee NJA, van der Werff SJA, Whalley H, Winter NR, Wittfeld K, Wright MJ, Wu MJ, Völzke H, Yang TT, Zannias V, de Zubicaray GI, Zunta-Soares GB, Abé C, Alda M, Andreassen OA, Bøen E, Bonnin CM, Canales-Rodriguez EJ, Cannon D, Caseras X, Chaim-Avancini TM, Elvsåshagen T, Favre P, Foley SF, Fullerton JM, Goikolea JM, Haarman BCM, Hajek T, Henry C, Houenou J, Howells FM, Ingvar M, Kuplicki R, Lafer B, Landén M, Machado-Vieira R, Malt UF, McDonald C, Mitchell PB, Nabulsi L, Otaduy MCG, Overs BJ, Polosan M, Pomarol-Clotet E, Radua J, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Savitz J, Schene AH, Schofield PR, Serpa MH, Sim K, Soeiro-de-Souza MG, Sutherland AN, Temmingh HS, Timmons GM, Uhlmann A, Vieta E, Wolf DH, Zanetti MV, Jahanshad N, Thompson PM, Veltman DJ, Penninx BWJH, Marquand AF, Cole JH, and Schmaal L

Subjects
Adolescent, Adult, Aged, Aging, Brain diagnostic imaging, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Young Adult, Depressive Disorder, Major
Abstract

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates., (© 2020. The Author(s).)

Published
2021
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4. Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression.

Author

Papmeyer M, Sussmann JE, Stewart T, Giles S, Centola JG, Zannias V, Lawrie SM, Whalley HC, and McIntosh AM

Subjects
Adult, Disease Susceptibility, Family, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Risk, Young Adult, Bipolar Disorder pathology, Brain pathology, Depressive Disorder, Major pathology
Abstract

Subcortical volumetric brain abnormalities have been observed in mood disorders. However, it is unknown whether these reflect adverse effects predisposing to mood disorders or emerge at illness onset. Magnetic resonance imaging was conducted at baseline and after two years in 111 initially unaffected young adults at increased risk of mood disorders because of a close family history of bipolar disorder and 93 healthy controls (HC). During the follow-up, 20 high-risk subjects developed major depressive disorder (HR-MDD), with the others remaining well (HR-well). Volumes of the lateral ventricles, caudate, putamen, pallidum, thalamus, hippocampus and amygdala were extracted for each hemisphere. Using linear mixed-effects models, differences and longitudinal changes in subcortical volumes were investigated between groups (HC, HR-MDD, HR-well). There were no significant differences for any subcortical volume between groups controlling for multiple testing. Additionally, no significant differences emerged between groups over time. Our results indicate that volumetric subcortical brain abnormalities of these regions using the current method appear not to form familial trait markers for vulnerability to mood disorders in close relatives of bipolar disorder patients over the two-year time period studied. Moreover, they do not appear to reduce in response to illness onset at least for the time period studied., (Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.)

Published
2016
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