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370 results on '"Zangeneh, Akram"'

16. Green synthesis of gold nanoparticles using potato starch as a phytochemical template, green reductant and stabilizing agent and investigating its cytotoxicity, antioxidant and anti-ovarian cancer effects

Author

Li, Ju, primary, Feizipour, Saba, additional, Delirezh, Nowruz, additional, Sheikhzadeh, Sanaz, additional, Hobbenaghi, Rahim, additional, Amraii, Sara Amirpour, additional, Khorasani, Fatemeh, additional, Hemmati, Saba, additional, Joshani, Zeinab, additional, Kamangar, Sheida Ahany, additional, Abbasi, Naser, additional, Zangeneh, Akram, additional, Saremi, Shokoufeh Ghahri, additional, and Almasi, Maryam, additional

Published
2023
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42. Antidiabetic, hematoprotective and nephroprotective effects of the aqueous extract of Falcaria vulgaris in diabetic male mice

Author

Zangeneh Mohammad Mahdi, Zangeneh Akram, Tahvilian Reza, and Moradi Rohallah

Subjects
Falcaria vulgaris, aqueous extract, hypoglycemic activity, nephroprotective activity, streptozotocin, Biology (General), QH301-705.5
Abstract

Falcaria vulgaris has been used in medicine as an antimicrobial agent. The aims of this study were to evaluate the hypoglycemic and nephroprotective activities of the aqueous extract of F. vulgaris in diabetic mice. Diabetes was experimentally induced by intraperitoneal injection of streptozotocin (STZ). The mice were divided randomly into 6 groups as follows: nondiabetic, untreated diabetic, a group that received orally 0.5 mg/kg glibenclamide, and three groups that were given orally 200, 600 and 1800 μg/kg of F. vulgaris, respectively, for 20 days. On the 20th day, the mice were dissected, and blood and kidney samples were collected for analysis of hematological, biochemical and stereological parameters. F. vulgaris at all doses, particularly 1800 μg/kg, significantly (p≤0.05) reduced the levels of urea, creatinine, WBC, eosinophils, basophiles, platelet and increased RBC, Hb, PCV, MCV, MCH, MCHC, lymphocytes and monocytes that were raised after diabetes induction, compared to the untreated diabetic group. Multiple doses of F. vulgaris, particularly1800 μg/kg, significantly (p≤0.05) decreased the total volumes of the kidney cortex, medulla, vessels and renal tubules, as well as the lengths of the vessels and renal tubules, compared to the untreated diabetic group. Also, F. vulgaris at all doses significantly prevented glomerular hypertrophy and reduction of glomeruli numbers in comparison with the untreated diabetic group. In conclusion, F. vulgaris possesses antidiabetic, hematoprotective and nephroprotective properties and can improve renal structural and blood biomarkers in STZ-induced nephrotoxicity in mice.

Published
2018
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49. Ameliorative effects of the ethanolic extract of Allium saralicum R.M. Fritsch on CCl4-induced nephrotoxicity in mice: A stereological examination

Author

Sherkatolabbasieh Hamidreza, Hagh-Nazari Lida, Shafiezadeh Shiva, Goodarzi Nader, Zangeneh Mohammad Mehdi, and Zangeneh Akram

Subjects
carbon tetrachloride, Allium saralicum, kidney, nephrotoxicity, stereology, Biology (General), QH301-705.5
Abstract

The present study was carried out to investigate the nephroprotective effect of the ethanolic extract of Allium saralicum R.M. Fritsch (ASRMF) in mice. Thirty-five male mice were divided into five groups (n=7). Group 1 (positive control) received 1 mL/kg olive oil intraperitoneally (i.p.) and 0.5 mL distilled water orally; Group 2 (negative control) received CCl4 (50% in olive oil, 1 mg/kg; i.p.); Groups 3, 4 and 5 received CCl4 and 200, 800 and 1600 μg/kg of ASRMF extract, respectively. The renal volume and cortex in Groups 1 and 2 were increased by 55% and 62% (p≤0.001) following CCl4 administration, respectively, and were improved after ASRMF administration. The volume of proximal convoluted tubules (PCTs), glomeruli, vessels and interstitial tissue increased 80%, 150%, 83% and 64% (p≤0.05), respectively, in CCl4-treated mice, and decreased significantly with 800 and 1600 μg/kg of ASRMF. The length of PCTs and vessels increased 51% and 45% and decreased (p≤0.05) with 200, 800 and 1600 μg/kg of ASRMF, respectively. CCl4-treated mice lost 22.5% of glomeruli; the loss was inhibited significantly (p≤0.05) by ASRMF. Urea and creatinine concentrations were increased (p≤0.05) in CCl4-induced nephrotoxicity as compared to the controls, whereas different doses of ASRMF restored the levels of these biomarkers compared to the negative controls. In conclusion, ASRMF has a potent nephroprotective property and can improve renal structural and serum biomarkers in CCl4-induced nephrotoxicity in mice.

Published
2017
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