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2. Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysis

Author

Galán-Sánchez, Fátima, Gracia-Ahufinger, Irene, Martínez-Martínez, Luis, Liébana-Martos, Carmen, Roldán, Carolina, Sánchez-Calvo, Juan Manuel, Clavijo, Encarnación, Mora-Navas, Laura, Aznar, Javier, Lepe, José Antonio, Rodríguez-Villodres, Ángel, Recacha, Esther, Casas-Círia, Francisco Javier, Martínez-Rubio, Carmen, Sempere-Alcocer, Marco Antonio, Martín-Hita, Lina, Seral, Cristina, López-Calleja, Ana Isabel, Aspiroz, Carmen, Monforte, Marisa, Iglesia-Martínez, Pedro de la, Jimenez-Guerra, Gemma, Riera-Pérez, Elena, Collado, Carmen, Gallegos, Carmen, Mulet, Xavier, Fernández-Muñoz, Almudena, Sastre-Femenía, Miquel Àngel, Gomis-Font, María Antonia, Zamorano, Laura, Oliver, Antonio, Siller-Ruiz, María, Calvo, Jorge, Quesada, Dolores, Wang, Jun Hao, Pitart, Cristina, Marco, Francesc, Prim, Nuria, Horcajada, Juan Pablo, Padilla, Eduardo, Del Barrio-Tofiño, Ester, Viñado-Pérez, Belen, Larrosa, Nieves, Tubau, Fe, Capilla, Silvia, Casabella, Antonio, Pérez-Moreno, Mar Olga, Padilla, Emma, Ballestero, Mónica, Rivera, Alba, Navarro, Ferrán, Gómez-Bertomeu, Fréderic, Pardo-Granell, Sergio, Picó-Plana, Ester, Guerrero, Dolores, Sarvisé-Buil, Carolina, Belles-Belles, Alba, Fernández-Esgueva, Marta, Ortega-Lafont, María del Pilar, García, Inmaculada, Arenal-Andrés, Noelia, Hernando-Real, Susana, Ibáñez, Rosario, Martínez, Jesús, Becerra, Federico, Aldea-Mansilla, Carmen, Alaoui-Sosse, Asmaa, González, José Carlos, Guzman-Puche, Julia, Blázquez-Andrada, Miguel Ángel, Martínez-Ramírez, Nora Mariela, Beteta, Alicia, Gomila-Sard, Bárbara, Almaraz, Salvador Giner, Garduño, Eugenio, Juiz-González, Pedro Miguel, Arca-Suárez, Jorge, Alba, Javier, Alonso, Pilar, Rodríguez, Ana Isabel, Paz-Vidal, María Isabel, García-Campello, Marta, Camacho, Pablo, Pallarés, María de los Ángeles, Pérez del Molino, María Luisa, Coira, Amparo, Barbeito, Gema, Rincón, Anniris, Vasallo-Vidal, Francisco José, Alonso-Acero, Laura, Iglesias-Llorente, Laura, Bordes-Benites, Ana, Florén-Zabala, Laura, Azcona, José Manuel, Alonso, Carla Andrea, Sáenz, Yolanda, Lamata-Subero, Marta, Molina, David, González-Torralba, Ana, Villa, Jennifer, Viedma, Esther, Cercenado, Emilia, Alarcón, Teresa, Vargas, Paula, Díez, María, Cantón, Rafael, Ruiz, Patricia, Sánchez-Romero, María Isabel, Pérez-García, Felipe, Yagüe-Guirao, Genoveva, Oteiza, Amaia Concepción, Leiva, José, Portillo, María Eugenia, Canut-Blasco, Andrés, Vidal, Matxalen, Alonso, Iker, Zuriarrain, Maider, Barrios-Andrés, José Luis, Sastre-Femenia, Miquel Àngel, Taltavull, Biel, López-Causapé, Carla, and Oteo-Iglesias, Jesús

Published
2023
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3. Correction for Barceló et al., “Transferable AmpCs in Klebsiella pneumoniae : interplay with peptidoglycan recycling, mechanisms of hyperproduction, and virulence implications”

Author

Barceló, Isabel M., primary, Escobar-Salom, María, additional, Cabot, Gabriel, additional, Perelló-Bauzà, Pau, additional, Jordana-Lluch, Elena, additional, Taltavull, Biel, additional, Torrens, Gabriel, additional, Rojo-Molinero, Estrella, additional, Zamorano, Laura, additional, Pérez, Astrid, additional, Oliver, Antonio, additional, and Juan, Carlos, additional

Published
2024
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5. Predicting Pseudomonas aeruginosa susceptibility phenotypes from whole genome sequence resistome analysis

Author

Martínez-Martínez, Luis, Bou, Germán, Zamorano, Laura, Sánchez-Diener, Irina, Galán, Fátima, Gracia, Irene, Rodríguez, Manuel Antonio, Martín, Lina, Sánchez, Juan Manuel, Viñuela, Laura, García, M<ce:sup loc='post">a</ce:sup> Victoria, Lepe, José Antonio, Aznar, Javier, López-Hernández, Inma, Seral, Cristina, Castillo-García, Francisco Javier, López-Calleja, Ana Isabel, Aspiroz, Carmen, Iglesia, Pedro de la, Ramón, Susana, Riera, Elena, Pérez, María Cruz, Gallegos, Carmen, Calvo, Jorge, Quesada, María Dolores, Pitart, Cristina, Marco, Francesc, Hoyos, Yannick, Horcajada, Juan Pablo, Larrosa, Nieves, González, Juan José, Tubau, Fe, Capilla, Silvia, Pérez-Moreno, Mar Olga, Centelles, M<ce:sup loc='post">a</ce:sup> José, Padilla, Emma, Rivera, Alba, Mirelis, Beatriz, Rodríguez-Tarazona, Raquel Elisa, Arenal-Andrés, Noelia, Ortega, María del Pilar, Megías, Gregoria, García, Inmaculada, Colmenarejo, Cristina, González, José Carlos, Martínez, Nora Mariela, Gomila, Bárbara, Giner, Salvador, Tormo, Nuria, Garduño, Eugenio, Agulla, José Andrés, Seoane, Alejandro, Pita, Julia, Vidal, Isabel Paz, Guzmán, David Mauricio, García, Marta, Pérez del Molino, María Luisa, Barbeito, Gema, Artiles, Fernando, Azcona-Gutiérrez, José Manuel, Sáenz, Yolanda, Oteo, José Antonio, González, Ana, Villa, Jennifer, Chaves, Fernando, Cercenado, Emilia, Alarcón, Teresa, Zurita, Nelly Daniela, Gijón, Desiré, Merino, Irene, Morosini, María Isabel, Cantón, Rafael, Sánchez, María Isabel, Moreno, Laura, Yagüe, Genoveva, Leiva, José, Barrios, José Luis, Canut, Andrés, Oteo, Jesús, Cortes-Lara, Sara, Barrio-Tofiño, Ester del, López-Causapé, Carla, and Oliver, Antonio

Published
2021
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8. Genetic variation within a stick-insect species associated with community-level traits.

Author

Sinclair-Waters, Marion, Zamorano, Laura S, Gompert, Zachariah, Parchman, Tom, Tyukmaeva, Venera, Hopkins, David P, and Nosil, Patrik

Subjects
*PHASMIDA, *GENETIC variation, *GENOME-wide association studies, *ECOSYSTEM dynamics, *PHENOTYPIC plasticity
Abstract

Phenotypic variation within species can affect the ecological dynamics of populations and communities. Characterizing the genetic variation underlying such effects can help parse the roles of genetic evolution and plasticity in "eco-evolutionary dynamics" and inform how genetic variation may shape patterns of evolution. Here, we employ genome-wide association (GWA) methods in Timema cristinae stick insects and their co-occurring arthropod communities to identify genetic variation associated with community-level traits. Previous studies have shown that maladaptation (i.e. imperfect crypsis) of T. cristinae can reduce the abundance and species richness of other arthropods due to an increase in bird predation. Whether genetic variation that is independent of crypsis has similar effects is unknown and was tested here using genome-wide genotyping-by-sequencing data of stick insects, arthropod community information, and GWA mapping with Bayesian sparse linear mixed models. We find associations between genetic variation in stick insects and arthropod community traits. However, these associations disappear when host-plant traits are accounted for. We thus use path analysis to disentangle interrelationships among stick-insect genetic variation, host-plant traits, and community traits. This revealed that host-plant size has large effects on arthropod communities, while genetic variation in stick insects has a smaller, but still significant effect. Our findings demonstrate that (1) genetic variation in a species can be associated with community-level traits but that (2) interrelationships among multiple factors may need to be analyzed to disentangle whether such associations represent causal relationships. This work helps to build a framework for genomic studies of eco-evolutionary dynamics. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysis

Author

Sastre-Femenia, Miquel Àngel, primary, Fernández-Muñoz, Almudena, additional, Gomis-Font, María Antonia, additional, Taltavull, Biel, additional, López-Causapé, Carla, additional, Arca-Suárez, Jorge, additional, Martínez-Martínez, Luis, additional, Cantón, Rafael, additional, Larrosa, Nieves, additional, Oteo-Iglesias, Jesús, additional, Zamorano, Laura, additional, Oliver, Antonio, additional, Galán-Sánchez, Fátima, additional, Gracia-Ahufinger, Irene, additional, Liébana-Martos, Carmen, additional, Roldán, Carolina, additional, Sánchez-Calvo, Juan Manuel, additional, Clavijo, Encarnación, additional, Mora-Navas, Laura, additional, Aznar, Javier, additional, Lepe, José Antonio, additional, Rodríguez-Villodres, Ángel, additional, Recacha, Esther, additional, Casas-Círia, Francisco Javier, additional, Martínez-Rubio, Carmen, additional, Sempere-Alcocer, Marco Antonio, additional, Martín-Hita, Lina, additional, Seral, Cristina, additional, López-Calleja, Ana Isabel, additional, Aspiroz, Carmen, additional, Monforte, Marisa, additional, Iglesia-Martínez, Pedro de la, additional, Jimenez-Guerra, Gemma, additional, Riera-Pérez, Elena, additional, Collado, Carmen, additional, Gallegos, Carmen, additional, Mulet, Xavier, additional, Sastre-Femenía, Miquel Àngel, additional, Siller-Ruiz, María, additional, Calvo, Jorge, additional, Quesada, Dolores, additional, Wang, Jun Hao, additional, Pitart, Cristina, additional, Marco, Francesc, additional, Prim, Nuria, additional, Horcajada, Juan Pablo, additional, Padilla, Eduardo, additional, Del Barrio-Tofiño, Ester, additional, Viñado-Pérez, Belen, additional, Tubau, Fe, additional, Capilla, Silvia, additional, Casabella, Antonio, additional, Pérez-Moreno, Mar Olga, additional, Padilla, Emma, additional, Ballestero, Mónica, additional, Rivera, Alba, additional, Navarro, Ferrán, additional, Gómez-Bertomeu, Fréderic, additional, Pardo-Granell, Sergio, additional, Picó-Plana, Ester, additional, Guerrero, Dolores, additional, Sarvisé-Buil, Carolina, additional, Belles-Belles, Alba, additional, Fernández-Esgueva, Marta, additional, Ortega-Lafont, María del Pilar, additional, García, Inmaculada, additional, Arenal-Andrés, Noelia, additional, Hernando-Real, Susana, additional, Ibáñez, Rosario, additional, Martínez, Jesús, additional, Becerra, Federico, additional, Aldea-Mansilla, Carmen, additional, Alaoui-Sosse, Asmaa, additional, González, José Carlos, additional, Guzman-Puche, Julia, additional, Blázquez-Andrada, Miguel Ángel, additional, Martínez-Ramírez, Nora Mariela, additional, Beteta, Alicia, additional, Gomila-Sard, Bárbara, additional, Almaraz, Salvador Giner, additional, Garduño, Eugenio, additional, Juiz-González, Pedro Miguel, additional, Alba, Javier, additional, Alonso, Pilar, additional, Rodríguez, Ana Isabel, additional, Paz-Vidal, María Isabel, additional, García-Campello, Marta, additional, Camacho, Pablo, additional, Pallarés, María de los Ángeles, additional, Pérez del Molino, María Luisa, additional, Coira, Amparo, additional, Barbeito, Gema, additional, Rincón, Anniris, additional, Vasallo-Vidal, Francisco José, additional, Alonso-Acero, Laura, additional, Iglesias-Llorente, Laura, additional, Bordes-Benites, Ana, additional, Florén-Zabala, Laura, additional, Azcona, José Manuel, additional, Alonso, Carla Andrea, additional, Sáenz, Yolanda, additional, Lamata-Subero, Marta, additional, Molina, David, additional, González-Torralba, Ana, additional, Villa, Jennifer, additional, Viedma, Esther, additional, Cercenado, Emilia, additional, Alarcón, Teresa, additional, Vargas, Paula, additional, Díez, María, additional, Ruiz, Patricia, additional, Sánchez-Romero, María Isabel, additional, Pérez-García, Felipe, additional, Yagüe-Guirao, Genoveva, additional, Oteiza, Amaia Concepción, additional, Leiva, José, additional, Portillo, María Eugenia, additional, Canut-Blasco, Andrés, additional, Vidal, Matxalen, additional, Alonso, Iker, additional, Zuriarrain, Maider, additional, and Barrios-Andrés, José Luis, additional

Published
2023
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17. Influence of Virulence Genotype and Resistance Profile in the Mortality of Pseudomonas aeruginosa Bloodstream Infections

Author

Spanish Network for Research in Infectious Diseases (REIPI), Peña, Carmen, Cabot, Gabriel, Gómez-Zorrilla, Silvia, Zamorano, Laura, Ocampo-Sosa, Alain, Murillas, Javier, Almirante, Benito, Pomar, Virginia, Aguilar, Manuela, Granados, Ana, Calbo, Esther, Rodríguez-Baño, Jesús, Rodríguez-López, Fernando, Tubau, Fe, Martínez-Martínez, Luis, and Oliver, Antonio

Published
2015

22. Predicting Pseudomonas aeruginosa susceptibility phenotypes from whole genome sequence resistome analysis

Author

Cortes-Lara, Sara, primary, Barrio-Tofiño, Ester del, additional, López-Causapé, Carla, additional, Oliver, Antonio, additional, Martínez-Martínez, Luis, additional, Bou, Germán, additional, Zamorano, Laura, additional, Sánchez-Diener, Irina, additional, Galán, Fátima, additional, Gracia, Irene, additional, Rodríguez, Manuel Antonio, additional, Martín, Lina, additional, Sánchez, Juan Manuel, additional, Viñuela, Laura, additional, García, Ma Victoria, additional, Lepe, José Antonio, additional, Aznar, Javier, additional, López-Hernández, Inma, additional, Seral, Cristina, additional, Castillo-García, Francisco Javier, additional, López-Calleja, Ana Isabel, additional, Aspiroz, Carmen, additional, Iglesia, Pedro de la, additional, Ramón, Susana, additional, Riera, Elena, additional, Pérez, María Cruz, additional, Gallegos, Carmen, additional, Calvo, Jorge, additional, Quesada, María Dolores, additional, Pitart, Cristina, additional, Marco, Francesc, additional, Hoyos, Yannick, additional, Horcajada, Juan Pablo, additional, Larrosa, Nieves, additional, González, Juan José, additional, Tubau, Fe, additional, Capilla, Silvia, additional, Pérez-Moreno, Mar Olga, additional, Centelles, Ma José, additional, Padilla, Emma, additional, Rivera, Alba, additional, Mirelis, Beatriz, additional, Rodríguez-Tarazona, Raquel Elisa, additional, Arenal-Andrés, Noelia, additional, Ortega, María del Pilar, additional, Megías, Gregoria, additional, García, Inmaculada, additional, Colmenarejo, Cristina, additional, González, José Carlos, additional, Martínez, Nora Mariela, additional, Gomila, Bárbara, additional, Giner, Salvador, additional, Tormo, Nuria, additional, Garduño, Eugenio, additional, Agulla, José Andrés, additional, Seoane, Alejandro, additional, Pita, Julia, additional, Vidal, Isabel Paz, additional, Guzmán, David Mauricio, additional, García, Marta, additional, Pérez del Molino, María Luisa, additional, Barbeito, Gema, additional, Artiles, Fernando, additional, Azcona-Gutiérrez, José Manuel, additional, Sáenz, Yolanda, additional, Oteo, José Antonio, additional, González, Ana, additional, Villa, Jennifer, additional, Chaves, Fernando, additional, Cercenado, Emilia, additional, Alarcón, Teresa, additional, Zurita, Nelly Daniela, additional, Gijón, Desiré, additional, Merino, Irene, additional, Morosini, María Isabel, additional, Cantón, Rafael, additional, Sánchez, María Isabel, additional, Moreno, Laura, additional, Yagüe, Genoveva, additional, Leiva, José, additional, Barrios, José Luis, additional, Canut, Andrés, additional, and Oteo, Jesús, additional

Published
2021
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23. In vitroevolution of cefepime/zidebactam (WCK 5222) resistance inPseudomonas aeruginosa: dynamics, mechanisms, fitness trade-off and impact onin vivoefficacy

Author

Barceló, Isabel, primary, Cabot, Gabriel, additional, Palwe, Snehal, additional, Joshi, Prashant, additional, Takalkar, Swapna, additional, Periasamy, Hariharan, additional, Cortés-Lara, Sara, additional, Zamorano, Laura, additional, Sánchez-Diener, Irina, additional, Moya, Bartolome, additional, Bhagwat, Sachin, additional, Patel, Mahesh, additional, and Oliver, Antonio, additional

Published
2021
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24. Photograph captions from: Spence J, Kavanaugh D, Maddison DR, Boyd O, Brandmayr P, Garner B, Maveety S, Mosquera D, Moore W, Riley K, Shorthouse J, Sims L, Steiner W, Swing K, Turin H, Zamorano LS, Penev L (2021) Memories of Terry Erwin. In: Spence J, Casale A, Assmann T, Liebherr JК, Penev L (Eds) Systematic Zoology and Biodiversity Science: A tribute to Terry Erwin (1940-2020). ZooKeys 1044: 1001-1036. https://doi.org/10.3897/zookeys.1044.68648

Author

Spence, John, primary, Kavanaugh, David, additional, Maddison, David R., additional, Boyd, Olivia, additional, Brandmayr, Pietro, additional, Garner, Beulah, additional, Maveety, Sarah, additional, Mosquera, Diego, additional, Moore, Wendy, additional, Riley, Kathryn, additional, Shorthouse, Joseph, additional, Sims, Linda, additional, Steiner, Warren, additional, Swing, Kelly, additional, Turin, Hans, additional, Zamorano, Laura S., additional, and Penev, Lyubomir, additional

Published
2021
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25. Photograph captions A from: Spence J, Kavanaugh D, Maddison DR, Boyd O, Brandmayr P, Garner B, Maveety S, Mosquera D, Moore W, Riley K, Shorthouse J, Sims L, Steiner W, Swing K, Turin H, Zamorano LS, Penev L (2021) Memories of Terry Erwin. In: Spence J, Casale A, Assmann T, Liebherr JК, Penev L (Eds) Systematic Zoology and Biodiversity Science: A tribute to Terry Erwin (1940-2020). ZooKeys 1044: 1001-1036. https://doi.org/10.3897/zookeys.1044.68648

Author

Spence, John, primary, Kavanaugh, David, additional, Maddison, David R., additional, Boyd, Olivia, additional, Brandmayr, Pietro, additional, Garner, Beulah, additional, Maveety, Sarah, additional, Mosquera, Diego, additional, Moore, Wendy, additional, Riley, Kathryn, additional, Shorthouse, Joseph, additional, Sims, Linda, additional, Steiner, Warren, additional, Swing, Kelly, additional, Turin, Hans, additional, Zamorano, Laura S., additional, and Penev, Lyubomir, additional

Published
2021
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26. Memories of Terry Erwin

Author

Spence, John, primary, Kavanaugh, David, additional, Maddison, David R., additional, Boyd, Olivia, additional, Brandmayr, Pietro, additional, Garner, Beulah, additional, Maveety, Sarah, additional, Mosquera, Diego, additional, Moore, Wendy, additional, Riley, Kathryn, additional, Shorthouse, Joseph, additional, Sims, Linda, additional, Steiner, Warren, additional, Swing, Kelly, additional, Turin, Hans, additional, Zamorano, Laura S., additional, and Penev, Lyubomir, additional

Published
2021
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27. Metagenomics analysis reveals an extraordinary inner bacterial diversity in Anisakids (Nematoda: Anisakidae) L3 larvae

Author

Ministerio de Economía y Competitividad (España), Arcos, Susana C., Lira, Felipe, Robertson, Lee, González-López, María Rosa, Carballeda-Sangiao, Noelia, Sánchez Alonso, Isabel, Zamorano, Laura, Careche, Mercedes, Jiménez-Ruiz, Yolanda, Ramos, Ricardo, Llorens, Carlos, González Muñoz, Miguel, Oliver, Antonio, Martínez, J. L., Navas, Alfonso, Ministerio de Economía y Competitividad (España), Arcos, Susana C., Lira, Felipe, Robertson, Lee, González-López, María Rosa, Carballeda-Sangiao, Noelia, Sánchez Alonso, Isabel, Zamorano, Laura, Careche, Mercedes, Jiménez-Ruiz, Yolanda, Ramos, Ricardo, Llorens, Carlos, González Muñoz, Miguel, Oliver, Antonio, Martínez, J. L., and Navas, Alfonso

Abstract

L3 larvae of anisakid nematodes are an important problem for the fisheries industry and pose a potential risk for human health by acting as infectious agents causing allergies and as potential vectors of pathogens and microrganisms. In spite of the close bacteria–nematode relationship very little is known of the anisakids microbiota. Fresh fish could be contaminated by bacteria vectored in the cuticle or in the intestine of anisakids when the L3 larvae migrate through the muscles. As a consequence, the bacterial inoculum will be spread, with potential effects on the quality of the fish, and possible clinical effects cannot be discarded. A total of 2,689,113 16S rRNA gene sequences from a total of 113 L3 individuals obtained from fish captured along the FAO 27 fishing area were studied. Bacteria were taxonomically characterized through 1803 representative operational taxonomic units (OTUs) sequences. Fourteen phyla, 31 classes, 52 orders, 129 families and 187 genera were unambiguously identified. We have found as part of microbiome an average of 123 OTUs per L3 individual. Diversity indices (Shannon and Simpson) indicate an extraordinary diversity of bacteria at an OTU level. There are clusters of anisakids individuals (samples) defined by the associated bacteria which, however, are not significantly related to fish hosts or anisakid taxa. This suggests that association or relationship among bacteria in anisakids, exists without the influence of fishes or nematodes. The lack of relationships with hosts of anisakids taxa has to be expressed by the association among bacterial OTUs or other taxonomical levels which range from OTUs to the phylum level. There are significant biological structural associations of microbiota in anisakid nematodes which manifest in clusters of bacteria ranging from phylum to genus level, which could also be an indicator of fish contamination or the geographic zone of fish capture. Actinobacteria, Aquificae, Firmicutes, and Proteobacteria are

Published
2021

28. Metagenomics Analysis Reveals an Extraordinary Inner Bacterial Diversity in Anisakids (Nematoda: Anisakidae) L3 Larvae

Author

Arcos, Susana C., primary, Lira, Felipe, additional, Robertson, Lee, additional, González, María Rosa, additional, Carballeda-Sangiao, Noelia, additional, Sánchez-Alonso, Isabel, additional, Zamorano, Laura, additional, Careche, Mercedes, additional, Jiménez-Ruíz, Yolanda, additional, Ramos, Ricardo, additional, Llorens, Carlos, additional, González-Muñoz, Miguel, additional, Oliver, Antonio, additional, Martínez, José L., additional, and Navas, Alfonso, additional

Published
2021
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29. Susceptibility profiles and resistance genomics of Pseudomonas aeruginosa isolates from European ICUs participating in the ASPIRE-ICU trial.

Author

Torrens, Gabriel, Schalk, Thomas Ewout van der, Cortes-Lara, Sara, Timbermont, Leen, Barrio-Tofiño, Ester del, Xavier, Basil Britto, Zamorano, Laura, Lammens, Christine, Ali, Omar, Ruzin, Alexey, Goossens, Herman, Kumar-Singh, Samir, Kluytmans, Jan, Paling, Fleur, MacLean, R Craig, Köhler, Thilo, López-Causapé, Carla, Malhotra-Kumar, Surbhi, Oliver, Antonio, and team, the ASPIRE-ICU study

Subjects
CEFTAZIDIME, INTENSIVE care units, RESEARCH, CLINICAL trials, RESEARCH methodology, ORGANIC compounds, EVALUATION research, CEPHALOSPORINS, COMPARATIVE studies, PSEUDOMONAS diseases, GENOMICS, RESEARCH funding, PSEUDOMONAS, DRUG resistance in microorganisms, LONGITUDINAL method, MICROBIAL sensitivity tests, ANTIBIOTICS, PHARMACODYNAMICS
Abstract

Objectives: To determine the susceptibility profiles and the resistome of Pseudomonas aeruginosa isolates from European ICUs during a prospective cohort study (ASPIRE-ICU).Methods: 723 isolates from respiratory samples or perianal swabs of 402 patients from 29 sites in 11 countries were studied. MICs of 12 antibiotics were determined by broth microdilution. Horizontally acquired β-lactamases were analysed through phenotypic and genetic assays. The first respiratory isolates from 105 patients providing such samples were analysed through WGS, including the analysis of the resistome and a previously defined genotypic resistance score. Spontaneous mutant frequencies and the genetic basis of hypermutation were assessed.Results: All agents except colistin showed resistance rates above 20%, including ceftolozane/tazobactam and ceftazidime/avibactam. 24.9% of the isolates were XDR, with a wide intercountry variation (0%-62.5%). 13.2% of the isolates were classified as DTR (difficult-to-treat resistance). 21.4% of the isolates produced ESBLs (mostly PER-1) or carbapenemases (mostly NDM-1, VIM-1/2 and GES-5). WGS showed that these determinants were linked to high-risk clones (particularly ST235 and ST654). WGS revealed a wide repertoire of mutation-driven resistance mechanisms, with multiple lineage-specific mutations. The most frequently mutated genes were gyrA, parC, oprD, mexZ, nalD and parS, but only two of the isolates were hypermutable. Finally, a good accuracy of the genotypic score to predict susceptibility (91%-100%) and resistance (94%-100%) was documented.Conclusions: An overall high prevalence of resistance is documented European ICUs, but with a wide intercountry variability determined by the dissemination of XDR high-risk clones, arguing for the need to reinforce infection control measures. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Association between Pseudomonas aeruginosa O-antigen serotypes, resistance profiles and high-risk clones: results from a Spanish nationwide survey

Author

Del Barrio-Tofiño, Ester, Sánchez-Diener, Irina, Zamorano, Laura, Cortes-Lara, Sara, López-Causapé, Carla, Cabot, Gabriel, Bou, Germán, Martínez-Martínez, Luis, Oliver, Antonio, on behalf of the GEMARA-SEIMC/REIPI Pseudomonas study group, Castillo-García, Francisco Javier, and Seral, Cristina

Abstract

Objectives: To evaluate the correlation of O-antigen serotypes with resistance profiles and high-risk clones in a Spanish nationwide survey. Methods: Up to 30 consecutive healthcare-associated Pseudomonas aeruginosa isolates were collected during October 2017 from each of 51 hospitals (covering all Spanish regions) with a total of 1445 isolates studied. MICs of 13 antipseudomonal agents and MDR/XDR profiles had been previously determined, as well as whole-genome sequences of 185 representative XDR isolates. O-antigen serotypes (O1–O16) were determined by agglutination using serotype-specific antisera (BioRad). The Pseudomonas aeruginosa serotyper (PAst) program was used for in silico serotyping. Results: The most frequent serotypes were O6 (17.8%), O1 (15.4%) and O11 (13.3%). In contrast, the most frequent serotype among XDR isolates (17.3%) was O4 (34.1%), distantly followed by O11 (15.9%). Within serotypes, XDR phenotypes were more frequent for O12 (60.0%) and O4 (57.3%). The most frequent clone among the XDR isolates was ST175 (40.9%), followed by CC235 (10.7%), ST308 (5.2%) and CC111 (3.6%). Up to 81.6%of XDR ST175 isolates typed O4, whereas 18.4% were non-typeable. O4 genotype was detected in all sequenced (n=55) ST175 isolates. On the other hand, CC235 and ST308 were associated with O11, whereas CC111 was linked to serotype O12. Conclusions: O4 serotype is linked to the MDR/XDR profile of widespread ST175 (typically only susceptible to colistin, amikacin and the novel combinations ceftolozane/tazobactam and ceftazidime/avibactam) and therefore, after local validation, its detection in the microbiology laboratory might be useful for guiding semi-empirical antipseudomonal therapies and infection control measures in Spanish hospitals.

Published
2020

34. Metagenomics Analysis Reveals An Extraordinary Bacterial Diversity in Anisakids (Nematoda: Anisakidae) L3 Larvae

Author

Arcos, Susana C., primary, Lira, Felipe, additional, Robertson, Lee, additional, González, María Rosa, additional, Carballeda-Sangiao, Noelia, additional, Sanchez-Alonso, Isabel, additional, Zamorano, Laura, additional, Careche, Mercedes, additional, Jiménez-Ruíz, Yolanda, additional, Ramos, Ricardo, additional, Llorens, Carlos, additional, González-Muñoz, Miguel, additional, Oliver, Antonio, additional, Martínez, José Luis, additional, and Navas, Alfonso, additional

Published
2020
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37. Pathogenic characteristics of Pseudomonas aeruginosa bacteraemia isolates in a high-endemicity setting for ST175 and ST235 high-risk clones

Author

Recio, Raúl, primary, Sánchez-Diener, Irina, additional, Viedma, Esther, additional, Meléndez-Carmona, María Ángeles, additional, Villa, Jennifer, additional, Orellana, María Ángeles, additional, Mancheño, Mikel, additional, Juan, Carlos, additional, Zamorano, Laura, additional, Lora-Tamayo, Jaime, additional, Chaves, Fernando, additional, and Oliver, Antonio, additional

Published
2019
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40. Pseudophorticus notatus Zamorano & Erwin & Kavanaugh 2019, new combination

Author

Zamorano, Laura S., Erwin, Terry L., and Kavanaugh, David H.

Subjects
Coleoptera, Insecta, Arthropoda, Pseudophorticus notatus, Pseudophorticus, Animalia, Biodiversity, Carabidae, Taxonomy
Abstract

Pseudophorticus notatus (Chaudoir, 1850), new combination Lachnophorus notatus Chaudoir 1850: 401. Lectotype female. Designated herein by Zamorano / Erwin 2017 and so labeled. Chaudoir��� s description does not give a locality. However, the type matches specimens from Costa Rica. Lachnophorus humeralis Bates 1883: 153. New synonymy. Lectotype female: Panama, Bugaba (MCZ). Designated herein by Zamorano/Erwin 2017 and so labeled. There is an L. notatus determination label by Jasinski on the lectotype in the MNHN. The specimen was labeled by D. H. Kavanaugh in 2016 as ���???. notatus Chd. ��� and stands by the L. notatus Chaudoir label. Anchonoderus humeralis (Bates, 1883). Liebherr 1988: 25 (new combination)., Published as part of Zamorano, Laura S., Erwin, Terry L. & Kavanaugh, David H., 2019, Nomenclatural Changes in the Lachnophorini (Coleoptera: Carabidae) of the Western Hemisphere, pp. 121-126 in The Coleopterists Bulletin 73 (1) on page 124, DOI: 10.1649/0010-065X-73.1.121, http://zenodo.org/record/5332892, {"references":["Chaudoir, M. de. 1850. Memoire sur la familla des carabiques. Bulletin de la Societe Imperiale des Naturalistas de Moscou 23: 349 - 460.","Bates, H. W. 1883. Coleoptera, Carabidae, Cicindelidae [vol. 1, pt. 1, Supplement, pp. 153 - 255]. In: Biologia Centrali-Americana (F. D. Godman and O. Salvin, editors.). Taylor and Francis, London, UK.","Liebherr, J. K. 1988. Redefinition of the supertribe Odacanthitae, and revision of the West Indian Lachnophorini (Coleoptera: Carabidae). Quaestiones Entomolgicae 24 (1): 1 - 42."]}

Published
2019
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41. Pseudophorticus submaculatus Zamorano & Erwin & Kavanaugh 2019, new combination

Author

Zamorano, Laura S., Erwin, Terry L., and Kavanaugh, David H.

Subjects
Coleoptera, Insecta, Arthropoda, Pseudophorticus submaculatus, Pseudophorticus, Animalia, Biodiversity, Carabidae, Taxonomy
Abstract

Pseudophorticus submaculatus (Bates, 1871), new combination Lachnophorus submaculatus Bates 1871: 56. Lectotype female: Brazil, Amazonas, Ega (Tefé) (MNHN). Designated herein by Zamorano / Erwin 2017 and so labeled.

Published
2019
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42. Peruphorticus rugatus Zamorano & Erwin & Kavanaugh 2019, new combination

Author

Zamorano, Laura S., Erwin, Terry L., and Kavanaugh, David H.

Subjects
Coleoptera, Insecta, Arthropoda, Animalia, Peruphorticus, Biodiversity, Carabidae, Peruphorticus rugatus, Taxonomy
Abstract

Peruphorticus rugatus (Reiche, 1843), new combination Anchonoderus rugatus Reiche 1843: 40 Lectotype male: Colombia (���Novae-Granatae���) (MNHN). Designated herein by Zamorano/Erwin 2017 and so labeled., Published as part of Zamorano, Laura S., Erwin, Terry L. & Kavanaugh, David H., 2019, Nomenclatural Changes in the Lachnophorini (Coleoptera: Carabidae) of the Western Hemisphere, pp. 121-126 in The Coleopterists Bulletin 73 (1) on page 124, DOI: 10.1649/0010-065X-73.1.121, http://zenodo.org/record/5332892, {"references":["Reiche, L. 1843. Coleoptera colombiana. Revue Zoologique 1843: 37 - 41, 75 - 79, 141 - 145, 177 - 180."]}

Published
2019
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43. Pseudophorticus foveatus Zamorano & Erwin & Kavanaugh 2019, new combination

Author

Zamorano, Laura S., Erwin, Terry L., and Kavanaugh, David H.

Subjects
Coleoptera, Insecta, Arthropoda, Pseudophorticus foveatus, Pseudophorticus, Animalia, Biodiversity, Carabidae, Taxonomy
Abstract

Pseudophorticus foveatus (Bates, 1871), new combination Lachnophorus foveatus Bates 1871: 55. Lectotype male: Brazil, Amazonas, “upper Amazon” (MNHN). Labeled lectotype by A. Jasinski 1999 (not published). Designated herein by Zamorano / Erwin 2017 and so labeled.

Published
2019
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44. Peruphorticus pallipes Zamorano & Erwin & Kavanaugh 2019, new combination

Author

Zamorano, Laura S., Erwin, Terry L., and Kavanaugh, David H.

Subjects
Coleoptera, Insecta, Arthropoda, Peruphorticus pallipes, Animalia, Peruphorticus, Biodiversity, Carabidae, Taxonomy
Abstract

Peruphorticus pallipes (Reiche, 1843), new combination Lachnophorus pallipes Reiche 1843: 179. Lectotype female: Colombia (���Novae-Granatae���) (MNHN). Designated herein by Zamorano/Erwin 2017 and so labeled., Published as part of Zamorano, Laura S., Erwin, Terry L. & Kavanaugh, David H., 2019, Nomenclatural Changes in the Lachnophorini (Coleoptera: Carabidae) of the Western Hemisphere, pp. 121-126 in The Coleopterists Bulletin 73 (1) on page 124, DOI: 10.1649/0010-065X-73.1.121, http://zenodo.org/record/5332892, {"references":["Reiche, L. 1843. Coleoptera colombiana. Revue Zoologique 1843: 37 - 41, 75 - 79, 141 - 145, 177 - 180."]}

Published
2019
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45. Pseudophorticus tibialis Zamorano & Erwin & Kavanaugh 2019, new combination

Author

Zamorano, Laura S., Erwin, Terry L., and Kavanaugh, David H.

Subjects
Coleoptera, Insecta, Arthropoda, Pseudophorticus, Animalia, Biodiversity, Carabidae, Pseudophorticus tibialis, Taxonomy
Abstract

Pseudophorticus tibialis (Bates, 1871), new combination Lachnophorus tibialis Bates 1871: 56. Lectotype male: Brazil, Amazonas, Sao ~ Paulo de Olivinça (MNHN). Labeled lectotype by Erwin 1978 and again by A. Jasinski 1999 (not published). Designated herein by Zamorano / Erwin 2017 and so labeled.

Published
2019
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46. Aporesthus Bates 1871

Author

Zamorano, Laura S., Erwin, Terry L., and Kavanaugh, David H.

Subjects
Coleoptera, Insecta, Arthropoda, Aporesthus, Animalia, Biodiversity, Carabidae, Taxonomy
Abstract

Aporesthus Bates, 1871 Aporesthus Bates 1871: 103. Phaedrusium Liebke 1941: 249. Erwin 1991: 44. Aporesthus anomalus Bates, 1871 Aporesthus anomalus Bates 1871: 103. Holotype male: Brazil, Rio de Janeiro (MNHN). Labeled by Zamorano/Erwin 2017. Calybe Laporte de Castelnau, 1834 Calybe Laporte de Castelnau 1834: 92. Chalybe Lacordaire 1854: 378. Calybe leprieuri Laporte de Castelnau, 1834 Calybe leprieuri Laporte de Castelnau 1834: 92. Lectotype male: Guyane, Cayenne (MNHN). Designated herein by Zamorano/Erwin 2017 and so labeled., Published as part of Zamorano, Laura S., Erwin, Terry L. & Kavanaugh, David H., 2019, Nomenclatural Changes in the Lachnophorini (Coleoptera: Carabidae) of the Western Hemisphere, pp. 121-126 in The Coleopterists Bulletin 73 (1) on page 122, DOI: 10.1649/0010-065X-73.1.121, http://zenodo.org/record/5332892, {"references":["Bates, H. W. 1871. Notes on Carabidae, and descriptions of new species (No. 7). Entomologist' s Monthly Magazine 8: 77 - 81.","Liebke, M. 1941. Carabidae truncatipenne Col. [pp. 215 - 266]. In: Beitrage zur Fauna Perus. Nach der Ausbeute der Hamburger Sudperu- Expedition 1936, anderer Sammlungen, wie auch auf Grund von Literaturamgaben, I (E. Titschack, editor). [All but 6 copies destroyed in WWII. Reprinted, 1951, Beitrage zur Fauna Perus. Nach der Ausbeute der Hamburger Sudperu- Expedition 1936, anderer Sammlungen, wie auch auf Grund von Literaturamgaben, II. iv + 403 pp. Verkag von Gustav Fisher, Jena].","Erwin, T. L. 1991. Natural history of the carabid beetles at the BIOLAT Rio Manu Biological Station, Pakitza, Peru. Revista Peruana de Entomologia (1990) 33: 1 - 85.","Laporte de Castelnau, F. L. 1834. Etudes entomologiques, ou descriptions d' insectes nouveaux et observations sur la synonymie [pp. 1 - 94]. Mequignon-Marvis, Paris 4.","Lacordaire, J. T. 1854. Histoire Naturelle des Insectes. Genera des coleopteres ou expose methodique et critique de tous les genres proposes jusqu' ici dans cet ordre d' insectes. Tome premier contenant les familles des cicindeletes, carabiques, dytiscides, gyrinides et palpicornes. Roret, Paris, France."]}

Published
2019
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47. Pseudophorticus ochropus Zamorano & Erwin & Kavanaugh 2019, new combination

Author

Zamorano, Laura S., Erwin, Terry L., and Kavanaugh, David H.

Subjects
Coleoptera, Insecta, Arthropoda, Pseudophorticus, Pseudophorticus ochropus, Animalia, Biodiversity, Carabidae, Taxonomy
Abstract

Pseudophorticus ochropus (Bates, 1871), new combination Lachnophorus ochropus Bates 1871: 56. Lectotype female: Brazil, Amazonas, Ega (Tefé) (MNHN). Designated herein by Zamorano / Erwin 2017 and so labeled.

Published
2019
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48. Anchonoderus Reiche 1843

Author

Zamorano, Laura S., Erwin, Terry L., and Kavanaugh, David H.

Subjects
Coleoptera, Insecta, Arthropoda, Animalia, Biodiversity, Carabidae, Anchonoderus, Taxonomy
Abstract

Anchonoderus Reiche, 1843 Anchonoderus Reiche 1843: 38. Axylosius Liebke 1936: 461. Liebherr 1988: 24., Published as part of Zamorano, Laura S., Erwin, Terry L. & Kavanaugh, David H., 2019, Nomenclatural Changes in the Lachnophorini (Coleoptera: Carabidae) of the Western Hemisphere, pp. 121-126 in The Coleopterists Bulletin 73 (1) on page 122, DOI: 10.1649/0010-065X-73.1.121, http://zenodo.org/record/5332892, {"references":["Reiche, L. 1843. Coleoptera colombiana. Revue Zoologique 1843: 37 - 41, 75 - 79, 141 - 145, 177 - 180.","Liebke, M. 1936. Die Gattung Lachnophorus Dejean (Col. Carabidae). Revista de Entomologia 6: 461 - 468.","Liebherr, J. K. 1988. Redefinition of the supertribe Odacanthitae, and revision of the West Indian Lachnophorini (Coleoptera: Carabidae). Quaestiones Entomolgicae 24 (1): 1 - 42."]}

Published
2019
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50. In vitro evolution of cefepime/zidebactam (WCK 5222) resistance in Pseudomonas aeruginosa: dynamics, mechanisms, fitness trade-off and impact on in vivo efficacy.

Author

Barceló, Isabel, Cabot, Gabriel, Palwe, Snehal, Joshi, Prashant, Takalkar, Swapna, Periasamy, Hariharan, Cortés-Lara, Sara, Zamorano, Laura, Sánchez-Diener, Irina, Moya, Bartolome, Bhagwat, Sachin, Patel, Mahesh, and Oliver, Antonio

Subjects
CEFEPIME, LUNG infections, PSEUDOMONAS aeruginosa, CAENORHABDITIS elegans, LUNGS, GENETIC mutation, RESEARCH, ANIMAL experimentation, RESEARCH methodology, ORGANIC compounds, MEDICAL cooperation, EVALUATION research, HYDROLASES, HYDROCARBONS, PIPERIDINE, CEPHALOSPORINS, COMPARATIVE studies, RESEARCH funding, PSEUDOMONAS, MICE, MICROBIAL sensitivity tests, ANTIBIOTICS, PHARMACODYNAMICS
Abstract

Objectives: To study the dynamics, mechanisms and fitness cost of resistance selection to cefepime, zidebactam and cefepime/zidebactam in Pseudomonas aeruginosa.Methods: WT P. aeruginosa PAO1 and its ΔmutS derivative (PAOMS) were exposed to stepwise increasing concentrations of cefepime, zidebactam and cefepime/zidebactam. Selected mutants were characterized for change in susceptibility profiles, acquired mutations, fitness, virulence and in vivo susceptibility to cefepime/zidebactam. Mutations were identified through WGS. In vitro fitness was assessed by measuring growth in minimal medium and human serum-supplemented Mueller-Hinton broth. Virulence was determined in Caenorhabditis elegans and neutropenic mice lung infection models. In vivo susceptibility to a human-simulated regimen (HSR) of cefepime/zidebactam was studied in neutropenic mice lung infection.Results: Resistance development was lower for the cefepime/zidebactam combination than for the individual components and high-level resistance was only achieved for PAOMS. Cefepime resistance development was associated with mutations leading to the hyperexpression of AmpC or MexXY-OprM, combined with PBP3 mutations and/or large chromosomal deletions involving galU. Zidebactam resistance was mainly associated with mutations in PBP2. On the other hand, resistance to cefepime/zidebactam required multiple mutations in genes encoding MexAB-OprM and its regulators, as well as PBP2 and PBP3. Cumulatively, these mutations inflicted significant fitness cost and cefepime/zidebactam-resistant mutants (MIC = 16-64 mg/L) remained susceptible in vivo to the HSR.Conclusions: Development of cefepime/zidebactam resistance in P. aeruginosa required multiple simultaneous mutations that were associated with a significant impairment of fitness and virulence. [ABSTRACT FROM AUTHOR]

Published
2021
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