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1. Pressure-Controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction: The PiCSO-AMI-I Trial

Author

De Maria, Giovanni Luigi, Greenwood, John P., Zaman, Azfar G., Carrié, Didier, Coste, Pierre, Valgimigli, Marco, Behan, Miles, Berry, Colin, Erglis, Andrejs, Panoulas, Vasileios F., Van Belle, Eric, Juhl Terkelsen, Christian, Hunziker Munsch, Lukas, Jain, Ajay K., Lassen, Jens Flensted, Palmer, Nick, Stone, Gregg W., and Banning, Adrian P.

Published
2024
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2. Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial

Author

Stables, Rodney H., Mullen, Liam J., Elguindy, Mostafa, Nicholas, Zoe, Aboul-Enien, Yousra H., Kemp, Ian, O’Kane, Peter, Hobson, Alex, Johnson, Thomas W., Khan, Sohail Q., Wheatcroft, Stephen B., Garg, Scot, Zaman, Azfar G., Mamas, Mamas A., Nolan, James, Jadhav, Sachin, Berry, Colin, Watkins, Stuart, Hildick-Smith, David, Gunn, Julian, Conway, Dwayne, Hoye, Angels, Fazal, Iftikhar A., Hanratty, Colm G., De Bruyne, Bernard, and Curzen, Nick

Published
2022
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4. Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention: Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry

Author

Godschalk, Thea C., Byrne, Robert A., Adriaenssens, Tom, Malik, Nikesh, Feldman, Laurent J., Guagliumi, Giulio, Alfonso, Fernando, Neumann, Franz-Josef, Trenk, Dietmar, Joner, Michael, Schulz, Christian, Steg, Philippe G., Goodall, Alison H., Wojdyla, Roman, Dudek, Dariusz, Wykrzykowska, Joanna J., Hlinomaz, Ota, Zaman, Azfar G., Curzen, Nick, Dens, Jo, Sinnaeve, Peter, Desmet, Walter, Gershlick, Anthony H., Kastrati, Adnan, Massberg, Steffen, and ten Berg, Jurriën M.

Published
2017
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7. Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study

Author

Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., Heymans, S. R. B., Al-Ali, A. K., Al-Muhanna, F. A., Al-Windy, N. Y. Y., Almubarak, Y. A., Alnafie, A. N., Alshahrani, M., Alshehri, A. M., Anthonio, R. L., Aujayeb, A., ten Berg, J. M., van Boxem, A. J. M., Captur, G., Caputo, M., Charlotte, N., Dark, P., de Sutter, J., Delsing, C. E., Dorman, H. G. R., Drost, J. T., Emans, M. E., Ferreira, J. B., Gabriel, L., van Gilst, W. H., Groenemeijer, B. E., Haerkens-Arends, H. E., van der Harst, P., Hedayat, B., van der Heijden, D. J., Hellou, E., Hermanides, R. S., Hermans-van Ast, J. F., van Hessen, M. W. J., van Ierssel, S. H., Jewbali, L. S., Kearney, M. T., van Kesteren, H. A. M., Kietselaer, B. L. J. H., Koning, A. M. H., Kopylov, P. Y., Kuijper, A. F. M., Kwakkel-van Erp, J. M., van der Linden, M. M. J. M., Linssen, G. C. M., Macias Ruiz, R., Martens, F. M. A. C., McCann, G. P., van der Meer, P., Meijs, M. F. L., Messiaen, P., Monraats, P. S., Montagna, L., Moriarty, A., Mosterd, A., Nierop, P. R., van Ofwegen-Hanekamp, C. E. E., Pinto, Y. M., Poorhosseini, H., Prasad, S., Redón, J., Reidinga, A. C., Ribeiro, M. I. A., Ripley, D. P., Salah, R., Saneei, E., Saxena, M., Schaap, J., Schellings, D. A. A. M., Schut, A., Shafiee, A., Shore, A. C., Siebelink, H. J., Smits, P. C., Pisters, R., Tessitore, E., Tieleman, R. G., Timmermans, P., Tio, R. A., Tjong, F. V. Y., den Uil, C. A., van Craenenbroeck, E. M., van Veen, H. P. A. A., Veneman, T., Verschure, D. O., de Vries, J. K., van de Wal, R. M. A., van de Watering, D. J., Westendorp, I. C. D., Westendorp, P. H. M., Weytjens, C., Wierda, E., Williams, B., Woudstra, P., Wu, K. W., Zaal, R., Zaman, A. G., van der Zee, P. M., Cardiology, ACS - Heart failure & arrhythmias, CAPACITY-COVID collaborative consortium, Cardiologie, RS: Carim - H02 Cardiomyopathy, MUMC+: DA KG Lab Centraal Lab (9), Klinische Neurowetenschappen, MUMC+: HZC Med Staf Spec Klinische Neurofys (9), RS: MHeNs - R3 - Neuroscience, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H04 Arrhythmogenesis and cardiogenetics, MUMC+: MA Med Staf Artsass Cardiologie (9), RS: Carim - V04 Surgical intervention, Intensive Care, MUMC+: MA Medische Staf IC (9), MUMC+: MA Intensive Care (3), Interne Geneeskunde, and MUMC+: MA Alg Interne Geneeskunde (9)

Subjects
Male, SARS-CoV-2, COVID-19, Comorbidity, Hospitalization, Risk Factors, Humans, Mediation analysis, Female, Hospital Mortality, Human medicine, Geriatrics and Gerontology, Mortality, Aged, Retrospective Studies, Netherlands
Abstract

Background Age and comorbidities increase COVID-19 related in-hospital mortality risk, but the extent by which comorbidities mediate the impact of age remains unknown. Methods In this multicenter retrospective cohort study with data from 45 Dutch hospitals, 4806 proven COVID-19 patients hospitalized in Dutch hospitals (between February and July 2020) from the CAPACITY-COVID registry were included (age 69[58–77]years, 64% men). The primary outcome was defined as a combination of in-hospital mortality or discharge with palliative care. Logistic regression analysis was performed to analyze the associations between sex, age, and comorbidities with the primary outcome. The effect of comorbidities on the relation of age with the primary outcome was evaluated using mediation analysis. Results In-hospital COVID-19 related mortality occurred in 1108 (23%) patients, 836 (76%) were aged ≥70 years (70+). Both age 70+ and female sex were univariably associated with outcome (odds ratio [OR]4.68, 95%confidence interval [4.02–5.45], OR0.68[0.59–0.79], respectively;both pp Conclusions Age is the main determinant of COVID-19 related in-hospital mortality, with negligible mediation effect of pre-existing comorbidities. Trial registration CAPACITY-COVID (NCT04325412)

Published
2022

10. Clinical Predictors for Procedural Stroke and Implications for Embolic Protection Devices during TAVR: Results from the Multicenter Transcatheter Aortic Valve Replacement In-Hospital Stroke (TASK) Study

Author

Berkovitch, Anat, primary, Segev, Amit, additional, Maor, Elad, additional, Sedaghat, Alexander, additional, Finkelstein, Ariel, additional, Saccocci, Matteo, additional, Kornowski, Ran, additional, Latib, Azeem, additional, De La Torre Hernandez, Jose M., additional, Søndergaard, Lars, additional, Mylotte, Darren, additional, Van Royen, Niels, additional, Zaman, Azfar G., additional, Robert, Pierre, additional, Sinning, Jan-Malte, additional, Steinvil, Arie, additional, Maisano, Francesco, additional, Orvin, Katia, additional, Iannopollo, Gianmarco, additional, Lee, Dae-Hyun, additional, De Backer, Ole, additional, Mercanti, Federico, additional, van der Wulp, Kees, additional, Shome, Joy, additional, Tchétché, Didier, additional, and Barbash, Israel M., additional

Published
2022
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11. Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries

Author

Linschoten, M., Uijl, A., Schut, A., Jakob, C. E. M., Romao, L. R., Bell, R. M., McFarlane, E., Stecher, M., Zondag, A. G. M., van Iperen, E. P. A., Hermans-van Ast, J. F., Lea, N. C., Schaap, J., Jewbali, L. S., Smits, P. C., Patel, R. S., Aujayeb, A., van Smeden, M., Siebelink, H. J., Williams, S., Pilgram, L., Tieleman, R. G., Williams, B., Asselbergs, F. W., Al-Ali, A. K., Al-Muhanna, F. A., Al-Rubaish, A. M., Al-Windy, N. Y. Y., Alkhalil, M., Almubarak, Y. A., Al Nafie, A. N., Al Shahrani, M., Al Shehri, A. M., Anning, C., Anthonio, R. L., Badings, E. A., Ball, C., Van Beek, E. A., Ten Berg, J. M., Von Bergwelt-Baildon, M., Bianco, M., Blagova, O., V, Bleijendaal, H., Bor, W. L., Borgmann, S., van Boxem, A. J. M., van den Brink, F. S., Bucciarelli-Ducci, C., Van Bussel, B. C. T., Byrom-Goulthorp, R., Captur, G., Caputo, M., Charlotte, N., vom Dahl, J., Dark, P., De Sutter, J., Degenhardt, C., Delsing, C. E., Dolff, S., Dorman, H. G. R., Drost, J. T., Eberwein, L., Emans, M. E., Er, A. G., Ferreira, J. B., Forner, M. J., Friedrichs, A., Gabriel, L., Groenemeijer, B. E., Groenendijk, A. L., Gruener, B., Guggemos, W., Haerkens-Arends, H. E., Hanses, F., Hedayat, B., Heigener, D., van der Heijden, D. J., Hellou, E., Hellwig, K., Henkens, M. T. H. M., Hermanides, R. S., Hermans, W. R. M., van Hessen, M. W. J., Heymans, S. R. B., Hilt, A. D., van der Horst, I. C. C., Hower, M., van Ierssel, S. H., Isberner, N., Jensen, B., Kearney, M. T., Kielstein, J. T., Kietselaer, B. L. J. H., Kochanek, M., Kolk, M. Z. H., Koning, A. M. H., Kopylov, P. Y., Kuijper, A. F. M., Kwakkel-van, E. R. P. J. M., Lanznaster, J., van der Linden, M. M. J. M., van der Lingen, A. C. J., Linssen, G. C. M., Lomas, D., Maarse, M., Magdelijns, F. J. H., Magro, M., Markart, P., Martens, F. M. A. C., Mazzilli, S. G., McCann, G. P., van der Meer, P., Meijs, M. F. L., Merle, U., Messiaen, P., Milovanovic, M., Monraats, P. S., Montagna, L., Moriarty, A., Moss, A. J., Mosterd, A., Nadalin, S., Nattermann, J., Neufang, M., Nierop, P. R., Offerhaus, J. A., Van Ofwegen-Hanekamp, C. E. E., Parker, E., Persoon, A. M., Piepel, C., Pinto, Y. M., Poorhosseini, H., Prasad, S., Raafs, A. G., Raichle, C., Rauschning, D., Redon, J., Reidinga, A. C., Ribeiro, M. I. A., Riedel, C., Rieg, S., Ripley, D. P., Rommele, C., Rothfuss, K., Ruddel, J., Ruthrich, M. M., Salah, R., Saneei, E., Saxena, M., Schellings, D. A. A. M., Scholte, N. T. B., Schubert, J., Seelig, J., Shafiee, A., Shore, A. C., Spinner, C., Stieglitz, S., Strauss, R., Sturkenboom, N. H., Tessitore, E., Thomson, R. J., Timmermans, P. J. R., Tio, R. A., Tjong, F. V. Y., Tometten, L., Trauth, J., Van Craenenbroeck, E. M., van Veen, H. P. A. A., den Uil, C. A., Vehreschild, M. J. G. T., Veldhuis, L., I, Veneman, T., Verschure, D. O., Voigt, I, Walter, L., vande Watering, D. J., de Vries, J. K., vande Wal, R. M. A., Westendorp, I. C. D., Westendorp, P. H. M., Westhoff, T., Weytjens, C., Wierda, E., Wille, K., de With, K., Worm, M., Woudstra, P., Wu, K. W., Zaal, R., Zaman, A. G., van der Zee, P. M., Zijlstra, L. E., Alling, T. E., Ahmed, R., Bayraktar-Verver, E. C. E., van Aken, K., Jimenes, Bermudez F. J., Biole, C. A., Den Boer-Penning, P., Bontje, M., Bos, M., Bosch, L., Broekman, M., Broeyer, F. J. F., de Bruijn, E. A. W., Bruinsma, S., Cardoso, N. M., Cosyns, B., Len, van Da D. H., Dekimpe, E., Domange, J., van Doorn, J. L., van DOorn, P., Dormal, F., Drost, I. M. J., Dunnink, A., van Eck, J. W. M., Elshinawy, K., Gevers, R. M. M., Gognieva, D. G., van der Graaf, M., Grangeon, S., Guclu, A., Habib, A., Haenen, N. A., Hamilton, K., Handgraaf, S., Heidbuchel, H., Hendriks-van Woerden, M., Hessels-Linnemeijer, B. M., Hosseini, K., Huisman, J., Jacobs, T. C., Jansen, S. E., Janssen, A., Jourdan, K., ten Kate, G. L., van Kempen, M. J., Kievit, C. M., Kleikers, P., Knufman, N., van der Kooi, S. E., Koole, B. A. S., Koole, M. A. C., Kui, K. K., Kuipers-Elferink, L., Lemoine, I, Lensink, E., van Marrewijk, V, Meijer, E. J., Melein, A. J., Mesitskaya, D. F., van Nes, C. P. M., Paris, F. M. A., Perrelli, M. G., Pieterse-Rots, A., Pisters, R., Polkerman, B. C., van Poppel, A., Reinders, S., Reitsma, M. J., Ruiter, A. H., Selder, J. L., van der Sluis, A., Sousa, A. I. C., Tajdini, M., Sanchez, Tercedor L., Van de Heyning, C. M., Vial, H., Vlieghe, E., Vonkeman, H. E., Vreugdenhil, P., de Vries, T. A. C., Willems, A. M., Wils, A. M., Zoet-Nugteren, S. K., Linschoten, M., Uijl, A., Schut, A., Jakob, C. E. M., Romao, L. R., Bell, R. M., McFarlane, E., Stecher, M., Zondag, A. G. M., van Iperen, E. P. A., Hermans-van Ast, J. F., Lea, N. C., Schaap, J., Jewbali, L. S., Smits, P. C., Patel, R. S., Aujayeb, A., van Smeden, M., Siebelink, H. J., Williams, S., Pilgram, L., Tieleman, R. G., Williams, B., Asselbergs, F. W., Al-Ali, A. K., Al-Muhanna, F. A., Al-Rubaish, A. M., Al-Windy, N. Y. Y., Alkhalil, M., Almubarak, Y. A., Al Nafie, A. N., Al Shahrani, M., Al Shehri, A. M., Anning, C., Anthonio, R. L., Badings, E. A., Ball, C., Van Beek, E. A., Ten Berg, J. M., Von Bergwelt-Baildon, M., Bianco, M., Blagova, O., V, Bleijendaal, H., Bor, W. L., Borgmann, S., van Boxem, A. J. M., van den Brink, F. S., Bucciarelli-Ducci, C., Van Bussel, B. C. T., Byrom-Goulthorp, R., Captur, G., Caputo, M., Charlotte, N., vom Dahl, J., Dark, P., De Sutter, J., Degenhardt, C., Delsing, C. E., Dolff, S., Dorman, H. G. R., Drost, J. T., Eberwein, L., Emans, M. E., Er, A. G., Ferreira, J. B., Forner, M. J., Friedrichs, A., Gabriel, L., Groenemeijer, B. E., Groenendijk, A. L., Gruener, B., Guggemos, W., Haerkens-Arends, H. E., Hanses, F., Hedayat, B., Heigener, D., van der Heijden, D. J., Hellou, E., Hellwig, K., Henkens, M. T. H. M., Hermanides, R. S., Hermans, W. R. M., van Hessen, M. W. J., Heymans, S. R. B., Hilt, A. D., van der Horst, I. C. C., Hower, M., van Ierssel, S. H., Isberner, N., Jensen, B., Kearney, M. T., Kielstein, J. T., Kietselaer, B. L. J. H., Kochanek, M., Kolk, M. Z. H., Koning, A. M. H., Kopylov, P. Y., Kuijper, A. F. M., Kwakkel-van, E. R. P. J. M., Lanznaster, J., van der Linden, M. M. J. M., van der Lingen, A. C. J., Linssen, G. C. M., Lomas, D., Maarse, M., Magdelijns, F. J. H., Magro, M., Markart, P., Martens, F. M. A. C., Mazzilli, S. G., McCann, G. P., van der Meer, P., Meijs, M. F. L., Merle, U., Messiaen, P., Milovanovic, M., Monraats, P. S., Montagna, L., Moriarty, A., Moss, A. J., Mosterd, A., Nadalin, S., Nattermann, J., Neufang, M., Nierop, P. R., Offerhaus, J. A., Van Ofwegen-Hanekamp, C. E. E., Parker, E., Persoon, A. M., Piepel, C., Pinto, Y. M., Poorhosseini, H., Prasad, S., Raafs, A. G., Raichle, C., Rauschning, D., Redon, J., Reidinga, A. C., Ribeiro, M. I. A., Riedel, C., Rieg, S., Ripley, D. P., Rommele, C., Rothfuss, K., Ruddel, J., Ruthrich, M. M., Salah, R., Saneei, E., Saxena, M., Schellings, D. A. A. M., Scholte, N. T. B., Schubert, J., Seelig, J., Shafiee, A., Shore, A. C., Spinner, C., Stieglitz, S., Strauss, R., Sturkenboom, N. H., Tessitore, E., Thomson, R. J., Timmermans, P. J. R., Tio, R. A., Tjong, F. V. Y., Tometten, L., Trauth, J., Van Craenenbroeck, E. M., van Veen, H. P. A. A., den Uil, C. A., Vehreschild, M. J. G. T., Veldhuis, L., I, Veneman, T., Verschure, D. O., Voigt, I, Walter, L., vande Watering, D. J., de Vries, J. K., vande Wal, R. M. A., Westendorp, I. C. D., Westendorp, P. H. M., Westhoff, T., Weytjens, C., Wierda, E., Wille, K., de With, K., Worm, M., Woudstra, P., Wu, K. W., Zaal, R., Zaman, A. G., van der Zee, P. M., Zijlstra, L. E., Alling, T. E., Ahmed, R., Bayraktar-Verver, E. C. E., van Aken, K., Jimenes, Bermudez F. J., Biole, C. A., Den Boer-Penning, P., Bontje, M., Bos, M., Bosch, L., Broekman, M., Broeyer, F. J. F., de Bruijn, E. A. W., Bruinsma, S., Cardoso, N. M., Cosyns, B., Len, van Da D. H., Dekimpe, E., Domange, J., van Doorn, J. L., van DOorn, P., Dormal, F., Drost, I. M. J., Dunnink, A., van Eck, J. W. M., Elshinawy, K., Gevers, R. M. M., Gognieva, D. G., van der Graaf, M., Grangeon, S., Guclu, A., Habib, A., Haenen, N. A., Hamilton, K., Handgraaf, S., Heidbuchel, H., Hendriks-van Woerden, M., Hessels-Linnemeijer, B. M., Hosseini, K., Huisman, J., Jacobs, T. C., Jansen, S. E., Janssen, A., Jourdan, K., ten Kate, G. L., van Kempen, M. J., Kievit, C. M., Kleikers, P., Knufman, N., van der Kooi, S. E., Koole, B. A. S., Koole, M. A. C., Kui, K. K., Kuipers-Elferink, L., Lemoine, I, Lensink, E., van Marrewijk, V, Meijer, E. J., Melein, A. J., Mesitskaya, D. F., van Nes, C. P. M., Paris, F. M. A., Perrelli, M. G., Pieterse-Rots, A., Pisters, R., Polkerman, B. C., van Poppel, A., Reinders, S., Reitsma, M. J., Ruiter, A. H., Selder, J. L., van der Sluis, A., Sousa, A. I. C., Tajdini, M., Sanchez, Tercedor L., Van de Heyning, C. M., Vial, H., Vlieghe, E., Vonkeman, H. E., Vreugdenhil, P., de Vries, T. A. C., Willems, A. M., Wils, A. M., and Zoet-Nugteren, S. K.

Abstract

Aims Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and in-hospital mortality. Methods and results We used data from the CAPACITY-COVID registry and LEOSS study. Multivariable Poisson regression models were fitted to assess the association between different types of pre-existing heart disease and in-hospital mortality. A total of 16 511 patients with COVID-19 were included (21.1% aged 66-75 years; 40.2% female) and 31.5% had a history of heart disease. Patients with heart disease were older, predominantly male, and often had other comorbid conditions when compared with those without. Mortality was higher in patients with cardiac disease (29.7%; n= 1545 vs. 15.9%; n= 1797). However, following multivariable adjustment, this difference was not significant [adjusted risk ratio (aRR) 1.08, 95% confidence interval (CI) 1.02-1.15; P = 0.12 (corrected for multiple testing)]. Associations with in-hospital mortality by heart disease subtypes differed considerably, with the strongest association for heart failure (aRR 1.19, 95% CI 1.10-1.30; P <0.018) particularly for severe (New York Heart Association class III/IV) heart failure (aRR 1.41, 95% CI 1.20-1.64; P < 0.018). None of the other heart disease subtypes, including ischaemic heart disease, remained significant after multivariable adjustment. Serious cardiac complications were diagnosed in <1% of patients. Conclusion Considerable heterogeneity exists in the strength of association between heart disease subtypes and in-hospital mortality. Of all patients with heart disease, those with heart failure are at greatest risk of death when hospitalized with COVID-19. Serious cardiac complications are rare during hospitalization. [GRAPHICS] .

Published
2022

12. Clinical Predictors for Procedural Stroke and Implications for Embolic Protection Devices during TAVR:Results from the Multicenter Transcatheter Aortic Valve Replacement In-Hospital Stroke (TASK) Study

Author

Berkovitch, Anat, Segev, Amit, Maor, Elad, Sedaghat, Alexander, Finkelstein, Ariel, Saccocci, Matteo, Kornowski, Ran, Latib, Azeem, Hernandez, Jose M.De La Torre, Søndergaard, Lars, Mylotte, Darren, Royen, Niels Van, Zaman, Azfar G., Robert, Pierre, Sinning, Jan Malte, Steinvil, Arie, Maisano, Francesco, Orvin, Katia, Iannopollo, Gianmarco, Lee, Dae Hyun, Backer, Ole De, Mercanti, Federico, van der Wulp, Kees, Shome, Joy, Tchétché, Didier, Barbash, Israel M., Berkovitch, Anat, Segev, Amit, Maor, Elad, Sedaghat, Alexander, Finkelstein, Ariel, Saccocci, Matteo, Kornowski, Ran, Latib, Azeem, Hernandez, Jose M.De La Torre, Søndergaard, Lars, Mylotte, Darren, Royen, Niels Van, Zaman, Azfar G., Robert, Pierre, Sinning, Jan Malte, Steinvil, Arie, Maisano, Francesco, Orvin, Katia, Iannopollo, Gianmarco, Lee, Dae Hyun, Backer, Ole De, Mercanti, Federico, van der Wulp, Kees, Shome, Joy, Tchétché, Didier, and Barbash, Israel M.

Abstract

Background: Data to support the routine use of embolic protection devices for stroke prevention during transcatheter aortic valve replacement (TAVR) are controversial. Identifying patients at high risk for peri-procedural cerebrovascular events may facilitate effective patient selection for embolic protection devices during TAVR. Aim: To generate a risk score model for stratifying TAVR patients according to peri-procedural cerebrovascular events risk. Methods and results: A total of 8779 TAVR patients from 12 centers worldwide were included. Peri-procedural cerebrovascular events were defined as an ischemic stroke or a transient ischemic attack occurring ≤24 h from TAVR. The peri-procedural cerebrovascular events rate was 1.4% (n = 127), which was independently associated with 1-year mortality (hazards ratio (HR) 1.78, 95% confidence interval (CI) 1.06–2.98, p < 0.028). The TASK risk score parameters were history of stroke, use of a non-balloon expandable valve, chronic kidney disease, and peripheral vascular disease, and each parameter was assigned one point. Each one-point increment was associated with a significant increase in peri-procedural cerebrovascular events risk (OR 1.96, 95% CI 1.56–2.45, p < 0.001). The TASK score was dichotomized into very-low, low, intermediate, and high (0, 1, 2, 3–4 points, respectively). The high-risk TASK score group (OR 5.4, 95% CI 2.06–14.16, p = 0.001) was associated with a significantly higher risk of peri-procedural cerebrovascular events compared with the low TASK score group. Conclusions: The proposed novel TASK risk score may assist in the pre-procedural risk stratification of TAVR patients for peri-procedural cerebrovascular events.

Published
2022

26. Contributors

Author

Brener, Sorin, primary, Caplin, John, additional, Christofferson, Ryan D., additional, Columbo, Antonio, additional, Cotton, James, additional, Cribier, Alain, additional, Cusack, Michael, additional, de Belder, Adam, additional, de Belder, Mark Andrew, additional, Duffy, Brendan, additional, Ettles, Duncan, additional, Falluji, Nezar M., additional, Galla, John M., additional, Gershlick, Anthony, additional, Grech, Ever, additional, Hall, Roger V., additional, Herath, Jagath, additional, Heuser, Richard R, additional, Hildick-Smith, David, additional, Holmes, David R., additional, Iakovou, Ioannis, additional, Kapadia, Samir R., additional, Karha, Juhana, additional, Khan, Sadia, additional, Khogali, Saib, additional, Kim, Young-Hak, additional, Kuchulakanti, Pramod, additional, Kunadian, Babu, additional, Lever, Harry M., additional, Lincoff, A. Michael, additional, Lo, Ted, additional, Lovell, Matthew, additional, Malik, Iqbal, additional, Mathur, Anthony, additional, Meier, Bernhard, additional, Moliterno, David J., additional, Moore, Roger KG, additional, Nicholson, Tony, additional, Nolan, James, additional, Norell, Michael S., additional, Ong, Andrew T.L., additional, Park, Seung-Jung, additional, Perrins, John, additional, Perry, Raphael A., additional, Potluri, Srinivasa P., additional, Prendergast, Bernard, additional, Qureshi, Shakeel Ahmed, additional, Ramee, Stephen, additional, Ramsdale, David R., additional, Schofield, Peter, additional, Sebastian, Arun, additional, Seidel, Amy L., additional, Serruys, Patrick W., additional, Shaia, Norman, additional, Shiu, Man Fai, additional, Smith, David, additional, Sorajja, Paul, additional, Stables, Rod, additional, Starkey, Ian R., additional, Thomas, Martyn, additional, Thomson, John, additional, Tuzcuu, Murat, additional, Uren, Neal, additional, Vahanian, Alec, additional, Vaina, Sophia, additional, Waksman, Ron, additional, Whitlow, Patrick L., additional, Windecker, Stephan, additional, and Zaman, Azfar G., additional

Published
2008
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33. Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

Author

Stasiak, Joanna R., primary, Serrani, Marta, additional, Biral, Eugenia, additional, Taylor, James V., additional, Zaman, Azfar G., additional, Jones, Samantha, additional, Ness, Thomas, additional, De Gaetano, Francesco, additional, Costantino, Maria Laura, additional, Bruno, Vito D., additional, Suleiman, Saadeh, additional, Ascione, Raimondo, additional, and Moggridge, Geoff D., additional

Published
2020
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34. Correction: Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

Author

Stasiak, Joanna R., primary, Serrani, Marta, additional, Biral, Eugenia, additional, Taylor, James V., additional, Zaman, Azfar G., additional, Jones, Samantha, additional, Ness, Thomas, additional, De Gaetano, Francesco, additional, Costantino, Maria Laura, additional, Bruno, Vito D., additional, Suleiman, Saadeh, additional, Ascione, Raimondo, additional, and Moggridge, Geoff D., additional

Published
2020
Full Text
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