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Your search keyword '"Zalunardo, Marco P."' showing total 35 results
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35 results on '"Zalunardo, Marco P."'

12. Swiss recommendations for non-anaesthesiologist administered procedural sedation and analgesia in adults

Author

Zalunardo, Marco P., primary, Krayer, Sebastian, additional, Hartmeier, Stefan, additional, Bauerfeind, Peter, additional, Walder, Bernard, additional, von Garnier, Christophe, additional, Ehmann, Tobias, additional, Ammann, Peter, additional, Weilenmann, Daniel, additional, Jacob, Ludwig A., additional, and Franzen, Daniel P., additional

Published
2019
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21. Anesthetic-induced Improvement of the Inflammatory Response to One-lung Ventilation

Author

De Conno, Elisena, primary, Steurer, Marc P., additional, Wittlinger, Moritz, additional, Zalunardo, Marco P., additional, Weder, Walter, additional, Schneiter, Didier, additional, Schimmer, Ralph C., additional, Klaghofer, Richard, additional, Neff, Thomas A., additional, Schmid, Edith R., additional, Spahn, Donat R., additional, Z’graggen, Birgit Roth, additional, Urner, Martin, additional, and Beck-Schimmer, Beatrice, additional

Published
2009
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30. Video-Assisted Thoracoscopic Volume Reduction Surgery in Patients with Diffuse Pulmonary Emphysema

Author

ZOLLINGER, ANDREAS, primary, ZAUGG, MICHAEL, additional, WEDER, WALTER, additional, RUSSI, ERICH W., additional, BLUMENTHAL, STEPHAN, additional, ZALUNARDO, MARCO P., additional, STOEHR, SIMONE, additional, THURNHEER, ROBERT, additional, STAMMBERGER, U Z, additional, SPAHN, DONAT R., additional, PASCH, THOMAS, additional, and Pizov, Reuven, additional

Published
1998
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33. Patterns of Changes in Arterial PO2 During One-Lung Ventilation: A Comparison Between Patients With Severe Pulmonary Emphysema and Patients With Preserved Lung Function.

Author

Aschkenasy, Schlomo V., Hofer, Christoph K., Zalunardo, Marco P., Zaugg, Michael, Weder, Walter, Seifert, Burkhardt, Pasch, Thomas, and Zollinger, Andreas

Subjects
PULMONARY emphysema, OBSTRUCTIVE lung diseases, ANALYSIS of variance, UNIVERSITY hospitals
Abstract

Objectives: One-lung ventilation (OLV) during thoracoscopic surgery is associated with a significant decline in arterial PO2 in patients with severe pulmonary emphysema and patients with preserved lung function. The authors hypothesized that patterns of arterial PO2 changes are different in these 2 patient groups. Design: Prospective nonrandomized study. Setting: University hospital. Participants: Twenty-five patients undergoing thoracoscopic interventions: 16 with severe pulmonary emphysema and 9 patients without emphysema. Interventions: Continuous arterial blood gas measurement (PaO2, PaCO2, pHa) during OLV of the left lung in left lateral position using the Paratrend 7 blood gas monitoring system (PT7; Pfizer Hospital Products Group, High Wycombe, UK). Main Results: The decrease of PaO2 was delayed in patients with severe emphysema. Steady state (defined as ΔPaO2 <7.5mmHg/min) was reached after 18 ± 4 minutes compared with 11 ± 3 minutes (mean ± standard deviation) in patients with normal lung function (p = 0.0002). PaO2 values at steady state were comparable (p = 0.49); the pattern of changes in PaO2 for the first 15 minutes of left-sided OLV was significantly different between the groups (p = 0.0004). The difference of predicted versus measured PaO2 at steady state was −48 ± 160 mmHg for patients with emphysema and −51 ± 60 mmHg for patients with normal lung function (p = 0.019). Conclusion: During OLV, oxygenation is better preserved for a longer period of time in patients with severe pulmonary emphysema as compared with patients with normal lung function. In contrast to patients without emphysema, prediction of oxygenation during OLV for the individual patient with emphysema is unreliable because of large interindividual differences. [Copyright &y& Elsevier]

Published
2005
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34. Impact of cytokine release on ventricular function after hepatic reperfusion: a prospective observational echocardiographic study with tissue Doppler imaging

Author

Martin Schläpfer, Donat R. Spahn, Burkhardt Seifert, Beatrice Beck-Schimmer, Marco P. Zalunardo, Dominique Bettex, University of Zurich, and Zalunardo, Marco P

Subjects
Adult, Male, Cardiac function curve, medicine.medical_specialty, Mean arterial pressure, Adolescent, medicine.medical_treatment, Diastole, Hemodynamics, 610 Medicine & health, Liver transplantation, Doppler imaging, Young Adult, Internal medicine, medicine, Humans, Ventricular Function, Arterial Pressure, Prospective Studies, Contraindication, Aged, business.industry, Cardiac function, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Postreperfusion syndrome, Middle Aged, Echocardiography, Doppler, Color, Anesthesiology and Pain Medicine, Blood pressure, Cardiology, Cytokines, Female, 2703 Anesthesiology and Pain Medicine, business, Echocardiography, Transesophageal, Research Article
Abstract

Background Postreperfusion syndrome and haemodynamic instability are predictors for poor outcome after liver transplantation. Cytokine release has been claimed to be responsible for postreperfusion syndrome. However, the underlying pathophysiologic mechanism is not clarified. The aim of this prospective observational study was to correlate cardiac performance (measured by transoesophageal echocardiography (TEE), Doppler and Tissue Doppler Imaging (TDI)) to plasmatic cytokines: IL-6, IL-8, CXCL1, TGF-β and CD40L at 5 different time points during liver transplantation. Methods Seventeen consecutive patients scheduled for orthotopic liver transplantation, age 18 to 75 years without contraindication for transoesophageal echocardiography were included. Patients were monitored with TEE and TDI. Systolic and diastolic cardiac function, MAP, MPAP, CVP, PCWP, CO and blood samples for cytokine assays were recorded or collected after induction, 15 min after vena cava inferior clamping, 2 to 5 min after reperfusion, 60 min after reperfusion and at the end of surgery. Results Mean arterial pressure and catecholamine requirements remained unchanged, MPAP, CVP and CO increased, SVR decreased after unclamping. Postreperfusion syndrome did not develop. The haemodynamic parameters and the variations of TEE parameters were consistent with the volume load changes during clamping and declamping and did not reveal systolic or diastolic cardiac dysfunction. All cytokines, except TGF-β, increased. Conclusion These findings suggest, that significant cytokine release during liver transplantation is not necessarily coincident with haemodynamic instability and impaired cardiac function. Trial registration ClinicalTrials.gov: NCT00547924

Published
2015

35. Preoperative clonidine blunts hyperadrenergic and hyperdynamic responses to prolonged tourniquet pressure during general anesthesia

Author

Andreas Zollinger, Burkhardt Seifert, Patricia Szelloe, Marco P. Zalunardo, Fabia Weisser, Daniel Serafino, Thomas Pasch, University of Zurich, and Zalunardo, Marco P

Subjects
Adult, Male, Mean arterial pressure, Hemodynamics, 610 Medicine & health, Blood Pressure, Anesthesia, General, Clonidine, Norepinephrine (medication), Norepinephrine, Double-Blind Method, Heart rate, medicine, Humans, Tourniquet, business.industry, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Middle Aged, Tourniquets, equipment and supplies, body regions, surgical procedures, operative, Anesthesiology and Pain Medicine, Epinephrine, Blood pressure, Anesthesia, Multivariate Analysis, Female, 2703 Anesthesiology and Pain Medicine, business, medicine.drug
Abstract

UNLABELLED Although the mechanism of tourniquet-induced hypertension is still unclear, plasma norepinephrine concentrations continuously increase in parallel to arterial blood pressure during tourniquet inflation. Clonidine attenuates hyperadrenergic and hyperdynamic responses. We investigated the effects of clonidine on prolonged tourniquet inflation. Twenty-nine patients scheduled for elective orthopedic surgery were randomly assigned to receive IV clonidine (3 microg/kg; n = 14) or placebo (n = 15) before tourniquet inflation of the lower limbs under general anesthesia in a double-blinded manner. Arterial blood pressure, heart rate, epinephrine, and norepinephrine plasma concentrations were measured before tourniquet inflation, 60 min after tourniquet inflation, just before tourniquet deflation, and 20 min after tourniquet deflation. Mean arterial blood pressure and norepinephrine plasma-concentrations were significantly lower in the Clonidine group compared with Control after 60 min tourniquet inflation (P = 0.016; P = 0.006). Immediately before deflation of the tourniquet, the difference for mean arterial pressure between groups was even more pronounced (P = 0.005). Twenty minutes after deflation mean arterial blood pressure in the Control group was still increased and significantly higher compared with the Clonidine group (P = 0.002). In conclusion, preoperative IV clonidine blunts hyperadrenergic and hyperdynamic responses resulting from prolonged tourniquet inflation under general anesthesia in ASA class I--II patients. IMPLICATIONS Tourniquet inflation is associated with a continuous increase in arterial blood pressure and sympathetic outflow. This study shows that IV clonidine effectively blunts increases of both arterial blood pressure and plasma norepinephrine concentrations.

Published
2002
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