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15 results on '"Zalin, Anjali"'

1. Patient and operative factors influence delayed discharge following bariatric surgery in an enhanced recovery setting

Author

Katz-Summercorn, Annalise C., Arhi, Chanpreet, Agyemang-Yeboah, David, Cirocchi, Nicholas, Musendeki, Debbie, Fitt, Irene, McGrandles, Rosie, Zalin, Anjali, Foldi, Istvan, Rashid, Farhan, Adil, Md Tanveer, Jain, Vigyan, Mamidanna, Ravikrishna, Jambulingam, Periyathambi, Munasinghe, Aruna, Whitelaw, Douglas E., and Al-Taan, Omer

Published
2024
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2. Stress hyperglycaemia in the acute care setting

Author

Zalin, Anjali, Bell, Derek, and Shotliff, Kevin

Subjects
610
Abstract

Introduction: Stress hyperglycaemia (SH), defined as transient hyperglycaemia during illness, is seen in up to 50% of inpatients and may progress to glucose intolerance in a significant proportion. SH is also associated with increased mortality. Despite this, there is no consensus on definition and management. Existing work focuses on single disease groups, frequently reporting adverse outcomes and variable success with therapies. There is, however, a scarcity of work profiling individuals with SH in detail. It is hoped that this approach may contribute to individualised management and improved outcomes for people with the condition. Methods: The central hypotheses of this work focus on metabolic profiling and were examined through a prospective observational study. Participants were allocated into study groups based on glucose levels. A 30-day follow-up was organised for people with SH. Novel biomarkers, tools and a diabetes risk calculator were employed to provide the most detailed profile currently available of individuals with stress hyperglycaemia. Finally, results from the first multicentre trial to bear on the effect of metformin in SH are presented. Results: The prevalence of SH was 34% and 31% in prospective (n=62) and metformin (n=52) studies respectively. People with SH had lower fasting insulin levels and insulin resistance. Otherwise, few differences were found. Metabolic profile, glycaemic variability, and HbA1c values were similar in both groups. Metabolic abnormalities and marked glycaemic excursions were also seen in both groups. Metformin was well tolerated but did not result in significantly reduced glucose variability or levels during the study period. Conclusions: People with SH do not appear to be phenotypically different from people without the condition. Marked hyper- and hypoglycaemia are common in hospital patients despite apparent normal glucose levels. Increased vigilance as well as timely and appropriate interventions could significantly improve outcomes for these individuals.

Published
2016
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7. BS P02 Sleeve gastrectomy and gastric bypass day surgery: outcomes and experience from a single centre

Author

Katz-Summercorn, Annalise, primary, Shah, Runil, additional, Arhi, Chanpreet, additional, Musendeki, Debbie, additional, Fitt, Irene, additional, McGrandles, Rosie, additional, Zalin, Anjali, additional, Rashid, Farhan, additional, Adil, Md Tanveer, additional, Jain, Vigyan, additional, Mamidanna, Ravikrishna, additional, Jambulingam, Periyathambi, additional, Munasinghe, Aruna, additional, Whitelaw, Douglas, additional, and Al-Taan, Omer, additional

Published
2022
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12. Stress hyperglycaemia in the acute care setting

Author

Zalin, Anjali, Bell, Professor Derek, Shotliff, Dr Kevin, and Chelsea and Westminster Hospital NHS Foundation Trust

Abstract

Introduction: Stress hyperglycaemia (SH), defined as transient hyperglycaemia during illness, is seen in up to 50% of inpatients and may progress to glucose intolerance in a significant proportion. SH is also associated with increased mortality. Despite this, there is no consensus on definition and management. Existing work focuses on single disease groups, frequently reporting adverse outcomes and variable success with therapies. There is, however, a scarcity of work profiling individuals with SH in detail. It is hoped that this approach may contribute to individualised management and improved outcomes for people with the condition. Methods: The central hypotheses of this work focus on metabolic profiling and were examined through a prospective observational study. Participants were allocated into study groups based on glucose levels. A 30-day follow-up was organised for people with SH. Novel biomarkers, tools and a diabetes risk calculator were employed to provide the most detailed profile currently available of individuals with stress hyperglycaemia. Finally, results from the first multicentre trial to bear on the effect of metformin in SH are presented. Results: The prevalence of SH was 34% and 31% in prospective (n=62) and metformin (n=52) studies respectively. People with SH had lower fasting insulin levels and insulin resistance. Otherwise, few differences were found. Metabolic profile, glycaemic variability, and HbA1c values were similar in both groups. Metabolic abnormalities and marked glycaemic excursions were also seen in both groups. Metformin was well tolerated but did not result in significantly reduced glucose variability or levels during the study period. Conclusions: People with SH do not appear to be phenotypically different from people without the condition. Marked hyper- and hypoglycaemia are common in hospital patients despite apparent normal glucose levels. Increased vigilance as well as timely and appropriate interventions could significantly improve outcomes for these individuals. Open Access

Published
2015

14. Bariatric surgery: Practical aspects of primary care management.

Author

Zalin, Anjali, Munro, Neil, and Greener, Veronica

Subjects
TYPE 2 diabetes, BARIATRIC surgery, PATIENT monitoring, PRIMARY health care, DISEASE remission, NUTRITIONAL status
Abstract

Bariatric surgery is an effective treatment for obesity and can lead to remission of its related complications, including type 2 diabetes. However, recipients need appropriate preoperative advice and management from dietitians and psychologists to ensure suitability for surgery and ability to change behaviour. Certain procedures also require lifelong nutritional supplementation, and all recipients will need long-term monitoring and management, which currently takes place in primary care. This article is a review of bariatric surgery and the role of primary care in supporting people who undergo it. [ABSTRACT FROM AUTHOR]

Published
2017

15. The Challenges of Conducting Research on the Acute Medical Unit.

Author

O'Dell T, Zalin A, and Vaughan L

Subjects
Acute Disease, Female, Humans, Hyperglycemia diagnosis, Length of Stay statistics & numerical data, Male, Patient Care Team organization & administration, Research Design, Risk Assessment, Biomedical Research organization & administration, Emergency Service, Hospital organization & administration, Hyperglycemia therapy, Patient Discharge statistics & numerical data, Triage
Abstract

Conducting research on the Acute Medical Unit (AMU) poses unique challenges; the environment is one that sees a diverse range of patient groups and pathologies and holds the potential for easy patient recruitment to research studies, however is geared towards a specific set of triage and discharge goals. We conducted a study into Stress Hyperglycaemia (SH) on a busy AMU, which involved profiling glycaemic changes using specialist equipment and interventions in patients with unscheduled medical admissions, and experienced a number of challenges. This article discusses these challenges and proposes potential solutions. Conducting research on a busy AMU was complicated by factors including rapid patient and staff turnover, the differing goals of the AMU system and suboptimal staff engagement in labour intensive research. We endeavored to follow patients up in further visits after discharge but found they lacked engagement after the resolution of the acute illness requiring initial admission. In this article, we discuss these issues in more detail and suggest approaches for future AMU researchers.

Published
2016

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