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OaPAC is a recently discovered blue-light-using flavin adenosine dinucleotide (BLUF) photoactivated adenylate cyclase from the cyanobacterium Oscillatoria acuminata that uses adenosine triphosphate and translates the light signal into the production of cyclic adenosine monophosphate. Here, we report crystal structures of the enzyme in the absence of its natural substrate determined from room-temperature serial crystallography data collected at both an X-ray free-electron laser and a synchrotron, and we compare these structures with cryo-macromolecular crystallography structures obtained at a synchrotron by us and others. These results reveal slight differences in the structure of the enzyme due to data collection at different temperatures and X-ray sources. We further investigate the effect of the Y6W mutation in the BLUF domain, a mutation which results in a rearrangement of the hydrogen-bond network around the flavin and a notable rotation of the side chain of the critical Gln48 residue. These studies pave the way for picosecond–millisecond time-resolved serial crystallography experiments at X-ray free-electron lasers and synchrotrons in order to determine the early structural intermediates and correlate them with the well studied picosecond–millisecond spectroscopic intermediates.

Administering gadolinium-based contrast agent before electroporation allows the contrast agent to enter the cells and enables MRI assessment of reversibly electroporated regions. The aim of this study was evaluation of contrast agent entrapment in Chinese hamster ovary (CHO) cells and comparison of these results with those determined by standard in vitro methods for assessing cell membrane permeability, cell membrane integrity and cell survival following electroporation.

The article explores how intercultural relations can be fostered at the level of an undergraduate university degree during the pandemic. It offers one specific intervention within intercultural education to provide new ways of thinking about how intercultural relations can and do happen. By drawing on the "self-reflexive narratives" of the article's authors -- a university lecturer and three students -- we consider the ways in which intercultural education can enable people from diverse cultures to build a learning community. On the basis of a thematic analysis, we explore the role of reflection and action in the creation of intercultural knowledge that can lead towards developing meaningful relations and can assist in further supporting students in their well-being. We first map some key issues in intercultural education at the university level and provide a short literature review. Secondly, we briefly describe our intercultural initiative. We put our narratives into conversation in order to facilitate deeper understanding of how to build meaningful intercultural relationships, while learning, and collaborating together. Our goal is to reflect on perceptions of "the quality" of intercultural relationship experiences at the level of a university degree and to show how complex relational work fostered intercultural collaboration during the pandemic. On the basis of our inductive research, we offer an original approach to fostering intercultural education based on four stages: constructing and fostering an initial encounter; promoting group participation; emphasising reciprocity; and constructing activities to promote trust and care. Our experience demonstrated how forming intercultural relationships can meaningfully help students with their expectations, aspirations, and ultimately, careers.

Single individuals of the Greater Spotted Eagle (Clanga clanga), Indian Spotted Eagle (Clanga hastata), Tawny Eagle (Aquila rapax), Western Marsh Harrier (Circus aeruginosus), and two Pallid Harriers (Circus macrourus) were deployed with satellite transmitters in 2021 to study their home ranges, habitat associations, movement, and migration patterns. Data were collected for a combined number of 2291 days, providing 84,544 locations. Home ranges were calculated as kernel utilization distributions and expressed as 95% KDE and core areas as 50% KDE. Overall, eagles had larger home ranges (mean ± SD) of 942.70 ± 937.83 km2 compared to harriers, 43.84 ± 35.55 km2. Among eagles, the Greater Spotted Eagle had the largest home-range size of 2147.03 km2 calculated in Kazakhstan, while the female Pallid Harrier had the smallest home range of 5.74 km2 in Russia. Daily and monthly distances varied among eagles and harriers. The female Pallid Harrier covered the longest average monthly distance of 8585.43 ± 11,943.39 km, while the shortest monthly distance of 1338.22 ± 716.38 km was traveled by the Indian Spotted Eagle. All tagged birds migrated toward higher latitudes in the Northern hemisphere, except the Indian Spotted Eagle, which migrated to Pakistan. The male Western Marsh Harrier covered the longest migration distance in a shorter span of time, while the female Pallid Harrier took the longest to cover its migration distance. Overall, the daily distance covered during migration varied from 115.09 km traveled by the Indian Spotted Eagle to an overwhelming distance of 2035.85 km covered by the male Western Marsh Harrier. Scrubs, water bodies, croplands, and settlements were important habitat features associated with eagles, while croplands, open scrub, and built-up areas were associated with the female Pallid Harrier. The male Western Marsh Harrier was found to be primarily associated with saltpans and salt-affected areas having emergent vegetation. This study presents new insights into the movement and spatial ecology of long-distance migrant raptors that winter in Western India. We provide preliminary support for the use of the Western Circum–Himalayan Corridor as one of the important corridors of the Central Asian Flyway that warrants much appreciation among the current set of flyway corridors.

Abstract Long-term synaptic plasticity is critical for adaptive function of the brain, but presynaptic mechanisms of functional plasticity remain poorly understood. Here, we show that changes in synaptic efficacy induced by activation of the cannabinoid type-1 receptor (CB1R), one of the most widespread G-protein coupled receptors in the brain, requires contractility of the neuronal actomyosin cytoskeleton. Specifically, using a synaptophysin-pHluorin probe (sypH2), we show that inhibitors of non-muscle myosin II (NMII) ATPase as well as one of its upstream effectors Rho-associated kinase (ROCK) prevent the reduction of synaptic vesicle release induced by CB1R activation. Using 3D STORM super-resolution microscopy, we find that activation of CB1R induces a redistribution of synaptic vesicles within presynaptic boutons in an actomyosin dependent manner, leading to vesicle clustering within the bouton and depletion of synaptic vesicles from the active zone. We further show, using sypH2, that inhibitors of NMII and ROCK specifically restore the release of the readily releasable pool of synaptic vesicles from the inhibition induced by CB1R activation. Finally, using slice electrophysiology, we find that activation of both NMII and ROCK is necessary for the long-term, but not the short-term, form of CB1R induced synaptic plasticity at excitatory cortico-striatal synapses. We thus propose a novel mechanism underlying CB1R-induced plasticity, whereby CB1R activation leads to a contraction of the actomyosin cytoskeleton inducing a reorganization of the functional presynaptic vesicle pool, preventing vesicle release and inducing long-term depression.

Abstract Intracranial aneurysms (IAs) are a common vascular pathology and are associated with a risk of rupture, which is often fatal. Aneurysm growth of more than 1 mm is considered a surrogate of rupture risk, therefore, this study presents a comprehensive analysis of intracranial aneurysm measurements utilizing a dataset comprising 358 IA from 248 computed tomography angiography (CTA) scans measured by four junior raters and one senior rater. The study explores the variability in sizing assessments by employing both human raters and an Artificial Intelligence (AI) system. Our findings reveal substantial inter- and intra-rater variability among junior raters, contrasting with the lower intra-rater variability observed in the senior rater. Standard deviations of all raters were above the threshold for IA growth (1 mm). Additionally, the study identifies a systemic bias, indicating a tendency for human experts to measure aneurysms smaller than the AI system. Our findings emphasize the challenges in human assessment while also showcasing the capacity of AI technology to improve the precision and reliability of intracranial aneurysm assessments, especially beneficial for junior raters. The potential of AI was particularly evident in the task of monitoring IA at various intervals, where the AI-based approach surpassed junior raters and achieved performance comparable to senior raters.

Incidentalom nadledvičnice je sprememba brez simptomov, naključno odkrita pri slikovnih preiskavah zaradi razlogov, ki ne vključujejo bolezni nadledvičnic. Njihova prevalenca strmo narašča na račun vedno večjega števila opravljenih slikovnih preiskav. Pretežno gre za benigne, hormonsko neaktivne adenome. Ob odkritju incidentaloma moramo razlikovati med benignimi in malignimi spremembami ter ugotoviti morebitno hormonsko aktivnost. Sodobno obravnavo incidentalomov predstavljava na izjemnem kliničnem primeru bolnice z drobnim incidentalomom leve nadledvičnice. Kljub visoki gostoti na nativni računalniški tomografiji (CT) smo na podlagi izplavljanja kontrasta v skladu s takratno prakso spremembo označili za benigno in odsvetovali nadaljnje morfološko spremljanje. Kljub temu je bolnica v naslednjih letih zaradi različnih zdravstvenih težav opravila več slikovnih preiskav, vendar spremembe velikosti tumorja ni bilo. Šele 6 let od odkritja so zaradi posledic covida-19 svetovali CT prsnega koša, ki je razkril izrazito rast tumorja. Bolnico smo napotili na levostransko laparoskopsko adrenalektomijo. Patohistološko je bil potrjen karcinom skorje nadledvične žleze, zato smo uvedli adjuvantno adrenolitično zdravljenje z mitotanom. Incidentalomi nadledvičnic so pretežno benigni in klinično nepomembni, včasih pa lahko ogrozijo življenje. Zato je pomembno, da jih obravnavamo v skladu s predstavljenimi smernicami. V izjemnih primerih z atipičnim potekom, kot je bilo pri naši bolnici, bo za ugoden razplet ključna obravnava znotraj interdisciplinarnega tima.

This study aimed to assess the prevalence of edentulism and tooth loss in the Slovenian elderly population, along with the associated risk factors, and investigate the association between systemic and oral health.

Abstract Background The concurrent circulation of SARS-CoV-2 with other respiratory viruses is unstoppable and represents a new diagnostic reality for clinicians and clinical microbiology laboratories. Multiplexed molecular testing on automated platforms that focus on the simultaneous detection of multiple respiratory viruses in a single tube is a useful approach for current and future diagnosis of respiratory infections in the clinical setting. Methods Two time periods were included in the study: from February to April 2022, an early 2022 period, during the gradual lifting of COVID-19 prevention measures in the country, and from October 2022 to April 2023, the 2022/23 respiratory infections season. We analysed a total of 1,918 samples in the first period and 18,131 respiratory samples in the second period using a multiplex molecular assay for the simultaneous detection of Influenza A (Flu-A), Influenza B (Flu-B), Human Respiratory Syncytial Virus (HRSV) and SARS-CoV-2. Results The results from early 2022 showed a strong dominance of SARS-CoV-2 infections with 1,267/1,918 (66.1%) cases. Flu-A was detected in 30/1,918 (1.6%) samples, HRSV in 14/1,918 (0.7%) samples, and Flu-B in 2/1,918 (0.1%) samples. Flu-A/SARS-CoV-2 co-detections were observed in 11/1,267 (0.9%) samples, and HRSV/SARS-CoV-2 co-detection in 5/1,267 (0.4%) samples. During the 2022/23 winter respiratory season, SARS-CoV-2 was detected in 1,738/18,131 (9.6%), Flu-A in 628/18,131 (3.5%), Flu-B in 106/18,131 (0.6%), and HRSV in 505/18,131 (2.8%) samples. Interestingly, co-detections were present to a similar extent as in early 2022. Conclusion The results show that the multiplex molecular approach is a valuable tool for the simultaneous laboratory diagnosis of SARS-CoV-2, Flu-A/B, and HRSV in hospitalized and outpatients. Infections with Flu-A/B, and HRSV occurred shortly after the COVID-19 control measures were lifted, so a strong reoccurrence of various respiratory infections and co-detections in the post COVID-19 period was to be expected.

Oral protein delivery technologies often depend on encapsulating or enclosing the protein cargo to protect it against pH-driven degradation in the stomach or enzymatic digestion in the small intestine. An emergent methodology is to encapsulate therapeutics in microscale, asymmetric, planar microparticles, referred to as microdevices. Previous work has shown that, compared to spherical particles, planar microdevices have longer residence times in the GI tract, but it remains unclear how specific design choices (e.g., material selection, particle diameter) impact microdevice behavior in vivo. Recent advances in microdevice fabrication through picoliter printing have expanded the range of device sizes that can be fabricated in a rapid manner. However, relatively little work has explored how device size governs their behavior in the intestinal environment. In this study, we probe the impact of geometry of planar microdevices on their transit and accumulation in the murine GI tract. Additionally, we present a strategy to label, image, and quantify these distributions in intact tissue in a continuous manner, enabling a more detailed understanding of device distribution and transit kinetics than previously possible. We show that smaller particles (194.6 ± 7 μm.diameter) tend to empty from the stomach faster than midsize (293.2 ± 7 μm.diameter) and larger devices (440.9 ± 9 μm.diameter) and that larger devices distribute more broadly in the GI tract and exit slower than other geometries. In general, we observed an inverse correlation between device diameter and GI transit rate. These results inform the future design of drug delivery systems, using particle geometry as an engineering design parameter to control device accumulation and distribution in the GI tract. Additionally, our image analysis process provides greater insight into the tissue level distribution and transit of particle populations. Using this technique, we demonstrate that microdevices act and translocate independently, as opposed to transiting in one homogeneous mass, meaning that target sites will likely be exposed to devices multiple times over the course of hours post administration. This imaging technique and associated findings enable data-informed design of future particle delivery systems, allowing orthogonal control of transit and distribution kinetics in vivo independent of material and cargo selection.

Introdução objetivos: Adultos de 50 a 59 anos de idade com condições médicas crônicas específicas apresentam risco aumentado de doença grave por vírus sincicial respiratório (VSR). Relatamos dados de imunogenicidade e segurança da vacina RSVPreF3OA em adultos de 50 a 59 anos com/sem condições crônicas que aumentam o risco de doença por VSR. Materiais métodos: Este estudo multinacional de fase 3, cego para observadores e controlado por placebo (NCT05590403) selecionou adultos de 50 a 59 anos de idade, incluindo aqueles com risco aumentado para doença por VSR (RA-VSR) devido a condições crônicas específicas. Os participantes foram randomizados (2:1) para receber vacina RSVPreF3OA (RA-VSR, não-RA-VSR) ou placebo (RA-placebo, não-RA-placebo). Um grupo controle de adultos ≥ 60 anos (OA-RSV) recebeu a vacina RSVPreF3OA. Avaliamos a não inferioridade da resposta imune humoral em pessoas com 50-59 anos versus ≥ 60 anos, além da imunidade celular e segurança. Resultados: 1.533 participantes receberam vacina RSVPreF3OA ou placebo. Critérios de não inferioridade foram demonstrados para títulos de neutralização de VSR-A e VSR-B. As frequências medianas de células T CD4+ específicas para RSVPreF3 aumentaram 1 mês após a vacinação comparado a pré-vacinação em todos os grupos com VSR. Alguns eventos adversos (EAs) solicitados foram relatados com incidências mais altas, mas com gravidade e duração semelhantes em 50-59 anos versus ≥ 60 anos. Em todos os grupos, 10,5%-16,3% dos participantes relataram EAs não solicitados dentro de 30 dias após a vacinação, e 0,5%-3,6% dos participantes relataram EAs graves em até 6 meses após a vacinação. Uma potencial doença imunomediada (anemia hemolítica autoimune a frio no grupo OA-RSV) foi considerada relacionada à vacina pelo investigador. Nenhuma morte foi relatada. Conclusões: As respostas imunes à vacina RSVPreF3OA em adultos com 50-59 anos não foram inferiores às respostas imunes em ≥ 60 anos, nos quais a eficácia já está demonstrada. O perfil de segurança global em pacientes 50-59 anos foi consistente com o perfil de segurança favorável nos ≥ 60 anos. Palavras-chave: Virus Sincicial Respiratorio, Vacina VSR, Vacinação em adultos. Conflitos interesse: LM, SD, M-PD, DD, HAH, MDH, JH, VH, CV são/foram funcionários da GSK no momento em que o estudo foi realizado/desenvolvido. SD, M-PD, DD, HAH, MDH, JH, VH detêm ações da GSK como parte da remuneração como funcionários. M-PD é co-requerente de uma patente pendente para a GSK. MF recebeu pagamentos relacionados ao estudo para treinamento e condução do estudo da GSK. TFS recebeu honorário da AstraZeneca, Bavarian Nordic, Biogen, CSL-Seqirus, GSK, Janssen-Cilag, Merck-Serono, Moderna, Novavax, MSD, Pfizer, Roche, Sanofi-Aventis, Takeda; e participou de conselhos consultivos da Bavarian Nordic, CSL-Seqirus, BioNTech, GSK, Moderna, Novavax, Takeda. SAN recebeu apoio da GSK para sua instituição e para participar de reuniões de investigadores. JR-G recebeu honorários por educação médica continuada da GSK, Pfizer e Sanofi; suporte para participação em reuniões e/ou viagens da Pfizer e Sanofi; participação em conselhos de monitoramento de segurança de dados ou conselhos consultivos da GSK, SEQUIRUS e Pfizer. CZ recebeu bolsas da GSK para a realização deste estudo e apoio para participar de reuniões. JG declara pagamentos relacionados a estudos da GSK; doações da Novartis, Pharmalog, New Amsterdam Pharma, Syneos, Winecker Pharma e Lilly; honorários de consultoria, pagamento por depoimentos de especialistas e suporte para participação em reuniões e/ou viagens da GSK. CV-P é empregado da QPS Netherlands B.V. MM, BS, NT, DOM, and HM não tem nada a declarar. Todos os autores não declaram quaisquer outros interesses, relacionamentos e atividades financeiras ou não financeiras. Agradecimentos: À plataforma Business & Decision Life Sciences por fornecer assistência editorial e coordenar a publicação em nome da GSK. Os autores agradecem a Catherine Gérard (CL&AP) pela aquisição e interpretação dos dados, e a Mathilde Laffitte (Biostats) pela análise dos dados. Grupo de estudo Khalid S. Abd-Elaziz, Mark S. Adams, Ashley E. Fuller, Agnieszka Barts, Kevin Cannon, Matthew Davis, Sonia de las Fuentes Galán, Marta de los Ríos Rodríguez, Maria Cristina De Salvo, Lauren DeGregoria, Víctor del Campo Pérez, Torsten Drescher, Peter Dzongowski, Jose Ma Echave-Sustaeta, Tamara Julia Eckermann, Jaume Garí Parera, Jean Sebastien Gauthier, Steven Geller, Wayne Ghesquiere, Antonio Gonzalez, Patricia González Cediel, Anton Grasch, Laura L. Helman, María Herranz Urbasos, Nicolas Itcovici, Terry Klein, Kristen Marks, Jorge Labrador Gómez, Antonio Lalueza Blanco, Ryan Leblanc, Matthias Luttermann, Cristina Masuet-Aumatell, Leonie Möckesch, Tamara Michelle Moreno Silva, Silvia Narejos Perez, Jérôme C. Oude Nijhuis, Jean-Sebastien Paquette, Bonavuth Pek, Georg Plassmann, Robert Pritt, Mireia Puig Palma, Rebecca Dunsmoor-Su, Robert J. Noveck, Claudio Rocha-Calderon, Paule Royer David Shu, Ying Tung Sia, Angelika Sieber, Leslie Sinclair, Joseph Soufer, Ana Suarez Simón, Susan Hernandez, Todd Simmons, Genoveva Vilardell Rifa, María Teresa Vilella Moreno, Ulrich Weber, William B. Smith, Alba María Yañez de la Higuera, Pedro Ylisastigui. Ética e financiamentos: Financiamento GlaxoSmithKline Biologicals SA.

Uvod: Prekinitev nosečnosti predstavlja stisko za žensko, partnerja in družino. Pomembno je, da zdravstveno osebje v celovito zdravstveno obravnavo vključi tudi duhovno oskrbo. Namen pregleda literature je ugotoviti, kakšno duhovno oskrbo najpogosteje potrebujejo ženske po spontani prekinitvi nosečnosti. Metode: Izveden je bil sistematični pregled literature v bazah podatkov CINAHL Ultimative, Science Direct, Wiley Online Library in Web of Science z iskalnim nizom v angleškem jeziku. Za prikaz iskanja, pregleda in izbora člankov za analizo je bil uporabljen diagram poteka PRISMA. Izvedena je bila kritična ocena člankov s kontrolnimi seznami Joanna Briggs Institute. Zbrani podatki so bili analizirani po metodi vsebinske analize. Rezultati: Iskanje je dalo 490 zadetkov, od katerih je bilo v končno analizo vključenih devet raziskav. Glavno kategorijo smo oblikovali na osnovi treh podkategorij: (1) čustvovanje in počutje, (2) medosebni odnosi in (3) duhovna rast. Diskusija in zaključek: Ugotovitve kažejo, da je pri zagotavljanju duhovne oskrbe ključno razumevanje duhovnih potreb in stisk, ki jih doživljajo ženske po spontani prekinitvi nosečnosti. Poleg medicinske oskrbe si zelo želijo tudi dobro duhovno oskrbo. Ženske svoje duhovne potrebe izražajo skozi čustva in občutke, ki jih morajo medicinske sestre in babice prepoznati ter se nanje ustrezno odzvati. Duhovna oskrba mora temeljiti na razumevanju, sočutju in podpori.

The primary goal of lubricating a worm gearbox is to encourage sliding between teeth, which lowers the coefficient of friction and regulates the temperature rise brought on by rolling and sliding friction. Due to both non-load-dependent and load-dependent power losses, the worm gearbox has a relatively poor efficiency. Nonetheless, to meet the needs, there is now a greater need for more efficient worm gearboxes. Lowering churning power losses, can be accomplished. Bearing friction losses and gear friction losses make up the load-dependent losses. The non-load dependent losses are the bearing churning losses, gear windage losses, gear churning losses and oil seal losses. Numerous factors, including speed, direction of rotation, oil amount, and immersion depth, affect the non-load dependent losses.Only the impact of lubricant temperature and its relationship to non-load-dependent losses will be the focus of this study. A thorough experimental investigation was conducted utilizing the direct torque measuring method. A brand-new test rig was created, assembled, and placed into service to gauge input torque in the absence of load. We kept an eye on the fluctuating impacts of lubricant temperature on churning power loss.

High-throughput sequencing (HTS), more specifically RNA sequencing of plant tissues, has become an indispensable tool for plant virologists to detect and identify plant viruses. During the data analysis step, plant virologists typically compare the obtained sequences to reference virus databases. In this way, they are neglecting sequences without homologies to viruses, which usually represent the majority of sequencing reads. We hypothesized that traces of other pathogens might be detected in this unused sequence data. In the present study, our goal was to investigate whether total RNA-seq data, as generated for plant virus detection, is also suitable for the detection of other plant pathogens and pests. As proof of concept, we first analyzed RNA-seq datasets of plant materials with confirmed infections by cellular pathogens in order to check whether these non-viral pathogens could be easily detected in the data. Next, we set up a community effort to re-analyze existing Illumina RNA-seq datasets used for virus detection to check for the potential presence of non-viral pathogens or pests. In total, 101 datasets from 15 participants derived from 51 different plant species were re-analyzed, of which 37 were selected for subsequent in-depth analyses. In 29 of the 37 selected samples (78%), we found convincing traces of non-viral plant pathogens or pests. The organisms most frequently detected in this way were fungi (15/37 datasets), followed by insects (13/37) and mites (9/37). The presence of some of the detected pathogens was confirmed by independent (q)PCRs analyses. After communicating the results, 6 out of the 15 participants indicated that they were unaware of the possible presence of these pathogens in their sample(s). All participants indicated that they would broaden the scope of their bioinformatic analyses in future studies and thus check for the presence of non-viral pathogens. In conclusion, we show that it is possible to detect non-viral pathogens or pests from total RNA-seq datasets, in this case primarily fungi, insects, and mites. With this study, we hope to raise awareness among plant virologists that their data might be useful for fellow plant pathologists in other disciplines (mycology, entomology, bacteriology) as well.

Izhodišča: Telemedicina lahko izboljša glikemične in porodne izide nosečnostne sladkorne bolezni (NSB), čeprav še ni jasno, za katere posameznice naj bi bila telemedicinska orodja najbolj primerna. Namen naše raziskave je bil preveriti povezavo nekaterih psiholoških dejavnikov z glikemičnimi parametri pri ženskah z NSB, ki smo jih spremljali s telemedicinsko obravnavo. Analizirati smo želeli zadovoljstvo nosečnic s telemedicinsko obravnavo in opredeliti osebnostne značilnosti žensk, ki jim telemedicinska obravnava bolj ustreza. Metode: Vključene nosečnice so izpolnile Vprašalnik Velikih pet (angl. Big Five Inventory, BFI) in Vprašalnik o opolnomočenju v zvezi z vodenjem sladkorne bolezni (angl. Diabetes Empowerment Scale, DES). Podatke o samomeritvah koncentracije glukoze v krvi smo pridobili iz glukometrov. Povezanost med spremenljivkami smo izračunali s Spearmanovim koeficientom korelacije (Spearman ρ). Rezultati: V raziskavo je bilo vključenih 50 žensk (starost 32,0 ± 4,3 let) z NSB, ki so bile vodene telemedicinsko. Od osebnostnih dimenzij sta bili sprejemljivost (Spearman ρ=0.422, p=0.003) in vestnost (Spearman ρ = 0.346, p = 0.016) pozitivno povezani s skupno realizacijo meritev glukoze v krvi. Ugotovili smo povezavo med povprečno koncentracijo glukoze v krvi po obrokih in skupnim dosežkom pri Vprašalniku DES (Spearman q = 0.324, p = 0.030) ter dvema podlestvicama, tj. Obvladovanjem psihosocialnih vidikov NSB (Spearman q = 0.326, p = 0.029) in Nezadovoljstvom in pripravljenostjo na spremembe (Spearman q = 0.363, p = 0.014). Zaključek: Naši rezultati predstavljajo korak k opredelitvi skupka psiholoških značilnosti žensk z NSB, ki bi lahko bil pomemben napovednik učinkovitosti telemedicinske obravnave. Potrebne so še nadaljnje raziskave, tudi o drugih psiholoških vidikih.