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10 results on '"Zaky, Weam"'

1. Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

Author

Dussupt, Vincent, Sankhala, Rajeshwer S., Mendez-Rivera, Letzibeth, Townsley, Samantha M., Schmidt, Fabian, Wieczorek, Lindsay, Lal, Kerri G., Donofrio, Gina C., Tran, Ursula, Jackson, Nathaniel D., Zaky, Weam I., Zemil, Michelle, Tritsch, Sarah R., Chen, Wei-Hung, Martinez, Elizabeth J., Ahmed, Aslaa, Choe, Misook, Chang, William C., Hajduczki, Agnes, Jian, Ningbo, Peterson, Caroline E., Rees, Phyllis A., Rutkowska, Magdalena, Slike, Bonnie M., Selverian, Christopher N., Swafford, Isabella, Teng, I-Ting, Thomas, Paul V., Zhou, Tongqing, Smith, Clayton J., Currier, Jeffrey R., Kwong, Peter D., Rolland, Morgane, Davidson, Edgar, Doranz, Benjamin J., Mores, Christopher N., Hatziioannou, Theodora, Reiley, William W., Bieniasz, Paul D., Paquin-Proulx, Dominic, Gromowski, Gregory D., Polonis, Victoria R., Michael, Nelson L., Modjarrad, Kayvon, Joyce, M. Gordon, and Krebs, Shelly J.

Published
2021
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2. Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor

Author

Dussupt, Vincent, Sankhala, Rajeshwer S., Gromowski, Gregory D., Donofrio, Gina, De La Barrera, Rafael A., Larocca, Rafael A., and Zaky, Weam

Subjects
Diagnosis, Care and treatment, Patient outcomes, Health aspects, Vaccination -- Patient outcomes, Dengue fever -- Diagnosis -- Care and treatment, Antibodies -- Health aspects, Zika virus infection -- Diagnosis -- Care and treatment, Dengue -- Diagnosis -- Care and treatment, Viral antibodies -- Health aspects
Abstract

Author(s): Vincent Dussupt [sup.1] [sup.2] [sup.3] , Rajeshwer S. Sankhala [sup.1] [sup.2] [sup.3] , Gregory D. Gromowski [sup.4] , Gina Donofrio [sup.1] [sup.2] [sup.3] , Rafael A. De La Barrera [...], Zika virus (ZIKV) has caused significant disease, with widespread cases of neurological pathology and congenital neurologic defects. Rapid vaccine development has led to a number of candidates capable of eliciting potent ZIKV-neutralizing antibodies (reviewed in refs. .sup.1-3). Despite advances in vaccine development, it remains unclear how ZIKV vaccination affects immune responses in humans with prior flavivirus immunity. Here we show that a single-dose immunization of ZIKV purified inactivated vaccine (ZPIV).sup.4-7 in a dengue virus (DENV)-experienced human elicited potent cross-neutralizing antibodies to both ZIKV and DENV. Using a unique ZIKV virion-based sorting strategy, we isolated and characterized multiple antibodies, including one termed MZ4, which targets a novel site of vulnerability centered on the Envelope (E) domain I/III linker region and protects mice from viremia and viral dissemination following ZIKV or DENV-2 challenge. These data demonstrate that Zika vaccination in a DENV-experienced individual can boost pre-existing flavivirus immunity and elicit protective responses against both ZIKV and DENV. ZPIV vaccination in Puerto Rican individuals with prior flavivirus experience yielded similar cross-neutralizing potency after a single vaccination, highlighting the potential benefit of ZIKV vaccination in flavivirus-endemic areas. Zika virus vaccination elicits Zika and dengue virus cross-neutralizing antibodies in flavivirus-exposed individuals, potentially enhancing the protective efficacy of the vaccine in flavivirus-endemic regions.

Published
2020
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3. Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes

Author

Sankhala, Rajeshwer S., primary, Dussupt, Vincent, additional, Donofrio, Gina, additional, Gromowski, Gregory D., additional, De La Barrera, Rafael A., additional, Larocca, Rafael A., additional, Mendez-Rivera, Letzibeth, additional, Lee, Anna, additional, Choe, Misook, additional, Zaky, Weam, additional, Mantus, Grace, additional, Jensen, Jaime L., additional, Chen, Wei-Hung, additional, Gohain, Neelakshi, additional, Bai, Hongjun, additional, McCracken, Michael K., additional, Mason, Rosemarie D., additional, Leggat, David, additional, Slike, Bonnie M., additional, Tran, Ursula, additional, Jian, Ningbo, additional, Abbink, Peter, additional, Peterson, Rebecca, additional, Mendes, Eric Araujo, additional, Freitas de Oliveira Franca, Rafael, additional, Calvet, Guilherme Amaral, additional, Bispo de Filippis, Ana Maria, additional, McDermott, Adrian, additional, Roederer, Mario, additional, Hernandez, Mayda, additional, Albertus, Amie, additional, Davidson, Edgar, additional, Doranz, Benjamin J., additional, Rolland, Morgane, additional, Robb, Merlin L., additional, Lynch, Rebecca M., additional, Barouch, Dan H., additional, Jarman, Richard G., additional, Thomas, Stephen J., additional, Modjarrad, Kayvon, additional, Michael, Nelson L., additional, Krebs, Shelly J., additional, and Joyce, M. Gordon, additional

Published
2023
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