Search

Your search keyword '"Zajarias, Alan"' showing total 511 results
Start Over Author "Zajarias, Alan"
511 results on '"Zajarias, Alan"'

1. Metabolic Signatures of Cardiac Dysfunction, Multimorbidity, and Post-Transcatheter Aortic Valve Implantation Death.

Author

Perry, Andrew, Zhao, Shilin, Murthy, Venkatesh, Gupta, Deepak, Fearon, William, Kim, Juyong, Kapadia, Samir, Kumbhani, Dharam, Gillam, Linda, Whisenant, Brian, Quader, Nishath, Zajarias, Alan, Mallugari, Ravinder, Clark, Daniel, Patel, Jay, Gonzales, Holly, Welt, Frederick, Bavry, Anthony, Coylewright, Megan, Piana, Robert, Vatterott, Anna, Jackson, Natalie, Gerszten, Robert, Lindman, Brian, Shah, Ravi, and Elmariah, Sammy

Subjects
aortic stenosis, metabolomics, outcomes, remodeling, Humans, Female, Animals, Mice, Aged, 80 and over, Male, Transcatheter Aortic Valve Replacement, Multimorbidity, Prospective Studies, Treatment Outcome, Aortic Valve, Aortic Valve Stenosis, Ventricular Function, Left
Abstract

Background Studies in mice and small patient subsets implicate metabolic dysfunction in cardiac remodeling in aortic stenosis, but no large comprehensive studies of human metabolism in aortic stenosis with long-term follow-up and characterization currently exist. Methods and Results Within a multicenter prospective cohort study, we used principal components analysis to summarize 12 echocardiographic measures of left ventricular structure and function pre-transcatheter aortic valve implantation in 519 subjects (derivation). We used least absolute shrinkage and selection operator regression across 221 metabolites to define metabolic signatures for each structural pattern and measured their relation to death and multimorbidity in the original cohort and up to 2 validation cohorts (N=543 for overall validation). In the derivation cohort (519 individuals; median age, 84 years, 45% women, 95% White individuals), we identified 3 axes of left ventricular remodeling, broadly specifying systolic function, diastolic function, and chamber volumes. Metabolite signatures of each axis specified both known and novel pathways in hypertrophy and cardiac dysfunction. Over a median of 3.1 years (205 deaths), a metabolite score for diastolic function was independently associated with post-transcatheter aortic valve implantation death (adjusted hazard ratio per 1 SD increase in score, 1.54 [95% CI, 1.25-1.90]; P

Published
2023

2. Global Longitudinal Strain and Biomarkers of Cardiac Damage and Stress as Predictors of Outcomes After Transcatheter Aortic Valve Implantation

Author

Perry, Andrew S, Stein, Elliot J, Biersmith, Michael, Fearon, William F, Elmariah, Sammy, Kim, Juyong B, Clark, Daniel E, Patel, Jay N, Gonzales, Holly, Baker, Michael, Piana, Robert N, Mallugari, Ravinder R, Kapadia, Samir, Kumbhani, Dharam J, Gillam, Linda, Whisenant, Brian, Quader, Nishath, Zajarias, Alan, Welt, Frederick G, Bavry, Anthony A, Coylewright, Megan, Gupta, Deepak K, Vatterott, Anna, Jackson, Natalie, Huang, Shi, and Lindman, Brian R

Subjects
Cardiovascular, Clinical Research, Heart Disease, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Aortic Valve, Aortic Valve Stenosis, Biomarkers, Humans, Natriuretic Peptide, Brain, Prospective Studies, Retrospective Studies, Stroke Volume, Transcatheter Aortic Valve Replacement, Troponin, Ventricular Function, Left, aortic stenosis, biomarkers, cardiac remodeling, echocardiography, global longitudinal strain, outcomes, transcatheter aortic valve implantation, Cardiorespiratory Medicine and Haematology
Abstract

Background Global longitudinal strain (GLS) is a sensitive measure of left ventricular function and a risk marker in severe aortic stenosis. We sought to determine whether biomarkers of cardiac damage (cardiac troponin) and stress (NT-proBNP [N-terminal pro-B-type natriuretic peptide]) could complement GLS to identify patients with severe aortic stenosis at highest risk. Methods and Results From a multicenter prospective cohort of patients with symptomatic severe aortic stenosis who underwent transcatheter aortic valve implantation, we measured absolute GLS (aGLS), cardiac troponin, and NT-proBNP at baseline in 499 patients. Left ventricular ejection fraction 2; P≤0.002 for each) when the other biomarker was elevated, but not when the other biomarker was normal (interaction P=0.015). Conclusions Among patients with symptomatic severe aortic stenosis undergoing transcatheter aortic valve implantation, elevations in circulating cardiac troponin and NT-proBNP are more common as GLS worsens. Biomarkers of cardiac damage and stress are independently associated with mortality after transcatheter aortic valve implantation, whereas GLS is not. These findings may have implications for risk stratification of asymptomatic patients to determine optimal timing of valve replacement.

Published
2022

3. Neutrophil‐to‐Lymphocyte Ratios in Patients Undergoing Aortic Valve Replacement: The PARTNER Trials and Registries

Author

Shahim, Bahira, Redfors, Björn, Lindman, Brian R, Chen, Shmuel, Dahlen, Torsten, Nazif, Tamim, Kapadia, Samir, Gertz, Zachary M, Crowley, Aaron C, Li, Ditian, Thourani, Vinod H, Kodali, Susheel K, Zajarias, Alan, Babaliaros, Vasilis C, Guyton, Robert A, Elmariah, Sammy, Herrmann, Howard C, Cohen, David J, Mack, Michael J, Smith, Craig R, Leon, Martin B, and George, Isaac

Subjects
Heart Disease, Clinical Research, Transplantation, Cardiovascular, Aortic Valve, Aortic Valve Stenosis, Heart Valve Prosthesis Implantation, Humans, Lymphocytes, Neutrophils, Registries, Risk Factors, Severity of Illness Index, Treatment Outcome, aortic stenosis, neutrophil-to-lymphocyte ratio, NLR, surgical aortic valve replacement, transcatheter aortic valve replacement, neutrophil‐to‐lymphocyte ratio, Cardiorespiratory Medicine and Haematology
Abstract

Background The neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammation has been associated with worse prognosis in several chronic disease states, including heart failure. However, few data exist on the prognostic impact of elevated baseline NLR or change in NLR levels during follow-up in patients undergoing transcatheter or surgical aortic valve replacement (TAVR or SAVR) for aortic stenosis. Methods and Results NLR was available in 5881 patients with severe aortic stenosis receiving TAVR or SAVR in PARTNER (Placement of Aortic Transcatheter Valves) I, II, and S3 trials/registries (median [Q1, Q3] NLR, 3.30 [2.40, 4.90]); mean NLR, 4.10; range, 0.5-24.9) and was evaluated as continuous variable and categorical tertiles (low: NLR ≤2.70, n=1963; intermediate: NLR 2.70-4.20, n=1958; high: NLR ≥4.20, n=1960). No patients had known baseline infection. High baseline NLR was associated with increased risk of death or rehospitalization at 3 years (58.4% versus 41.0%; adjusted hazard ratio [aHR], 1.39; 95% CI, 1.18-1.63; P

Published
2022

4. Left Ventricular Hypertrophy and Biomarkers of Cardiac Damage and Stress in Aortic Stenosis

Author

Stein, Elliot J, Fearon, William F, Elmariah, Sammy, Kim, Juyong B, Kapadia, Samir, Kumbhani, Dharam J, Gillam, Linda, Whisenant, Brian, Quader, Nishath, Zajarias, Alan, Welt, Frederick G, Bavry, Anthony A, Coylewright, Megan, Piana, Robert N, Mallugari, Ravinder R, Clark, Daniel E, Patel, Jay N, Gonzales, Holly, Gupta, Deepak K, Vatterott, Anna, Jackson, Natalie, Huang, Shi, and Lindman, Brian R

Subjects
Cardiovascular, Prevention, Heart Disease, Clinical Research, Patient Safety, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Aortic Valve, Aortic Valve Stenosis, Biomarkers, Female, Humans, Hypertrophy, Left Ventricular, Male, Natriuretic Peptide, Brain, Peptide Fragments, Risk Factors, biomarkers, left ventricular hypertrophy, mortality, NT-proBNP, transcatheter aortic valve implantation, transcatheter aortic valve replacement, troponin, NT‐proBNP, Cardiorespiratory Medicine and Haematology
Abstract

Background Left ventricular hypertrophy (LVH) is associated with increased mortality risk and rehospitalization after transcatheter aortic valve replacement among those with severe aortic stenosis. Whether cardiac troponin (cTnT) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) risk stratify patients with aortic stenosis and without LVH is unknown. Methods and Results In a multicenter prospective registry of 923 patients with severe aortic stenosis undergoing transcatheter aortic valve replacement, we included 674 with core-laboratory-measured LV mass index, cTnT, and NT-proBNP. LVH was defined by sex-specific guideline cut-offs and elevated biomarker levels were based on age and sex cut-offs. Adjusted Cox proportional hazards models evaluated associations between LVH and biomarkers and all-cause death out to 5 years. Elevated cTnT and NT-proBNP were present in 82% and 86% of patients with moderate/severe LVH, respectively, as compared with 66% and 69% of patients with no/mild LVH, respectively (P

Published
2022

5. Associations of Sarcopenia and Body Composition Measures With Mortality After Transcatheter Aortic Valve Replacement

Author

Stein, Elliot J., Neill, Colin, Nair, Sangeeta, Terry, J. Greg, Carr, J. Jeffrey, Fearon, William F., Elmariah, Sammy, Kim, Juyong B., Kapadia, Samir, Kumbhani, Dharam J., Gillam, Linda, Whisenant, Brian, Quader, Nishath, Zajarias, Alan, Welt, Frederick G., Bavry, Anthony A., Coylewright, Megan, Piana, Robert, Mallugari, Ravinder R., Vatterott, Anna, Jackson, Natalie, Huang, Shi, and Lindman, Brian R.

Published
2024
Full Text
View/download PDF

7. Association of Depression and Cognitive Dysfunction With Patient-Centered Outcomes After Transcatheter Aortic Valve Replacement

Author

El-Sabawi, Bassim, Cloud, Harrison, Patel, Jay N., Bell, Susan P., Elmariah, Sammy, Fearon, William F., Kim, Juyong B., Piana, Robert N., Kapadia, Samir R., Kumbhani, Dharam J., Gillam, Linda D., Whisenant, Brian K., Quader, Nishath, Zajarias, Alan, Welt, Frederick G., Bavry, Anthony A., Coylewright, Megan, Vatterott, Anna, Jackson, Natalie, Huang, Shi, and Lindman, Brian R.

Published
2023
Full Text
View/download PDF

8. One-Year Outcomes of Transseptal Mitral Valve-in-Valve in Intermediate Surgical Risk Patients.

Author

Malaisrie, S. Chris, Guerrero, Mayra, Davidson, Charles, Williams, Mathew, de Brito, Fábio Sândoli, Abizaid, Alexandre, Shah, Pinak, Tsuyoshi Kaneko, Poon, Karl, Levisay, Justin, Xiao Yu, Pibarot, Philippe, Hahn, Rebecca T., Blanke, Philipp, Leon, Martin B., Mack, Michael J., and Zajarias, Alan

Abstract

BACKGROUND: Transcatheter mitral valve-in-valve replacement offers a less-invasive alternative for high-risk patients with bioprosthetic valve failure. Limited experience exists in intermediate-risk patients. We aim to evaluate 1-year outcomes of the PARTNER 3 mitral valve-in-valve study. METHODS: This prospective, single-arm, multicenter study enrolled symptomatic patients with a failing mitral bioprosthesis demonstrating greater than or equal to moderate stenosis and regurgitation and Society of Thoracic Surgeons score ≥3% and <8%. A balloon-expandable transcatheter heart valve (SAPIEN 3, Edwards Lifesciences) was used via a transeptal approach. The primary end point was the composite of all-cause mortality and stroke at 1 year. RESULTS: A total of 50 patients from 12 sites underwent mitral valve-in-valve from 2018 to 2021. The mean age was 70.1±9.7 years, mean Society of Thoracic Surgeons score was 4.1%±1.6%, and 54% were female. There were no primary end point events (mortality or stroke) through 1 year, and no left-ventricular outflow tract obstruction, endocarditis, or mitral valve reintervention was reported. Six patients (12%) required rehospitalization, including heart failure (n=2), minor procedural side effects (n=2), and valve thrombosis (n=2; both resolved with anticoagulation). An additional valve thrombosis was associated with no significant clinical sequelae. From baseline to 1 year, all subjects with available data had none/trace or mild (grade 1+) mitral regurgitation and the New York Heart Association class improved in 87.2% (41/47) of patients. CONCLUSIONS: Mitral valve-in-valve with a balloon-expandable valve via transseptal approach in intermediate-risk patients was associated with improved symptoms and quality of life, adequate transcatheter valve performance, and no mortality or stroke at 1-year follow-up. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Mitral Regurgitation in Low-Flow, Low-Gradient Aortic Stenosis Patients Undergoing TAVR: Insights From the TOPAS-TAVI Registry

Author

Freitas-Ferraz, Afonso B., Lerakis, Stamatios, Barbosa Ribeiro, Henrique, Gilard, Martine, Cavalcante, João L., Makkar, Raj, Herrmann, Howard C., Windecker, Stephan, Enriquez-Sarano, Maurice, Cheema, Asim N., Nombela-Franco, Luis, Amat-Santos, Ignacio, Muñoz-García, Antonio J., Garcia del Blanco, Bruno, Zajarias, Alan, Lisko, John C., Hayek, Salim, Babaliaros, Vasilis, Le Ven, Florent, Gleason, Thomas G., Chakravarty, Tarun, Szeto, Wilson Y., Clavel, Marie-Annick, de Agustin, Alberto, Serra, Vicenç, Schindler, John T., Dahou, Abdellaziz, Annabi, Mohamed-Salah, Pelletier-Beaumont, Emilie, Pibarot, Philippe, and Rodés-Cabau, Josep

Published
2020
Full Text
View/download PDF

12. Health Status After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis

Author

Baron, Suzanne J., Magnuson, Elizabeth A., Lu, Michael, Wang, Kaijun, Chinnakondepalli, Khaja, Mack, Michael, Thourani, Vinod H., Kodali, Susheel, Makkar, Raj, Herrmann, Howard C., Kapadia, Samir, Babaliaros, Vasilis, Williams, Mathew R., Kereiakes, Dean, Zajarias, Alan, Alu, Maria C., Webb, John G., Smith, Craig R., Leon, Martin B., and Cohen, David J.

Published
2019
Full Text
View/download PDF

16. Incidence and Clinical Significance of Worsening Tricuspid Regurgitation Following Surgical or Transcatheter Aortic Valve Replacement: Analysis From the PARTNER IIA Trial

Author

Cremer, Paul C., Wang, Tom Kai Ming, Rodriguez, L. Leonardo, Lindman, Brian R., Zhang, Yiran, Zajarias, Alan, Hahn, Rebecca T., Lerakis, Stamatios, Malaisrie, S. Chris, Douglas, Pamela S., Pibarot, Philippe, Svensson, Lars G., Kapadia, Samir, Leon, Martin B., and Jaber, Wael A.

Published
2021
Full Text
View/download PDF

18. Outcomes after Transcatheter and Surgical Aortic Valve Replacement in Intermediate Risk Patients with Preoperative Mitral Regurgitation: Analysis of PARTNER II Randomized Cohort

Author

Malaisrie, S. Chris, Hodson, Robert W., McAndrew, Thomas C., Davidson, Charles, Swanson, Jeffrey, Hahn, Rebecca T., Pibarot, Philippe, Jaber, Wael A., Quader, Nishath, Zajarias, Alan, Svensson, Lars, George, Isaac, Trento, Alfredo, Thourani, Vinod H., Szeto, Wilson Y., Dewey, Todd, Smith, Craig R., Leon, Martin B., and Webb, John G.

Published
2018
Full Text
View/download PDF

19. Implications of Concomitant Tricuspid Regurgitation in Patients Undergoing Transcatheter Aortic Valve Replacement for Degenerated Surgical Aortic Bioprosthesis: Insights From the PARTNER 2 Aortic Valve-in-Valve Registry

Author

Sathananthan, Janarthanan, Murdoch, Dale J., Lindman, Brian R., Zajarias, Alan, Jaber, Wael A., Cremer, Paul, Wood, David, Moss, Robert, Cheung, Anson, Ye, Jian, Hahn, Rebecca T., Crowley, Aaron, Leon, Martin B., Mack, Michael J., and Webb, John G.

Published
2018
Full Text
View/download PDF

20. Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis: The TOPAS-TAVI Registry

Author

Ribeiro, Henrique Barbosa, Lerakis, Stamatios, Gilard, Martine, Cavalcante, João L., Makkar, Raj, Herrmann, Howard C., Windecker, Stephan, Enriquez-Sarano, Maurice, Cheema, Asim N., Nombela-Franco, Luis, Amat-Santos, Ignacio, Muñoz-García, Antonio J., Garcia del Blanco, Bruno, Zajarias, Alan, Lisko, John C., Hayek, Salim, Babaliaros, Vasilis, Le Ven, Florent, Gleason, Thomas G., Chakravarty, Tarun, Szeto, Wilson Y., Clavel, Marie-Annick, de Agustin, Alberto, Serra, Vicenç, Schindler, John T., Dahou, Abdellaziz, Puri, Rishi, Pelletier-Beaumont, Emilie, Côté, Melanie, Pibarot, Philippe, and Rodés-Cabau, Josep

Published
2018
Full Text
View/download PDF

26. METABOLIC SIGNATURES OF CARDIAC DYSFUNCTION ARE ASSOCIATED WITH MULTIMORBIDITY AND POST-TRANSCATHETER AORTIC VALVE IMPLANTATION MORTALITY

Author

Perry, Andrew, primary, Zhao, Shilin, additional, Murthy, Venkatesh Locharla, additional, Gupta, Deepak K., additional, Fearon, William Fuller, additional, Kim, Juyong Brian, additional, Kapadia, Samir R., additional, Kumbhani, Dharam J., additional, Gillam, Linda D., additional, Whisenant, Brian K., additional, Quader, Nishath, additional, Zajarias, Alan, additional, Mallugari, Ravinder, additional, Clark, Daniel Eugene, additional, Patel, Jay, additional, Gonzales, Holly, additional, Welt, Frederick G.P., additional, Bavry, Anthony A., additional, Coylewright, Megan, additional, Piana, Robert N., additional, Jackson, Natalie, additional, Gerszten, Robert E., additional, Lindman, Brian R., additional, Shah, Ravi, additional, and Elmariah, Sammy, additional

Published
2023
Full Text
View/download PDF

31. Clinical and Functional Outcomes Associated With Myocardial Injury After Transfemoral and Transapical Transcatheter Aortic Valve Replacement: A Subanalysis From the PARTNER Trial (Placement of Aortic Transcatheter Valves)

Author

Paradis, Jean-Michel, Maniar, Hersh S., Lasala, John M., Kodali, Susheel, Williams, Mathew, Lindman, Brian R., Damiano, Ralph J., Jr., Moon, Marc R., Makkar, Raj R., Thourani, Vinod H., Babaliaros, Vasilis, Xu, Ke, Ayele, Girma Minalu, Svensson, Lars, Leon, Martin B., and Zajarias, Alan

Published
2015
Full Text
View/download PDF

35. Analysis of Early Out-of Hospital Mortality After Transcatheter Aortic Valve Implantation Among Patients With Aortic Stenosis Successfully Discharged from the Hospital and Alive at 30 Days (from the Placement of Aortic Transcatheter Valves Trial)

Author

Beohar, Nirat, Zajarias, Alan, Thourani, Vinod H., Herrmann, Howard C., Mack, Michael, Kapadia, Samir, Green, Philip, Arnold, Suzanne V., Cohen, David J., Généreux, Philippe, Xu, Ke, Leon, Martin B., and Kirtane, Ajay J.

Published
2014
Full Text
View/download PDF

36. Outcomes After Transfemoral Transcatheter Aortic Valve Replacement: A Comparison of the Randomized PARTNER (Placement of AoRTic TraNscathetER Valves) Trial With the NRCA (Nonrandomized Continued Access) Registry

Author

Fearon, William F., Kodali, Susheel, Doshi, Darshan, Fischbein, Michael P., Yeung, Alan C., Tuzcu, E. Murat, Rihal, Charanjit S., Babaliaros, Vasilis, Zajarias, Alan, Herrmann, Howard C., Brown, David L., Mack, Michael, Teirstein, Paul S., Whisenant, Brian K., Makkar, Raj, Kapadia, Samir, and Leon, Martin B.

Published
2014
Full Text
View/download PDF

40. Predictive Factors, Management, and Clinical Outcomes of Coronary Obstruction Following Transcatheter Aortic Valve Implantation: Insights From a Large Multicenter Registry

Author

Ribeiro, Henrique B., Webb, John G., Makkar, Raj R., Cohen, Mauricio G., Kapadia, Samir R., Kodali, Susheel, Tamburino, Corrado, Barbanti, Marco, Chakravarty, Tarun, Jilaihawi, Hasan, Paradis, Jean-Michel, de Brito, Fabio S., Jr., Cánovas, Sergio J., Cheema, Asim N., de Jaegere, Peter P., del Valle, Raquel, Chiam, Paul T.L., Moreno, Raúl, Pradas, Gonzalo, Ruel, Marc, Salgado-Fernández, Jorge, Sarmento-Leite, Rogerio, Toeg, Hadi D., Velianou, James L., Zajarias, Alan, Babaliaros, Vasilis, Cura, Fernando, Dager, Antonio E., Manoharan, Ganesh, Lerakis, Stamatios, Pichard, Augusto D., Radhakrishnan, Sam, Perin, Marco Antonio, Dumont, Eric, Larose, Eric, Pasian, Sergio G., Nombela-Franco, Luis, Urena, Marina, Tuzcu, E. Murat, Leon, Martin B., Amat-Santos, Ignacio J., Leipsic, Jonathon, and Rodés-Cabau, Josep

Published
2013
Full Text
View/download PDF

46. Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients

Author

Leon, Martin B., Smith, Craig R., Mack, Michael J., Makkar, Raj R., Svensson, Lars G., Kodali, Susheel K., Thourani, Vinod H., Tuzcu, Murat E., Miller, Craig D., Herrmann, Howard C., Doshi, Darshan, Cohen, David J., Pichard, Augusto D., Kapadia, Samir, Dewey, Todd, Babaliaros, Vasilis, Szeto, Wilson Y., Williams, Mathew R., Kereiakes, Dean, Zajarias, Alan, Greason, Kevin L., Whisenant, Brian K., Hodson, Robert W., Moses, Jeffrey W., Trento, Alfredo, Brown, David L., Fearon, William F., Pibarot, Philippe, Hahn, Rebecca T., Jaber, Wael A., Anderson, William N., Alu, Maria C., and Webb, John G.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results