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9 results on '"Zaikokuji, Ryogen"'

1. Neutrophil Elastase Damages the Pulmonary Endothelial Glycocalyx in Lipopolysaccharide-Induced Experimental Endotoxemia

Author

Suzuki, Kodai, Okada, Hideshi, Takemura, Genzou, Takada, Chihiro, Kuroda, Ayumi, Yano, Hirohisa, Zaikokuji, Ryogen, Morishita, Kentaro, Tomita, Hiroyuki, Oda, Kazumasa, Matsuo, Saori, Uchida, Akihiro, Fukuta, Tetsuya, Sampei, So, Miyazaki, Nagisa, Kawaguchi, Tomonori, Watanabe, Takatomo, Yoshida, Takahiro, Ushikoshi, Hiroaki, Yoshida, Shozo, Maekawa, Yoichi, and Ogura, Shinji

Published
2019
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2. Neutrophil Elastase Inhibition Ameliorates Endotoxin-induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx

Author

Fukuta, Tetsuya, Okada, Hideshi, Takemura, Genzou, Suzuki, Kodai, Takada, Chihiro, Tomita, Hiroyuki, Suzuki, Akio, Oda, Kazumasa, Uchida, Akihiro, Matsuo, Saori, Fukuda, Hirotsugu, Yano, Hirohisa, Muraki, Isamu, Zaikokuji, Ryogen, Kuroda, Ayumi, Nishio, Ayane, Sampei, So, Miyazaki, Nagisa, Hotta, Yasuaki, Yamada, Noriaki, Watanabe, Takatomo, Morishita, Kentaro, Doi, Tomoaki, Yoshida, Takahiro, Ushikoshi, Hiroaki, Yoshida, Shozo, Maekawa, Yoichi, and Ogura, Shinji

Published
2020
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3. Brain-Specific Ultrastructure of Capillary Endothelial Glycocalyx and Its Possible Contribution for Blood Brain Barrier

Author

Ando, Yoshiaki, Okada, Hideshi, Takemura, Genzou, Suzuki, Kodai, Takada, Chihiro, Tomita, Hiroyuki, Zaikokuji, Ryogen, Hotta, Yasuaki, Miyazaki, Nagisa, Yano, Hirohisa, Muraki, Isamu, Kuroda, Ayumi, Fukuda, Hirotsugu, Kawasaki, Yuki, Okamoto, Haruka, Kawaguchi, Tomonori, Watanabe, Takatomo, Doi, Tomoaki, Yoshida, Takahiro, Ushikoshi, Hiroaki, Yoshida, Shozo, and Ogura, Shinji

Published
2018
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4. Recombinant thrombomodulin protects against LPS‐induced acute respiratory distress syndrome via preservation of pulmonary endothelial glycocalyx

Author

Suzuki, Kodai, primary, Okada, Hideshi, additional, Takemura, Genzou, additional, Takada, Chihiro, additional, Tomita, Hiroyuki, additional, Yano, Hirohisa, additional, Muraki, Isamu, additional, Zaikokuji, Ryogen, additional, Kuroda, Ayumi, additional, Fukuda, Hirotsugu, additional, Nishio, Ayane, additional, Takashima, Shigeo, additional, Suzuki, Akio, additional, Miyazaki, Nagisa, additional, Fukuta, Tetsuya, additional, Yamada, Noriaki, additional, Watanabe, Takatomo, additional, Doi, Tomoaki, additional, Yoshida, Takahiro, additional, Kumada, Keisuke, additional, Ushikoshi, Hiroaki, additional, Yoshida, Shozo, additional, and Ogura, Shinji, additional

Published
2020
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5. Open Access

Author

Suzuki, Kodai, Okada, Hideshi, Takemura, Genzou, Takada, Chihiro, Kuroda, Ayumi, Yano, Hirohisa, Zaikokuji, Ryogen, Morishita, Kentaro, Tomita, Hiroyuki, Oda, Kazumasa, Matsuo, Saori, Uchida, Akihiro, Fukuta, Tetsuya, Sampei, So, Miyazaki, Nagisa, Kawaguchi, Tomonori, Watanabe, Takatomo, Yoshida, Takahiro, Ushikoshi, Hiroaki, Yoshida, Shozo, Maekawa, Yoichi, Ogura, Shinji, Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Department of Internal Medicine, Asahi University School of Dentistry, Department of Emergency and Disaster Medicine, Gifu University Graduate School of MedicineLaboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Department of Tumor Pathology, Gifu University Graduate School of Medicine, Department of Clinical Laboratory, Gifu University Hospital, and Department of Parasitology and Infectious Diseases, Gifu University Graduate School of MedicineDomain of Integrated Life Systems, Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University

Subjects
0301 basic medicine, Lipopolysaccharides, medicine.medical_specialty, Lipopolysaccharide, Endothelium, Glycine, Granulocyte, Thrombomodulin, Glycocalyx, Pathology and Forensic Medicine, Proinflammatory cytokine, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Internal medicine, medicine, Animals, Survival rate, Lung, Mice, Knockout, Sulfonamides, biology, business.industry, Sivelestat, 030208 emergency & critical care medicine, Endotoxemia, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, chemistry, Neutrophil elastase, biology.protein, business, Leukocyte Elastase
Abstract

Neutrophil elastase (NE) is necessary for effective sterilization of phagocytosed bacterial and fungal pathogens; however, NE increases alveolocapillary permeability and induces proinflammatory cytokine production in sepsis-induced acute respiratory distress syndrome. Under septic conditions, the pulmonary endothelial glycocalyx covering on the healthy endothelium surface is injured, but the contribution of NE to this injury remains unknown. Our aim was to examine whether NE-induced pulmonary endothelial injury is associated with endotoxemia. Lipopolysaccharide (LPS; 20 mg/kg) was injected intraperitoneally into 9- to 12-week-old granulocyte colony-stimulating factor knockout (G-CSFKO) mice, which harbor few neutrophils, and littermate control mice; in a second assay, mice were injected with the NE-inhibitor sivelestat (0.2 mg/kg) at 3, 6, 9, and 12 hours after LPS administration. Subsequently, vascular endothelial injury was evaluated through ultrastructural analysis. At 48 hours after LPS injection, survival rate was more than threefold higher among G-CSFKO than control mice, and degradation of both thrombomodulin and syndecan-1 was markedly attenuated in G-CSFKO compared with control mice. Ultrastructural analysis revealed attenuated vascular endothelial injury and clear preservation of the endothelial glycocalyx in G-CSFKO mice. Moreover, after LPS exposure, survival rate was approximately ninefold higher among sivelestat-injected mice than control mice, and sivelestat treatment potently preserved vascular endothelial structures and the endothelial glycocalyx. In conclusion, NE is associated with pulmonary endothelial injury under LPS-induced endotoxemic conditions.

Published
2018

6. Neutrophil Elastase Inhibition Ameliorates Endotoxin-induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx

Author

Fukuta, Tetsuya, primary, Okada, Hideshi, additional, Takemura, Genzou, additional, Suzuki, Kodai, additional, Takada, Chihiro, additional, Tomita, Hiroyuki, additional, Suzuki, Akio, additional, Oda, Kazumasa, additional, Uchida, Akihiro, additional, Matsuo, Saori, additional, Fukuda, Hirotsugu, additional, Yano, Hirohisa, additional, Muraki, Isamu, additional, Zaikokuji, Ryogen, additional, Kuroda, Ayumi, additional, Nishio, Ayane, additional, Sampei, So, additional, Miyazaki, Nagisa, additional, Hotta, Yasuaki, additional, Yamada, Noriaki, additional, Watanabe, Takatomo, additional, Morishita, Kentaro, additional, Doi, Tomoaki, additional, Yoshida, Takahiro, additional, Ushikoshi, Hiroaki, additional, Yoshida, Shozo, additional, Maekawa, Yoichi, additional, and Ogura, Shinji, additional

Published
2019
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7. Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination

Author

Oda, Kazumasa, primary, Okada, Hideshi, additional, Suzuki, Akio, additional, Tomita, Hiroyuki, additional, Kobayashi, Ryo, additional, Sumi, Kazuyuki, additional, Suzuki, Kodai, additional, Takada, Chihiro, additional, Ishihara, Takuma, additional, Suzuki, Keiko, additional, Kano, Soichiro, additional, Kondo, Kohei, additional, Iwashita, Yuki, additional, Yano, Hirohisa, additional, Zaikokuji, Ryogen, additional, Sampei, So, additional, Fukuta, Tetsuya, additional, Kitagawa, Yuichiro, additional, Okamoto, Haruka, additional, Watanabe, Takatomo, additional, Kawaguchi, Tomonori, additional, Kojima, Takao, additional, Deguchi, Fumiko, additional, Miyazaki, Nagisa, additional, Yamada, Noriaki, additional, Doi, Tomoaki, additional, Yoshida, Takahiro, additional, Ushikoshi, Hiroaki, additional, Yoshida, Shozo, additional, Takemura, Genzou, additional, and Ogura, Shinji, additional

Published
2019
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8. Ultrastructural Alteration of Pulmonary Capillary Endothelial Glycocalyx During Endotoxemia

Author

Inagawa, Risa, primary, Okada, Hideshi, additional, Takemura, Genzou, additional, Suzuki, Kodai, additional, Takada, Chihiro, additional, Yano, Hirohisa, additional, Ando, Yoshiaki, additional, Usui, Takahiro, additional, Hotta, Yasuaki, additional, Miyazaki, Nagisa, additional, Tsujimoto, Akiko, additional, Zaikokuji, Ryogen, additional, Matsumoto, Atsumu, additional, Kawaguchi, Tomonori, additional, Doi, Tomoaki, additional, Yoshida, Takahiro, additional, Yoshida, Shozo, additional, Kumada, Keisuke, additional, Ushikoshi, Hiroaki, additional, Toyoda, Izumi, additional, and Ogura, Shinji, additional

Published
2018
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9. Three-dimensional ultrastructure of capillary endothelial glycocalyx under normal and experimental endotoxemic conditions

Author

Okada, Hideshi, primary, Takemura, Genzou, additional, Suzuki, Kodai, additional, Oda, Kazumasa, additional, Takada, Chihiro, additional, Hotta, Yasuaki, additional, Miyazaki, Nagisa, additional, Tsujimoto, Akiko, additional, Muraki, Isamu, additional, Ando, Yoshiaki, additional, Zaikokuji, Ryogen, additional, Matsumoto, Atsumu, additional, Kitagaki, Hiroki, additional, Tamaoki, Yuto, additional, Usui, Takahiro, additional, Doi, Tomoaki, additional, Yoshida, Takahiro, additional, Yoshida, Shozo, additional, Ushikoshi, Hiroaki, additional, Toyoda, Izumi, additional, and Ogura, Shinji, additional

Published
2017
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