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1. An update on the global disparities in kidney disease burden and care across world countries and regions

Author

Abu-Alfa, Ali K., Amouzegar, Atefeh, Anand, Shuchi, Arogundade, Fatiu Abiola, Ashuntantang, Gloria E., Bavanandan, Sunita, Coppo, Rosanna, Diongole, Hassane M., Divyaveer, Smita, Ekrikpo, Udeme E., Ethier, Isabelle, Fung, Winston Wing-Shing, Gaipov, Abduzhappar, Ghimire, Anukul, Houston, Ghenette, Ibrahim, Kwaifa Salihu, Irish, Georgina, Jindal, Kailash, Kelly, Dearbhla M., Lightstone, Liz, Madero, Magdalena, Nalado, Aisha M., Neuen, Brendon L., Olanrewaju, Timothy O., Osman, Mohamed A., Parekh, Rulan S., Petrova, Anna, Prasad, Narayan, Prikhodina, Larisa, Racki, Sanjin, Riaz, Parnian, Saad, Syed, Sakajiki, Aminu Muhammad, Savaj, Shokoufeh, Singh Shah, Dibya, Suzuki, Yusuke, Tesar, Vladimir, Tiv, Sophanny, Tungsanga, Somkanya, Tzanno-Martins, Carmen, Viecelli, Andrea, Wang, Angela Yee-Moon, Wong, Muh Geot, Zaidi, Deenaz, Bello, Aminu K, Okpechi, Ikechi G, Levin, Adeera, Ye, Feng, Damster, Sandrine, Arruebo, Silvia, Donner, Jo-Ann, Caskey, Fergus J, Cho, Yeoungjee, Davids, M Razeen, Davison, Sara N, Htay, Htay, Jha, Vivekanand, Lalji, Rowena, Malik, Charu, Nangaku, Masaomi, See, Emily, Sozio, Stephen M, Tonelli, Marcello, Wainstein, Marina, Yeung, Emily K, and Johnson, David W

Published
2024
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2. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in North America and the Caribbean

Author

Bello, Aminu K, McIsaac, Mark, Okpechi, Ikechi G, Johnson, David W, Jha, Vivekanand, Harris, David CH, Saad, Syed, Zaidi, Deenaz, Osman, Mohamed A, Ye, Feng, Lunney, Meaghan, Jindal, Kailash, Klarenbach, Scott, Kalantar-Zadeh, Kamyar, Kovesdy, Csaba P, Parekh, Rulan S, Prasad, Bhanu, Khan, Maryam, Riaz, Parnian, Tonelli, Marcello, Wolf, Myles, Levin, Adeera, and Board, ISN North America and the Caribbean Regional

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Clinical Research, Health Services, Renal and urogenital, Good Health and Well Being, chronic kidney disease, dialysis, funding, kidney failure, kidney registries, workforce, ISN North America and the Caribbean Regional Board, Other Medical and Health Sciences, Clinical sciences
Abstract

The International Society of Nephrology established the Global Kidney Health Atlas project to define the global capacity for kidney replacement therapy and conservative kidney care, and this second iteration was to describe the availability, accessibility, quality, and affordability of kidney failure (KF) care worldwide. This report presents results for the International Society of Nephrology North America and the Caribbean region. Relative to other regions, the North America and Caribbean region had better infrastructure and funding for health care and more health care workers relative to the population. Various essential medicines were also more available and accessible. There was substantial variation in the prevalence of treated KF in the region, ranging from 137.4 per million population (pmp) in Jamaica to 2196 pmp in the United States. A mix of public and private funding systems cover costs for nondialysis chronic kidney disease care in 60% of countries and for dialysis in 70% of countries. Although the median number of nephrologists is 18.1 (interquartile range, 15.3-29.5) pmp, which is approximately twice the global median of 9.9 (interquartile range, 1.2-22.7) pmp, some countries reported shortages of other health care workers. Dialysis was available in all countries, but peritoneal dialysis was underutilized and unavailable in Barbados, Cayman Islands, and Turks and Caicos. Kidney transplantation was primarily available in Canada and the United States. Economic factors were the major barriers to optimal KF care in the Caribbean countries, and few countries in the region have chronic kidney disease-specific national health care policies. To address regional gaps in KF care delivery, efforts should be directed toward augmenting the workforce, improving the monitoring and reporting of kidney replacement therapy indicators, and implementing noncommunicable disease and chronic kidney disease-specific policies in all countries.

Published
2021

3. International Society of Nephrology Global Kidney Health Atlas: structures, organization and services for the management of kidney failure in North and East Asia

Author

Zhang, Luxia, Wang, Jinwei, Yang, Chih-Wei, Tang, Sydney Chi-wai, Kashihara, Naoki, Kim, Yong-soo, Togtokh, Ariunaa, Saad, Syed, Ye, Feng, Khan, Maryam, Zaidi, Deenaz, Osman, Mohamed A., Lunney, Meaghan, Okpechi, Ikechi G., Jha, Vivekanand, Harris, David C.H., Levin, Adeera, Tonelli, Marcello, Johnson, David W., Bello, Aminu K., and Zhao, Ming-hui

Published
2021
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4. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Africa

Author

Oguejiofor, Fidelis, Kiggundu, Daniel S., Bello, Aminu K., Swanepoel, Charles R., Ashuntantang, Gloria, Jha, Vivekanand, Harris, David C.H., Levin, Adeera, Tonelli, Marcello, Niang, Abdou, Wearne, Nicola, Moloi, Mothusi Walter, Ulasi, Ifeoma, Arogundade, Fatiu A., Saad, Syed, Zaidi, Deenaz, Osman, Mohamed A., Ye, Feng, Lunney, Meaghan, Olanrewaju, Timothy O., Ekrikpo, Udeme, Umeizudike, Theophilus I., Abdu, Aliyu, Nalado, Aisha M., Makusidi, Muhammad Aliyu, Liman, Hamidu M., Sakajiki, Aminu, Diongole, Hassane M., Khan, Maryam, Benghanem Gharbi, Mohammed, Johnson, David W., and Okpechi, Ikechi G.

Published
2021
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5. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Western Europe

Author

Kelly, Dearbhla M., Anders, Hans-Joachim, Bello, Aminu K., Choukroun, Gabriel, Coppo, Rosanna, Dreyer, Gavin, Eckardt, Kai-Uwe, Johnson, David W., Jha, Vivekanand, Harris, David C.H., Levin, Adeera, Lunney, Meaghan, Luyckx, Valerie, Marti, Hans-Peter, Messa, Piergiorgio, Mueller, Thomas F., Saad, Syed, Stengel, Benedicte, Vanholder, Raymond C., Weinstein, Talia, Khan, Maryam, Zaidi, Deenaz, Osman, Mohamed A., Ye, Feng, Tonelli, Marcello, Okpechi, Ikechi G., and Rondeau, Eric

Published
2021
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7. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in South Asia

Author

Divyaveer, Smita S., Ramachandran, Raja, Sahay, Manisha, Singh Shah, Dibya, Akhtar, Fazal, Bello, Aminu K., Iyengar, Arpana, Johnson, David W., Harris, David C.H., Levin, Adeera, Lunney, Meaghan, Rahman, Muhibur, Rashid, Harun-Ur, Saad, Syed, Zaidi, Deenaz, Osman, Mohamed A., Varughese, Santosh, Wijewickrama, Eranga S., Khan, Maryam, Ye, Feng, Tonelli, Marcello, Okpechi, Ikechi G., and Jha, Vivekanand

Published
2021
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8. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Latin America

Author

Wainstein, Marina, Bello, Aminu K., Jha, Vivekanand, Harris, David C.H., Levin, Adeera, Gonzalez-Bedat, Maria C., Rosa-Diez, Guillermo J., Ferreiro Fuentes, Alejandro, Sola, Laura, Pecoits-Filho, Roberto, Claure-Del Granado, Rolando, Madero, Magdalena, Osman, Mohamed A., Saad, Syed, Zaidi, Deenaz, Lunney, Meaghan, Ye, Feng, Katz, Ivor J., Khan, Maryam, Shrapnel, Sally, Tonelli, Marcello, Okpechi, Ikechi G., and Johnson, David W.

Published
2021
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9. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Oceania and South East Asia

Author

Ethier, Isabelle, Johnson, David W., Bello, Aminu K., Ye, Feng, Osman, Mohamed A., Levin, Adeera, Harris, David C.H., Kerr, Peter, Liew, Adrian, Wong, Muh Geot, Lunney, Meaghan, Saad, Syed, Zaidi, Deenaz, Khan, Maryam, Jha, Vivekanand, Tonelli, Marcello, Okpechi, Ikechi G., and Viecelli, Andrea K.

Published
2021
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10. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Newly Independent States and Russia

Author

Zakharova, Elena, Gaipov, Abduzhappar, Bello, Aminu K., Johnson, David W., Jha, Vivekanand, Harris, David C.H., Levin, Adeera, Saad, Syed, Khan, Maryam, Zaidi, Deenaz, Osman, Mohamed A., Ye, Feng, Lunney, Meaghan, Tonelli, Marcello, Okpechi, Ikechi G., Zemchenkov, Alexander, and Tchokhonelidze, Irma

Published
2021
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11. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in the Middle East

Author

Amouzegar, Atefeh, Abu-Alfa, Ali K., Alrukhaimi, Mona N., Bello, Aminu K., Ghnaimat, Mohammad A., Johnson, David W., Jha, Vivekanand, Harris, David C.H., Levin, Adeera, Tonelli, Marcello, Lunney, Meaghan, Saad, Syed, Khan, Maryam, Zaidi, Deenaz, Osman, Mohamed A., Ye, Feng, Okpechi, Ikechi G., and Ossareh, Shahrzad

Published
2021
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12. Prevalence of polypharmacy and associated adverse health outcomes in adult patients with chronic kidney disease: protocol for a systematic review and meta-analysis

Author

Okpechi, Ikechi G., Tinwala, Mohammed M., Muneer, Shezel, Zaidi, Deenaz, Ye, Feng, Hamonic, Laura N., Khan, Maryam, Sultana, Naima, Brimble, Scott, Grill, Allan, Klarenbach, Scott, Lindeman, Cliff, Molnar, Amber, Nitsch, Dorothea, Ronksley, Paul, Shojai, Soroush, Soos, Boglarka, Tangri, Navdeep, Thompson, Stephanie, Tuot, Delphine, Drummond, Neil, Mangin, Dee, and Bello, Aminu K.

Published
2021
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15. Capacity for the management of kidney failure in the International Society of Nephrology North and East Asia region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Wing-Shing Fung, Winston, Park, Hyeong Cheon, Hirakawa, Yosuke, Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ueda, Seiji, Ye, Feng, Suzuki, Yusuke, Wang, Angela Yee-Moon, Amouzegar, Atefeh, Cai, Guangyan, Chang, Jer-Ming, Chen, Hung-Chun, Cheng, Yuk Lun, Cho, Yeoungjee, Davids, M. Razeen, Davison, Sara N., Diongole, Hassane M., Divyaveer, Smita, Doi, Kent, Ekrikpo, Udeme E., Ethier, Isabelle, Fukami, Kei, Ghimire, Anukul, Houston, Ghenette, Htay, Htay, Ibrahim, Kwaifa Salihu, Imaizumi, Takahiro, Irish, Georgina, Jindal, Kailash, Kashihara, Naoki, Kelly, Dearbhla M., Lalji, Rowena, Liu, Bi-Cheng, Maruyama, Shoichi, Nalado, Aisha M., Neuen, Brendon L., Nie, Jing, Nishiyama, Akira, Olanrewaju, Timothy O., Osman, Mohamed A., Petrova, Anna, Riaz, Parnian, Saad, Syed, Sakajiki, Aminu Muhammad, See, Emily, Sozio, Stephen M., Tang, Sydney C.W., Tiv, Sophanny, Tungsanga, Somkanya, Viecelli, Andrea, Wainstein, Marina, Yanagita, Motoko, Yang, Chih-Wei, Yang, Jihyun, Yeung, Emily K., Yu, Xueqing, Zaidi, Deenaz, Zhang, Hong, and Zhou, Lili

Abstract

Globally, there remain significant disparities in the capacity and quality of kidney care, as evidenced by the third edition of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA). In the ISN North and East Asia region, the chronic kidney disease (CKD) burden varied widely; Taiwan had the heaviest burden of treated kidney failure (3679 per million population [pmp]) followed by Japan and South Korea. Except in Hong Kong, hemodialysis (HD) was the main dialysis modality for all other countries in the region and was much higher than the global median prevalence. Kidney transplantation services were generally available in the region, but the prevalence was much lower than that of dialysis. Most countries had public funding for kidney replacement therapy (KRT). The median prevalence of nephrologists was 28.7 pmp, higher than that of any other ISN region, with variation across countries. Home HD was available in only 17% of the countries, whereas conservative kidney management was available in 50%. All countries had official registries for dialysis and transplantation; however, only China and Japan had CKD registries. Advocacy groups for CKD, kidney failure, and KRT were uncommon throughout the region. Overall, all countries in the region had capacity for KRT, albeit with some shortages in their kidney care workforce. These data are useful for stakeholders to address gaps in kidney care and to reduce workforce shortages through increased use of multidisciplinary teams and telemedicine, policy changes to promote prevention and treatment of kidney failure, and increased advocacy for kidney disease in the region.

Published
2024
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16. Capacity for the management of kidney failure in the International Society of Nephrology Middle East region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Karam, Sabine, Amouzegar, Atefeh, Alshamsi, Iman Rashed, Al Ghamdi, Saeed M.G., Anwar, Siddiq, Ghnaimat, Mohammad, Saeed, Bassam, Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ye, Feng, Abu-Alfa, Ali K., Savaj, Shokoufeh, Abou-Jaoudeh, Pauline, Al Hussain, Turki, Al Salmi, Issa Salim Amur, Alrukhaimi, Mona, Alyousef, Anas, Bahous, Sola Aoun, Cai, Guangyan, Cheikh Hassan, Hicham I., Cho, Yeoungjee, Davids, M. Razeen, Davison, Sara N., Diongole, Hassane M., Divyaveer, Smita, Ekrikpo, Udeme E., Ethier, Isabelle, Fung, Winston Wing-Shing, Ghimire, Anukul, Hooman, Nakysa, Houston, Ghenette, Htay, Htay, Ibrahim, Kwaifa Salihu, Irish, Georgina, Jindal, Kailash, Kelly, Dearbhla M., Lalji, Rowena, Mitwali, Ahmed, Mortazavi, Mojgan, Nalado, Aisha M., Neuen, Brendon L., Olanrewaju, Timothy O., Osman, Mohamed A., Ossareh, Shahrzad, Petrova, Anna, Riaz, Parnian, Saad, Syed, Sakajiki, Aminu Muhammad, See, Emily, Sozio, Stephen M., Tiv, Sophanny, Tungsanga, Somkanya, Viecelli, Andrea, Wainstein, Marina, Wannous, Hala, Yeung, Emily K., and Zaidi, Deenaz

Abstract

The highest financial and symptom burdens and the lowest health-related quality-of-life scores are seen in people with kidney failure. A total of 11 countries in the International Society of Nephrology (ISN) Middle East region responded to the ISN-Global Kidney Health Atlas. The prevalence of chronic kidney disease (CKD) in the region ranged from 4.9% in Yemen to 12.2% in Lebanon, whereas prevalence of kidney failure treated with dialysis or transplantation ranged from 152 per million population (pmp) in the United Arab Emirates to 869 pmp in Kuwait. Overall, the incidence of kidney transplantation was highest in Saudi Arabia (20.2 pmp) and was lowest in Oman (2.2 pmp). Chronic hemodialysis (HD) and peritoneal dialysis (PD) services were available in all countries, whereas kidney transplantation was available in most countries of the region. Public government funding that makes acute dialysis, chronic HD, chronic PD, and kidney transplantation medications free at the point of delivery was available in 54.5%, 72.7%, 54.5%, and 54.5% of countries, respectively. Conservative kidney management was available in 45% of countries. Only Oman had a CKD registry; 7 countries (64%) had dialysis registries, and 8 (73%) had kidney transplantation registries. The ISN Middle East region has a high burden of kidney disease and multiple challenges to overcome. Prevention and detection of kidney disease can be improved by the design of tailored guidelines, allocation of additional resources, improvement of early detection at all levels of care, and implementation of sustainable health information systems.

Published
2024
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17. Capacity for the management of kidney failure in the International Society of Nephrology South Asia region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Wijewickrama, Eranga, Alam, Muhammad Rafiqul, Bajpai, Divya, Divyaveer, Smita, Iyengar, Arpana, Kumar, Vivek, Qayyum, Ahad, Yadav, Shankar Prasad, Yadla, Manjusha, Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ye, Feng, Singh Shah, Dibya, Prasad, Narayan, Agarwal, Anil K., Ahmed, Ejaz, Alexander, Suceena, Amouzegar, Atefeh, Anandh, Urmila, Bansal, Shyam Bihari, Chhetri, Pramod Kumar, Cho, Yeoungjee, Choden, Ugyen, Chowdury, Nizamuddin, Conjeevaram, Arvind, Davids, M. Razeen, Davison, Sara N., Diongole, Hassane M., Ekrikpo, Udeme E., Ethier, Isabelle, Mervin, Edwin Fernando, Wing-Shing Fung, Winston, George, Reena Rachel, Ghimire, Anukul, Gopal, Basu, Guditi, Swarnalatha, Herath, Chula, Houston, Ghenette, Htay, Htay, Ibrahim, Kwaifa Salihu, Irish, Georgina, Jindal, Kailash, Kaihan, Ahmad Baseer, Kar, Shubharthi, Kashem, Tasnuva, Kelly, Dearbhla M., Khanam, Asia, Kher, Vijay, Lalji, Rowena, Mahajan, Sandeep, Nalado, Aisha M., Naqvi, Rubina, Nayak, K.S., Neuen, Brendon L., Olanrewaju, Timothy O., Osman, Mohamed A., Parameswaran, Sreejith, Paudel, Klara, Petrova, Anna, Rashid, Harun Ur, Riaz, Parnian, Saad, Syed, Sahay, Manisha, Sakajiki, Aminu Muhammad, See, Emily, Shankar, Mythri, Sharma, Ajay P., Sharma, Sourabh, Shiham, Ibrahim, Singh, Geetika, Sozio, Stephen M., Tiv, Sophanny, Trivedi, Mayuri, Tungsanga, Somkanya, Viecelli, Andrea, Wainstein, Marina, Wazil, Abdul, Wijayaratne, Dilushi, Yeung, Emily K., and Zaidi, Deenaz

Abstract

The South Asia region is facing a high burden of chronic kidney disease (CKD) with limited health resources and low expenditure on health care. In addition to the burden of CKD and kidney failure from traditional risk factors, CKD of unknown etiologies from India and Sri Lanka compounds the challenges of optimal management of CKD in the region. From the third edition of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA), we present the status of CKD burden, infrastructure, funding, resources, and health care personnel using the World Health Organization’s building blocks for health systems in the ISN South Asia region. The poor status of the public health care system and low health care expenditure resulted in high out-of-pocket expenditures for people with kidney disease, which further compounded the situation. There is insufficient country capacity across the region to provide kidney replacement therapies to cover the burden. The infrastructure was also not uniformly distributed among the countries in the region. There were no chronic hemodialysis centers in Afghanistan, and peritoneal dialysis services were only available in Bangladesh, India, Nepal, Pakistan, and Sri Lanka. Kidney transplantation was not available in Afghanistan, Bhutan, and Maldives. Conservative kidney management was reported as available in 63% (n = 5) of the countries, yet no country reported availability of the core CKM care components. There was a high hospitalization rate and early mortality because of inadequate kidney care. The lack of national registries and actual disease burden estimates reported in the region prevent policymakers’ attention to CKD as an important cause of morbidity and mortality. Data from the 2023 ISN-GKHA, although with some limitations, may be used for advocacy and improving CKD care in the region.

Published
2024
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18. Capacity for the management of kidney failure in the International Society of Nephrology Eastern and Central Europe region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Alparslan, Caner, Malyszko, Jolanta, Caskey, Fergus J., Aleckovic-Halilovic, Mirna, Hrušková, Zdenka, Arruebo, Silvia, Bello, Aminu K., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ye, Feng, Tesar, Vladimir, Racki, Sanjin, Amouzegar, Atefeh, Aydin, Zehra, Barbullushi, Myftar, Bek, Sibel, Bumblyte, Inga Arune, Cho, Yeoungjee, Davids, M. Razeen, Davison, Sara N., Deltas, Constantinos, Diongole, Hassane M., Divyaveer, Smita, Ekrikpo, Udeme E., Ethier, Isabelle, Fogo, Agnes B., Wing-Shing Fung, Winston, Ghimire, Anukul, Honsova, Eva, Houston, Ghenette, Htay, Htay, Ibrahim, Kwaifa Salihu, Irish, Georgina, Jindal, Kailash, Kazancıoğlu, Rümeyza, Kelly, Dearbhla M., Krajewska, Magdalena, Laganovic, Mario, Lalji, Rowena, Nalado, Aisha M., Naumovic, Radomir, Neuen, Brendon L., Nikolova-Vlahova, Milena Krasimirova, Nistor, Ionut, Olanrewaju, Timothy O., Osman, Mohamed A., Ots-Rosenberg, Mai, Petrova, Anna, Podracka, Ludmila, Resic, Halima, Riaz, Parnian, Rosivall, Laszlo, Saad, Syed, Sakajiki, Aminu Muhammad, See, Emily, Sever, Mehmet Sukru, Sozio, Stephen M., Spasovski, Goce, Tiv, Sophanny, Tuglular, Serhan, Tungsanga, Somkanya, Viecelli, Andrea, Wainstein, Marina, Yeung, Emily K., and Zaidi, Deenaz

Abstract

Delivery of care for kidney failure (KF) globally has a significant disparity; even in some countries, it means end of life for the person. The International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) tries to address gaps in KF care and standardize global nephrology care. From the third iteration of the ISN-GKHA, we present data for countries in the ISN Eastern and Central Europe region. The median prevalences of chronic kidney disease (12.8%) and treated KF (873.5 pmp) were higher than the global rates, respectively. Hemodialysis was the most preferred modality for KF in adults, whereas kidney replacement therapy was more balanced in children. Although most of the countries in the region had lower-middle–income and upper-middle–income levels, health expenditures for kidney health care were almost generally covered publicly. Nephrologists were responsible for the medical kidney care of people with KF in all countries. There was adequate infrastructure to provide all kinds of treatment for kidney care in the region. Regional characteristics such as high levels of obesity, smoking, and Balkan nephropathy as an endemic disease coupled with a shortage of workforce and finance continued to affect kidney care in the region negatively. By making organizational and legislative arrangements, partnerships with national authorities and societies may accelerate the improvement of kidney health care in the region.

Published
2024
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19. Capacity for the management of kidney failure in the International Society of Nephrology Western Europe region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Pippias, Maria, Alfano, Gaetano, Kelly, Dearbhla M., Soler, Maria Jose, De Chiara, Letizia, Olanrewaju, Timothy O., Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ye, Feng, Coppo, Rosanna, Lightstone, Liz, Amouzegar, Atefeh, Anders, Hans-Joachim, Baharani, Jyoti, Banerjee, Debasish, Bikbov, Boris, Brown, Edwina A., Cho, Yeoungjee, Claes, Kathleen, Clyne, Naomi, Davids, M. Razeen, Davison, Sara N., Diongole, Hassane M., Divyaveer, Smita, Dreyer, Gavin, Dudley, Jan, Ekrikpo, Udeme E., Ethier, Isabelle, Evans, Rhys D.R., Fan, Stanley L.S., Wing-Shing Fung, Winston, Gallieni, Maurizio, Ghimire, Anukul, Houston, Ghenette, Htay, Htay, Ibrahim, Kwaifa Salihu, Irish, Georgina, Jindal, Kailash, Khwaja, Arif, Lalji, Rowena, Liakopoulos, Vassilios, Luyckx, Valerie A., Macia, Manuel, Marti, Hans Peter, Messa, Piergiorgio, Müller, Thomas F., Nalado, Aisha M., Neuen, Brendon L., Nitsch, Dorothea, Nolasco, Fernando, Oberbauer, Rainer, Osman, Mohamed A., Papagianni, Aikaterini, Petrova, Anna, Piccoli, Giorgina Barbara, Plant, Liam, Remuzzi, Giuseppe, Riaz, Parnian, Roelofs, Joris J., Rudnicki, Michael, Saad, Syed, Sakajiki, Aminu Muhammad, Scheppach, Johannes B., See, Emily, Shroff, Rukshana, Solbu, Marit D., Sozio, Stephen M., Strippoli, Giovanni FM., Taal, Maarten W., Ashu, James Tataw, Tiv, Sophanny, Tungsanga, Somkanya, van der Net, Jeroen B., Vanholder, Raymond C., Viecelli, Andrea, Vinen, Katie, Vogt, Bruno, Wainstein, Marina, Weinstein, Talia, Wheeler, David C., Yeung, Emily K., and Zaidi, Deenaz

Abstract

Western Europe boasts advanced health care systems, robust kidney care guidelines, and a well-established health care workforce. Despite this, significant disparities in kidney replacement therapy incidence, prevalence, and transplant access exist. This paper presents the third International Society of Nephrology Global Kidney Health Atlas’s findings on kidney care availability, accessibility, affordability, and quality in 22 Western European countries, representing 99% of the region’s population. The known chronic kidney disease (CKD) prevalence across Western Europe averages 10.6%, slightly above the global median. Cardiovascular diseases account for a substantial portion of CKD-related deaths. Kidney failure incidence varies. Government health expenditure differs; however, most countries offer government-funded acute kidney injury, dialysis, and kidney transplantation care. Hemodialysis and peritoneal dialysis are universally available, with variations in the number of dialysis centers. Kidney transplantation is available in all countries (except for 3 microstates), with variable transplant center prevalence. Conservative kidney management (CKM) is increasingly accessible. The region’s kidney care workforce is substantial, exceeding global averages; however, workforce shortages are reported. Barriers to optimal kidney care include limited workforce capacity, lack of surveillance mechanisms, and suboptimal integration into national noncommunicable disease (NCD) strategies. Policy recognition of CKD as a health priority varies across countries. Although Western Europe exhibits strong kidney care infrastructure, opportunities for improvement exist, particularly in CKD prevention, surveillance, awareness, and policy implementation. Efforts to improve CKD care should include automated detection, educational support, and enhanced workflows. Based on these findings, health care professionals, stakeholders, and policymakers are called to act to enhance kidney care across the region.

Published
2024
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20. Capacity for the management of kidney failure in the International Society of Nephrology Newly Independent States and Russia region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Prikhodina, Larisa, Komissarov, Kirill, Bulanov, Nikolay, Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ye, Feng, Gaipov, Abduzhappar, Amouzegar, Atefeh, Kyzy, Aiperi Asanbek, Cho, Yeoungjee, Davids, M. Razeen, Davison, Sara N., Diongole, Hassane M., Divyaveer, Smita, Ekrikpo, Udeme E., Ethier, Isabelle, Wing-Shing Fung, Winston, Ghimire, Anukul, Houston, Ghenette, Htay, Htay, Ibrahim, Kwaifa Salihu, Irish, Georgina, Ivanov, Dmytro, Jindal, Kailash, Kelly, Dearbhla M., Khamzaev, Komiljon, Lalji, Rowena, Nalado, Aisha M., Neuen, Brendon L., Olanrewaju, Timothy O., Osman, Mohamed A., Riaz, Parnian, Saad, Syed, Sakajiki, Aminu Muhammad, Sarishvili, Nora, Sarkissian, Ashot, See, Emily, Sharapov, Olimkhon N., Sozio, Stephen M., Tchokhonelidze, Irma, Tiv, Sophanny, Tungsanga, Somkanya, Viecelli, Andrea, Vishnevskii, Konstantin, Vorobyeva, Olga A., Wainstein, Marina, Yeung, Emily K., Zaidi, Deenaz, and Zakharova, Elena

Abstract

The International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) was established to aid understanding of the status and capacity of countries to provide optimal kidney care worldwide. This report presents the current characteristics of kidney care in the ISN Newly Independent States (NIS) and Russia region. Although the median prevalence of chronic kidney disease (CKD) was higher (11.4%) than the global median (9.5%), the median CKD-related death rate (1.4%) and prevalence of treated kidney failure (KF) in the region (411 per million population [pmp]) were lower than they are globally (2.5% and 822.8 pmp, respectively). Capacity to provide an adequate frequency of hemodialysis (HD) and kidney transplantation services is present in all the countries (100%). In spite of significant economic advancement, the region has critical shortages of nephrologists, dietitians, transplant coordinators, social workers, palliative care physicians, and kidney supportive care nurses. Home HD remains unavailable in any country in the region. Although national registries for dialysis and kidney transplantation are available in most of the countries across the ISN NIS and Russia region, few registries exist for nondialysis CKD and acute kidney injury. Although a national strategy for improving care for CKD patients is presented in more than half of the countries, no country in the region had a CKD-specific policy. Strategies that incorporate workforce training, planning, and development for all KF caregivers could help ensure sustainable kidney care delivery in the ISN NIS and Russia region.

Published
2024
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21. Capacity for the management of kidney failure in the International Society of Nephrology Oceania and South East Asia (OSEA) region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Francis, Anna, Wainstein, Marina, Irish, Georgina, Abdul Hafidz, Muhammad Iqbal, Chen, Titi, Cho, Yeoungjee, Htay, Htay, Kanjanabuch, Talerngsak, Lalji, Rowena, Neuen, Brendon L., See, Emily, Shah, Anim, Smyth, Brendan, Tungsanga, Somkanya, Viecelli, Andrea, Yeung, Emily K., Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ye, Feng, Wong, Muh Geot, Bavanandan, Sunita, Abdul Gafor, Abdul Halim, Amouzegar, Atefeh, Bennett, Paul, Chicano, Sonia L., Davids, M. Razeen, Davison, Sara N., Diongole, Hassane M., Divyaveer, Smita, Ekrikpo, Udeme E., Ethier, Isabelle, Fong, Voon Ken, Fung, Winston Wing-Shing, Ghimire, Anukul, Gopal, Basu, Phan, Hai An Ha, Harris, David C.H., Houston, Ghenette, Ibrahim, Kwaifa Salihu, Jardine, Meg J., Jindal, Kailash, Kantachuvesiri, Surasak, Kelly, Dearbhla M., Kerr, Peter, Kim, Siah, Krishnasamy, Rathika, Kwek, Jia Liang, Lee, Vincent, Liew, Adrian, Lim, Chiao Yuen, Lydia, Aida, Nalado, Aisha M., Olanrewaju, Timothy O., Osman, Mohamed A., Petrova, Anna, Pyar, Khin Phyu, Riaz, Parnian, Saad, Syed, Sakajiki, Aminu Muhammad, Sengthavisouk, Noot, Sozio, Stephen M., Srisawat, Nattachai, Tan, Eddie, Tiv, Sophanny, Tomacruz Amante, Isabelle Dominique, Villanueva, Anthony Russell, Walker, Rachael, Walker, Robert, and Zaidi, Deenaz

Abstract

The International Society of Nephrology (ISN) region of Oceania and South East Asia (OSEA) is a mix of high- and low-income countries, with diversity in population demographics and densities. Three iterations of the ISN-Global Kidney Health Atlas (GKHA) have been conducted, aiming to deliver in-depth assessments of global kidney care across the spectrum from early detection of CKD to treatment of kidney failure. This paper reports the findings of the latest ISN-GKHA in relation to kidney-care capacity in the OSEA region. Among the 30 countries and territories in OSEA, 19 (63%) participated in the ISN-GKHA, representing over 97% of the region’s population. The overall prevalence of treated kidney failure in the OSEA region was 1203 per million population (pmp), 45% higher than the global median of 823 pmp. In contrast, kidney replacement therapy (KRT) in the OSEA region was less available than the global median (chronic hemodialysis, 89% OSEA region vs. 98% globally; peritoneal dialysis, 72% vs. 79%; kidney transplantation, 61% vs. 70%). Only 56% of countries could provide access to dialysis to at least half of people with incident kidney failure, lower than the global median of 74% of countries with available dialysis services. Inequalities in access to KRT were present across the OSEA region, with widespread availability and low out-of-pocket costs in high-income countries and limited availability, often coupled with large out-of-pocket costs, in middle- and low-income countries. Workforce limitations were observed across the OSEA region, especially in lower-middle–income countries. Extensive collaborative work within the OSEA region and globally will help close the noted gaps in kidney-care provision.

Published
2024
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22. Capacity for the management of kidney failure in the International Society of Nephrology Africa region: report from the 2023 ISN Global Kidney Atlas (ISN-GKHA)

Author

Tannor, Elliot Koranteng, Davidson, Bianca, Nlandu, Yannick, Bagasha, Peace, Bilchut, Workagegnehu Hailu, Davids, M. Razeen, Diongole, Hassane M., Ekrikpo, Udeme E., Hafiz, Ehab O.A., Ibrahim, Kwaifa Salihu, Kalyesubula, Robert, Nalado, Aisha M., Olanrewaju, Timothy O., Onu, Ugochi Chika, Pereira-Kamath, Nikhil, Sakajiki, Aminu Muhammad, Salah, Mohamed, Vincent, Lloyd, Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ye, Feng, Ashuntantang, Gloria Enow, Arogundade, Fatiu Abiola, Gawad, Mohammed Abdel, Abderrahim, Ezzedine, Akl, Ahmed, Amekoudi, Eyram Makafui Yoan, Amouzegar, Atefeh, Awobusuyi, Jacob Olugbenga, Bakoush, Omran, Chissico, Elsa R., Cho, Yeoungjee, Coker, Joshua, Cullis, Brett, Dahwa, Rumbidzai, Darwish, Rasha Ahmed, Davison, Sara N., Divyaveer, Smita, Ethier, Isabelle, Fagoonee, Kevin, Fofana, Aboubacar Sidiki, Freercks, Robert, Wing-Shing Fung, Winston, Gandzali-Ngabe, Pierre Eric, Ghimire, Anukul, Gouda, Zaghloul Elsafy, Habyarimana, Oswald, Htay, Htay, Wan, Davy Ip Min, Irish, Georgina, Ismail, Wesam, Jagne, Abubacarr, Jarraya, Faiçal, Jindal, Kailash, Kabllo, Babikir G., Kalebi, Ahmed Y., Kaze Folefack, François F., Kelly, Dearbhla M., Lalji, Rowena, Lomatayo, Ben, Mah, Sidi Mohamed, Zalba Mahamat Abderraman, Guillaume, McCulloch, Mignon, Mengistu, Yewondwossen Tadesse, Moloi, Mothusi Walter, Mwaba, Chisambo, Neuen, Brendon L., Ngigi, John, Niang, Abdou, Nyandwi, Joseph, Odeh, Emad, Osman, Mohamed A., Le Grand Ouanekpone, Cédric Patrick, Petrova, Anna, Ranivoharisoa, Eliane M., Riaz, Parnian, Saad, Syed, See, Emily, Sokwala, Ahmed, Solarin, Adaobi Uzoamaka, Sozio, Stephen M., Houssani, Tarik Sqalli, Kiswaya, Ernest Sumaili, Tia, Weu Melanie, Tiv, Sophanny, Ts'enoli, Thabang, Tungsanga, Somkanya, Ulasi, Ifeoma I., Vanglist, Ssentamu John, Viecelli, Andrea, Wadee, Shoyab, Wainstein, Marina, Wearne, Nicola, Yeung, Emily K., and Zaidi, Deenaz

Abstract

The burden of chronic kidney disease and associated risk of kidney failure are increasing in Africa. The management of people with chronic kidney disease is fraught with numerous challenges because of limitations in health systems and infrastructures for care delivery. From the third iteration of the International Society of Nephrology Global Kidney Health Atlas, we describe the status of kidney care in the ISN Africa region using the World Health Organization building blocks for health systems. We identified limited government health spending, which in turn led to increased out-of-pocket costs for people with kidney disease at the point of service delivery. The health care workforce across Africa was suboptimal and further challenged by the exodus of trained health care workers out of the continent. Medical products, technologies, and services for the management of people with nondialysis chronic kidney disease and for kidney replacement therapy were scarce due to limitations in health infrastructure, which was inequitably distributed. There were few kidney registries and advocacy groups championing kidney disease management in Africa compared with the rest of the world. Strategies for ensuring improved kidney care in Africa include focusing on chronic kidney disease prevention and early detection, improving the effectiveness of the available health care workforce (e.g., multidisciplinary teams, task substitution, and telemedicine), augmenting kidney care financing, providing quality, up-to-date health information data, and improving the accessibility, affordability, and delivery of quality treatment (kidney replacement therapy or conservative kidney management) for all people living with kidney failure.

Published
2024
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23. Capacity for the management of kidney failure in the International Society of Nephrology North America and the Caribbean region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Lowe-Jones, Racquel, Ethier, Isabelle, Fisher, Lori-Ann, Wong, Michelle M.Y., Thompson, Stephanie, Nakhoul, Georges, Sandal, Shaifali, Chanchlani, Rahul, Davison, Sara N., Ghimire, Anukul, Jindal, Kailash, Osman, Mohamed A., Riaz, Parnian, Saad, Syed, Sozio, Stephen M., Tungsanga, Somkanya, Cambier, Alexandra, Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ye, Feng, Parekh, Rulan S., Anand, Shuchi, Agarwal, Anil K., Amouzegar, Atefeh, Avila-Casado, Carmen, Barton, Everard N., Behera, Suman, Felix, Melvin Bonilla, Cerda, Jorge, Cho, Yeoungjee, Cybulsky, Andrey V., Davids, M. Razeen, Diaz-González de Ferris, María Esther, Diongole, Hassane M., Divyaveer, Smita, Ekrikpo, Udeme E., Fogo, Agnes B., Friedman, David, Wing-Shing Fung, Winston, Furth, Susan L., Gill, John, Houston, Ghenette, Hsiao, Li-Li, Hsu, Chi-yuan, Htay, Htay, Ibrahim, Kwaifa Salihu, Irish, Georgina, Karam, Sabine, Kelly, Dearbhla M., Lalji, Rowena, Lerma, Edgar V., Mac-Way, Fabrice, Macedo, Etienne, Mohammed, Hassina, Nair, Devika, Nalado, Aisha M., Neuen, Brendon L., Olanrewaju, Timothy O., Vela Parada, Xavier Fernanco, Pecoits-Filho, Roberto, Petrova, Anna, Prasad, Bhanu, Radix, Lisa, Raina, Rupesh, Ullur, Avinash Rao, Rosner, Mitchell H., Sakajiki, Aminu Muhammad, See, Emily, Seshan, Surya V., Teitelbaum, Isaac, Thomas, Ian, Tiv, Sophanny, Trask, Michele, Vachharajani, Tushar J., Viecelli, Andrea, Wainstein, Marina, Walsh, Michael, Wyatt, Christina, Yeates, Karen, Yeung, Emily K., Young-Peart, Sandrica, and Zaidi, Deenaz

Abstract

The International Society of Nephrology Global Kidney Health Atlas charts the availability and capacity of kidney care globally. In the North America and the Caribbean region, the Atlas can identify opportunities for kidney care improvement, particularly in Caribbean countries where structures for systematic data collection are lacking. In this third iteration, respondents from 12 of 18 countries from the region reported a 2-fold higher than global median prevalence of dialysis and transplantation, and a 3-fold higher than global median prevalence of dialysis centers. The peritoneal dialysis prevalence was lower than the global median, and transplantation data were missing from 6 of the 10 Caribbean countries. Government-funded payments predominated for dialysis modalities, with greater heterogeneity in transplantation payor mix. Services for chronic kidney disease, such as monitoring of anemia and blood pressure, and diagnostic capability relying on serum creatinine and urinalyses were universally available. Notable exceptions in Caribbean countries included non-calcium-based phosphate binders and kidney biopsy services. Personnel shortages were reported across the region. Kidney failure was identified as a governmental priority more commonly than was chronic kidney disease or acute kidney injury. In this generally affluent region, patients have better access to kidney replacement therapy and chronic kidney disease–related services than in much of the world. Yet clear heterogeneity exists, especially among the Caribbean countries struggling with dialysis and personnel capacity. Important steps to improve kidney care in the region include increased emphasis on preventive care, a focus on home-based modalities and transplantation, and solutions to train and retain specialized allied health professionals.

Published
2024
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24. Capacity for the management of kidney failure in the International Society of Nephrology Latin America region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Calice-Silva, Viviane, Neyra, Javier A., Ferreiro Fuentes, Alejandro, Singer Wallbach Massai, Krissia Kamile, Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ye, Feng, Madero, Magdalena, Tzanno Martins, Carmen, Alvarez, Guillermo, Amouzegar, Atefeh, Arellano-Mendez, Denisse, Martinez, Gustavo Aroca, Ferrari, Roger Ayala, Bonano, Carlos, Velarde, Edwin Castillo, Chavez Iñiguez, Jonathan Samuel, Cho, Yeoungjee, Claure-Del Granado, Rolando, Correa-Rotter, Ricardo, Cueto Manzano, Alfonso M., Cusumano, Ana Maria, Davids, M. Razeen, Davison, Sara N., Diongole, Hassane M., Divyaveer, Smita, Ekrikpo, Udeme E., Ethier, Isabelle, Figueiredo, Ana Elizabeth, Wing-Shing Fung, Winston, Garcia, Guillermo Garcia, Ghimire, Anukul, Gomez, Martin, Gonzalez Bedat, Maria Carlota, Houston, Ghenette, Htay, Htay, Ibrahim, Kwaifa Salihu, Irish, Georgina, Jindal, Kailash, Kelly, Dearbhla M., Lalji, Rowena, Moura-Neto, José A., Nalado, Aisha M., Neuen, Brendon L., Noboa, Oscar, Noronha, Irene L., Olanrewaju, Timothy O., Osman, Mohamed A., Pastor Ludena, Ana Cecilia, Petrova, Anna, Pio-Abreu, Andrea, Riaz, Parnian, Rico-Fontalvo, Jorge, Rosa-Diez, Guillermo, Saad, Syed, Sakajiki, Aminu Muhammad, Santacruz, Angel Cristóbal, Santacruz, Juan, See, Emily, Soares dos Santos Junior, Augusto Cesar, Sola, Laura, Sozio, Stephen M., Tiv, Sophanny, Trimarchi, Hernan, Tungsanga, Somkanya, Viecelli, Andrea, Wainstein, Marina, Yeung, Emily K., and Zaidi, Deenaz

Abstract

Successful management of chronic kidney disease (CKD) in Latin America (LA) continues to represent a challenge due to high disease burden and geographic disparities and difficulties in terms of capacity, accessibility, equity, and quality of kidney failure care. Although LA has experienced significant social and economic progress over the past decades, there are still important inequities in health care access. Through this third iteration of the International Society of Nephrology Global Kidney Health Atlas, the indicators regarding kidney failure care in LA are updated. Survey responses were received from 22 of 31 (71%) countries in LA representing 96.5% of its total population. Median CKD prevalence was 10.2% (interquartile range: 8.4%–12.3%), median CKD disability-adjusted life year was 753.4 days (interquartile range: 581.3–1072.5 days), and median CKD mortality was 5.5% (interquartile range: 3.2%–6.3%). Regarding dialysis modality, hemodialysis continued to be the most used therapy, whereas peritoneal dialysis reached a plateau and kidney transplantation increased steadily over the past 10 years. In 20 (91%) countries, >50% of people with kidney failure could access dialysis, and in only 2 (9%) countries, people who had access to dialysis could initiate dialysis with peritoneal dialysis. A mix of public and private systems collectively funded most aspects of kidney replacement therapy (dialysis and transplantation) with many people incurring up to 50% of out-of-pocket costs. Few LA countries had CKD/kidney replacement therapy registries, and almost no acute kidney injury registries were reported. There was large variability in the nature and extent of kidney failure care in LA mainly related to countries’ funding structures and limited surveillance and management initiatives.

Published
2024
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26. Availability and prioritisation of COVID-19 vaccines among patients with advanced chronic kidney disease and kidney failure during the height of the pandemic: a global survey by the International Society of Nephrology

Author

Wijewickrama, Eranga S, primary, Abdul Hafidz, Muhammad Iqbal, additional, Robinson, Bruce M, additional, Johnson, David W, additional, Liew, Adrian, additional, Dreyer, Gavin, additional, Caskey, Fergus J, additional, Bello, Aminu K, additional, Zaidi, Deenaz, additional, Damster, Sandrine, additional, Salaro, Silvia, additional, Luyckx, Valerie Ann, additional, and Bajpai, Divya, additional

Published
2022
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27. Trends in nephrology referral patterns for patients with chronic kidney disease: Retrospective cohort study

Author

Ghimire, Anukul, primary, Ye, Feng, additional, Hemmelgarn, Brenda, additional, Zaidi, Deenaz, additional, Jindal, Kailash K., additional, Tonelli, Marcello A., additional, Cooper, Matthew, additional, James, Matthew T., additional, Khan, Maryam, additional, Tinwala, Mohammed M., additional, Sultana, Naima, additional, Ronksley, Paul E., additional, Muneer, Shezel, additional, Klarenbach, Scott, additional, Okpechi, Ikechi G., additional, and Bello, Aminu K., additional

Published
2022
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29. A roadmap for kidney care in Africa: An analysis of International Society of Nephrology–Global Kidney Health Atlas Africa data describing current gaps and opportunities

Author

Okpechi, Ikechi, primary, Niang, Abdou, additional, Hafez, Mohammed, additional, Ashuntantang, Gloria, additional, Zaidi, Deenaz, additional, Ye, Feng, additional, Abdu, Aliyu, additional, Asinobi, Adanze, additional, Balogun, Rasheed, additional, Chukwuonye, Innocent, additional, Diongole, Hassane, additional, Effa, Emmanuel, additional, Ekrikpo, Udeme, additional, Gouda, Zaghloul, additional, Hussaini, Jibrin, additional, Kaze, Francois, additional, Kilonzo, Kajiru, additional, Kalyesubula, Robert, additional, Kununa, Amna, additional, Makusidi, Muhammad, additional, Mbah, Ikechukwu, additional, McCullough, Mignon, additional, Mengistu, Yewondwossen, additional, Moloi, Mothusi, additional, Moturi, George, additional, Ndlovu, Kwazi, additional, Ngigi, John, additional, Nklandu, Yannick, additional, Ntarindwa, Joseph, additional, Okel, Julius, additional, Olanrewaju, Timothy, additional, Osafo, Charlotte, additional, Samuel-Okpechi, Ugochi, additional, Shigidi, Mazin, additional, Sumaili, Ernest, additional, Ulasi, Ifeoma, additional, Umeizudike, Theophilus, additional, Wearne, Nicola, additional, Jha, Vivekanand, additional, Levin, Adeera, additional, Johnson, David, additional, and Bello, Aminu, additional

Published
2022
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30. The impact of community-based non-pharmacological interventions on cardiovascular and kidney disease outcomes in remote dwelling Indigenous communities: A scoping review protocol

Author

Okpechi, Ikechi G., primary, Hariramani, Vinash Kumar, additional, Sultana, Naima, additional, Ghimire, Anukul, additional, Zaidi, Deenaz, additional, Muneer, Shezel, additional, Tinwala, Mohammed M., additional, Ye, Feng, additional, Sebastianski, Megan, additional, Abdulrahman, Abdullah, additional, Braam, Branko, additional, Jindal, Kailash, additional, Khan, Maryam, additional, Klarenbach, Scott, additional, Shojai, Soroush, additional, Thompson, Stephanie, additional, and Bello, Aminu K., additional

Published
2022
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31. Availability and prioritisation of COVID-19 vaccines among patients with advanced chronic kidney disease and kidney failure during the height of the pandemic: a global survey by the International Society of Nephrology

Author

Wijewickrama, Eranga S, Abdul Hafidz, Muhammad Iqbal, Robinson, Bruce M, Johnson, David W, Liew, Adrian, Dreyer, Gavin, Caskey, Fergus J, Bello, Aminu K, Zaidi, Deenaz, Damster, Sandrine, Salaro, Silvia, Luyckx, Valerie Ann; https://orcid.org/0000-0001-7066-8135, Bajpai, Divya; https://orcid.org/0000-0003-2294-0506, Wijewickrama, Eranga S, Abdul Hafidz, Muhammad Iqbal, Robinson, Bruce M, Johnson, David W, Liew, Adrian, Dreyer, Gavin, Caskey, Fergus J, Bello, Aminu K, Zaidi, Deenaz, Damster, Sandrine, Salaro, Silvia, Luyckx, Valerie Ann; https://orcid.org/0000-0001-7066-8135, and Bajpai, Divya; https://orcid.org/0000-0003-2294-0506

Abstract

OBJECTIVE Patients with advanced chronic kidney disease (CKD) or kidney failure receiving replacement therapy (KFRT) are highly vulnerable to COVID-19 infection, morbidity and mortality. Vaccination is effective, but access differs around the world. We aimed to ascertain the availability, readiness and prioritisation of COVID-19 vaccines for this group of patients globally. SETTING AND PARTICIPANTS Collaborators from the International Society of Nephrology (ISN), Dialysis Outcomes and Practice Patterns Study and ISN-Global Kidney Health Atlas developed an online survey that was administered electronically to key nephrology leaders in 174 countries between 2 July and 4 August 2021. RESULTS Survey responses were received from 99 of 174 countries from all 10 ISN regions, among which 88/174 (50%) were complete. At least one vaccine was available in 96/99 (97%) countries. In 71% of the countries surveyed, patients on dialysis were prioritised for vaccination, followed by patients living with a kidney transplant (KT) (62%) and stage 4/5 CKD (51%). Healthcare workers were the most common high priority group for vaccination. At least 50% of patients receiving in-centre haemodialysis, peritoneal dialysis or KT were estimated to have completed vaccination at the time of the survey in 55%, 64% and 51% of countries, respectively. At least 50% of patients in all three patient groups had been vaccinated in >70% of high-income countries and in 100% of respondent countries in Western Europe.The most common barriers to vaccination of patients were vaccine hesitancy (74%), vaccine shortages (61%) and mass vaccine distribution challenges (48%). These were reported more in low-income and lower middle-income countries compared with high-income countries. CONCLUSION Patients with advanced CKD or KFRT were prioritised in COVID-19 vaccination in most countries. Multiple barriers led to substantial variability in the successful achievement of COVID-19 vaccination across the world, with high

Published
2022

32. Global eHealth capacity: secondary analysis of WHO data on eHealth and implications for kidney care delivery in low-resource settings

Author

Okpechi, Ikechi G, primary, Muneer, Shezel, additional, Ye, Feng, additional, Zaidi, Deenaz, additional, Ghimire, Anukul, additional, Tinwala, Mohammed M, additional, Saad, Syed, additional, Osman, Mohamed A, additional, Lunyera, Joseph, additional, Tonelli, Marcello, additional, Caskey, Fergus, additional, George, Cindy, additional, Kengne, Andre P, additional, Malik, Charu, additional, Damster, Sandrine, additional, Levin, Adeera, additional, Johnson, David, additional, Jha, Vivekanand, additional, and Bello, Aminu K, additional

Published
2022
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33. sj-pdf-1-cjk-10.1177_20543581221106248 – Supplemental material for Impact of Home Telemonitoring and Management Support on Blood Pressure Control in Nondialysis CKD: A Systematic Review and Meta-Analysis

Author

Muneer, Shezel, Okpechi, Ikechi G., Ye, Feng, Zaidi, Deenaz, Tinwala, Mohammed M., Hamonic, Laura N., Ghimire, Anukul, Sultana, Naima, Slabu, Dan, Khan, Maryam, Braam, Branko, Jindal, Kailash, Klarenbach, Scott, Padwal, Raj, Ringrose, Jennifer, Scott-Douglas, Nairne, Shojai, Soroush, Thompson, Stephanie, and Bello, Aminu K.

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-1-cjk-10.1177_20543581221106248 for Impact of Home Telemonitoring and Management Support on Blood Pressure Control in Nondialysis CKD: A Systematic Review and Meta-Analysis by Shezel Muneer, Ikechi G. Okpechi, Feng Ye, Deenaz Zaidi, Mohammed M. Tinwala, Laura N. Hamonic, Anukul Ghimire, Naima Sultana, Dan Slabu, Maryam Khan, Branko Braam, Kailash Jindal, Scott Klarenbach, Raj Padwal, Jennifer Ringrose, Nairne Scott-Douglas, Soroush Shojai, Stephanie Thompson and Aminu K. Bello in Canadian Journal of Kidney Health and Disease

Published
2022
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34. sj-pdf-1-cjk-10.1177_20543581221077500 ��� Supplemental material for Telemonitoring and Case Management for Hypertensive and Remote-Dwelling Patients With Chronic Kidney Disease���The Telemonitoring for Improved Kidney Outcomes Study (TIKO): A Clinical Research Protocol

Author

Okpechi, Ikechi G., Zaidi, Deenaz, Ye, Feng, Fradette, Miriam, Schick-Makaroff, Kara, Berendonk, Charlotte, Abdulrahman, Abdullah, Braam, Branko, Ghimire, Anukul, Hariramani, Vinash Kumar, Jindal, Kailash, Khan, Maryam, Klarenbach, Scott, Muneer, Shezel, Ringrose, Jennifer, Scott-Douglas, Nairne, Shojai, Soroush, Slabu, Dan, Sultana, Naima, Tinwala, Mohammed M., Thompson, Stephanie, Padwal, Raj, and Bello, Aminu K.

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-1-cjk-10.1177_20543581221077500 for Telemonitoring and Case Management for Hypertensive and Remote-Dwelling Patients With Chronic Kidney Disease���The Telemonitoring for Improved Kidney Outcomes Study (TIKO): A Clinical Research Protocol by Ikechi G. Okpechi, Deenaz Zaidi, Feng Ye, Miriam Fradette, Kara Schick-Makaroff, Charlotte Berendonk, Abdullah Abdulrahman, Branko Braam, Anukul Ghimire, Vinash Kumar Hariramani, Kailash Jindal, Maryam Khan, Scott Klarenbach, Shezel Muneer, Jennifer Ringrose, Nairne Scott-Douglas, Soroush Shojai, Dan Slabu, Naima Sultana, Mohammed M. Tinwala, Stephanie Thompson, Raj Padwal and Aminu K. Bello in Canadian Journal of Kidney Health and Disease

Published
2022
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36. Impact of Home Telemonitoring and Management Support on Blood Pressure Control in Nondialysis CKD: A Systematic Review and Meta-Analysis

Author

Muneer, Shezel, primary, Okpechi, Ikechi G., additional, Ye, Feng, additional, Zaidi, Deenaz, additional, Tinwala, Mohammed M., additional, Hamonic, Laura N., additional, Ghimire, Anukul, additional, Sultana, Naima, additional, Slabu, Dan, additional, Khan, Maryam, additional, Braam, Branko, additional, Jindal, Kailash, additional, Klarenbach, Scott, additional, Padwal, Raj, additional, Ringrose, Jennifer, additional, Scott-Douglas, Nairne, additional, Shojai, Soroush, additional, Thompson, Stephanie, additional, and Bello, Aminu K., additional

Published
2022
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37. Telemonitoring and Case Management for Hypertensive and Remote-Dwelling Patients With Chronic Kidney Disease—The Telemonitoring for Improved Kidney Outcomes Study (TIKO): A Clinical Research Protocol

Author

Okpechi, Ikechi G., primary, Zaidi, Deenaz, additional, Ye, Feng, additional, Fradette, Miriam, additional, Schick-Makaroff, Kara, additional, Berendonk, Charlotte, additional, Abdulrahman, Abdullah, additional, Braam, Branko, additional, Ghimire, Anukul, additional, Hariramani, Vinash Kumar, additional, Jindal, Kailash, additional, Khan, Maryam, additional, Klarenbach, Scott, additional, Muneer, Shezel, additional, Ringrose, Jennifer, additional, Scott-Douglas, Nairne, additional, Shojai, Soroush, additional, Slabu, Dan, additional, Sultana, Naima, additional, Tinwala, Mohammed M., additional, Thompson, Stephanie, additional, Padwal, Raj, additional, and Bello, Aminu K., additional

Published
2022
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39. Impact of home telemonitoring and management support on blood pressure control in non-dialysis CKD: a systematic review protocol

Author

Okpechi, Ikechi G, primary, Muneer, Shezel, additional, Tinwala, Mohammed M, additional, Zaidi, Deenaz, additional, Hamonic, Laura N, additional, Braam, Branko, additional, Jindal, Kailash, additional, Klarenbach, Scott, additional, Padwal, Raj S, additional, Shojai, Soroush, additional, Thompson, Stephanie, additional, and Bello, Aminu K, additional

Published
2021
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40. Passive immunization of lactating mice with stanniocalcin-1 antiserum reduces mammary gland development, milk fat content, and postnatal pup growth

Author

Zaidi, Deenaz, James, Kathi A., and Wagner, Graham F.

Subjects
Immunization -- Health aspects, Rodents -- Research, Rodents -- Behavior, Lipoprotein lipase -- Research, Biological sciences
Abstract

During pregnancy and lactation in rodents, stanniocalcin-1 (STC-1) production by the ovaries is upregulated markedly and released into the circulation. The mammary glands are one target of this systemically delivered hormone. The purpose of this study was to lower serum levels of STC-1 in lactating mice through passive immunization so as to monitor the effects on mammary gland function and postnatal pup growth. Passive immunization significantly reduced circulating hormone levels, and pup growth was significantly compromised (30%), even though control and experimental litters had ingested equal amounts of milk. When mammary glands were analyzed, the alveolar area was significantly reduced in antibody-treated mothers. An analysis of milk composition revealed no changes in lactose, protein, or electrolyte levels but an ~40% reduction in triglyceride levels. The latter was due to a significant reduction in mammary gland lipoprotein lipase activity and led to a significant buildup of triglycerides in the serum. Body fat content was also significantly reduced in pups from antibody-treated mothers, whereas pup fecal fat content was increased. In mothers, passive immunization also caused significant behavioral effects, in particular, increased locomotor and hindleg rearing activities. Collectively, the results suggest that systemically derived STC-1 has important effects on mammary gland development and the transfer of serum-based triglycerides into milk. Locomotor effects suggest that STC-1 also has a role in maternal behavior. development; lipoprotein lipase; behavior

Published
2006

41. Nuclear targeting of stanniocalcin to mammary gland alveolar cells during pregnancy and lactation

Author

Hasilo, Craig P., McCudden, Christopher R., Gillespie, J. Ryan J., James, Kathi A., Hirvi, Edward R., Zaidi, Deenaz, and Wagner, Graham F.

Subjects
Tissues -- Research, Polypeptides -- Research, Progesterone -- Research, Biological sciences
Abstract

In most mammalian tissues, the stanniocalcin-1 gene (STC-1) produces a 50-kDa polypeptide hormone known as STC50. Within the ovaries, however, the STC-1 gene generates three higher-molecular-mass variants known as big STC. Big STC is targeted locally to corpus luteal cells to block progesterone release. During pregnancy and lactation, however, ovarian big STC production increases markedly, and the hormone is released into the serum. During lactation, this increase in hormone production is dependent on a suckling stimulus, suggesting that ovarian big STC may have regulatory effects on the lactating mammary gland. In this report, we have addressed this possibility. Our results revealed that virgin mammary tissue contained large numbers of membrane- and mitochondrial-associated STC receptors. However, as pregnancy progressed into lactation, there was a decline in receptor densities on both organelles and a corresponding rise in nuclear receptor density, most of which were on milk-producing, alveolar cells. This was accompanied by nuclear sequestration of the ligand. Sequestered STC resolved as one ~135-kDa band in the native state and therefore had the appearance of a big STC variant. However, chemical reduction collapsed this one band into six closely spaced, lower-molecular-mass species (28-41 kDa). Mammary gland STC production also underwent a dramatic shift during pregnancy and lactation. High levels of STC gene expression were observed in mammary tissue from virgin and pregnant rats. However, gene expression then fell to nearly undetectable levels during lactation, coinciding with the rise in nuclear targeting. These findings have thus shown that the mammary glands are indeed targeted by STC, even in the virgin state. They have further shown that there are marked changes in this targeting pathway during pregnancy and lactation, accompanied by a switch in ligand source (endogenous to exogenous). They also represent the first example of nuclear targeting by STC. nucleus; mitochondria; membrane; receptor

Published
2005

42. Barriers and facilitators for implementation of electronic consultations (eConsult) to enhance access to specialist care: a scoping review

Author

Osman, Mohamed A., Schick-Makaroff, Kara, Thomas, Stephanie, Bialy, Liza, Featherstone, Robin, Kurzawa, Julia, Zaidi, Deenaz, Okpechi, Ikechi, Habib, Syed, Shojai, Soroush, Jindal, Kailash, Braam, Branko, Keely, Erin, Liddy, Clare, Manns, Braden, Tonelli, Macello, Hemmelgarn, Brenda, Klarenbach, Scott, and Bello, Aminu K.

Published
2019
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44. Barriers and facilitators for implementation of electronic consultations (eConsult) to enhance access to specialist care: a scoping review

Author

Osman, Mohamed A, primary, Schick-Makaroff, Kara, additional, Thompson, Stephanie, additional, Bialy, Liza, additional, Featherstone, Robin, additional, Kurzawa, Julia, additional, Zaidi, Deenaz, additional, Okpechi, Ikechi, additional, Habib, Syed, additional, Shojai, Soroush, additional, Jindal, Kailash, additional, Braam, Branko, additional, Keely, Erin, additional, Liddy, Clare, additional, Manns, Braden, additional, Tonelli, Marcello, additional, Hemmelgarn, Brenda, additional, Klarenbach, Scott, additional, and Bello, Aminu K, additional

Published
2019
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45. Barriers and Facilitators for Implementation of Electronic Consultations (eConsult) to Enhance Access to Specialist Care: A Scoping Review

Author

Osman, Mohamed A., primary, Schick-Makaroff, Kara, additional, Thompson, Stephanie, additional, Bialy, Liza, additional, Featherstone, Robin, additional, Kurzawa, Julia, additional, Zaidi, Deenaz, additional, Okpechi, Ikechi G., additional, Habib, Syed, additional, Shojai, Soroush, additional, Jindal, Kailash, additional, Braam, Branko, additional, Keely, Erin, additional, Liddy, Clare, additional, Manns, Braden, additional, Tonelli, Marcello, additional, Hemmelgarn, Brenda, additional, Klarenbach, Scott, additional, and Bello, Aminu K., additional

Published
2019
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46. Electronic Advice Request System for Nephrology in Alberta: Pilot Results and Implementation

Author

Bello, Aminu K, primary, Zaidi, Deenaz, additional, Braam, Branko, additional, Chou, Sophia, additional, Courtney, Mark, additional, Deved, Vinay, additional, Glassford, Jodi, additional, Jindal, Kailash, additional, Klarenbach, Scott, additional, Osman, Mohammed, additional, Scott-Douglas, Nairne, additional, Shurraw, Sabin, additional, Thompson, Stephanie, additional, Manns, Braden, additional, Hemmelgarn, Brenda, additional, and Tonelli, Marcello, additional

Published
2019
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47. Protocol: Improving Access to Specialist Nephrology Care Among Rural/Remote Dwellers of Alberta: The Role of Electronic Consultation in Improving Care for Patients With Chronic Kidney Disease

Author

Bello, Aminu, primary, Zaidi, Deenaz, additional, Braam, Branko, additional, Courtney, Mark, additional, Glassford, Jodi, additional, Jindal, Kailash, additional, Klarenbach, Scott, additional, Kurzawa, Julia, additional, Osman, Mohammed, additional, Scott-Douglas, Nairne, additional, Szigety, Sue, additional, Thompson, Stephanie, additional, Manns, Braden, additional, Hemmelgarn, Brenda, additional, and Tonelli, Marcello, additional

Published
2019
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50. Tumor necrosis factor α-induced protein 3 (A20) is dysregulated in pediatric Crohn disease

Author

Zaidi,Deenaz, Huynh,Hien, Carroll,Matthew, Baksh,Shairaz, Wine,Eytan, Zaidi,Deenaz, Huynh,Hien, Carroll,Matthew, Baksh,Shairaz, and Wine,Eytan

Abstract

Deenaz Zaidi,1,2 Hien Q Huynh,1 Matthew W Carroll,1 Shairaz Baksh,1,3,4 Eytan Wine1,2,5 1Department of Pediatrics, 2Department of Medicine, Centre of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR), 3Department of Biochemistry, 4Department of Oncology, Cancer Institute of Northern Alberta (CRINA), 5Department of Physiology, University of Alberta, Edmonton, AB, Canada Purpose: A significant feature of pediatric inflammatory bowel diseases (IBD), which include Crohn disease (CD), and ulcerative colitis (UC), is failure to suppress inflammation. The inability to regulate inflammation renders a major challenge toward establishing effective treatments in IBD. Nuclear factor kappa-light-chain-enhancer of activated B-cells-induced inflammation is inhibited by A20 through interactions with TAX1BP1 (Tax1-binding protein 1) and A20-binding inhibitor of NF-κβ activation (ABIN)-1 (A20 binding and inhibitor of NF-κβ) and upon phosphorylation by inhibitor of nuclear factor kappa-β kinase subunit beta (IKKβ), which stabilizes it. We hypothesized that dysregulation of A20 is an important factor in uncontrolled inflammation in pediatric IBD.Patients and methods: Gene expression of A20, IKKβ, ABIN-1, TAX1BP1, A20 protein, cytokine levels, and A20 phosphorylation was analyzed in the terminal ileum (TI) of 39 patients (14 non-IBD, 15 CD, and 10 UC). A20 expression and protein in T-84 cells and ex vivo biopsies of patients were measured after treatment with Escherichia coli strains or tumor necrosis factor (TNF)-α.Results: TNF-α levels and A20 expression were increased in the TI of CD patients. A20 protein levels and ABIN-1 expression were low, TAX1BP1 expression was high, and IKKβ was unchanged. A20 expression positively correlated with biopsy TNF-α levels and inflammatory markers in CD patients. A20 phosphorylation appe

Published
2018

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