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Purpose To develop and assess the accuracy of a hybrid deep learning construct for detecting keratoconus (KCN) based on corneal topographic maps. Methods We collected 3794 corneal images from 542 eyes of 280 subjects and developed seven deep learning models based on anterior and posterior eccentricity, anterior and posterior elevation, anterior and posterior sagittal curvature, and corneal thickness maps to extract deep corneal features. An independent subset with 1050 images collected from 150 eyes of 85 subjects from a separate center was used to validate models. We developed a hybrid deep learning model to detect KCN. We visualized deep features of corneal parameters to assess the quality of learning subjectively and computed area under the receiver operating characteristic curve (AUC), confusion matrices, accuracy, and F1 score to evaluate models objectively. Results In the development dataset, 204 eyes were normal, 123 eyes were suspected KCN, and 215 eyes had KCN. In the independent validation dataset, 50 eyes were normal, 50 eyes were suspected KCN, and 50 eyes were KCN. Images were annotated by three corneal specialists. The AUC of the models for the two-class and three-class problems based on the development set were 0.99 and 0.93, respectively. Conclusions The hybrid deep learning model achieved high accuracy in identifying KCN based on corneal maps and provided a time-efficient framework with low computational complexity. Translational Relevance Deep learning can detect KCN from non-invasive corneal images with high accuracy, suggesting potential application in research and clinical practice to identify KCN.

Tire defects are crucial for safe driving. Specialized experts or expensive tools such as stereo depth cameras and depth gages are usually used to investigate these defects. In image processing, feature extraction, reduction, and classification are presented as three challenging and symmetric ways to affect the performance of machine learning models. This paper proposes a hybrid system for cracked tire detection based on the adaptive selection of correlation features and deep belief neural networks. The proposed system has three steps: feature extraction, selection, and classification. First, the oriented gradient histogram extracts features from the tire images. Second, the proposed adaptive correlation feature selection selects important features with a threshold value adapted to the nature of the images. The last step of the system is to predict the image category based on the deep belief neural networks technique. The proposed model is tested and evaluated using real images of cracked and normal tires. The experimental results show that the proposed solution performs better than the current studies in effectively classifying tire defect images. The proposed hybrid cracked tire detection system based on adaptive correlation feature selection and Deep Belief Neural Networks’ performance provided better classification accuracy (88.90%) than that of Belief Neural Networks (81.6%) and Convolution Neural Networks (85.59%).