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The concept of livability has emerged alongside sustainability as a slogan in public discourse and planning. Planners and policymakers in relation to the creation or preservation of cities mention the concept of livability as a guiding principle for investment and decision-making and shaping the social, economic, physical and biological environment of the city, and livability is considered the standard of living and the general desirability of people living in a settlement like the city. This concept has various dimensions and indicators and is measured by them.The present study was conducted with the aim of providing an analysis of the factors affecting livability in district 8 of ​​Tabriz metropolitan, which by studying the principles and available resources to develop a livability model for the study area. Then, using the opinions of the residents of the area, the model is tested and finally the final model is presented using the second-order confirmatory factor analysis. The results show that 8 main components with 41 variables form the components of the model."Infrastructure quality" with a factor load of 0.88 is the most important dimension and "health facilities" with a load of 0.23 is the least important dimension in establishing livability. Therefore, based on the obtained results, it can be acknowledged that in order to achieve the desired livability and maintain it, the obtained effective components must be comprehensively addressed.

Kisspeptins (KPs) are major regulators of trophoblast and cancer invasion. Thus far, limited and conflicting data are available on KP-mediated modulation of breast cancer (BC) metastasis; mostly based on synthetic KP-10, the most active fragment of KP. Here, we report for the first time comprehensive functional effects of term placental KPs on proliferation, adhesion, Matrigel invasion, motility, MMP activity and pro-inflammatory cytokine production in MDA-MB-231 (estrogen receptor-negative) and MCF-7 (estrogen receptor-positive). KPs were expressed at high level by term placental syncytiotrophoblasts and released in soluble form. Placental explant conditioned medium containing KPs (CM) significantly reduced proliferation of both cell types compared to CM without (w/o) KP (CM-w/o KP) in a dose- and time-dependent manner. In MDA-MB-231 cells, placental KPs significantly reduced adhesive properties, while increased MMP9 and MMP2 activity and stimulated invasion. Increased invasiveness of MDA-MB-231 cells after CM treatment was inhibited by KP receptor antagonist, P-234. CM significantly reduced motility of MCF-7 cells at all time points (2-30 hr), while it stimulated motility of MDA-MB-231 cells. These effects were reversed by P-234. Co-treatment with selective ER modulators, Tamoxifen and Raloxifene, inhibited the effect of CM on motility of MCF-7 cells. The level of IL-6 in supernatant of MCF-7 cells treated with CM was higher compared to those treated with CM-w/o KP. Both cell types produced more IL-8 after treatment with CM compared to those treated with CM-w/o KP. Taken together, our observations suggest that placental KPs differentially modulate vital parameters of estrogen receptor-positive and -negative BC cells possibly through modulation of pro-inflammatory cytokine production.