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The Welland Canal is the only source of raw water to the largest drinking water treatment plant in the Niagara Region in southern Ontario. The water of the Welland Canal has historically been contaminated from different sources, and identifying these potential pollutants to drinking water relies on direct chemical analysis that is time-consuming and costly to identifying the critical contaminants of concern. Therefore, the aim of this research is to access and prioritize the chemicals of concern and the possible sources of contamination impacting the Welland Canal water. Metals and organic contaminants originating from industrial effluent, agricultural runoff, Port Colborne STP effluent, Lake Erie sediments and antifouling paints on ship vessels are identified as major contributors of pollutant loads into the Welland Canal. Specifically, atrazine, glyphosate, metolachlor, TBT, mercury, lead and zinc are identified as major contaminants that could pose a health risk to over 300,000 residents in the Niagara Region.

The mechanisms that govern cell interactions during organ formation are not fully understood. In this issue of Developmental Cell, Miao et al. demonstrate a channel-independent role for gap junction proteins in the establishment of contacts between three cell types that build up the micropyle during oocyte development in Drosophila.

Cell ablation is a key method in the research fields of developmental biology, tissue regeneration, and tissue homeostasis. Eliminating specific cell populations allows for characterizing interactions that control cell differentiation, death, behavior, and spatial organization of cells. Current methodologies for inducing cell death suffer from relatively slow kinetics, making them unsuitable for analyzing rapid events and following primary and immediate consequences of the ablation. To address this, we developed a cell-ablation system that is based on bacterial toxin/anti-toxin proteins and enables rapid and cell-autonomous elimination of specific cell types and organs in zebrafish embryos. A unique feature of this system is that it uses an anti-toxin, which allows for controlling the degree and timing of ablation and the resulting phenotypes. The transgenic zebrafish generated in this work represent a highly efficient tool for cell ablation, and this approach is applicable to other model organisms as demonstrated here for Drosophila.