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Abstract Background Lesion/tissue segmentation on digital medical images enables biomarker extraction, image-guided therapy delivery, treatment response measurement, and training/validation for developing artificial intelligence algorithms and workflows. To ensure data reproducibility, criteria for standardised segmentation are critical but currently unavailable. Methods A modified Delphi process initiated by the European Imaging Biomarker Alliance (EIBALL) of the European Society of Radiology (ESR) and the European Organisation for Research and Treatment of Cancer (EORTC) Imaging Group was undertaken. Three multidisciplinary task forces addressed modality and image acquisition, segmentation methodology itself, and standards and logistics. Devised survey questions were fed via a facilitator to expert participants. The 58 respondents to Round 1 were invited to participate in Rounds 2–4. Subsequent rounds were informed by responses of previous rounds. Results/conclusions Items with ≥ 75% consensus are considered a recommendation. These include system performance certification, thresholds for image signal-to-noise, contrast-to-noise and tumour-to-background ratios, spatial resolution, and artefact levels. Direct, iterative, and machine or deep learning reconstruction methods, use of a mixture of CE marked and verified research tools were agreed and use of specified reference standards and validation processes considered essential. Operator training and refreshment were considered mandatory for clinical trials and clinical research. Items with a 60–74% agreement require reporting (site-specific accreditation for clinical research, minimal pixel number within lesion segmented, use of post-reconstruction algorithms, operator training refreshment for clinical practice). Items with ≤ 60% agreement are outside current recommendations for segmentation (frequency of system performance tests, use of only CE-marked tools, board certification of operators, frequency of operator refresher training). Recommendations by anatomical area are also specified.

In its long history of airing the popular crime series Midsomer Murders does not only present various murder cases but also a glimpse into the opinions on gender, sexuality, age and ethnicity. These opinions mirror the attitude of the producers as well as the anticipated expectations of the audience. The dicussion of these aspects are inseperately linked to the categories of thrift and dwelling and it seems that the ways of living in Midsomer County are always overwriting the questions of guilt, atonement and punishment. Furthermore the episodes of the series offer strategies to an aesthetic evaluation of sociality in an fictional countryside. Here murders become not only a question of morality and crime but show the depth of human nature as a hidden reality underneath the scenery of rural purity.

The introduction of novel molecular tools in research and clinical medicine has created a need for more refined information management systems. This article describes the design and implementation of such a new information platform: the Molecular Imaging Portal (MIPortal). The platform was created to organize, archive, and rapidly retrieve large datasets using Web-based browsers as access points. The system has been implemented in a heterogeneous, academic research environment serving Macintosh, Unix, and Microsoft Windows clients and has been shown to be extraordinarily robust and versatile. In addition, it has served as a useful tool for clinical trials and collaborative multi-institutional small-animal imaging research.

In its long history of airing the popular crime series Midsomer Murders does not only present various murder cases but also a glimpse into the opinions on gender, sexuality, age and ethnicity. These opinions mirror the attitude of the producers as well as the anticipated expectations of the audience. The dicussion of these aspects are inseperately linked to the categories of thrift and dwelling and it seems that the ways of living in Midsomer County are always overwriting the questions of guilt, atonement and punishment. Furthermore the episodes of the series offer strategies to an aesthetic evaluation of sociality in an fictional countryside. Here murders become not only a question of morality and crime but show the depth of human nature as a hidden reality underneath the scenery of rural purity. [ABSTRACT FROM AUTHOR]

The article compares the self-representations in autobiographies of people from the Confederate States of America in the United States after its defeat to those of people from the German Democratic Republic of former East Germany after the unification of Germany. The author describes the former East Germany as defeated similarly to the American Southern Secessionists and also applies the description of secession to the separation of East Germany from the rest of Germany. Argued similarities between the people, politics, and ideologies of the Confederate States and of East Germany are then presented by the author.