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1. Detection of minimal residual disease in acute promyelocytic leukemia by polymerase chain reaction assay for PML/RARalpha (retinoic acid receptor-alpha) fusion transcript

Author

Nemet, Damir, Grahovac, Blaženka, Labar, Boris, Mrsić, Mirando, Bogdanić, Vinko, Hitrec, Vlasta, Zaher, Dunja, Zadro, Renata, Boban, Dubravka, Osmak, Maja, and Škrk, Janez

Subjects
neoplasms, acute promyelocytic leukemia, PML/RAR alpha, PCR assay, all-trans retinoic acid
Abstract

Seven patients with acute promyelocytic leukemia (APL)treated with all-trans retinoic acid (ATRA) for remission (CR) induction and with chemotherapy (CT) for consolidation of CR underwent residual disease monitoring through reverse transcription polymerase chain reaction (PCR) for PML/retinoic acid receptor alpha (PML/RAR alpha) fusion transcript. In six patients PCR was positive immediately after ATRA induced CR and/or after the first CT course.Two patients became PCR negative following repeated courses of CT and they are in remission 7 and 14 months, respectively. Four other patients relapsed. This pilot study indicates that PCR for PML/RAR alpha is very sensitive assay for detection of residual disease in APL.

Published
1996

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