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513 results on '"Zahedi, René P."'

4. Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation

Author

Zhang, Anni M.Y., Xia, Yi Han, Lin, Jeffrey S.H., Chu, Ken H., Wang, Wei Chuan K., Ruiter, Titine J.J., Yang, Jenny C.C., Chen, Nan, Chhuor, Justin, Patil, Shilpa, Cen, Haoning Howard, Rideout, Elizabeth J., Richard, Vincent R., Schaeffer, David F., Zahedi, Rene P., Borchers, Christoph H., Johnson, James D., and Kopp, Janel L.

Published
2023
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11. Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland

Author

Preston, Samuel E.J., Bartish, Margarita, Richard, Vincent R., Aghigh, Arash, Gonçalves, Christophe, Smith-Voudouris, Julian, Huang, Fan, Thébault, Paméla, Cleret-Buhot, Aurélie, Lapointe, Réjean, Légaré, François, Postovit, Lynne-Marie, Zahedi, René P., Borchers, Christoph H., Miller Jr., Wilson H., and del Rincón, Sonia V.

Published
2022
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13. Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors

Author

Plenker, Dennis, Riedel, Maximilian, Brägelmann, Johannes, Dammert, Marcel A, Chauhan, Rakhee, Knowles, Phillip P, Lorenz, Carina, Keul, Marina, Bührmann, Mike, Pagel, Oliver, Tischler, Verena, Scheel, Andreas H, Schütte, Daniel, Song, Yanrui, Stark, Justina, Mrugalla, Florian, Alber, Yannic, Richters, André, Engel, Julian, Leenders, Frauke, Heuckmann, Johannes M, Wolf, Jürgen, Diebold, Joachim, Pall, Georg, Peifer, Martin, Aerts, Maarten, Gevaert, Kris, Zahedi, René P, Buettner, Reinhard, Shokat, Kevan M, McDonald, Neil Q, Kast, Stefan M, Gautschi, Oliver, Thomas, Roman K, and Sos, Martin L

Subjects
Orphan Drug, Rare Diseases, Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Adenocarcinoma, Adenocarcinoma of Lung, Animals, Cell Line, Tumor, Cytoskeletal Proteins, Drug Resistance, Neoplasm, Gene Rearrangement, Heterocyclic Compounds, 4 or More Rings, Humans, Imidazoles, Lung Neoplasms, Mice, Mutation, NIH 3T3 Cells, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-ret, Pyridazines, Biological Sciences, Medical and Health Sciences
Abstract

Oncogenic fusion events have been identified in a broad range of tumors. Among them, RET rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas. We provide further evidence that current anti-RET drugs may not be potent enough to induce durable responses in such tumors. We report that potent inhibitors, such as AD80 or ponatinib, that stably bind in the DFG-out conformation of RET may overcome these limitations and selectively kill RET-rearranged tumors. Using chemical genomics in conjunction with phosphoproteomic analyses in RET-rearranged cells, we identify the CCDC6-RETI788N mutation and drug-induced mitogen-activated protein kinase pathway reactivation as possible mechanisms by which tumors may escape the activity of RET inhibitors. Our data provide mechanistic insight into the druggability of RET kinase fusions that may be of help for the development of effective therapies targeting such tumors.

Published
2017

14. HNRNPA1 de novoVariant Associated with Early Childhood Onset, Rapidly Progressive Generalized Myopathy

Author

Roos, Andreas, Häusler, Martin, Kollipara, Laxmikanth, Topf, Ana, Preusse, Corinna, Stucka, Rolf, Nolte, Kay, Strom, Tim, Berutti, Riccardo, Jiang, Xuehui, Koll, Randi, Lochmüller, Hanns, Schacht, Sabine Maria, Zahedi, René P., Weis, Joachim, and Senderek, Jan

Abstract

HNRNPA1variants are known to cause degenerative motoneuron and muscle diseases which manifests in middle age or later. We report on a girl with early childhood onset, rapidly progressive generalized myopathy including ultrastructural findings in line with a proteinopathy. Proteomics of patient-derived muscle and combined screening of genomic data for copy number variations identified a HNRNPA1de novo intragenic deletion as causative for the phenotype. Our report expands the spectrum of HNRNPA1-related diseases towards early-childhood onset and adds HNRNPA1to the growing list of ALS and myopathy genes for which certain mutations may cause severe pediatric phenotypes.

Published
2024
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18. Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

Author

van Geffen, Johanna P., Swieringa, Frauke, van Kuijk, Kim, Tullemans, Bibian M. E., Solari, Fiorella A., Peng, Bing, Clemetson, Kenneth J., Farndale, Richard W., Dubois, Ludwig J., Sickmann, Albert, Zahedi, René P., Ahrends, Robert, Biessen, Erik A. L., Sluimer, Judith C., Heemskerk, Johan W. M., and Kuijpers, Marijke J. E.

Published
2020
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20. The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier

Author

Schell, Christoph, Rogg, Manuel, Suhm, Martina, Helmstädter, Martin, Sellung, Dominik, Yasuda-Yamahara, Mako, Kretz, Oliver, Küttner, Victoria, Suleiman, Hani, Kollipara, Laxmikanth, Zahedi, René P., Sickmann, Albert, Eimer, Stefan, Shaw, Andrey S., Kramer-Zucker, Albrecht, Hirano-Kobayashi, Mariko, Abe, Takaya, Aizawa, Shinichi, Grahammer, Florian, Hartleben, Björn, Dengjel, Jörn, and Huber, Tobias B.

Published
2017

22. Impaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS

Author

Swieringa, Frauke, Solari, Fiorella A., Pagel, Oliver, Beck, Florian, Huang, Jingnan, Feijge, Marion A. H., Jurk, Kerstin, Körver-Keularts, Irene M. L. W., Mattheij, Nadine J. A., Faber, Jörg, Pohlenz, Joachim, Russo, Alexandra, Stumpel, Connie T. R. M., Schrander, Dirk E., Zieger, Barbara, van der Meijden, Paola E. J., Zahedi, René P., Sickmann, Albert, and Heemskerk, Johan W. M.

Published
2020
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24. The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.

Author

Luo, Vincent M., Shen, Connie, Worme, Samantha, Bhagrath, Aanya, Simo-Cheyou, Estelle, Findlay, Steven, Hébert, Steven, Wai Lam Poon, William, Aryanpour, Zahra, Zhang, Thomas, Zahedi, René P., Boulais, Jonathan, Buchwald, Zachary S., Borchers, Christoph H., Côté, Jean-Francois, Kleinman, Claudia L., Mandl, Judith N., and Orthwein, Alexandre

Subjects
B cells, PROTEOLYSIS, G protein coupled receptors, B cell receptors, UBIQUITINATION, POST-translational modification, ANTIGEN presentation, CELL migration, NATURAL immunity
Abstract

The ubiquitin proteasome system performs the covalent attachment of lysine 48-linked polyubiquitin chains to substrate proteins, thereby targeting them for degradation, while deubiquitylating enzymes (DUBs) reverse this process. This posttranslational modification regulates key features both of innate and adaptative immunity, including antigen presentation, protein homeostasis and signal transduction. Here we show that loss of one of the most highly expressed DUBs, Otub1, results in changes in murine splenic B cell subsets, leading to a significant increase in marginal zone and transitional B cells and a concomitant decrease in follicular B cells. We demonstrate that Otub1 interacts with the γ-subunit of the heterotrimeric G protein, Gng2, and modulates its ubiquitylation status, thereby controlling Gng2 stability. Proximal mapping of Gng2 revealed an enrichment in partners associated with chemokine signaling, actin cytoskeleton and cell migration. In line with these findings, we show that Otub1-deficient B cells exhibit greater Ca2+ mobilization, F-actin polymerization and chemotactic responsiveness to Cxcl12, Cxcl13 and S1P in vitro, which manifests in vivo as altered localization of B cells within the spleen. Together, our data establishes Otub1 as a novel regulator of G-protein coupled receptor signaling in B cells, regulating their differentiation and positioning in the spleen. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Data from A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

Author

Sirois, Isabelle, primary, Aguilar-Mahecha, Adriana, primary, Lafleur, Josiane, primary, Fowler, Emma, primary, Vu, Viet, primary, Scriver, Michelle, primary, Buchanan, Marguerite, primary, Chabot, Catherine, primary, Ramanathan, Aparna, primary, Balachandran, Banujan, primary, Légaré, Stéphanie, primary, Przybytkowski, Ewa, primary, Lan, Cathy, primary, Krzemien, Urszula, primary, Cavallone, Luca, primary, Aleynikova, Olga, primary, Ferrario, Cristiano, primary, Guilbert, Marie-Christine, primary, Benlimame, Naciba, primary, Saad, Amine, primary, Alaoui-Jamali, Moulay, primary, Saragovi, Horace Uri, primary, Josephy, Sylvia, primary, O'Flanagan, Ciara, primary, Hursting, Stephen D., primary, Richard, Vincent R., primary, Zahedi, René P., primary, Borchers, Christoph H., primary, Bareke, Eric, primary, Nabavi, Sheida, primary, Tonellato, Peter, primary, Roy, Josée-Anne, primary, Robidoux, André, primary, Marcus, Elizabeth A., primary, Mihalcioiu, Catalin, primary, Majewski, Jacek, primary, and Basik, Mark, primary

Published
2023
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29. Supplementary Data S18 from A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

Author

Sirois, Isabelle, primary, Aguilar-Mahecha, Adriana, primary, Lafleur, Josiane, primary, Fowler, Emma, primary, Vu, Viet, primary, Scriver, Michelle, primary, Buchanan, Marguerite, primary, Chabot, Catherine, primary, Ramanathan, Aparna, primary, Balachandran, Banujan, primary, Légaré, Stéphanie, primary, Przybytkowski, Ewa, primary, Lan, Cathy, primary, Krzemien, Urszula, primary, Cavallone, Luca, primary, Aleynikova, Olga, primary, Ferrario, Cristiano, primary, Guilbert, Marie-Christine, primary, Benlimame, Naciba, primary, Saad, Amine, primary, Alaoui-Jamali, Moulay, primary, Saragovi, Horace Uri, primary, Josephy, Sylvia, primary, O'Flanagan, Ciara, primary, Hursting, Stephen D., primary, Richard, Vincent R., primary, Zahedi, René P., primary, Borchers, Christoph H., primary, Bareke, Eric, primary, Nabavi, Sheida, primary, Tonellato, Peter, primary, Roy, Josée-Anne, primary, Robidoux, André, primary, Marcus, Elizabeth A., primary, Mihalcioiu, Catalin, primary, Majewski, Jacek, primary, and Basik, Mark, primary

Published
2023
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30. Supplementary Data - Tables S1-S17 from A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

Author

Sirois, Isabelle, primary, Aguilar-Mahecha, Adriana, primary, Lafleur, Josiane, primary, Fowler, Emma, primary, Vu, Viet, primary, Scriver, Michelle, primary, Buchanan, Marguerite, primary, Chabot, Catherine, primary, Ramanathan, Aparna, primary, Balachandran, Banujan, primary, Légaré, Stéphanie, primary, Przybytkowski, Ewa, primary, Lan, Cathy, primary, Krzemien, Urszula, primary, Cavallone, Luca, primary, Aleynikova, Olga, primary, Ferrario, Cristiano, primary, Guilbert, Marie-Christine, primary, Benlimame, Naciba, primary, Saad, Amine, primary, Alaoui-Jamali, Moulay, primary, Saragovi, Horace Uri, primary, Josephy, Sylvia, primary, O'Flanagan, Ciara, primary, Hursting, Stephen D., primary, Richard, Vincent R., primary, Zahedi, René P., primary, Borchers, Christoph H., primary, Bareke, Eric, primary, Nabavi, Sheida, primary, Tonellato, Peter, primary, Roy, Josée-Anne, primary, Robidoux, André, primary, Marcus, Elizabeth A., primary, Mihalcioiu, Catalin, primary, Majewski, Jacek, primary, and Basik, Mark, primary

Published
2023
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31. Suppl Figure 1-6, Suppl Table S0 and Suppl Methods from A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

Author

Sirois, Isabelle, primary, Aguilar-Mahecha, Adriana, primary, Lafleur, Josiane, primary, Fowler, Emma, primary, Vu, Viet, primary, Scriver, Michelle, primary, Buchanan, Marguerite, primary, Chabot, Catherine, primary, Ramanathan, Aparna, primary, Balachandran, Banujan, primary, Légaré, Stéphanie, primary, Przybytkowski, Ewa, primary, Lan, Cathy, primary, Krzemien, Urszula, primary, Cavallone, Luca, primary, Aleynikova, Olga, primary, Ferrario, Cristiano, primary, Guilbert, Marie-Christine, primary, Benlimame, Naciba, primary, Saad, Amine, primary, Alaoui-Jamali, Moulay, primary, Saragovi, Horace Uri, primary, Josephy, Sylvia, primary, O'Flanagan, Ciara, primary, Hursting, Stephen D., primary, Richard, Vincent R., primary, Zahedi, René P., primary, Borchers, Christoph H., primary, Bareke, Eric, primary, Nabavi, Sheida, primary, Tonellato, Peter, primary, Roy, Josée-Anne, primary, Robidoux, André, primary, Marcus, Elizabeth A., primary, Mihalcioiu, Catalin, primary, Majewski, Jacek, primary, and Basik, Mark, primary

Published
2023
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36. Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia

Author

Reboucas, Patricia, primary, Fillebeen, Carine, additional, Botta, Amy, additional, Cleverdon, Riley, additional, Steele, Alexandra P., additional, Richard, Vincent, additional, Zahedi, René P., additional, Borchers, Christoph H., additional, Burelle, Yan, additional, Hawke, Thomas J., additional, Pantopoulos, Kostas, additional, and Sweeney, Gary, additional

Published
2023
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39. The E3 Ubiquitin Ligase Nedd4L Acts as a Checkpoint Against Activation in Quiescent Muscle Stem Cells

Author

Blackburn, Darren M., primary, Sahinyan, Korin, additional, Hernandez-Corchado, Aldo, additional, Lazure, Felicia, additional, Richard, Vincent, additional, Raco, Laura, additional, Perron, Gabrielle, additional, Zahedi, René P., additional, Borchers, Christoph H., additional, Lepper, Christoph, additional, Kawabe, Hiroshi, additional, Jahani-Asl, Arezu, additional, Najafabadi, Hamed S., additional, and Soleimani, Vahab D., additional

Published
2023
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42. FYCO1 Increase and Effect of Arimoclomol–Treatment in Human VCP–Pathology

Author

Guettsches, Anne-Katrin, primary, Meyer, Nancy, additional, Zahedi, René P., additional, Evangelista, Teresinha, additional, Muentefering, Thomas, additional, Ruck, Tobias, additional, Lacene, Emmanuelle, additional, Heute, Christoph, additional, Gonczarowska-Jorge, Humberto, additional, Schoser, Benedikt, additional, Krause, Sabine, additional, Hentschel, Andreas, additional, Vorgerd, Matthias, additional, and Roos, Andreas, additional

Published
2022
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47. TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice

Author

Gotru, Sanjeev K., Chen, Wenchun, Kraft, Peter, Becker, Isabelle C., Wolf, Karen, Stritt, Simon, Zierler, Susanna, Hermanns, Heike M., Rao, Deviyani, Perraud, Anne-Laure, Schmitz, Carsten, Zahedi, René P., Noy, Peter J., Tomlinson, Michael G., Dandekar, Thomas, Matsushita, Masayuki, Chubanov, Vladimir, Gudermann, Thomas, Stoll, Guido, Nieswandt, Bernhard, and Braun, Attila

Published
2018
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