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本稿は、中・高等学校の授業における翻訳活動に関して、日本の大学生の意見を明確にすることを目的とする。そのため、本稿では、大学生の個人経験に基づく意見および1年生と2年生の回答を分析する。分析によると、翻訳は授業で過剰に使用される手法としてみなされているが、同時に効果については肯定的に捉えられていることが示唆される。1年生と２年生の回答において、大学授業での教授を1年間受けた2年生は、翻訳活動が英語会話の上達に有益であるという考えが薄れる傾向にあり、概念の変化が示唆される。更に本稿では、前述の差異を除いては1年生と2年生の回答におおむね相違がない点について、大学における教授法が、英語を科目ではなく言語として捉える大学生の概念の変化に影響を与えている観点から考察する。, This paper aims to highlight and elaborate on the perceptions of translation and its use in secondary school classrooms by students at a small liberal arts university in Japan. It explores student opinions on their personal experiences with translation, as well as compare responses between first and second year students. This paper suggests that students view translation both positively and it being used too much in their secondary school classrooms. The paper suggests a moderate potential shift in conceptualisation between first and second year students, where after a year of English instruction at a university, students were less inclined to believe that translation was useful for conversation. Additionally, this paper offers suggestions on why there were otherwise little significant differences between first year and second year responses, mainly that a shift from viewing English as a subject and English as a language coincides with a shift in classroom pedagogical focus.

本稿は、中・高等学校に勤務する日本人英語教師（JTEs）及び外国語指導助手（ALTs）による授業での翻訳活用に関する意見と文部科学省（MEXT）が定めた学習指導要領との関係を明確にすることを目的とする。そのため、本稿では、JTEs、ALTs、中・高等学校の教員の意見の差異及びALTsの外国語青年招致事業での経験に基づいた理念の変化を分析する。分析によると、翻訳は授業で過剰に活用されている手法としてみなされており、一般的な見解が政府の政策及び学説と異なっていることが示唆される。本稿は、授業での翻訳活用に関する調査を提示し、翻訳の理論及び授業での実践活用、翻訳の教具としての価値、入学試験の準備に対する効果及び日本の英語教育の中心的目標に対する翻訳の意義等ついて、JTEsとALTsの統計的に重要な意見の差異を検討する。

EDITOR’S PERSPECTIVE What We Already Know about This Topic Dantrolene effectively treats malignant hyperthermia, but there are discrepant recommendations for dantrolene availability in facilities that stock succinylcholine for airway rescue but do not use volatile anesthetics. What This Article Tells Us That Is New The authors performed an analysis of data from three databases and a systematic literature review. Providers frequently use succinylcholine, including during difficult mask ventilation. Succinylcholine given without volatile anesthetics triggered 24 malignant hyperthermia events, 13 of which were treated with dantrolene. Fourteen patients experienced substantial complications, and one died. Delayed dantrolene treatment worsened patient outcomes. Background Although dantrolene effectively treats malignant hyperthermia (MH), discrepant recommendations exist concerning dantrolene availability. Whereas Malignant Hyperthermia Association of the United States guidelines state dantrolene must be available within 10 min of the decision to treat MH wherever volatile anesthetics or succinylcholine are administered, a Society for Ambulatory Anesthesia protocol permits Class B ambulatory facilities to stock succinylcholine for airway rescue without dantrolene. The authors investigated (1) succinylcholine use rates, including for airway rescue, in anesthetizing/sedating locations; (2) whether succinylcholine without volatile anesthetics triggers MH warranting dantrolene; and (3) the relationship between dantrolene administration and MH morbidity/mortality. Methods The authors performed focused analyses of the Multicenter Perioperative Outcomes Group (2005 through 2016), North American MH Registry (2013 through 2016), and Anesthesia Closed Claims Project (1970 through 2014) databases, as well as a systematic literature review (1987 through 2017). The authors used difficult mask ventilation (grades III and IV) as a surrogate for airway rescue. MH experts judged dantrolene treatment. For MH morbidity/mortality analyses, the authors included U.S. and Canadian cases that were fulminant or scored 20 or higher on the clinical grading scale and in which volatile anesthetics or succinylcholine were given. Results Among 6,368,356 queried outcomes cases, 246,904 (3.9%) received succinylcholine without volatile agents. Succinylcholine was used in 46% (n = 710) of grade IV mask ventilation cases (median dose, 100 mg, 1.2 mg/kg). Succinylcholine without volatile anesthetics triggered 24 MH cases, 13 requiring dantrolene. Among 310 anesthetic-triggered MH cases, morbidity was 20 to 37%. Treatment delay increased complications every 10 min, reaching 100% with a 50-min delay. Overall mortality was 1 to 10%; 15 U.S. patients died, including 4 after anesthetics in freestanding facilities. Conclusions Providers use succinylcholine commonly, including during difficult mask ventilation. Succinylcholine administered without volatile anesthetics may trigger MH events requiring dantrolene. Delayed dantrolene treatment increases the likelihood of MH complications. The data reported herein support stocking dantrolene wherever succinylcholine or volatile anesthetics may be used.

Sepsis is a leading cause of death and is the most expensive condition to treat in U.S. hospitals. Despite targeted efforts to automate earlier detection of sepsis, current techniques rely exclusively on using either standard clinical data or novel biomarker measurements. In this study, we apply machine learning techniques to assess the predictive power of combining multiple biomarker measurements from a single blood sample with electronic medical record data (EMR) for the identification of patients in the early to peak phase of sepsis in a large community hospital setting. Combining biomarkers and EMR data achieved an area under the receiver operating characteristic (ROC) curve (AUC) of 0.81, while EMR data alone achieved an AUC of 0.75. Furthermore, a single measurement of six biomarkers (IL-6, nCD64, IL-1ra, PCT, MCP1, and G-CSF) yielded the same predictive power as collecting an additional 16 hours of EMR data(AUC of 0.80), suggesting that the biomarkers may be useful for identifying these patients earlier. Ultimately, supervised learning using a subset of biomarker and EMR data as features may be capable of identifying patients in the early to peak phase of sepsis in a diverse population and may provide a tool for more timely identification and intervention.

Sepsis is a leading cause of death and is the most expensive condition to treat in U.S. hospitals. Despite targeted efforts to automate earlier detection of sepsis, current techniques rely exclusively on using either standard clinical data or novel biomarker measurements. In this study, we apply machine learning techniques to assess the predictive power of combining multiple biomarker measurements from a single blood sample with electronic medical record data (EMR) for the identification of patients in the early to peak phase of sepsis in a large community hospital setting. Combining biomarkers and EMR data achieved an area under the receiver operating characteristic (ROC) curve (AUC) of 0.81, while EMR data alone achieved an AUC of 0.75. Furthermore, a single measurement of six biomarkers (IL-6, nCD64, IL-1ra, PCT, MCP1, and G-CSF) yielded the same predictive power as collecting an additional 16 hours of EMR data(AUC of 0.80), suggesting that the biomarkers may be useful for identifying these patients earlier. Ultimately, supervised learning using a subset of biomarker and EMR data as features may be capable of identifying patients in the early to peak phase of sepsis in a diverse population and may provide a tool for more timely identification and intervention.

What is Afro Asia? What are the political and cultural connections between Black Americans and Asian Americans? What does jazz have to do with martial arts? In 1997 Fred Ho began creating a series of Afro Asian jazz martial arts performance pieces that brought together a synthesis of martial arts practitioners, dancers, and jazz artists, reflecting the legacy of the Bandung Conference of 1955.

Although dantrolene effectively treats malignant hyperthermia (MH), discrepant recommendations exist concerning dantrolene availability. Whereas Malignant Hyperthermia Association of the United States guidelines state dantrolene must be available within 10 min of the decision to treat MH wherever volatile anesthetics or succinylcholine are administered, a Society for Ambulatory Anesthesia protocol permits Class B ambulatory facilities to stock succinylcholine for airway rescue without dantrolene. The authors investigated (1) succinylcholine use rates, including for airway rescue, in anesthetizing/sedating locations; (2) whether succinylcholine without volatile anesthetics triggers MH warranting dantrolene; and (3) the relationship between dantrolene administration and MH morbidity/mortality.The authors performed focused analyses of the Multicenter Perioperative Outcomes Group (2005 through 2016), North American MH Registry (2013 through 2016), and Anesthesia Closed Claims Project (1970 through 2014) databases, as well as a systematic literature review (1987 through 2017). The authors used difficult mask ventilation (grades III and IV) as a surrogate for airway rescue. MH experts judged dantrolene treatment. For MH morbidity/mortality analyses, the authors included U.S. and Canadian cases that were fulminant or scored 20 or higher on the clinical grading scale and in which volatile anesthetics or succinylcholine were given.Among 6,368,356 queried outcomes cases, 246,904 (3.9%) received succinylcholine without volatile agents. Succinylcholine was used in 46% (n = 710) of grade IV mask ventilation cases (median dose, 100 mg, 1.2 mg/kg). Succinylcholine without volatile anesthetics triggered 24 MH cases, 13 requiring dantrolene. Among 310 anesthetic-triggered MH cases, morbidity was 20 to 37%. Treatment delay increased complications every 10 min, reaching 100% with a 50-min delay. Overall mortality was 1 to 10%; 15 U.S. patients died, including 4 after anesthetics in freestanding facilities.Providers use succinylcholine commonly, including during difficult mask ventilation. Succinylcholine administered without volatile anesthetics may trigger MH events requiring dantrolene. Delayed dantrolene treatment increases the likelihood of MH complications. The data reported herein support stocking dantrolene wherever succinylcholine or volatile anesthetics may be used.

Sepsis, an adverse auto-immune response to an infection often causing life-threatening complications, results in the highest mortality and treatment cost of any illness in US hospitals. Several immune biomarker levels, including Interleukin 6 (IL-6), have shown a high correlation to the onset and progression of sepsis. Currently, no technology diagnoses and stratifies sepsis progression using biomarker levels. This paper reports a microfluidic biochip platform to detect proteins in undiluted human plasma samples. The device uses a differential enumeration platform that integrates Coulter counting principles, antigen specific capture chambers, and micro size bead based immunodetection to quantify cytokines. This microfluidic biochip was validated as a potential point of care technology by quantifying IL-6 from plasma samples (n = 29) with good correlation (R2 = 0.81) and agreement (Bland–Altman) compared to controls. In combination with previous applications, this point of care platform can potentially detect cell and protein biomarkers simultaneously for sepsis stratification.

Sepsis, a potentially life-threatening complication of an infection, has the highest burden of death and medical expenses in hospitals worldwide. Leukocyte count and CD64 expression on neutrophils (nCD64) are known to correlate strongly with improved sensitivity and specificity of sepsis diagnosis at its onset. A major challenge is the lack of a rapid and accurate point-of-care (PoC) device that can perform these measurements from a minute blood sample. Here, we report a PoC microfluidic biochip to enumerate leukocytes and quantify nCD64 levels from 10 μl of whole blood without any manual processing. Biochip measurements have shown excellent correlation with the results from flow cytometer. In clinical studies, we have used PoC biochip to monitor leukocyte counts and nCD64 levels from patients’ blood at different times of their stay in the hospital. Furthermore, we have shown the biochip’s utility for improved sepsis diagnosis by combining these measurements with electronic medical record (EMR)., Sepsis is a potentially life–threatening complication of infection and diagnosis depends on rapid assessment of leukocyte count and CD64 expression. Here the authors present a microfluidic chip that can quantify these parameters from minimal amounts of whole blood with no manual processing.

It is shown that every matrix in a large class of n -by- n doubly cyclic Z + matrices with negative determinant has exactly one eigenvalue in the closed left half-plane. This generalizes a result for n = 4 used in a recent analysis of cancer cell dynamics. A further conjecture is made based on computational evidence. All work relates to the inertia of certain doubly cyclic circulants.

Lukács' mature theory of Hegelian Marxism has been criticized for the determinacy with which it predicts utopia as a possibility for the future. This paper instead examines Lukács' early, pre-Marxist thinking, which asserts utopia only as the grounding concept for a procedure of cultural criticism, and not as the outcome of any foreseeable process of social change. I attempt to evaluate this non-Marxist utopianism of the young Lukács by focusing in particular on ‘The Foundering of Form Against Life: Søren Kierkegaard and Regine Olsen’, a 1910 essay in which Lukács criticizes Kierkegaard for failing to articulate any concept of utopia and for focusing instead on private ‘faith’ as a potential solution to the endemic problems of modernity, such as alienation and reification. Because young Lukács himself thus sets up Kierkegaard as a dystopian rival for his own utopian thought, I use a comparison between these two thinkers as a basis for speculation on the advantages and disadvantages of positing a normative concept of utopia as the basis for social criticism.