239 results on '"Zaccherini, Giacomo"'
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2. Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis
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Iannone, Giulia, Serri, Paola, Bertino, Gaetano, Balsano, Clara, Iapadre, Nerio, Maida, Marcello, Sacerdoti, David, Natola, Leonardo Antonio, Ciacci, Carolina, Santonicola, Antonella, Cozzolongo, Raffaele, Surace, Lorenzo Antonio, Fracanzani, Anna Ludovica, Cespiati, Annalisa, Federico, Alessandro, Romeo, Mario, Grieco, Antonio, Marrone, Giuseppe, Vizioli, Luca, Di Cola, Simone, D’Amico, Gennaro, Caraceni, Paolo, Schepis, Filippo, Loredana, Simone, Lampertico, Pietro, Toniutto, Pierluigi, Martini, Silvia, Maimone, Sergio, Colecchia, Antonio, Svegliati Barone, Gianluca, Alessandria, Carlo, Aghemo, Alessio, Crocè, Saveria Lory, Adinolfi, Luigi Elio, Rendina, Maria, Lapenna, Lucia, Pompili, Enrico, Zaccherini, Giacomo, Saltini, Dario, Iavarone, Massimo, Tosetti, Giulia, Martelletti, Carolina, Nassisi, Veronica, Ferrarese, Alberto, Giovo, Ilaria, Masetti, Chiara, Pugliese, Nicola, Campigotto, Michele, Nevola, Riccardo, and Merli, Manuela
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- 2024
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3. Real-world experience with long-term albumin in patients with cirrhosis and ascites
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Pompili, Enrico, Zaccherini, Giacomo, Piano, Salvatore, Toniutto, Pierluigi, Lombardo, Antonio, Gioia, Stefania, Iannone, Giulia, De Venuto, Clara, Tonon, Marta, Gagliardi, Roberta, Baldassarre, Maurizio, Tedesco, Greta, Bedogni, Giorgio, Domenicali, Marco, Di Marco, Vito, Nardelli, Silvia, Calvaruso, Vincenza, Bitetto, Davide, Angeli, Paolo, and Caraceni, Paolo
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- 2024
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4. Albumin administration in internal medicine: A journey between effectiveness and futility
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Pompili, Enrico, Zaccherini, Giacomo, Baldassarre, Maurizio, Iannone, Giulia, and Caraceni, Paolo
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- 2023
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5. Low haemoglobin level predicts early hospital readmission in patients with cirrhosis and acute decompensation
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Pompili, Enrico, Baldassarre, Maurizio, Zaccherini, Giacomo, Tufoni, Manuel, Iannone, Giulia, Pratelli, Dario, Palmese, Francesco, Vizioli, Luca, Faggiano, Chiara, Bedogni, Giorgio, Domenicali, Marco, and Caraceni, Paolo
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- 2023
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6. FRI-078-YI Long-term albumin administration in outpatients with decompensated cirrhosis and diabetes mellitus: post-hoc analysis of the ANSWER trial database
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Iannone, Giulia, primary, Zaccherini, Giacomo, additional, Pompili, Enrico, additional, Tedesco, Greta, additional, De Venuto, Clara, additional, Baldassarre, Maurizio, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco, additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegiati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Tortora, Annalisa, additional, De Marco, Rosanna, additional, Nardelli, Silvia, additional, Piano, Salvatore, additional, Elia, Chiara, additional, Caraceni, Paolo, additional, and Bernardi, Mauro, additional
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- 2024
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7. FRI-171 Paediatric solid organ transplant recipients (SOTR) demonstrate greater serological response to initial SARS-CoV-2 vaccination than adult SOTR, and comparable rates of antibody degradation
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Ballester, María Pilar, primary, Laue, Tobias, additional, Meoli, Lilianeleny, additional, Uson, Eva, additional, Mutschler, Frauke, additional, Grabitz, Carl, additional, McLin, Valérie, additional, D'Antiga, Lorenzo, additional, Pujadas, Montserrat, additional, Carvalho-Gomes, Ângela, additional, Sahuco, Iván, additional, Bono, Ariadna, additional, D'Amico, Federico, additional, Viganò, Raffaella, additional, Sempere, Elena Diago, additional, Tormo, Beatriz, additional, Inglese, Elvira, additional, Martinez, Dani, additional, Riva, Antonio, additional, Sharma, Rajni, additional, Tsou, Hio Lam Phoebe, additional, Harris, Nicola, additional, Broekhoven, Annelotte, additional, Kikkert, Marjolein, additional, Morales, Shessy, additional, Myeni, Sebenzile, additional, Barciela, Mar Riveiro, additional, Palom, Adriana, additional, Zeni, Nicola, additional, Brocca, Alessandra, additional, Cussigh, Annarosa, additional, Cmet, Sara, additional, Escudero-García, Desamparados, additional, Stocco, Matteo, additional, Natola, Leonardo, additional, Ieluzzi, Donatella, additional, Paon, Veronica, additional, Sangiovanni, Angelo, additional, Farina, Elisa, additional, Benedetto, Clara Di, additional, Sanchez-Torrijos, Yolanda María, additional, Valera, Ana Lucena, additional, Roman, Eva, additional, Sanchez, Elisabet, additional, Sánchez-Aldehuelo, Rubén, additional, López-Cardona, Julia, additional, Canas-Perez, Itzel, additional, Jackson, Christine, additional, Jeyanesan, Dhaarica, additional, Morocho, Alejandro Esquivel, additional, Cola, Simone Di, additional, Lapenna, Lucia, additional, Zaccherini, Giacomo, additional, Bongiovanni, Deborah, additional, Zanaga, Paola, additional, Sayaf, Katia, additional, Hossain, Sabir, additional, Crespo, Javier, additional, Robles-Díaz, Mercedes, additional, Madejón, Antonio, additional, Degroote, Helena, additional, Fernández, Javier, additional, Korenjak, Marko, additional, Verhelst, Xavier, additional, Garcia-Samaniego, Francisco Javier, additional, Andrade, Raul J., additional, Iruzubieta, Paula, additional, Wright, Gavin, additional, Caraceni, Paolo, additional, Merli, Manuela, additional, Patel, Vishal C., additional, Gander, Amir, additional, Albillos, Agustín, additional, Soriano, German, additional, Donato, Maria Francesca, additional, Sacerdoti, David, additional, Toniutto, Pierluigi, additional, Buti, Maria, additional, Duvoux, Christophe, additional, Grossi, Paolo Antonio, additional, Berg, Thomas, additional, Polak, Wojciech, additional, Puoti, Massimo, additional, Bosch, Anna, additional, Belli, Luca Saverio, additional, Burra, Patrizia, additional, Russo, Francesco Paolo, additional, Coenraad, Minneke, additional, Panero, José Luis Calleja, additional, Perricone, Giovanni, additional, Chokshi, Shilpa, additional, Berenguer, Marina, additional, Clària, Joan, additional, Moreau, Richard, additional, Arroyo, Vicente, additional, Angeli, Paolo, additional, Sanchez, Cristina, additional, Ampuero, Javier, additional, Piano, Salvatore, additional, and Nicastro, Emanuele, additional
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- 2024
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8. FRI-047-YI Predictors of ascites resolution in patients with cirrhosis receiving long-term albumin treatment. Results from a real-world study in Italy (Real-ANSWER)
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Pompili, Enrico, primary, Iannone, Giulia, additional, Piano, Salvatore, additional, Lombardo, Antonino, additional, Bitetto, Davide, additional, Gioia, Stefania, additional, Zaccherini, Giacomo, additional, Gagliardi, Roberta, additional, Calvaruso, Vincenza, additional, Tonon, Marta, additional, De Venuto, Clara, additional, Baldassarre, Maurizio, additional, Tedesco, Greta, additional, Nardelli, Silvia, additional, Toniutto, Pierluigi, additional, Di Marco, Vito, additional, Angeli, Paolo, additional, and Caraceni, Paolo, additional
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- 2024
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9. Long‐term albumin improves the outcomes of patients with decompensated cirrhosis and diabetes mellitus: Post hoc analysis of the ANSWER trial.
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Pompili, Enrico, Baldassarre, Maurizio, Iannone, Giulia, Tedesco, Greta, Nardelli, Silvia, Piano, Salvatore, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco G., Levantesi, Fabio, Caraceni, Paolo, Bernardi, Mauro, Zaccherini, Giacomo, Domenicali, Marco, Giannone, Ferdinando A, Antognoli, Agnese, Riggio, Oliviero, Merli, Manuela, Pasquale, Chiara, and Gioia, Stefania
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TYPE 2 diabetes ,THERAPEUTICS ,HEPATIC encephalopathy ,WATER-electrolyte imbalances ,BACTERIAL diseases - Abstract
Type‐2 diabetes mellitus is a frequent comorbidity of cirrhosis independently associated with cirrhosis‐related complications and mortality. This post hoc analysis of the ANSWER trial database assessed the effects of long‐term human albumin (HA) administration on top of the standard medical treatment (SMT) on the clinical outcomes of a subgroup of 85 outpatients with liver cirrhosis, uncomplicated ascites and insulin‐treated diabetes mellitus type 2 (ITDM). Compared to patients in the SMT arm, the SMT + HA group showed a better overall survival (86% vs. 57%, p =.016) and lower incidence rates of paracenteses, overt hepatic encephalopathy, bacterial infections, renal dysfunction and electrolyte disorders. Hospital admissions did not differ between the two arms, but the number of days spent in hospital was lower in the SMT + HA group. In conclusion, in a subgroup of ITDM outpatients with decompensated cirrhosis and ascites, long‐term HA administration was associated with better survival and a lower incidence of cirrhosis‐related complications. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis
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Di Cola, Simone, primary, D’Amico, Gennaro, additional, Caraceni, Paolo, additional, Schepis, Filippo, additional, Loredana, Simone, additional, Lampertico, Pietro, additional, Toniutto, Pierluigi, additional, Martini, Silvia, additional, Maimone, Sergio, additional, Colecchia, Antonio, additional, Svegliati Barone, Gianluca, additional, Alessandria, Carlo, additional, Aghemo, Alessio, additional, Crocè, Saveria Lory, additional, Adinolfi, Luigi Elio, additional, Rendina, Maria, additional, Lapenna, Lucia, additional, Pompili, Enrico, additional, Zaccherini, Giacomo, additional, Saltini, Dario, additional, Iavarone, Massimo, additional, Tosetti, Giulia, additional, Martelletti, Carolina, additional, Nassisi, Veronica, additional, Ferrarese, Alberto, additional, Giovo, Ilaria, additional, Masetti, Chiara, additional, Pugliese, Nicola, additional, Campigotto, Michele, additional, Nevola, Riccardo, additional, Merli, Manuela, additional, Iannone, Giulia, additional, Serri, Paola, additional, Bertino, Gaetano, additional, Balsano, Clara, additional, Iapadre, Nerio, additional, Maida, Marcello, additional, Sacerdoti, David, additional, Natola, Leonardo Antonio, additional, Ciacci, Carolina, additional, Santonicola, Antonella, additional, Cozzolongo, Raffaele, additional, Surace, Lorenzo Antonio, additional, Fracanzani, Anna Ludovica, additional, Cespiati, Annalisa, additional, Federico, Alessandro, additional, Romeo, Mario, additional, Grieco, Antonio, additional, Marrone, Giuseppe, additional, and Vizioli, Luca, additional
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- 2024
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11. Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbab le, gut-restricted adsorbent in models and patients with cirrhosis
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Liu, Jinxia, primary, MacNaughtan, Jane, additional, Kerbert, Annarein J C, additional, Portlock, Theo, additional, Martínez Gonzalez, Javier, additional, Jin, Yi, additional, Clasen, Frederick, additional, Habtesion, Abeba, additional, Ji, Huoyan, additional, Jin, Qin, additional, Phillips, Alexandra, additional, De Chiara, Francesco, additional, Ingavle, Ganesh, additional, Jimenez, Cesar, additional, Zaccherini, Giacomo, additional, Husi, Katherine, additional, Rodriguez Gandia, Miguel Angel, additional, Cordero, Paul, additional, Soeda, Junpei, additional, McConaghy, Lynda, additional, Oben, Jude, additional, Church, Karen, additional, Li, Jia V, additional, Wu, Haifeng, additional, Jalan, Aarti, additional, Gines, Pere, additional, Solà, Elsa, additional, Eaton, Simon, additional, Morgan, Carrie, additional, Kowalski, Michal, additional, Green, Daniel, additional, Gander, Amir, additional, Edwards, Lindsey A, additional, Cox, I Jane, additional, Cortez-Pinto, Helena, additional, Avery, Thomas, additional, Wiest, Reiner, additional, Durand, Francois, additional, Caraceni, Paolo, additional, Elosua, Roberto, additional, Vila, Joan, additional, Pavesi, Marco, additional, Arroyo, Vicente, additional, Davies, Nathan, additional, Mookerjee, Rajeshwar P, additional, Vargas, Victor, additional, Sandeman, Susan, additional, Mehta, Gautam, additional, Shoaie, Saeed, additional, Marchesi, Julian, additional, Albillos, Agustín, additional, Andreola, Fausto, additional, and Jalan, Rajiv, additional
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- 2024
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12. Acute-on-chronic liver failure: Definitions, pathophysiology and principles of treatment
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Zaccherini, Giacomo, Weiss, Emmanuel, and Moreau, Richard
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- 2021
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13. Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis.
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Jinxia Liu, MacNaughtan, Jane, Kerbert, Annarein J. C., Portlock, Theo, Gonzalez, Javier Martínez, Yi Jin, Clasen, Frederick, Habtesion, Abeba, Huoyan Ji, Qin Jin, Phillips, Alexandra, De Chiara, Francesco, Ingavle, Ganesh, Jimenez, Cesar, Zaccherini, Giacomo, Husi, Katherine, Rodriguez Gandia, Miguel Angel, Cordero, Paul, Soeda, Junpei, and McConaghy, Lynda
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HEPATORENAL syndrome ,DIABETIC nephropathies ,BETAINE ,CIRRHOSIS of the liver ,VITAMIN E ,ANIMAL tracks ,MEDICAL sciences - Published
- 2024
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14. Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial
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Pose, Elisa, Napoleone, Laura, Amin, Ahmed, Campion, Daniela, Jimenez, César, Piano, Salvatore, Roux, Olivier, Uschner, Frank Erhard, de Wit, Koos, Zaccherini, Giacomo, Alessandria, Carlo, Angeli, Paolo, Bernardi, Mauro, Beuers, Ulrich, Caraceni, Paolo, Durand, François, Mookerjee, Rajeshwar P, Trebicka, Jonel, Vargas, Victor, Andrade, Raúl J, Carol, Marta, Pich, Judit, Ferrero, Juan, Domenech, Gema, Llopis, Marta, Torres, Ferran, Kamath, Patrick S, Abraldes, Juan G, Solà, Elsa, and Ginès, Pere
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- 2020
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15. The Role of Transjugular Intrahepatic Portosystemic Shunt for the Management of Ascites in Patients with Decompensated Cirrhosis
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Iannone, Giulia, primary, Pompili, Enrico, additional, De Venuto, Clara, additional, Pratelli, Dario, additional, Tedesco, Greta, additional, Baldassarre, Maurizio, additional, Caraceni, Paolo, additional, and Zaccherini, Giacomo, additional
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- 2024
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16. Hemodynamic and Systemic Effects of Albumin in Patients with Advanced Liver Disease
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Tufoni, Manuel, Baldassarre, Maurizio, Zaccherini, Giacomo, Antognoli, Agnese, and Caraceni, Paolo
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- 2020
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17. Prediction of nosocomial acute-on-chronic liver failure in patients with cirrhosis admitted to hospital with acute decompensation
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Zaccherini, Giacomo, Baldassarre, Maurizio, Bartoletti, Michele, Tufoni, Manuel, Berardi, Sonia, Tamè, Mariarosa, Napoli, Lucia, Siniscalchi, Antonio, Fabbri, Angela, Marconi, Lorenzo, Antognoli, Agnese, Iannone, Giulia, Domenicali, Marco, Viale, Pierluigi, Trevisani, Franco, Bernardi, Mauro, and Caraceni, Paolo
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- 2019
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18. Hospital Care of Older Patients With COPD: Adherence to International Guidelines for Use of Inhaled Bronchodilators and Corticosteroids
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Mannucci, Pier Mannuccio, Nobili, Alessandro, Tettamanti, Mauro, Pasina, Luca, Franchi, Carlotta, Corrao, Salvatore, Marengoni, Alessandra, Salerno, Francesco, Cesari, Matteo, Perticone, Francesco, Licata, Giuseppe, Violi, Francesco, Corazza, Gino Roberto, Cortesi, Laura, Ardoino, Ilaria, Prisco, Domenico, Silvestri, Elena, Cenci, Caterina, Emmi, Giacomo, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Mannarino, Elmo, Lupattelli, Graziana, Bianconi, Vanessa, Paciullo, Francesco, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Olivieri, Oliviero, Girelli, Domenico, Matteazzi, Thomas, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Pontremoli, Roberto, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Angelucci, Ermanno, Valeriani, Emanuele, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Delitala, Giuseppe, Berria, Maria, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, D’Aurizio, Gabriella, Romanelli, Giuseppe, Zucchelli, Alberto, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell’Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, De Sando, Valeria, Pareo, Ilenia, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Agosti, Pasquale, Schilardi, Andrea, Loparco, Francesca, Fenoglio, Luigi, Bracco, Christian, Giraudo, Alessia Valentina, Fargion, Silvia, Periti, Giulia, Porzio, Marianna, Tiraboschi, Slivia, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Salmi, Raffaella, Gaudenzi, Piergiorgio, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Molaro, Marta, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Colangelo, Lidia, Falbo, Tania, Stanghellini, Vincenzo, De Giorgio, Roberto, Ruggeri, Eugenio, Vecchio, Sara del, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Gabrielli, Armando, Capeci, William, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Blanco, Julien, Zanoli, Luca, Pignataro, Samuele, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Patrizia, Tarsitani, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Antonino, Lasco, Basile, Giorgio, Antonino, Catalano, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, and Proietti, Marco
- Published
- 2019
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19. Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide
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Bartoletti, Michele, Brodersen, Carlos, Bruns, Tony, de Man, Robert A., Fialla, Annette Dam, Gambino, Carmine, Gautam, Vikas, Girala, Marcos, Juanola, Adria, Kim, Jeong Han, Kim, Tae Hun, Kumar, Pramod, Lattanzi, Barbara, Lee, Tae Hee, Rinaldi Lesmana, Cosmas A., Moreau, Richard, Nath, Preetam, Navarro, Gustavo, Park, Ji-Won, Pinero, Gisela, Pyrsopoulos, Nikolaos T., Restellini, Sophie, Romero, Gustavo, Sacco, Marco, Sevá-Pereira, Tiago, Simón-Talero, Macarena, Song, Do Seon, Suk, Ki Tae, Van Vlierberghe, Hans, Yim, Sun Young, Yoon, Eileen Laurel, Zaccherini, Giacomo, Piano, Salvatore, Singh, Virendra, Caraceni, Paolo, Maiwall, Rakhi, Alessandria, Carlo, Fernandez, Javier, Soares, Elza Cotrim, Kim, Dong Joon, Kim, Sung Eun, Marino, Monica, Vorobioff, Julio, Barea, Rita de Cassia Ribeiro, Merli, Manuela, Elkrief, Laure, Vargas, Victor, Krag, Aleksander, Singh, Shivaram Prasad, Lesmana, Laurentius Adrianto, Toledo, Claudio, Marciano, Sebastian, Verhelst, Xavier, Wong, Florence, Intagliata, Nicolas, Rabinowich, Liane, Colombato, Luis, Kim, Sang Gyune, Gerbes, Alexander, Durand, Francois, Roblero, Juan Pablo, Bhamidimarri, Kalyan Ram, Boyer, Thomas D., Maevskaya, Marina, Fassio, Eduardo, Kim, Hyoung Su, Hwang, Jae Seok, Gines, Pere, Gadano, Adrian, Sarin, Shiv Kumar, and Angeli, Paolo
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- 2019
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20. Albumin in hospitalized patients with complications of cirrhosis: Not a suit for all seasons.
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Pompili, Enrico, Zaccherini, Giacomo, and Caraceni, Paolo
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- 2024
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21. Predictors of clinical trajectories of patients with acutely decompensated cirrhosis. An external validation of the PREDICT study
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Pompili, Enrico, primary, Baldassarre, Maurizio, additional, Bedogni, Giorgio, additional, Zaccherini, Giacomo, additional, Iannone, Giulia, additional, De Venuto, Clara, additional, Pratelli, Dario, additional, Palmese, Francesco, additional, Domenicali, Marco, additional, and Caraceni, Paolo, additional
- Published
- 2023
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22. Predictors of clinical courses in patients wih acutely decompensated cirrhosis. An external validation of the PREDICT study
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Pompili, Enrico, primary, Baldassarre, Maurizio, additional, Bedogni, Giorgio, additional, Zaccherini, Giacomo, additional, Iannone, Giulia, additional, De Venuto, Clara, additional, Palmese, Francesco, additional, Tufoni, Manuel, additional, Domenicali, Marco, additional, and Caraceni, Paolo, additional
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- 2023
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23. Real-word experience of long-term albumin treatment in a large cohort of patients with cirrhosis and ascites (Real-Answer study)
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Iannone, Giulia, primary, De Venuto, Clara, additional, Piano, Salvatore, additional, Lombardo, Antonino, additional, Bitetto, Davide, additional, Gioia, Stefania, additional, Zaccherini, Giacomo, additional, gagliardi, roberta, additional, Calvaruso, Vincenza, additional, Pompili, Enrico, additional, Tonon, Marta, additional, Baldassarre, Maurizio, additional, Nardelli, Silvia, additional, Toniutto, Pierluigi, additional, Di Marco, Vito, additional, Angeli, Paolo, additional, and Caraceni, Paolo, additional
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- 2023
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24. Simvastatin plus Rifaximin to prevent ACLF in patients with decompensated cirrhosis. A randomised, double-blind, placebo-controlled, phase-3 trial: the liverhope efficacy trial
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Pose, Elisa, primary, Jiménez, César, additional, Zaccherini, Giacomo, additional, Campion, Daniela, additional, Piano, Salvatore, additional, Uschner, Frank Erhard, additional, de Wit, Koos, additional, Roux, Olivier, additional, Gananandan, Kohilan, additional, Laleman, Wim, additional, Solé, Cristina, additional, Alonso, Sonia, additional, Cuyas, Berta, additional, Ariza, Xavier, additional, Juanola, Adria, additional, Ma, Ann T, additional, Napoleone, Laura, additional, Gratacos, Jordi, additional, Tonon, Marta, additional, Pompili, Enrico, additional, Sánchez-Delgado, Jordi, additional, Carol, Marta, additional, Perez, Martina, additional, Fabrellas, Núria, additional, Pich, Judit, additional, Martell, Claudia, additional, Casanovas, Georgina, additional, Domenech, Gemma, additional, Torres, Ferran, additional, Manuel, Víctor, additional, Blasco, Vargas, additional, Caraceni, Paolo, additional, Alessandria, Carlo, additional, Angeli, Paolo, additional, Trebicka, Jonel, additional, Beuers, Ulrich, additional, Francoz, Claire, additional, Mookerjee, Raj, additional, Bañares, Rafael, additional, Soriano, German, additional, Hernaez, Ruben, additional, Allegretti, Andrew S., additional, Morales-Ruiz, Manuel, additional, Serra, Miquel, additional, Watson, Hugh, additional, Abraldes, Juan G, additional, Kamath, Patrick S., additional, and Ginès, Pere, additional
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- 2023
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25. Real-world treatment of decompensated liver cirrhosis in Italy: a propensity score-matched analysis of long-term versus acute albumin therapy
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Laleman, Wim, primary, Trebicka, Jonel, additional, Zaccherini, Giacomo, additional, Caraceni, Paolo, additional, Schmidt, Dirk Steffen, additional, Rodrigues, Joana, additional, Rodney, Kyle, additional, Schweiger, Sofia, additional, and Angeli, Paolo, additional
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- 2023
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26. Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis.
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Juanola, Adrià, Ann Thu Ma, Koos de Wit, Gananandan, Kohilan, Roux, Olivier, Zaccherini, Giacomo, Jiménez, César, Tonon, Marta, Solé, Cristina, Villaseca, Clara, Uschner, Frank E., Graupera, Isabel, Pose, Elisa, Moreta, Maria José, Campion, Daniela, Beuers, Ulrich, Mookerjee, Rajeshawar P., Francoz, Claire, Durand, Francois, and Vargas, Victor
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HEPATORENAL syndrome ,PROGNOSIS ,CIRRHOSIS of the liver ,HIGH mobility group proteins ,ORGAN transplant waiting lists - Published
- 2024
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27. Predictors of clinical trajectories of patients with acutely decompensated cirrhosis. An external validation of the PREDICT study.
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Pompili, Enrico, Baldassarre, Maurizio, Bedogni, Giorgio, Zaccherini, Giacomo, Iannone, Giulia, De Venuto, Clara, Pratelli, Dario, Palmese, Francesco, Domenicali, Marco, and Caraceni, Paolo
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CIRRHOSIS of the liver ,HEPATIC encephalopathy ,LIVER failure ,DEATH rate ,PATIENT readmissions - Abstract
Background and Aims: The PREDICT study recently showed that acutely decompensated (AD) patients with cirrhosis can present three different clinical phenotypes in the 90 days after admission: (1) pre‐ACLF, developing acute‐on‐chronic liver failure (ACLF); (2) unstable decompensated cirrhosis (UDC), being re‐admitted for AD without ACLF and (3) stable decompensated cirrhosis (SDC), not presenting readmission or ACLF. This study aimed to externally validate the existence of these three distinct trajectories and to identify predictors for the occurrence of each trajectory. Methods: Baseline data, 3‐month ACLF and readmission incidence and 1‐year survival were analysed in a prospective cohort of patients admitted for AD. A multinomial multivariable model was used to evaluate the association between baseline features and clinical trajectories. Results: Of the 311 patients enrolled, 55% met the criteria for SDC, 18% for UDC and 27% for pre‐ACLF, presenting a significantly different 1‐year mortality: pre‐ACLF 65%, UDC 46%, SDC 21% (p <.001). The presence of hepatic encephalopathy (HE) was associated with UDC (p =.043), while the absence of ascites to SDC (p =.017). Among laboratory parameters, an increase in MELD‐Na (p =.001) and C‐reactive protein (p =.009) and a decrease in haemoglobin (p =.004) and albumin (p =.008) levels were associated with pre‐ACLF. Conclusion: The present study confirms that AD patients have three different clinical trajectories with different mortality rates. Besides the severity of cirrhosis, the association with C‐reactive protein supports the predominant role of systemic inflammation in ACLF pathophysiology. Finally, HE is associated with the UDC phenotype highlighting the need for better management of this complication after discharge. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis
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Liu, Jinxia, MacNaughtan, Jane, Kerbert, Annarein J C, Portlock, Theo, Martínez Gonzalez, Javier, Jin, Yi, Clasen, Frederick, Habtesion, Abeba, Ji, Huoyan, Jin, Qin, Phillips, Alexandra, De Chiara, Francesco, Ingavle, Ganesh, Jimenez, Cesar, Zaccherini, Giacomo, Husi, Katherine, Rodriguez Gandia, Miguel Angel, Cordero, Paul, Soeda, Junpei, McConaghy, Lynda, Oben, Jude, Church, Karen, Li, Jia V, Wu, Haifeng, Jalan, Aarti, Gines, Pere, Solà, Elsa, Eaton, Simon, Morgan, Carrie, Kowalski, Michal, Green, Daniel, Gander, Amir, Edwards, Lindsey A, Cox, I Jane, Cortez-Pinto, Helena, Avery, Thomas, Wiest, Reiner, Durand, Francois, Caraceni, Paolo, Elosua, Roberto, Vila, Joan, Pavesi, Marco, Arroyo, Vicente, Davies, Nathan, Mookerjee, Rajeshwar P, Vargas, Victor, Sandeman, Susan, Mehta, Gautam, Shoaie, Saeed, Marchesi, Julian, Albillos, Agustín, Andreola, Fausto, and Jalan, Rajiv
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ObjectiveTargeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, Yaq-001 in models of cirrhosis and acute-on-chronic liver failure (ACLF) and, its safety and tolerability in a clinical trial in cirrhosis.DesignPerformance of Yaq-001 was evaluated in vitro. Two-rat models of cirrhosis and ACLF, (4 weeks, bile duct ligation with or without lipopolysaccharide), receiving Yaq-001 for 2 weeks; and two-mouse models of cirrhosis (6-week and 12-week carbon tetrachloride (CCl4)) receiving Yaq-001 for 6 weeks were studied. Organ and immune function, gut permeability, transcriptomics, microbiome composition and metabolomics were analysed. The effect of faecal water on gut permeability from animal models was evaluated on intestinal organoids. A multicentre, double-blind, randomised, placebo-controlled clinical trial in 28 patients with cirrhosis, administered 4 gr/day Yaq-001 for 3 months was performed.ResultsYaq-001 exhibited rapid adsorption kinetics for endotoxin. In vivo, Yaq-001 reduced liver injury, progression of fibrosis, portal hypertension, renal dysfunction and mortality of ACLF animals significantly. Significant impact on severity of endotoxaemia, hyperammonaemia, liver cell death, systemic inflammation and organ transcriptomics with variable modulation of inflammation, cell death and senescence in the liver, kidneys, brain and colon was observed. Yaq-001 reduced gut permeability in the organoids and impacted positively on the microbiome composition and metabolism. Yaq-001 regulated as a device met its primary endpoint of safety and tolerability in the clinical trial.ConclusionsThis study provides strong preclinical rationale and safety in patients with cirrhosis to allow clinical translation.Trial registration numberNCT03202498.
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- 2024
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29. Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)
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Weiss, Emmanuel, primary, de la Peña-Ramirez, Carlos, additional, Aguilar, Ferran, additional, Lozano, Juan-Jose, additional, Sánchez-Garrido, Cristina, additional, Sierra, Patricia, additional, Martin, Pedro Izquierdo-Bueno, additional, Diaz, Juan Manuel, additional, Fenaille, François, additional, Castelli, Florence A, additional, Gustot, Thierry, additional, Laleman, Wim, additional, Albillos, Agustín, additional, Alessandria, Carlo, additional, Domenicali, Marco, additional, Caraceni, Paolo, additional, Piano, Salvatore, additional, Saliba, Faouzi, additional, Zeuzem, Stefan, additional, Gerbes, Alexander L, additional, Wendon, Julia A, additional, Jansen, Christian, additional, Gu, Wenyi, additional, Papp, Maria, additional, Mookerjee, Raj, additional, Gambino, Carmine Gabriele, additional, Jiménez, Cesar, additional, Giovo, Ilaria, additional, Zaccherini, Giacomo, additional, Merli, Manuela, additional, Putignano, Antonella, additional, Uschner, Frank Erhard, additional, Berg, Thomas, additional, Bruns, Tony, additional, Trautwein, Christian, additional, Zipprich, Alexander, additional, Bañares, Rafael, additional, Presa, José, additional, Genesca, Joan, additional, Vargas, Victor, additional, Fernández, Javier, additional, Bernardi, Mauro, additional, Angeli, Paolo, additional, Jalan, Rajiv, additional, Claria, Joan, additional, Junot, Christophe, additional, Moreau, Richard, additional, Trebicka, Jonel, additional, and Arroyo, Vicente, additional
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- 2023
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30. Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients: the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study
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Bertolotti, Marco, Franchi, Carlotta, Rocchi, Marco B. L., Miceli, Andrea, Libbra, M. Vittoria, Nobili, Alessandro, Lancellotti, Giulia, Carulli, Lucia, Mussi, Chiara, Mannucci, Pier Mannuccio, Nobili, Alessandro, Tettamanti, Mauro, Pasina, Luca, Franchi, Carlotta, Perticone, Francesco, Salerno, Francesco, Corrao, Salvatore, Marengoni, Alessandra, Licata, Giuseppe, Violi, Francesco, Corazza, Gino Roberto, Marcucci, Maura, Eldin, Tarek Kamal, Di Blanca, Maria Pia Donatella, Lanzo, Giovanna, Astuto, Sarah, Tettamanti, Mauro, Ardoino, Ilaria, Cortesi, Laura, Prisco, Domenico, Silvestri, Elena, Cenci, Caterina, Emmi, Giacomo, Biolo, Gianni, Guarnieri, Gianfranco, Zanetti, Michela, Fernandes, Giovanni, Chiuch, Massimiliano, Vanoli, Massimo, Grignani, Giulia, Casella, Gianluca, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Mannarino, Elmo, Lupattelli, Graziana, Bianconi, Vanessa, Paciullo, Francesco, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Salvatore, Teresa, Sasso, Ferdinando Carlo, Girelli, Domenico, Olivieri, Oliviero, Matteazzi, Thomas, Barbagallo, Mario, Plances, Lidia, Alcamo, Roberta, Licata, Giuseppe, Calvo, Luigi, Valenti, Maria, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Bicchi, Maurizio, Palasciano, Giuseppe, Modeo, Maria Ester, Peragine, Maria, Pappagallo, Fabrizio, Pugliese, Stefania, Di Gennaro, Carla, Postiglione, Alfredo, Barbella, Maria Rosaria, De Stefano, Francesco, Cappellini, Maria Domenica, Fabio, Giovanna, Seghezzi, Sonia, De Amicis, Margherita Migone, Mancarella, Marta, Mari, Daniela, Rossi, Paolo Dionigi, Damanti, Sarah, Ottolini, Barbara Brignolo, Bonini, Giulia, Corazza, Gino Roberto, Miceli, Emanuela, Lenti, Marco Vincenzo, Padula, Donatella, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Davì, Giovanni, Guagnano, Maria Teresa, Sestili, Simona, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Meroni, Maria Rachele, Perin, Paolo Cavallo, Lorenzati, Bartolomeo, Gruden, Gabriella, Bruno, Graziella, Amione, Cristina, Fornengo, Paolo, Tassara, Rodolfo, Melis, Deborah, Rebella, Lara, Delitala, Giuseppe, Pretti, Vincenzo, Masala, Maristella Salvatora, Pes, Chiara, Bolondi, Luigi, Rasciti, Leonardo, Serio, Ilaria, Fanelli, Filippo Rossi, Amoroso, Antonio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, Franceschi, Francesco, De Marco, Guido, Chiara, Cordischi, Marta, Sabbatini, D’Aurizio, Gabriella, Romanelli, Giuseppe, Amolini, Claudia, Chiesa, Deborah, Marengoni, Alessandra, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Annoni, Giorgio, Corsi, Maurizio, Zazzetta, Sara, Bellelli, Giuseppe, Szabo, Hajnalka, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Sesti, Giorgio, Loria, Paola, Becchi, Maria Angela, Martucci, Gianfranco, Fantuzzi, Alessandra, Maurantonio, Mauro, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Di Corato, Paola, Agnelli, Giancarlo, Marchesini, Emanuela, Fabris, Fabrizio, Carlon, Michela, Turatto, Francesca, Baritusso, Aldo, Turatto, Francesca, Amabile, Annalisa, Omenetto, Elisabetta, Scarinzi, Paolo, Manfredini, Roberto, Molino, Christian, Pala, Marco, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Laieta, Maria Teresa, Rini, Giovanbattista, Mansueto, Pasquale, Pepe, Ilenia, Borghi, Claudio, Strocchi, Enrico, De Sando, Valeria, Pareo, Ilaria, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Valerio, Raffaella, Agosti, Pasquale, Fontana, Flavia, Loparco, Francesca, Pugliese, Stefania, Capobianco, Caterina, Fenoglio, Luigi, Bracco, Christian, Giraudo, Alessia Valentina, Testa, Elisa, Serraino, Cristina, Fargion, Silvia, Bonara, Paola, Periti, Giulia, Porzio, Marianna, Tiraboschi, Slivia, Peyvandi, Flora, Tedeschi, Alberto, Rossio, Raffaella, Ferrari, Barbara, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Salerno, Maria Magnini Francesco, Conca, Alessio, Gobbo, Giulia, Conca, Alessio, Pallini, Giada, Valenti, Miriam, Balduini, Carlo L., Bertolino, Giampiera, Provini, Stella, Quaglia, Federica, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Chin, Wu Sheng, Carassale, Laura, Caporotundo, Silvia, Traisci, Giancarlo, De Feudis, Lucrezia, Di Carlo, Silvia, Liberato, Nicola Lucio, Buratti, Alberto, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Montrucchio, Giuseppe, Greco, Elisabetta, Tizzani, Pietro, Petitti, Paolo, Perciccante, Antonio, Coralli, Alessia, Salmi, Raffaella, Gaudenzi, Piergiorgio, Gamberini, Susanna, Semplicini, Andrea, Gottardo, Lucia, Vendemiale, Gianluigi, Serviddio, Gaetano, Forlano, Roberta, Masala, Cesare, Mammarella, Antonio, Raparelli, Valeria, Violi, Francesco, Basili, Stefania, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Vallone, Carla, Bellusci, Martino, Setti, Donatella, Pedrazzoli, Filippo, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Molaro, Marta, Bertolotti, Marco, Mussi, Chiara, Libbra, Maria Vittoria, Miceli, Andrea, Pellegrini, Elisa, Carulli, Lucia, Veltri, Francesca, Perticone, Francesco, Sciacqua, Angela, Quero, Michele, Bagnato, Chiara, Colangelo, Lidia, Falbo, Tania, De Giorgio, Roberto, Serra, Mauro, Grasso, Valentina, Ruggeri, Eugenio, Ilaria, Benzoni, Salvi, Andrea, Leonardi, Roberto, Grassini, Chiara, Mascherona, Ilenia, Minelli, Giorgio, Maltese, Francesca, Damiani, Giampaolo, Capeci, William, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Ormas, Monica, Pettinari, Pietro, Romiti, Roberto, Corrao, Salvatore, Messina, Silvia, Cavallaro, Federica, Ghio, Riccardi, Favorini, Serena, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Afeltra, Antonella, Alemanno, Pamela, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Blanco, Julien, Zanoli, Luca, Cattaneo, Marco, Fracasso, Paola, Amoruso, Maria Valentina, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Durante, Vittorio, Eusebi, Giovanna, Tirotta, Daniela, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Scopelliti, Francesco, Gasparini, Francesca, Cocca, Melissa, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Ghidoni, Silvia, Amione, Cristina, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Nieves, Ramirez Duque, Alberto, Muela Molinero, Pedro, Abad Requejo, Vanessa, Lopez Pelaez, Lara, Tamargo, Xavier, Corbella Viros, Francesc, Formiga, Jesus, Diez Manglano, Esperanza, Bejarano Tello, Esther, Del Corral Behamonte, Maria, Sevil Puras, Romero, Manuel, Blanca, Pinilla Llorente, Cristina, Lopez Gonzalez-Cobos, Victoria, Villalba Garcia M., Saez, Lopez, Bosco, Juan, Susana, Sanz Baena, Marta, Arroyo Gallego, Concepcion, Gonzalez Becerra, Antonio, Fernandez Moyano, Hernandez, Mercedes Gomez, Borrego, Manuel Poyato, Raquel, Pacheco Cuadros, Florencia, Perez Rojas, Beatriz, Garcia Olid, Sara, Carrascosa Garcia, Alfonso, Gonzalez-Cruz Cervellera, Marta, Peinado Martinez, Garcia, Sara Carrascosa, Alberto, Ruiz Cantero, Antonio, Albarracín Arraigosa, Montserrat, Godoy Guerrero, Ángel, Barón Ramos Miguel, Manuel, Machin Jose, Ignacio, Novo Veleiro, Lucía, Alvela Suarez, Alfonso, Lopez, David, Rubal Bran, Iria, Iñiguez Vazquez, Monica, Rios Prego, and On behalf of REPOSI Investigators
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- 2017
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31. Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF
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Moreau, Richard, Clària, Joan, Aguilar, Ferran, Fenaille, François, Lozano, Juanjo, Junot, Christophe, Colsch, Benoit, Caraceni, Paolo, Trebicka, Jonel, Pavesi, Marco, Alessandria, Carlo, Nevens, Frederik, Saliba, Faouzi, Welzel, Tania M., Albillos, Agustin, Gustot, Thierry, Fernández, Javier, Moreno, Christophe, Baldasarre, Maurizio, Zaccherini, Giacomo, Piano, Salvatore, Montagnese, Sara, Vargas, Victor, Genescà, Joan, Solà, Elsa, Bernal, William, Butin, Noémie, Hautbergue, Thaïs, Cholet, Sophie, Castelli, Florence, Jansen, Christian, Steib, Christian, Campion, Daniela, Mookerjee, Raj, Rodríguez-Gandía, Miguel, Soriano, German, Durand, François, Benten, Daniel, Bañares, Rafael, Stauber, Rudolf E., Gronbaek, Henning, Coenraad, Minneke J., Ginès, Pere, Gerbes, Alexander, Jalan, Rajiv, Bernardi, Mauro, Arroyo, Vicente, Angeli, Paolo, BALDASSARRE, MAURIZIO, Service de Pharmacologie et d'Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Moreau, Richard, Clària, Joan, Aguilar, Ferran, Fenaille, Françoi, Lozano, Juanjo, Junot, Christophe, Colsch, Benoit, Caraceni, Paolo, Trebicka, Jonel, Pavesi, Marco, Alessandria, Carlo, Nevens, Frederik, Saliba, Faouzi, Welzel, Tania M., Albillos, Agustin, Gustot, Thierry, Fernández, Javier, Moreno, Christophe, Baldasarre, Maurizio, Zaccherini, Giacomo, Piano, Salvatore, Montagnese, Sara, Vargas, Victor, Genescà, Joan, Solà, Elsa, Bernal, William, Butin, Noémie, Hautbergue, Thaï, Cholet, Sophie, Castelli, Florence, Jansen, Christian, Steib, Christian, Campion, Daniela, Mookerjee, Raj, Rodríguez-Gandía, Miguel, Soriano, German, Durand, Françoi, Benten, Daniel, Bañares, Rafael, Stauber, Rudolf E., Gronbaek, Henning, Coenraad, Minneke J., Ginès, Pere, Gerbes, Alexander, Jalan, Rajiv, Bernardi, Mauro, Arroyo, Vicente, and Angeli, Paolo
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0301 basic medicine ,Cirrhosis ,Inflammation ,Systemic inflammation ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Metabolome ,Decompensation ,Biomarkers ,CANONIC study ,Multiorgan failure, Small-molecules ,Kidney ,Hepatology ,Catabolism ,business.industry ,Lipidomic ,Organ dysfunction ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,Biomarker ,medicine.disease ,3. Good health ,030104 developmental biology ,medicine.anatomical_structure ,Multiorgan failure ,Small-molecules ,Immunology ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
Background & Aims: Acute-on-chronic liver failure (ACLF), which develops in patients with cirrhosis, is characterized by intense systemic inflammation and organ failure(s). Because systemic inflammation is energetically expensive, its metabolic costs may result in organ dysfunction/failure. Therefore, we aimed to analyze the blood metabolome in patients with cirrhosis, with and without ACLF. Methods: We performed untargeted metabolomics using liquid chromatography coupled to high-resolution mass spectrometry in serum from 650 patients with AD (acute decompensation of cirrhosis, without ACLF), 181 with ACLF, 43 with compensated cirrhosis, and 29 healthy individuals. Results: Of the 137 annotated metabolites identified, 100 were increased in patients with ACLF of any grade, relative to those with AD, and 38 comprised a distinctive blood metabolite fingerprint for ACLF. Among patients with ACLF, the intensity of the fingerprint increased across ACLF grades, and was similar in patients with kidney failure and in those without, indicating that the fingerprint reflected not only decreased kidney excretion but also altered cell metabolism. The higher the ACLF-associated fingerprint intensity, the higher the plasma levels of inflammatory markers, tumor necrosis factor alpha, soluble CD206, and soluble CD163. ACLF was characterizedbyintense proteolysis andlipolysis; aminoacid catabolism; extra-mitochondrial glucose metabolism through glycolysis, pentose phosphate, and D-glucuronate pathways; depressed mitochondrial ATP-producing fatty acid beta-oxidation; and extramitochondrial amino acid metabolism giving rise to metabotoxins. Conclusions: In ACLF, intense systemic inflammation is associated with blood metabolite accumulation and profound alterations in major metabolic pathways, in particular inhibition of mitochondrial energy production, which may contribute to the development of organ failures. Lay summary: Acute-on-chronic liver failure (ACLF), which develops in patients with cirrhosis, is characterized by intense systemic inflammation and organ failure(s). Because systemic inflammation is energetically expensive, its metabolic costs may result in organ dysfunction/failure. We identified a 38-metabolite blood fingerprint specific for ACLF that revealed mitochondrial dysfunction in peripheral organs. This may contribute to organ failures. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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- 2020
32. Low hemoglobin level predicts early hospital readmission in patients with cirrhosis and acute decompensation
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Pompili, Enrico, primary, Baldassarre, Maurizio, additional, Zaccherini, Giacomo, additional, Tufoni, Manuel, additional, Iannone, Giulia, additional, Pratelli, Dario, additional, De Venuto, Clara, additional, Domenicali, Marco, additional, and Caraceni, Paolo, additional
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- 2022
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33. Correction and prevention of hyponatremia in patients with cirrhosis and ascites-post hoc analysis of the ANSWER study database
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Zaccherini, Giacomo, primary, Baldassarre, Maurizio, additional, Tufoni, Manuel, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco Giuseppe, additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegiati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Tortora, Annalisa, additional, De Marco, Rosanna, additional, Nardelli, Silvia, additional, Piano, Salvatore, additional, Elia, Chiara, additional, Bernardi, Mauro, additional, and Caraceni, Paolo, additional
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- 2022
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34. Clinical and pathophysiological characterization of patients with acutely decompensated cirrhosis and acute-on-chronic liver failure
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Zaccherini, Giacomo and Domenicali, Marco
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MED/09 Medicina interna - Abstract
In the last decade, our understanding of the pathophysiological mechanisms underlying decompensated cirrhosis has greatly increased. Moreover, acute-on-chronic liver failure (ACLF) was defined as a distinct syndrome with specific features. Our research activities aimed to provide a contribution in characterizing patients with acutely decompensated cirrhosis and ACLF from a clinical and a pathophysiological perspective. As a first project, we addressed the clinical issue of predicting in-hospital development of ACLF in patients hospitalized for acute decompensation of cirrhosis. As a second contribution, we performed a reassessment of the whole metabolomic dataset obtained from 831 patients enrolled in the CANONIC study, focusing on amino acids, with the aim to uncover alterations in amino acids metabolic pathways. As a third perspective, we performed a GWAS on 270 patients with acute decompensation and ACLF included in the first clinical study. We categorized patients in 4 groups, according to their clinical presentation and their clinical course. We then performed two comparisons: group 1 vs group 4 (i.e., the most severe vs the mildest clinical courses), and group 1 vs group 2 (i.e., patients with different 1-year outcomes from a common clinical presentation with ACLF or bacterial infection). Three SNPs (rs9354118 on chromosome 6q16.1; rs1146878 on chromosome 13q22.2; rs6479397 on chromosome 9q22.31) were significantly associated with the selected phenotypes, but all of them were located in non-codifying DNA regions. However, their potential role as candidate Cis-Regulatory Elements (cCREs) opened interesting hypotheses on effects on the expression of neighboring genes. Indeed, four of them (FUT9 and UFL1 for SNP rs9354118, LMO7 and ACOD1 for rs1146878) are involved in the modulation of immune system activation and systemic inflammation. The results of the GWAS did not confirm previous findings reported in literature and presented some limitations. However, it provided the basis for further research in this still open issue.
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- 2022
35. Clinical and pathophysiological characterization of patients with acutely decompensated cirrhosis and acute-on-chronic liver failure
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Domenicali, Marco, Zaccherini, Giacomo <1985>, Domenicali, Marco, and Zaccherini, Giacomo <1985>
- Abstract
In the last decade, our understanding of the pathophysiological mechanisms underlying decompensated cirrhosis has greatly increased. Moreover, acute-on-chronic liver failure (ACLF) was defined as a distinct syndrome with specific features. Our research activities aimed to provide a contribution in characterizing patients with acutely decompensated cirrhosis and ACLF from a clinical and a pathophysiological perspective. As a first project, we addressed the clinical issue of predicting in-hospital development of ACLF in patients hospitalized for acute decompensation of cirrhosis. As a second contribution, we performed a reassessment of the whole metabolomic dataset obtained from 831 patients enrolled in the CANONIC study, focusing on amino acids, with the aim to uncover alterations in amino acids metabolic pathways. As a third perspective, we performed a GWAS on 270 patients with acute decompensation and ACLF included in the first clinical study. We categorized patients in 4 groups, according to their clinical presentation and their clinical course. We then performed two comparisons: group 1 vs group 4 (i.e., the most severe vs the mildest clinical courses), and group 1 vs group 2 (i.e., patients with different 1-year outcomes from a common clinical presentation with ACLF or bacterial infection). Three SNPs (rs9354118 on chromosome 6q16.1; rs1146878 on chromosome 13q22.2; rs6479397 on chromosome 9q22.31) were significantly associated with the selected phenotypes, but all of them were located in non-codifying DNA regions. However, their potential role as candidate Cis-Regulatory Elements (cCREs) opened interesting hypotheses on effects on the expression of neighboring genes. Indeed, four of them (FUT9 and UFL1 for SNP rs9354118, LMO7 and ACOD1 for rs1146878) are involved in the modulation of immune system activation and systemic inflammation. The results of the GWAS did not confirm previous findings reported in literature and presented some limitations. However, it pro
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- 2022
36. Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl4-induced advanced cirrhosis
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Giannone, Ferdinando A, Baldassarre, Maurizio, Domenicali, Marco, Zaccherini, Giacomo, Trevisani, Franco, Bernardi, Mauro, and Caraceni, Paolo
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- 2012
- Full Text
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37. Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis
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Pose, Elisa, primary, Solà, Elsa, additional, Lozano, Juan J., additional, Juanola, Adrià, additional, Sidorova, Julia, additional, Zaccherini, Giacomo, additional, de Wit, Koos, additional, Uschner, Frank, additional, Tonon, Marta, additional, Kazankov, Konstantin, additional, Jiménez, Cesar, additional, Campion, Daniela, additional, Napoleone, Laura, additional, Ma, Ann T., additional, Carol, Marta, additional, Morales-Ruiz, Manuel, additional, Alessandria, Carlo, additional, Beuers, Ulrich, additional, Caraceni, Paolo, additional, Francoz, Claire, additional, Durand, François, additional, Mookerjee, Rajeshwar P., additional, Trebicka, Jonel, additional, Vargas, Victor, additional, Piano, Salvatore, additional, Watson, Hugh, additional, Abraldes, Juan G., additional, Kamath, Patrick S., additional, Davis, Mark M., additional, Ginès, Pere, additional, Schulz, M., additional, Ferstl, P., additional, Giovo, I., additional, Roux, O., additional, Simon-Talero, M., additional, Pérez-Guasch, M., additional, Rubio, A. B., additional, Cervera, M., additional, Martínez, S., additional, Fabrellas, N., additional, Pich, J., additional, Vives, A., additional, Avitabile, E., additional, Graupera, I., additional, Solé, C., additional, Bassegoda, O., additional, Gratacós-Ginès, J., additional, Joyera, M., additional, Palacio, E., additional, Aban, M., additional, Lanzillotti, T., additional, Nicolao, G., additional, Chiappa, M. T., additional, Esnault, V., additional, Andrade, R., additional, Pavesi, M., additional, Korenjak, M., additional, Farrés, J., additional, Serra-Burriel, M., additional, and Angeli, P., additional
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- 2022
- Full Text
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38. Hyposplenism as a cause of pneumococcal meningoencephalitis in an adult patient with coeliac disease
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Caraceni, Paolo, Benazzi, Barbara, Caio, Giacono, Zaccherini, Giacomo, Domenicali, Marco, and Volta, Umberto
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- 2011
- Full Text
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39. Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis
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Pose, Elisa, Solà, Elsa, Lozano, Juan J., Juanola, Adrià, Sidorova, Julia, Zaccherini, Giacomo, Wit, Koos, Uschner, Frank, Tonon, Marta, Kazankov, Konstantin, Jiménez, Cesar, Campion, Daniela, Napoleone, Laura, Ma, Ann T., Carol, Marta, Morales‐Ruiz, Manuel, Alessandria, Carlo, Beuers, Ulrich, Caraceni, Paolo, Francoz, Claire, Durand, François, Mookerjee, Rajeshwar P., Trebicka, Jonel, Vargas, Victor, Piano, Salvatore, Watson, Hugh, Abraldes, Juan G., Kamath, Patrick S., Davis, Mark M., Ginès, Pere, Schulz, M., Ferstl, P., Giovo, I., Roux, O., Simon‐Talero, M., Pérez‐Guasch, M., Rubio, A.B., Cervera, M., Martínez, S., Fabrellas, N., Pich, J., Vives, A., Avitabile, E., Graupera, I., Solé, C., Bassegoda, O., Gratacós‐Ginès, J., Joyera, M., Palacio, E., Aban, M., Lanzillotti, T., Nicolao, G., Chiappa, M.T., Esnault, V., Andrade, R., Pavesi, M., Korenjak, M., Farrés, J., Serra‐Burriel, M., Angeli, P., Pose E., Sola E., Lozano J.J., Juanola A., Sidorova J., Zaccherini G., de Wit K., Uschner F., Tonon M., Kazankov K., Jimenez C., Campion D., Napoleone L., Ma A.T., Carol M., Morales-Ruiz M., Alessandria C., Beuers U., Caraceni P., Francoz C., Durand F., Mookerjee R.P., Trebicka J., Vargas V., Piano S., Watson H., Abraldes J.G., Kamath P.S., Davis M.M., Gines P., Schulz M., Ferstl P., Giovo I., Roux O., Simon-Talero M., Perez-Guasch M., Rubio A.B., Cervera M., Martinez S., Fabrellas N., Pich J., Vives A., Avitabile E., Graupera I., Sole C., Bassegoda O., Gratacos-Gines J., Joyera M., Palacio E., Aban M., Lanzillotti T., Nicolao G., Chiappa M.T., Esnault V., Andrade R., Pavesi M., Korenjak M., Farres J., Serra-Burriel M., Angeli P., Gastroenterology and Hepatology, Graduate School, Tytgat Institute for Liver and Intestinal Research, and Amsterdam Gastroenterology Endocrinology Metabolism
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Liver Cirrhosis ,0303 health sciences ,Simvastatin ,Hepatology ,Kynurenine/therapeutic use ,Tryptophan ,Acute-On-Chronic Liver Failure ,Tryptophan/therapeutic use ,Rifaximin ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,simvastatin and rifaximin ,Simvastatin/therapeutic use ,Carnitine ,Humans ,Metabolomics ,030211 gastroenterology & hepatology ,Carnitine/therapeutic use ,Rifaximin/therapeutic use ,Kynurenine ,030304 developmental biology ,Liver Cirrhosis/drug therapy - Abstract
Patients with decompensated cirrhosis, particularly those with acute-on-chronic liver failure (ACLF), show profound alterations in plasma metabolomics. The aim of this study was to investigate the effect of treatment with simvastatin and rifaximin on plasma metabolites of patients with decompensated cirrhosis, specifically on compounds characteristic of the ACLF plasma metabolomic profile. Two cohorts of patients were investigated. The first was a descriptive cohort of patients with decompensated cirrhosis (n = 42), with and without ACLF. The second was an intervention cohort from the LIVERHOPE-SAFETY randomized, double-blind, placebo-controlled trial treated with simvastatin 20 mg/day plus rifaximin 1,200 mg/day (n = 12) or matching placebo (n = 13) for 3 months. Plasma samples were analyzed using ultrahigh performance liquid chromatography-tandem mass spectroscopy for plasma metabolomics characterization. ACLF was characterized by intense proteolysis and lipid alterations, specifically in pathways associated with inflammation and mitochondrial dysfunction, such as the tryptophan-kynurenine and carnitine beta-oxidation pathways. An ACLF-specific signature was identified. Treatment with simvastatin and rifaximin was associated with changes in 161 of 985 metabolites in comparison to treatment with placebo. A remarkable reduction in levels of metabolites from the tryptophan-kynurenine and carnitine pathways was found. Notably, 18 of the 32 metabolites of the ACLF signature were affected by the treatment. Conclusion: Treatment with simvastatin and rifaximin modulates some of the pathways that appear to be key in ACLF development. This study unveils some of the mechanisms involved in the effects of treatment with simvastatin and rifaximin in decompensated cirrhosis and sets the stage for the use of metabolomics to investigate new targeted therapies in cirrhosis to prevent ACLF development.
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- 2021
40. Correction and Prevention of Hyponatremia in Patients With Cirrhosis and Ascites: Post Hoc Analysis of the ANSWER Study Database.
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Zaccherini, Giacomo, Baldassarre, Maurizio, Tufoni, Manuel, Nardelli, Silvia, Piano, Salvatore, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco Giuseppe, Levantesi, Fabio, Bedogni, Giorgio, Domenicali, Marco, Bernardi, Mauro, and Caraceni, Paolo
- Subjects
- *
DATABASES , *HYPONATREMIA , *ASCITES , *CIRRHOSIS of the liver , *THERAPEUTICS - Abstract
INTRODUCTION: We assessed the impact of long-term albumin administration to hyponatremic patients with ascites enrolled in the ANSWER trial. METHODS: The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated. RESULTS: The hyponatremia normalization rate was higher with albumin than with standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167–0.359], P < 0.001). DISCUSSION: Long-term albumin administration improves hyponatremia and reduces episodes of at least moderate hyponatremia in outpatients with cirrhosis and ascites. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
- View/download PDF
41. Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register
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Mannucci, Pier Mannuccio, Nobili, Alessandro, Pasina, Luca, Tettamanti, Mauro, Franchi, Carlotta, Corrao, Salvatore, Marengoni, Alessandra, Salerno, Francesco, Cesari, Matteo, Perticone, Francesco, Licata, Giuseppe, Violi, Francesco, Corazza, Gino Roberto, Cortesi, Laura, Ardoino, Ilaria, Prisco, Domenico, Silvestri, Elena, Cenci, Caterina, Emmi, Giacomo, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Mannarino, Elmo, Lupattelli, Graziana, Bianconi, Vanessa, Paciullo, Francesco, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Olivieri, Oliviero, Girelli, Domenico, Matteazzi, Thomas, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Angelucci, Ermanno, Valeriani, Emanuele, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Delitala, Giuseppe, Berria, Maria, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, D’Aurizio, Gabriella, Romanelli, Giuseppe, Zucchelli, Alberto, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell’Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, De Sando, Valeria, Pareo, Ilenia, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Agosti, Pasquale, Schilardi, Andrea, Loparco, Francesca, Fenoglio, Luigi, Bracco, Christian, Giraudo, Alessia Valentina, Fargion, Silvia, Periti, Giulia, Porzio, Marianna, Tiraboschi, Slivia, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Salmi, Raffaella, Gaudenzi, Piergiorgio, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Molaro, Marta, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, COLANGELO, LIDIA, Falbo, Tania, Stanghellini, Vincenzo, De Giorgio, Roberto, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, LEONARDI, ROBERTO, Damiani, Giampaolo, Gabrielli, Armando, Capeci, William, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Blanco, Julien, Zanoli, Luca, Pignataro, Samuele, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, DI PASQUALE, MARIA GRAZIA, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Patrizia, Tarsitani, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Antonino, Lasco, Basile, Giorgio, Antonino, Catalano, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Nieves, Ramirez Duque, Alberto, Muela Molinero, Pedro, Abad Requejo, Vanessa, Lopez Pelaez, Lara, Tamargo, Xavier, Corbella Viros, Francesc, Formiga, Jesus, Diez Manglano, Esperanza, Bejarano Tello, Esther, Del Corral Behamonte, Maria, Sevil Puras, Romero, Manuel, Blanca, Pinilla Llorente, Cristina, Lopez Gonzalez-Cobos, Victoria, Villalba Garcia M., Saez, Lopez, Bosco, Juan, Susana, Sanz Baena, Marta, Arroyo Gallego, Concepcion, Gonzalez Becerra, Antonio, Fernandez Moyano, Hernandez, Mercedes Gomez, Borrego, Manuel Poyato, Raquel, Pacheco Cuadros, Florencia, Perez Rojas, Beatriz, Garcia Olid, Sara, Carrascosa Garcia, Alfonso, Gonzalez-Cruz Cervellera, Marta, Peinado Martinez, Garcia, Sara Carrascosa, Alberto, Ruiz Cantero, Antonio, Albarracín Arraigosa, Montserrat, Godoy Guerrero, Ángel, Barón Ramos Miguel, Manuel, Machin Jose, Ignacio, Novo Veleiro, Lucía, Alvela Suarez, Alfonso, Lopez, David, Rubal Bran, Iria, Iñiguez Vazquez, Monica, Rios Prego, Mannucci, Pier Mannuccio, Nobili, Alessandro, Pasina, Luca, Tettamanti, Mauro, Franchi, Carlotta, Corrao, Salvatore, Marengoni, Alessandra, Salerno, Francesco, Cesari, Matteo, Perticone, Francesco, Licata, Giuseppe, Violi, Francesco, Corazza, Gino Roberto, Cortesi, Laura, Ardoino, Ilaria, Prisco, Domenico, Silvestri, Elena, Cenci, Caterina, Emmi, Giacomo, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Mannarino, Elmo, Lupattelli, Graziana, Bianconi, Vanessa, Paciullo, Francesco, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Olivieri, Oliviero, Girelli, Domenico, Matteazzi, Thoma, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Angelucci, Ermanno, Valeriani, Emanuele, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Delitala, Giuseppe, Berria, Maria, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, D’Aurizio, Gabriella, Romanelli, Giuseppe, Zucchelli, Alberto, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell’Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, De Sando, Valeria, Pareo, Ilenia, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Agosti, Pasquale, Schilardi, Andrea, Loparco, Francesca, Fenoglio, Luigi, Bracco, Christian, Giraudo, Alessia Valentina, Fargion, Silvia, Periti, Giulia, Porzio, Marianna, Tiraboschi, Slivia, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Salmi, Raffaella, Gaudenzi, Piergiorgio, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Molaro, Marta, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Colangelo, Lidia, Falbo, Tania, Stanghellini, Vincenzo, De Giorgio, Roberto, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Gabrielli, Armando, Capeci, William, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Blanco, Julien, Zanoli, Luca, Pignataro, Samuele, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Patrizia, Tarsitani, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Antonino, Lasco, Basile, Giorgio, Antonino, Catalano, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Nieves, Ramirez Duque, Alberto, Muela Molinero, Pedro, Abad Requejo, Vanessa, Lopez Pelaez, Lara, Tamargo, Xavier, Corbella Viro, Francesc, Formiga, Jesus, Diez Manglano, Esperanza, Bejarano Tello, Esther, Del Corral Behamonte, Maria, Sevil Pura, Romero, Manuel, Blanca, Pinilla Llorente, Cristina, Lopez Gonzalez-Cobo, Victoria, Villalba Garcia M., Saez, Lopez, Bosco, Juan, Susana, Sanz Baena, Marta, Arroyo Gallego, Concepcion, Gonzalez Becerra, Antonio, Fernandez Moyano, Hernandez, Mercedes Gomez, Borrego, Manuel Poyato, Raquel, Pacheco Cuadro, Florencia, Perez Roja, Beatriz, Garcia Olid, Sara, Carrascosa Garcia, Alfonso, Gonzalez-Cruz Cervellera, Marta, Peinado Martinez, Garcia, Sara Carrascosa, Alberto, Ruiz Cantero, Antonio, Albarracín Arraigosa, Montserrat, Godoy Guerrero, Ángel, Barón Ramos Miguel, Manuel, Machin Jose, Ignacio, Novo Veleiro, Lucía, Alvela Suarez, Alfonso, Lopez, David, Rubal Bran, Iria, Iñiguez Vazquez, Monica, Rios Prego, Pier Mannuccio Mannucci, Alessandro Nobili, Luca Pasina, REPOSI Collaborators [.., Gino Roberto Corazza, Elena Silvestri, Mauro Bernardi, Silvia Li Bassi, Luca Santi, Giacomo Zaccherini, Marco Zoli, Ilaria Lazzari, Mattia Brunori, Claudio Borghi, Enrico Strocchi, Valeria De Sando, Ilenia Pareo, Vincenzo Stanghellini, Roberto De Giorgio, Eugenio Ruggeri, Sara del Vecchio, ], Mannucci, P, Nobili, A, Pasina, L, Dominguez Rodriguez, L, Barbagallo, M, Licata, A, Tettamanti, M, Franchi, C, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Perticone, F, Licata, G, Violi, F, Corazza, G, Cortesi, L, Ardoino, I, Prisco, D, Silvestri, E, Cenci, C, Emmi, G, Biolo, G, Zanetti, M, Guadagni, M, Zaccari, M, Vanoli, M, Grignani, G, Pulixi, E, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Mannarino, E, Lupattelli, G, Bianconi, V, Paciullo, F, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Olivieri, O, Girelli, D, Matteazzi, T, Dominguez, L, Cocita, F, Beneduce, V, Plances, L, Zoli, M, Lazzari, I, Brunori, M, Pasini, F, Capecchi, P, Palasciano, G, Modeo, M, di Gennaro, C, Cappellini, M, Maira, D, di Stefano, V, Fabio, G, Seghezzi, S, Mancarella, M, Rossi, P, Damanti, S, Clerici, M, Conti, F, Miceli, E, Lenti, M, Pisati, M, Dominioni, C, Murialdo, G, Marra, A, Cattaneo, F, Secchi, M, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Angelucci, E, Valeriani, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Muscaritoli, M, Molfino, A, Petrillo, E, Zuccala, G, D'Aurizio, G, Romanelli, G, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Annoni, G, Corsi, M, Bellelli, G, Zazzetta, S, Mazzola, P, Szabo, H, Bonfanti, A, Arturi, F, Succurro, E, Rubino, M, Serra, M, Bleve, M, Gasbarrone, L, Sajeva, M, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, de Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Borghi, C, Strocchi, E, de Sando, V, Pareo, I, Sabba, C, Vella, F, Suppressa, P, Agosti, P, Schilardi, A, Loparco, F, Fenoglio, L, Bracco, C, Giraudo, A, Fargion, S, Periti, G, Porzio, M, Tiraboschi, S, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, N, Tognin, T, Bianchi, G, Giaquinto, S, Purrello, F, di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Salmi, R, Gaudenzi, P, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Molaro, M, Grossi, A, Bertolotti, M, Mussi, C, Libbra, M, Dondi, G, Pellegrini, E, Carulli, L, Colangelo, L, Falbo, T, Stanghellini, V, De Giorgio, R, Ruggeri, E, del Vecchio, S, Salvi, A, Leonardi, R, Damiani, G, Gabrielli, A, Capeci, W, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ghio, R, Col, A, Minisola, S, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Blanco, J, Zanoli, L, Pignataro, S, Saracco, V, Fogliati, M, Bussolino, C, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Sirico, D, Moreo, G, Gasparini, F, Prolo, S, Pina, G, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, M, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffre, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Patrizia, T, Castello, R, Pasino, M, Ceda, G, Maggio, M, Morganti, S, Artoni, A, Giacco, S, Firinu, D, Losa, F, Paoletti, G, Montalto, G, Malerba, V, Antonino, L, Basile, G, Antonino, C, Malatino, L, Stancanelli, B, Terranova, V, di Marca, S, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, G, Sola, D, Porta, M, Riva, P, Quadri, R, Scanzi, G, Mengoli, C, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Nieves, R, Alberto, M, Pedro, A, Vanessa, L, Lara, T, Xavier, C, Francesc, F, Jesus, D, Esperanza, B, Esther, D, Maria, S, Romero, M, Blanca, P, Cristina, L, Victoria, V, Saez, L, Bosco, J, Susana, S, Marta, A, Concepcion, G, Antonio, F, Hernandez, M, Borrego, M, Raquel, P, Florencia, P, Beatriz, G, Sara, C, Alfonso, G, Marta, P, Garcia, S, Alberto, R, Antonio, A, Montserrat, G, Angel, B, Manuel, M, Ignacio, N, Lucia, A, Alfonso, L, David, R, Iria, I, Monica, R, DI PASQUALE, MARIA GRAZIA, di Gennaro, Carla, di Stefano, Valeria, de Giorgi, Alfredo, de Sando, Valeria, di Pino, Antonino, Giacco, Stefano Del, and di Marca, Salvatore
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Male ,medicine.medical_specialty ,Population ageing ,Deprescribing ,Inappropriate prescription ,Medication reconciliation ,Multimorbidity ,Polypharmacy ,Population ,Socio-culturale ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,80 and over ,Internal Medicine ,Emergency Medicine ,medicine ,Deprescribing, Inappropriate prescription, Medication reconciliation, Multimorbidity, Polypharmacy ,Humans ,Registries ,030212 general & internal medicine ,Medical prescription ,Adverse effect ,education ,Aged ,Aged, 80 and over ,Geriatrics ,education.field_of_study ,business.industry ,Patient Discharge ,Hospitalization ,Female ,Italy ,Family medicine ,business - Abstract
As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration andinevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug-drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.
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- 2018
42. Management of Ascites in Patients with Cirrhosis: An Update
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Zaccherini, Giacomo, primary, Tufoni, Manuel, additional, Iannone, Giulia, additional, and Caraceni, Paolo, additional
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- 2021
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43. Prevention of Cirrhosis Complications: Looking for Potential Disease Modifying Agents
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Zaccherini, Giacomo, primary, Tufoni, Manuel, additional, Bernardi, Mauro, additional, and Caraceni, Paolo, additional
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- 2021
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44. O09 A double blind, randomised, placebo-controlled study to assess safety and tolerability of oral enterosorbent Carbalive (Yaq-001) in cirrhotic patients
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Macnaughtan, Jane, primary, Albillos, Agustin, additional, Kerbert, Annarein, additional, Vargas, Victor, additional, Durand, Francois, additional, Gines, Pere, additional, Sola, Elsa, additional, Edwards, Lindsey, additional, Eaton, Simon, additional, Cox, Jane, additional, Andreola, Fausto, additional, Gander, Amir, additional, Martinez, Javier, additional, Zaccherini, Giacomo, additional, Mehta, Gautam, additional, Jimenez, César, additional, Husi, Kathrin, additional, Stabile-Barnett, Christopher, additional, Rodriguez-Gandia, Miguel, additional, Obiols, Mar Hernandez, additional, Elosua, Roberto, additional, Villa, Joan, additional, Navarro, Alicia, additional, Morgan, Carrie, additional, Church, Karen, additional, Kowalski, Michal, additional, Guillabert, Edouard, additional, Avery, Katherine, additional, Avery, Tom, additional, Green, Daniel, additional, McConaghy, Lynda, additional, Sandeman, Susi, additional, Davies, Nathan, additional, Pavesi, Marco, additional, Mookerjee, Raj, additional, Arroyo, Vicento, additional, Cortez-Pinto, Helena, additional, Wiest, Reiner, additional, Caraceni, Paolo, additional, and Jalan, Rajiv, additional
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- 2021
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45. Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications
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Baldassarre, Maurizio, primary, Naldi, Marina, additional, Zaccherini, Giacomo, additional, Bartoletti, Michele, additional, Antognoli, Agnese, additional, Laggetta, Maristella, additional, Gagliardi, Martina, additional, Tufoni, Manuel, additional, Domenicali, Marco, additional, Waterstradt, Katja, additional, Paterini, Paola, additional, Baldan, Anna, additional, Leoni, Simona, additional, Bartolini, Manuela, additional, Viale, Pierluigi, additional, Trevisani, Franco, additional, Bernardi, Mauro, additional, and Caraceni, Paolo, additional
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- 2021
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46. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
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Trebicka, Jonel, primary, Fernandez, Javier, additional, Papp, Maria, additional, Caraceni, Paolo, additional, Laleman, Wim, additional, Gambino, Carmine, additional, Giovo, Ilaria, additional, Uschner, Frank Erhard, additional, Jansen, Christian, additional, Jimenez, Cesar, additional, Mookerjee, Rajeshwar, additional, Gustot, Thierry, additional, Albillos, Agustin, additional, Bañares, Rafael, additional, Jarcuska, Peter, additional, Steib, Christian, additional, Reiberger, Thomas, additional, Acevedo, Juan, additional, Gatti, Pietro, additional, Shawcross, Debbie L., additional, Zeuzem, Stefan, additional, Zipprich, Alexander, additional, Piano, Salvatore, additional, Berg, Thomas, additional, Bruns, Tony, additional, Danielsen, Karen Vagner, additional, Coenraad, Minneke, additional, Merli, Manuela, additional, Stauber, Rudolf, additional, Zoller, Heinz, additional, Ramos, José Presa, additional, Solé, Cristina, additional, Soriano, Germán, additional, de Gottardi, Andrea, additional, Gronbaek, Henning, additional, Saliba, Faouzi, additional, Trautwein, Christian, additional, Kani, Haluk Tarik, additional, Francque, Sven, additional, Ryder, Stephen, additional, Nahon, Pierre, additional, Romero-Gomez, Manuel, additional, Van Vlierberghe, Hans, additional, Francoz, Claire, additional, Manns, Michael, additional, Garcia-Lopez, Elisabet, additional, Tufoni, Manuel, additional, Amoros, Alex, additional, Pavesi, Marco, additional, Sanchez, Cristina, additional, Praktiknjo, Michael, additional, Curto, Anna, additional, Pitarch, Carla, additional, Putignano, Antonella, additional, Moreno, Esau, additional, Bernal, William, additional, Aguilar, Ferran, additional, Clària, Joan, additional, Ponzo, Paola, additional, Vitalis, Zsuzsanna, additional, Zaccherini, Giacomo, additional, Balogh, Boglarka, additional, Gerbes, Alexander, additional, Vargas, Victor, additional, Alessandria, Carlo, additional, Bernardi, Mauro, additional, Ginès, Pere, additional, Moreau, Richard, additional, Angeli, Paolo, additional, Jalan, Rajiv, additional, Arroyo, Vicente, additional, Maschmeier, Miriam, additional, Semela, David, additional, Elkrief, Laure, additional, Elsharkawy, Ahmed, additional, Tornai, Tamas, additional, Tornai, Istvan, additional, Altorjay, Istvan, additional, Antognoli, Agnese, additional, Baldassarre, Maurizio, additional, Gagliardi, Martina, additional, Bertoli, Eleonora, additional, Mareso, Sara, additional, Brocca, Alessandra, additional, Campion, Daniela, additional, Saracco, Giorgio Maria, additional, Rizzo, Martina, additional, Lehmann, Jennifer, additional, Pohlmann, Alessandra, additional, Brol, Maximilian J., additional, Chang, Johannes, additional, Schierwagen, Robert, additional, Solà, Elsa, additional, Amari, Nesrine, additional, Rodriguez, Miguel, additional, Nevens, Frederik, additional, Clemente, Ana, additional, Janicko, Martin, additional, Markwardt, Daniel, additional, Mandorfer, Mattias, additional, Welsch, Christoph, additional, Welzel, Tanja M., additional, Ciraci, Emanuela, additional, Patel, Vish, additional, Ripoll, Cristina, additional, Herber, Adam, additional, Horn, Paul, additional, Bendtsen, Flemming, additional, Gluud, Lise Lotte, additional, Schaapman, Jelte, additional, Riggio, Oliviero, additional, Rainer, Florian, additional, Moritz, Jörg Tobiasch, additional, Mesquita, Mónica, additional, Alvarado-Tapias, Edilmar, additional, Akpata, Osagie, additional, Aamann, Luise, additional, Samuel, Didier, additional, Tresson, Sylvie, additional, Strnad, Pavel, additional, Amathieu, Roland, additional, Simón-Talero, Macarena, additional, Smits, Francois, additional, van den Ende, Natalie, additional, Martinez, Javier, additional, Garcia, Rita, additional, Rupprechter, Harald, additional, Engelmann, Cornelius, additional, and Özdogan, Osman Cavit, additional
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- 2021
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47. Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF
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Zaccherini, Giacomo, primary, Aguilar, Ferran, additional, Caraceni, Paolo, additional, Clària, Joan, additional, Lozano, Juan José, additional, Fenaille, François, additional, Castelli, Florence, additional, Junot, Christophe, additional, Curto, Anna, additional, Formentin, Chiara, additional, Weiss, Emmanuel, additional, Bernardi, Mauro, additional, Jalan, Rajiv, additional, Angeli, Paolo, additional, Moreau, Richard, additional, and Arroyo, Vicente, additional
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- 2021
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48. Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature
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Zaccherini,Giacomo, Tufoni,Manuel, and Bernardi,Mauro
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Evidence and Research [Hepatic Medicine] - Abstract
Giacomo Zaccherini, Manuel Tufoni, Mauro Bernardi Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna 40138, ItalyCorrespondence: Mauro Bernardi Email mauro.bernardi@unibo.itAbstract: The use of albumin in patients with cirrhosis has been extensively discussed over recent years. Current treatment approaches depend on targeting related complications, aiming to treat and/or prevent circulatory dysfunction, bacterial infections and multi-organ failure. Albumin has been shown to prolong survival and reduce complications in patients with cirrhosis. This review aims to ascertain whether the use of albumin is justified in patients with cirrhosis. A systematic review of randomized controlled trials (RCTs) and meta-analyses evaluating albumin use in patients with cirrhosis published between 1985 and February 2020 was conducted; the quality and risk of bias of the included studies were assessed. In total, 45 RCTs and 10 meta-analyses were included. Based on the included evidence, albumin is superior at preventing and controlling the incidence of cirrhosis complications vs other plasma expanders. Recent studies reported that long-term albumin administration to patients with decompensated cirrhosis improves survival with a 38% reduction in the mortality hazard ratio compared with standard medical treatment alone. Albumin infusions are justified for routine use in patients with cirrhosis, and the use of albumin either alone or in combination with other treatments leads to clinical benefits. Long-term administration of albumin should be considered in some patients.Keywords: albumin, ascites, hepatorenal syndrome, liver cirrhosis, paracentesis, peritonitis
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- 2020
49. Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry
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Argano, Christiano, Scichilone, Nicola, Natoli, Giuseppe, Nobili, Alessandro, Corazza, Gino Roberto, Mannucci, Pier Mannuccio, Perticone, Francesco, Corrao, Salvatore, Pietrangelo, Antonello, Licata, Giuseppe, Violi, Francesco, Marengoni, Alessandra, Salerno, Francesco, Cesari, Matteo, Tettamanti, Mauro, Pasina, Luca, Franchi, Carlotta, Miglio, Gabriella, Cortesi, Laura, Ardoino, Ilaria, Novella, Alessio, Prisco, Domenico, Silvestri, Elena, Emmi, Giacomo, Bettiol, Alessandra, Caterina, Cenci, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Chiuch, Massimiliano, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Lupattelli, Graziana, Mannarino, Elmo, Bianconi, Vanessa, Paciullo, Francesco, Alcidi, Riccardo, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Girelli, Domenico, Busti, Fabiana, Marchi, Giacomo, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Mularo, Salvatore, Raspanti, Massimo, Cavallaro, Federica, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Fabbri, Elisa, Magalotti, Donatella, Arnò, Raffaella, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, De Amicis, Margherita Migone, De Luca, Giacomo, Scaramellini, Natalia, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Bonini, Giulia, Ottolini, Barbara Brignolo, Di Sabatino, Antonio, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Pontremoli, Roberto, Beccati, Valentina, Nobili, Giulia, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Valeriani, Emanuele, Rossi, Ilaria, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Delitala, Giuseppe, Berria, Maria, Pes, Chiara, Delitala, Alessandro, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, D’Aurizio, Gabriella, Romanelli, Giuseppe, Zucchelli, Alberto, Manzoni, Francesca, Volpini, Andrea, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell’Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Tassone, Bruno, Sesti, Giorgio, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Scarinzi, Paolo, Amabile, Annalisa, Omenetto, Elisabetta, Prandini, Tancredi, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, De Giorgio, Roberto, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, Ianniello, Eugenia, Soldati, Mario, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Schilardi, Andrea, Loparco, Francesca, De Vincenzo, Giovanni Michele, Comitangelo, Alessio, Amoruso, Emanuele, Fenoglio, Luigi, Falcetta, Andrea, Bracco, Christian, Fracanzani Silvia Fargion, Anna L., Tiraboschi, Silvia, Cespiati, Annalisa, Oberti, Giovanna, Sigon, Giordano, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Agosti, Pasquale, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Peasso, Paolo, Favale, Edoardo, Poletto, Cesare, Salmi, Raffaella, Gaudenzi, Piergiorgio, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Campiotti, Leonardo, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Lancellotti, Giulia, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Galassi, Matteo, Grassi, Yasmine, Perticone, Maria, Battaglia, Rosa, FIlice, Marco, Maio, Raffaele, Stanghellini, Vincenzo, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Capeci, William, Gabrielli, Armando, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Cilli, Mirella, Labbadia, Giancarlo, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Zanoli, Luca, Pignataro, Samuele, Gennaro, Alfio, Blanco, Julien, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Tarsitani, Patrizia, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Costanzo, Giulia, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Montalto, Filippo Alessandro, Lasco, Antonino, Basile, Giorgio, Catalano, Antonino, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Di Quattro, Rosario, La Malfa, Lara, Caruso, Rossella, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Nouvenne, Antonio, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Larovere, Erica, Novelli, Marco, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Napoli, Federico, Argano, Christiano, Scichilone, Nicola, Natoli, Giuseppe, Nobili, Alessandro, Corazza, Gino Roberto, Mannucci, Pier Mannuccio, Perticone, Francesco, Corrao, Salvatore, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Argano, C., Scichilone, N., Natoli, G., Nobili, A., Corazza, G. R., Mannucci, P. M., Perticone, F., Corrao, S., Pietrangelo, A., Licata, G., Violi, F., Marengoni, A., Salerno, F., Cesari, M., Tettamanti, M., Pasina, L., Franchi, C., Miglio, G., Cortesi, L., Ardoino, I., Novella, A., Prisco, D., Silvestri, E., Emmi, G., Bettiol, A., Caterina, C., Biolo, G., Zanetti, M., Guadagni, M., Zaccari, M., Chiuch, M., Vanoli, M., Grignani, G., Pulixi, E. A., Bernardi, M., Bassi, S. L., Santi, L., Zaccherini, G., Lupattelli, G., Mannarino, E., Bianconi, V., Paciullo, F., Alcidi, R., Nuti, R., Valenti, R., Ruvio, M., Cappelli, S., Palazzuoli, A., Girelli, D., Busti, F., Marchi, G., Barbagallo, M., Dominguez, L., Cocita, F., Beneduce, V., Plances, L., Mularo, S., Raspanti, M., Cavallaro, F., Zoli, M., Lazzari, I., Brunori, M., Fabbri, E., Magalotti, D., Arno, R., Pasini, F. L., Capecchi, P. L., Palasciano, G., Modeo, M. E., Di Gennaro, C., Cappellini, M. D., Maira, D., Di Stefano, V., Fabio, G., Seghezzi, S., Mancarella, M., De Amicis, M. M., De Luca, G., Scaramellini, N., Rossi, P. D., Damanti, S., Clerici, M., Conti, F., Bonini, G., Ottolini, B. B., Di Sabatino, A., Miceli, E., Lenti, M. V., Pisati, M., Dominioni, C. C., Murialdo, G., Marra, A., Cattaneo, F., Pontremoli, R., Beccati, V., Nobili, G., Secchi, M. B., Ghelfi, D., Anastasio, L., Sofia, L., Carbone, M., Cipollone, F., Guagnano, M. T., Valeriani, E., Rossi, I., Mancuso, G., Calipari, D., Bartone, M., Delitala, G., Berria, M., Pes, C., Delitala, A., Muscaritoli, M., Molfino, A., Petrillo, E., Zuccala, G., D'Aurizio, G., Romanelli, G., Zucchelli, A., Manzoni, F., Volpini, A., Picardi, A., Gentilucci, U. V., Gallo, P., Dell'Unto, C., Annoni, G., Corsi, M., Bellelli, G., Zazzetta, S., Mazzola, P., Szabo, H., Bonfanti, A., Arturi, F., Succurro, E., Rubino, M., Tassone, B., Sesti, G., Serra, M. G., Bleve, M. A., Gasbarrone, L., Sajeva, M. R., Brucato, A., Ghidoni, S., Fabris, F., Bertozzi, I., Bogoni, G., Rabuini, M. V., Cosi, E., Scarinzi, P., Amabile, A., Omenetto, E., Prandini, T., Manfredini, R., Fabbian, F., Boari, B., De Giorgi, A., Tiseo, R., De Giorgio, R., Paolisso, G., Rizzo, M. R., Borghi, C., Strocchi, E., Ianniello, E., Soldati, M., Sabba, C., Vella, F. S., Suppressa, P., Schilardi, A., Loparco, F., De Vincenzo, G. M., Comitangelo, A., Amoruso, E., Fenoglio, L., Falcetta, A., Bracco, C., Fracanzani Silvia Fargion, A. L., Tiraboschi, S., Cespiati, A., Oberti, G., Sigon, G., Peyvandi, F., Rossio, R., Ferrari, B., Colombo, G., Agosti, P., Monzani, V., Savojardo, V., Folli, C., Ceriani, G., Pallini, G., Dallegri, F., Ottonello, L., Liberale, L., Caserza, L., Salam, K., Liberato, N. L., Tognin, T., Bianchi, G. B., Giaquinto, S., Purrello, F., Di Pino, A., Piro, S., Rozzini, R., Falanga, L., Spazzini, E., Ferrandina, C., Montrucchio, G., Petitti, P., Peasso, P., Favale, E., Poletto, C., Salmi, R., Gaudenzi, P., Perri, L., Landolfi, R., Montalto, M., Mirijello, A., Guasti, L., Castiglioni, L., Maresca, A., Squizzato, A., Campiotti, L., Grossi, A., Bertolotti, M., Mussi, C., Lancellotti, G., Libbra, M. V., Dondi, G., Pellegrini, E., Carulli, L., Galassi, M., Grassi, Y., Perticone, M., Battaglia, R., Filice, M., Maio, R., Stanghellini, V., Ruggeri, E., del Vecchio, S., Salvi, A., Leonardi, R., Damiani, G., Capeci, W., Gabrielli, A., Mattioli, M., Martino, G. P., Biondi, L., Pettinari, P., Ghio, R., Col, A. D., Minisola, S., Colangelo, L., Cilli, M., Labbadia, G., Afeltra, A., Marigliano, B., Pipita, M. E., Castellino, P., Zanoli, L., Pignataro, S., Gennaro, A., Blanco, J., Saracco, V., Fogliati, M., Bussolino, C., Mete, F., Gino, M., Cittadini, A., Vigorito, C., Arcopinto, M., Salzano, A., Bobbio, E., Marra, A. M., Sirico, D., Moreo, G., Gasparini, F., Prolo, S., Pina, G., Ballestrero, A., Ferrando, F., Berra, S., Dassi, S., Nava, M. C., Graziella, B., Baldassarre, S., Fragapani, S., Gruden, G., Galanti, G., Mascherini, G., Petri, C., Stefani, L., Girino, M., Piccinelli, V., Nasso, F., Gioffre, V., Pasquale, M., Scattolin, G., Martinelli, S., Turrin, M., Sechi, L., Catena, C., Colussi, G., Passariello, N., Rinaldi, L., Berti, F., Famularo, G., Tarsitani, P., Castello, R., Pasino, M., Ceda, G. P., Maggio, M. G., Morganti, S., Artoni, A., Del Giacco, S., Firinu, D., Losa, F., Paoletti, G., Costanzo, G., Montalto, G., Licata, A., Malerba, V., Montalto, F. A., Lasco, A., Basile, G., Catalano, A., Malatino, L., Stancanelli, B., Terranova, V., Di Marca, S., Di Quattro, R., La Malfa, L., Caruso, R., Mecocci, P., Ruggiero, C., Boccardi, V., Meschi, T., Lauretani, F., Ticinesi, A., Nouvenne, A., Minuz, P., Fondrieschi, L., Pirisi, M., Fra, G. P., Sola, D., Porta, M., Riva, P., Quadri, R., Larovere, E., Novelli, M., Scanzi, G., Mengoli, C., Provini, S., Ricevuti, L., Simeone, E., Scurti, R., Tolloso, F., Tarquini, R., Valoriani, A., Dolenti, S., Vannini, G., Tedeschi, A., Trotta, L., Volpi, R., Bocchi, P., Vignali, A., Harari, S., Lonati, C., Cattaneo, M., Napoli, F., Argano, C, Scichilone, N, Natoli, G, Nobili, A, Corazza, G, Mannucci, P, Perticone, F, Corrao, S, Pietrangelo, A, Licata, G, Violi, F, Marengoni, A, Salerno, F, Cesari, M, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Cortesi, L, Ardoino, I, Novella, A, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Caterina, C, Biolo, G, Zanetti, M, Guadagni, M, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Lupattelli, G, Mannarino, E, Bianconi, V, Paciullo, F, Alcidi, R, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Cocita, F, Beneduce, V, Plances, L, Mularo, S, Raspanti, M, Cavallaro, F, Zoli, M, Lazzari, I, Brunori, M, Fabbri, E, Magalotti, D, Arno, R, Pasini, F, Capecchi, P, Palasciano, G, Modeo, M, Di Gennaro, C, Cappellini, M, Maira, D, Di Stefano, V, Fabio, G, Seghezzi, S, Mancarella, M, De Amicis, M, De Luca, G, Scaramellini, N, Rossi, P, Damanti, S, Clerici, M, Conti, F, Bonini, G, Ottolini, B, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Dominioni, C, Murialdo, G, Marra, A, Cattaneo, F, Pontremoli, R, Beccati, V, Nobili, G, Secchi, M, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Valeriani, E, Rossi, I, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Pes, C, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Zuccala, G, D'Aurizio, G, Romanelli, G, Zucchelli, A, Manzoni, F, Volpini, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Annoni, G, Corsi, M, Bellelli, G, Zazzetta, S, Mazzola, P, Szabo, H, Bonfanti, A, Arturi, F, Succurro, E, Rubino, M, Tassone, B, Sesti, G, Serra, M, Bleve, M, Gasbarrone, L, Sajeva, M, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Cosi, E, Scarinzi, P, Amabile, A, Omenetto, E, Prandini, T, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, De Giorgio, R, Paolisso, G, Rizzo, M, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Sabba, C, Vella, F, Suppressa, P, Schilardi, A, Loparco, F, De Vincenzo, G, Comitangelo, A, Amoruso, E, Fenoglio, L, Falcetta, A, Bracco, C, Fracanzani Silvia Fargion, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Agosti, P, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, N, Tognin, T, Bianchi, G, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Peasso, P, Favale, E, Poletto, C, Salmi, R, Gaudenzi, P, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Dondi, G, Pellegrini, E, Carulli, L, Galassi, M, Grassi, Y, Perticone, M, Battaglia, R, Filice, M, Maio, R, Stanghellini, V, Ruggeri, E, del Vecchio, S, Salvi, A, Leonardi, R, Damiani, G, Capeci, W, Gabrielli, A, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ghio, R, Col, A, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Pignataro, S, Gennaro, A, Blanco, J, Saracco, V, Fogliati, M, Bussolino, C, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Sirico, D, Moreo, G, Gasparini, F, Prolo, S, Pina, G, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, M, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffre, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Ceda, G, Maggio, M, Morganti, S, Artoni, A, Del Giacco, S, Firinu, D, Losa, F, Paoletti, G, Costanzo, G, Montalto, G, Licata, A, Malerba, V, Montalto, F, Lasco, A, Basile, G, Catalano, A, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, G, Sola, D, Porta, M, Riva, P, Quadri, R, Larovere, E, Novelli, M, Scanzi, G, Mengoli, C, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Napoli, F, Argano C., Scichilone N., Natoli G., Nobili A., Corazza G.R., Mannucci P.M., Perticone F., Corrao S., Pietrangelo A., Licata G., Violi F., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Miglio G., Cortesi L., Ardoino I., Novella A., Prisco D., Silvestri E., Emmi G., Bettiol A., Caterina C., Biolo G., Zanetti M., Guadagni M., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E.A., Bernardi M., Bassi S.L., Santi L., Zaccherini G., Lupattelli G., Mannarino E., Bianconi V., Paciullo F., Alcidi R., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Cocita F., Beneduce V., Plances L., Mularo S., Raspanti M., Cavallaro F., Zoli M., Lazzari I., Brunori M., Fabbri E., Magalotti D., Arno R., Pasini F.L., Capecchi P.L., Palasciano G., Modeo M.E., Di Gennaro C., Cappellini M.D., Maira D., Di Stefano V., Fabio G., Seghezzi S., Mancarella M., De Amicis M.M., De Luca G., Scaramellini N., Rossi P.D., Damanti S., Clerici M., Conti F., Bonini G., Ottolini B.B., Di Sabatino A., Miceli E., Lenti M.V., Pisati M., Dominioni C.C., Murialdo G., Marra A., Cattaneo F., Pontremoli R., Beccati V., Nobili G., Secchi M.B., Ghelfi D., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M.T., Valeriani E., Rossi I., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Pes C., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Zuccala G., D'Aurizio G., Romanelli G., Zucchelli A., Manzoni F., Volpini A., Picardi A., Gentilucci U.V., Gallo P., Dell'Unto C., Annoni G., Corsi M., Bellelli G., Zazzetta S., Mazzola P., Szabo H., Bonfanti A., Arturi F., Succurro E., Rubino M., Tassone B., Sesti G., Serra M.G., Bleve M.A., Gasbarrone L., Sajeva M.R., Brucato A., Ghidoni S., Fabris F., Bertozzi I., Bogoni G., Rabuini M.V., Cosi E., Scarinzi P., Amabile A., Omenetto E., Prandini T., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., De Giorgio R., Paolisso G., Rizzo M.R., Borghi C., Strocchi E., Ianniello E., Soldati M., Sabba C., Vella F.S., Suppressa P., Schilardi A., Loparco F., De Vincenzo G.M., Comitangelo A., Amoruso E., Fenoglio L., Falcetta A., Bracco C., Fracanzani Silvia Fargion A.L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Peyvandi F., Rossio R., Ferrari B., Colombo G., Agosti P., Monzani V., Savojardo V., Folli C., Ceriani G., Pallini G., Dallegri F., Ottonello L., Liberale L., Caserza L., Salam K., Liberato N.L., Tognin T., Bianchi G.B., Giaquinto S., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Spazzini E., Ferrandina C., Montrucchio G., Petitti P., Peasso P., Favale E., Poletto C., Salmi R., Gaudenzi P., Perri L., Landolfi R., Montalto M., Mirijello A., Guasti L., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Bertolotti M., Mussi C., Lancellotti G., Libbra M.V., Dondi G., Pellegrini E., Carulli L., Galassi M., Grassi Y., Perticone M., Battaglia R., FIlice M., Maio R., Stanghellini V., Ruggeri E., del Vecchio S., Salvi A., Leonardi R., Damiani G., Capeci W., Gabrielli A., Mattioli M., Martino G.P., Biondi L., Pettinari P., Ghio R., Col A.D., Minisola S., Colangelo L., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M.E., Castellino P., Zanoli L., Pignataro S., Gennaro A., Blanco J., Saracco V., Fogliati M., Bussolino C., Mete F., Gino M., Cittadini A., Vigorito C., Arcopinto M., Salzano A., Bobbio E., Marra A.M., Sirico D., Moreo G., Gasparini F., Prolo S., Pina G., Ballestrero A., Ferrando F., Berra S., Dassi S., Nava M.C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Galanti G., Mascherini G., Petri C., Stefani L., Girino M., Piccinelli V., Nasso F., Gioffre V., Pasquale M., Scattolin G., Martinelli S., Turrin M., Sechi L., Catena C., Colussi G., Passariello N., Rinaldi L., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Ceda G.P., Maggio M.G., Morganti S., Artoni A., Del Giacco S., Firinu D., Losa F., Paoletti G., Costanzo G., Montalto G., Licata A., Malerba V., Montalto F.A., Lasco A., Basile G., Catalano A., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Lauretani F., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Pirisi M., Fra G.P., Sola D., Porta M., Riva P., Quadri R., Larovere E., Novelli M., Scanzi G., Mengoli C., Provini S., Ricevuti L., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Tedeschi A., Trotta L., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Cattaneo M., and Napoli F.
- Subjects
Male ,medicine.medical_specialty ,Chronic Obstructive ,Cirrhosis ,Socio-culturale ,Comorbidity ,030204 cardiovascular system & hematology ,comorbidities ,elderly ,Pulmonary Disease ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Internal medicine ,medicine ,80 and over ,COPD ,Humans ,030212 general & internal medicine ,LS4_4 ,Registries ,Hospital Mortality ,COPD, comorbidities, elderly, internal medicine, in-hospital mortality ,Depression (differential diagnoses) ,Cause of death ,Aged ,Retrospective Studies ,1-year mortality ,3-month mortality ,internal medicine ,in-hospital mortality ,Aged, 80 and over ,business.industry ,medicine.disease ,Im - Original ,Female ,Internal Medicine ,Clinical diagnosis ,Cohort ,Emergency Medicine ,1-year mortality, 3-month mortality, COPD, comorbidities, elderly, internal medicine, in-hospital mortality ,Observational study ,business ,1 year mortality - Abstract
Currently, chronic obstructive pulmonary disease (COPD) represents the fourth cause of death worldwide with significant economic burden. Comorbidities increase in number and severity with age and are identified as important determinants that influence the prognosis. In this observational study, we retrospectively analyzed data collected from the RePoSI register. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients with the clinical diagnosis of COPD. Socio-demographic, clinical characteristics and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up were analyzed. Among 4696 in-patients, 932 (19.8%) had a diagnosis of COPD. Patients with COPD had more hospitalization, a significant overt cognitive impairment, a clinically significant disability and more depression in comparison with non-COPD subjects. COPD patients took more drugs, both at admission, in-hospital stay, discharge and 3-month and 1-year follow-up. 14 comorbidities were more frequent in COPD patients. Cerebrovascular disease was an independent predictor of in-hospital mortality. At 3-month follow-up, male sex and hepatic cirrhosis were independently associated with mortality. ICS-LABA therapy was predictor of mortality at in-hospital, 3-month and 1-year follow-up. This analysis showed the severity of impact of COPD and its comorbidities in the real life of internal medicine and geriatric wards. Electronic supplementary material The online version of this article (10.1007/s11739-020-02412-1) contains supplementary material, which is available to authorized users.
- Published
- 2020
50. WED-320 - Real-word experience of long-term albumin treatment in a large cohort of patients with cirrhosis and ascites (Real-Answer study)
- Author
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Iannone, Giulia, De Venuto, Clara, Piano, Salvatore, Lombardo, Antonino, Bitetto, Davide, Gioia, Stefania, Zaccherini, Giacomo, gagliardi, roberta, Calvaruso, Vincenza, Pompili, Enrico, Tonon, Marta, Baldassarre, Maurizio, Nardelli, Silvia, Toniutto, Pierluigi, Di Marco, Vito, Angeli, Paolo, and Caraceni, Paolo
- Published
- 2023
- Full Text
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