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11 results on '"Zaccarini, Marco"'

2. JAK/STAT Inhibition Normalizes Lipid Composition in 3D Human Epidermal Equivalents Challenged with Th2 Cytokines.

Author

Flori, Enrica, Cavallo, Alessia, Mosca, Sarah, Kovacs, Daniela, Cota, Carlo, Zaccarini, Marco, Di Nardo, Anna, Bottillo, Grazia, Maiellaro, Miriam, Camera, Emanuela, and Cardinali, Giorgia

Subjects
METABOLIC regulation, CYTOKINES, LIPID metabolism, LIPIDS, FILAGGRIN, CARBONIC anhydrase
Abstract

Derangement of the epidermal barrier lipids and dysregulated immune responses are key pathogenic features of atopic dermatitis (AD). The Th2-type cytokines interleukin IL-4 and IL-13 play a prominent role in AD by activating the Janus Kinase/Signal Transduction and Activator of Transcription (JAK/STAT) intracellular signaling axis. This study aimed to investigate the role of JAK/STAT in the lipid perturbations induced by Th2 signaling in 3D epidermal equivalents. Tofacitinib, a low-molecular-mass JAK inhibitor, was used to screen for JAK/STAT-mediated deregulation of lipid metabolism. Th2 cytokines decreased the expression of elongases 1, 3, and 4 and serine-palmitoyl-transferase and increased that of sphingolipid delta(4)-desaturase and carbonic anhydrase 2. Th2 cytokines inhibited the synthesis of palmitoleic acid and caused depletion of triglycerides, in association with altered phosphatidylcholine profiles and fatty acid (FA) metabolism. Overall, the ceramide profiles were minimally affected. Except for most sphingolipids and very-long-chain FAs, the effects of Th2 on lipid pathways were reversed by co-treatment with tofacitinib. An increase in the mRNA levels of CPT1A and ACAT1, reduced by tofacitinib, suggests that Th2 cytokines promote FA beta-oxidation. In conclusion, pharmacological inhibition of JAK/STAT activation prevents the lipid disruption caused by the halted homeostasis of FA metabolism. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The Activation of PPARγ by (2Z,4E,6E)-2-methoxyocta-2,4,6-trienoic Acid Counteracts the Epithelial–Mesenchymal Transition Process in Skin Carcinogenesis

Author

Flori, Enrica, primary, Mosca, Sarah, additional, Cardinali, Giorgia, additional, Briganti, Stefania, additional, Ottaviani, Monica, additional, Kovacs, Daniela, additional, Manni, Isabella, additional, Truglio, Mauro, additional, Mastrofrancesco, Arianna, additional, Zaccarini, Marco, additional, Cota, Carlo, additional, Piaggio, Giulia, additional, and Picardo, Mauro, additional

Published
2023
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5. Altered epidermal proliferation, differentiation, and lipid composition: Novel key elements in the vitiligo puzzle

Author

Kovacs, Daniela, primary, Bastonini, Emanuela, additional, Briganti, Stefania, additional, Ottaviani, Monica, additional, D’Arino, Andrea, additional, Truglio, Mauro, additional, Sciuto, Lorenzo, additional, Zaccarini, Marco, additional, Pacifico, Alessia, additional, Cota, Carlo, additional, Iacovelli, Paolo, additional, and Picardo, Mauro, additional

Published
2022
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6. Sebocytes contribute to melasma onset

Author

Flori, Enrica, primary, Mastrofrancesco, Arianna, additional, Mosca, Sarah, additional, Ottaviani, Monica, additional, Briganti, Stefania, additional, Cardinali, Giorgia, additional, Filoni, Angela, additional, Cameli, Norma, additional, Zaccarini, Marco, additional, Zouboulis, Christos C., additional, and Picardo, Mauro, additional

Published
2022
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7. Bcl-2-like protein-10 increases aggressive features of melanoma cells

Author

Del Bufalo, Donatella, primary, Di Martile, Marta, additional, Valentini, Elisabetta, additional, Manni, Isabella, additional, Masi, Ilenia, additional, D'Amore, Antonella, additional, Filippini, Antonio, additional, Nicoletti, Carmine, additional, Zaccarini, Marco, additional, Cota, Carlo, additional, Castro, Maria Victoria, additional, Quezada, María Josefina, additional, Rosanò, Laura, additional, Lopez-Bergami, Pablo, additional, and D'Aguanno, Simona, additional

Published
2022
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8. Anti-Inflammatory and Pro-Differentiating Properties of the Aryl Hydrocarbon Receptor Ligands NPD-0614-13 and NPD-0614-24: Potential Therapeutic Benefits in Psoriasis

Author

Cardinali, Giorgia, primary, Flori, Enrica, additional, Mastrofrancesco, Arianna, additional, Mosca, Sarah, additional, Ottaviani, Monica, additional, Dell’Anna, Maria Lucia, additional, Truglio, Mauro, additional, Vento, Antonella, additional, Zaccarini, Marco, additional, Zouboulis, Christos C., additional, and Picardo, Mauro, additional

Published
2021
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