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2. MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis

Author

Zhao, Helong, Pomicter, Anthony D., Eiring, Anna M., Franzini, Anca, Ahmann, Jonathan, Hwang, Jae-Yeon, Senina, Anna, Helton, Bret, Iyer, Siddharth, Yan, Dongqing, Khorashad, Jamshid S., Zabriskie, Matthew S., Agarwal, Anupriya, Redwine, Hannah M., Bowler, Amber D., Clair, Phillip M., McWeeney, Shannon K., Druker, Brian J., Tyner, Jeffrey W., Stirewalt, Derek L., Oehler, Vivian G., Varambally, Sooryanarayana, Berrett, Kristofer C., Vahrenkamp, Jeffery M., Gertz, Jason, Varley, Katherine E., Radich, Jerald P., and Deininger, Michael W.

Published
2022
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4. Supplementary Figures from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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5. Supplementary Table 1 from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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6. Supplementary Table 8 from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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7. Supplementary Table 5 from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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8. Supplementary Table 3 from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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9. Supplementary Table 7 from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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10. Data from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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11. Supplementary Table 6 from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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12. Supplementary Table 4 from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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13. Supplementary Table 2 from SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, primary, Pomicter, Anthony D., primary, Halverson, Brayden J., primary, Antelope, Orlando, primary, Mason, Clinton C., primary, Ahmann, Jonathan M., primary, Senina, Anna V., primary, Vellore, Nadeem A., primary, Jones, Courtney L., primary, Zabriskie, Matthew S., primary, Than, Hein, primary, Xiao, Michael J., primary, van Scoyk, Alexandria, primary, Patel, Ami B., primary, Clair, Phillip M., primary, Heaton, William L., primary, Owen, Shawn C., primary, Andersen, Joshua L., primary, Egbert, Christina M., primary, Reisz, Julie A., primary, D'Alessandro, Angelo, primary, Cox, James E., primary, Gantz, Kevin C., primary, Redwine, Hannah M., primary, Iyer, Siddharth M., primary, Khorashad, Jamshid S., primary, Rajabi, Nima, primary, Olsen, Christian A., primary, O'Hare, Thomas, primary, and Deininger, Michael W., primary

Published
2023
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14. Supplementary Figure S1 from A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer

Author

Drilon, Alexander, primary, Somwar, Romel, primary, Wagner, Jacob P., primary, Vellore, Nadeem A., primary, Eide, Christopher A., primary, Zabriskie, Matthew S., primary, Arcila, Maria E., primary, Hechtman, Jaclyn F., primary, Wang, Lu, primary, Smith, Roger S., primary, Kris, Mark G., primary, Riely, Gregory J., primary, Druker, Brian J., primary, O'Hare, Thomas, primary, Ladanyi, Marc, primary, and Davare, Monika A., primary

Published
2023
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15. Supplementary Figure Legends and Tables from A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer

Author

Drilon, Alexander, primary, Somwar, Romel, primary, Wagner, Jacob P., primary, Vellore, Nadeem A., primary, Eide, Christopher A., primary, Zabriskie, Matthew S., primary, Arcila, Maria E., primary, Hechtman, Jaclyn F., primary, Wang, Lu, primary, Smith, Roger S., primary, Kris, Mark G., primary, Riely, Gregory J., primary, Druker, Brian J., primary, O'Hare, Thomas, primary, Ladanyi, Marc, primary, and Davare, Monika A., primary

Published
2023
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16. Data from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis

Author

O'Hare, Thomas, primary, Eide, Christopher A., primary, Agarwal, Anupriya, primary, Adrian, Lauren T., primary, Zabriskie, Matthew S., primary, MacKenzie, Ryan J., primary, LaTocha, Dorian H., primary, Johnson, Kara J., primary, You, Huihong, primary, Luo, Jenny, primary, Riddle, Steven M., primary, Marks, Bryan D., primary, Vogel, Kurt W., primary, Koop, Dennis R., primary, Apgar, John, primary, Tyner, Jeffrey W., primary, Deininger, Michael W., primary, and Druker, Brian J., primary

Published
2023
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17. Supplementary Methods from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis

Author

O'Hare, Thomas, primary, Eide, Christopher A., primary, Agarwal, Anupriya, primary, Adrian, Lauren T., primary, Zabriskie, Matthew S., primary, MacKenzie, Ryan J., primary, LaTocha, Dorian H., primary, Johnson, Kara J., primary, You, Huihong, primary, Luo, Jenny, primary, Riddle, Steven M., primary, Marks, Bryan D., primary, Vogel, Kurt W., primary, Koop, Dennis R., primary, Apgar, John, primary, Tyner, Jeffrey W., primary, Deininger, Michael W., primary, and Druker, Brian J., primary

Published
2023
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18. Supplementary Figures 1 - 6 from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis

Author

O'Hare, Thomas, primary, Eide, Christopher A., primary, Agarwal, Anupriya, primary, Adrian, Lauren T., primary, Zabriskie, Matthew S., primary, MacKenzie, Ryan J., primary, LaTocha, Dorian H., primary, Johnson, Kara J., primary, You, Huihong, primary, Luo, Jenny, primary, Riddle, Steven M., primary, Marks, Bryan D., primary, Vogel, Kurt W., primary, Koop, Dennis R., primary, Apgar, John, primary, Tyner, Jeffrey W., primary, Deininger, Michael W., primary, and Druker, Brian J., primary

Published
2023
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19. Supplementary Figure Legend from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis

Author

O'Hare, Thomas, primary, Eide, Christopher A., primary, Agarwal, Anupriya, primary, Adrian, Lauren T., primary, Zabriskie, Matthew S., primary, MacKenzie, Ryan J., primary, LaTocha, Dorian H., primary, Johnson, Kara J., primary, You, Huihong, primary, Luo, Jenny, primary, Riddle, Steven M., primary, Marks, Bryan D., primary, Vogel, Kurt W., primary, Koop, Dennis R., primary, Apgar, John, primary, Tyner, Jeffrey W., primary, Deininger, Michael W., primary, and Druker, Brian J., primary

Published
2023
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20. Supplementary Tables 1 - 2 from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis

Author

O'Hare, Thomas, primary, Eide, Christopher A., primary, Agarwal, Anupriya, primary, Adrian, Lauren T., primary, Zabriskie, Matthew S., primary, MacKenzie, Ryan J., primary, LaTocha, Dorian H., primary, Johnson, Kara J., primary, You, Huihong, primary, Luo, Jenny, primary, Riddle, Steven M., primary, Marks, Bryan D., primary, Vogel, Kurt W., primary, Koop, Dennis R., primary, Apgar, John, primary, Tyner, Jeffrey W., primary, Deininger, Michael W., primary, and Druker, Brian J., primary

Published
2023
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22. shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance

Author

Khorashad, Jamshid S., Eiring, Anna M., Mason, Clinton C., Gantz, Kevin C., Bowler, Amber D., Redwine, Hannah M., Yu, Fan, Kraft, Ira L., Pomicter, Anthony D., Reynolds, Kimberly R., Iovino, Anthony J., Zabriskie, Matthew S., Heaton, William L., Tantravahi, Srinivas K., Kauffman, Michael, Shacham, Sharon, Chenchik, Alex, Bonneau, Kyle, Ullman, Katharine S., O'Hare, Thomas, and Deininger, Michael W.

Published
2015
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24. BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia

Author

Zabriskie, Matthew S., Eide, Christopher A., Tantravahi, Srinivas K., Vellore, Nadeem A., Estrada, Johanna, Nicolini, Franck E., Khoury, Hanna J., Larson, Richard A., Konopleva, Marina, Cortes, Jorge E., Kantarjian, Hagop, Jabbour, Elias J., Kornblau, Steven M., Lipton, Jeffrey H., Rea, Delphine, Stenke, Leif, Barbany, Gisela, Lange, Thoralf, Hernández-Boluda, Juan-Carlos, Ossenkoppele, Gert J., Press, Richard D., Chuah, Charles, Goldberg, Stuart L., Wetzler, Meir, Mahon, Francois-Xavier, Etienne, Gabriel, Baccarani, Michele, Soverini, Simona, Rosti, Gianantonio, Rousselot, Philippe, Friedman, Ran, Deininger, Marie, Reynolds, Kimberly R., Heaton, William L., Eiring, Anna M., Pomicter, Anthony D., Khorashad, Jamshid S., Kelley, Todd W., Baron, Riccardo, Druker, Brian J., Deininger, Michael W., and O’Hare, Thomas

Published
2014
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25. BCR-ABL1 compound mutations in tyrosine kinase inhibitor–resistant CML: frequency and clonal relationships

Author

Khorashad, Jamshid S., Kelley, Todd W., Szankasi, Philippe, Mason, Clinton C., Soverini, Simona, Adrian, Lauren T., Eide, Christopher A., Zabriskie, Matthew S., Lange, Thoralf, Estrada, Johanna C., Pomicter, Anthony D., Eiring, Anna M., Kraft, Ira L., Anderson, David J., Gu, Zhimin, Alikian, Mary, Reid, Alistair G., Foroni, Letizia, Marin, David, Druker, Brian J., O'Hare, Thomas, and Deininger, Michael W.

Published
2013
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26. Spatially resolved transcriptomics for evaluation of intracranial vessels in a rabbit model: Proof of concept.

Author

Zabriskie, Matthew S., Cooke, Daniel L., Wang, Chuanzhuo, and Alexander, Matthew D.

Subjects
*PROOF of concept, *GENE expression, *K-means clustering, *RABBITS, *CEREBROVASCULAR disease
Abstract

Background: Better understanding of vessel biology and vascular pathophysiology is needed to improve understanding of cerebrovascular disorders. Tissue from diseased vessels can offer the best data. Rabbit models can be effective for studying intracranial vessels, filling gaps resulting from difficulties acquiring human tissue. Spatially-resolved transcriptomics (SRT) in particular hold promise for studying such models as they build on RNA sequencing methods, augmenting such data with histopathology. Methods: Rabbit brains with intact arteries were flash frozen, cryosectioned, and stained with H&E to confirm adequate inclusion of intracranial vessels before proceeding with tissue optimization and gene expression analysis using the Visium SRT platform. SRT results were analyzed with k-means clustering analysis, and differential gene expression was examined, comparing arteries to veins. Results: Cryosections were successfully mounted on Visium proprietary slides. Quality control thresholds were met. Optimum permeabilization was determined to be 24 min for the tissue optimization step. In analysis of SRT data, k-means clustering distinguished vascular tissue from parenchyma. When comparing gene expression traits, the most differentially expressed genes were those found in smooth muscle cells. These genes were more commonly expressed in arteries compared to veins. Conclusions: Intracranial vessels from model rabbits can be processed and analyzed with the Visium SRT platform. Face validity is found in the ability of SRT data to distinguish vessels from parenchymal tissue and differential expression analysis accurately distinguishing arteries from veins. SRT should be considered for future animal model investigations into cerebrovascular diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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31. MS4A3 Promotes Differentiation in Chronic Myeloid Leukemia By Enhancing Common β Chain Cytokine Receptor Endocytosis

Author

Zhao, Helong, primary, Pomicter, Anthony D., additional, Eiring, Anna M., additional, Franzini, Anca, additional, Ahmann, Jonathan, additional, Hwang, Jae-Yeon, additional, Senina, Anna V., additional, Helton, Bret, additional, Iyer, Siddharth, additional, Yan, Dongqing, additional, Khorashad, Jamshid, additional, Zabriskie, Matthew S., additional, Agarwal, Anupriya, additional, Redwine, Hannah M, additional, Bowler, Amber D., additional, Clair, Phillip M., additional, McWeeney, Shannon K., additional, Druker, Brian J., additional, Tyner, Jeffrey W., additional, Stirewalt, Derek, additional, Oehler, Vivian G., additional, Varambally, Sooryanarayana, additional, Berrett, Kristofer, additional, Vahrenkamp, Jeffrey, additional, Gertz, Jason, additional, Varley, Katherine, additional, Radich, Jerald P., additional, and Deininger, Michael W., additional

Published
2021
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32. Abstract LB109: A critical role for SIRT5 in acute myeloid leukemia metabolism

Author

Yan, Dongqing, primary, Franzini, Anca, additional, Pomicter, Anthony D., additional, Halverson, Brayden J., additional, Antelope, Orlando, additional, Mason, Clinton C., additional, Ahmann, Jonathan M., additional, Senina, Anna V., additional, Jones, Courtney L. L., additional, Zabriskie, Matthew S., additional, Than, Hein, additional, Xiao, Michael J., additional, van Scoyk, Alexandria, additional, Patel, Ami B., additional, Heaton, William L. L., additional, Owen, Shawn C., additional, Andersen, Joshua L., additional, Egbert, Christina M., additional, Reisz, Julie A., additional, D'Alessandro, Angelo, additional, Cox, James E., additional, Gantz, Kevin C., additional, Redwine, Hannah M., additional, Iyer, Siddharth M., additional, Khorashad, Jamshid S., additional, Rajabi, Nima, additional, Olsen, Christian A., additional, O'Hare, Thomas, additional, and Deininger, Michael W., additional

Published
2021
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33. SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D., Halverson, Brayden J., Antelope, Orlando, Mason, Clinton C., Ahmann, Jonathan M., Senina, Anna V., Vellore, Nadeem A., Jones, Courtney L., Zabriskie, Matthew S., Than, Hein, Xiao, Michael J., van Scoyk, Alexandria, Patel, Ami B., Clair, Phillip M., Heaton, William L., Owen, Shawn C., Andersen, Joshua L., Egbert, Christina M., Reisz, Julie A., D'Alessandro, Angelo, Cox, James E., Gantz, Kevin C., Redwine, Hannah M., Iyer, Siddharth M., Khorashad, Jamshid S., Rajabi, Nima, Olsen, Christian A., O'Hare, Thomas, Deininger, Michael W., Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D., Halverson, Brayden J., Antelope, Orlando, Mason, Clinton C., Ahmann, Jonathan M., Senina, Anna V., Vellore, Nadeem A., Jones, Courtney L., Zabriskie, Matthew S., Than, Hein, Xiao, Michael J., van Scoyk, Alexandria, Patel, Ami B., Clair, Phillip M., Heaton, William L., Owen, Shawn C., Andersen, Joshua L., Egbert, Christina M., Reisz, Julie A., D'Alessandro, Angelo, Cox, James E., Gantz, Kevin C., Redwine, Hannah M., Iyer, Siddharth M., Khorashad, Jamshid S., Rajabi, Nima, Olsen, Christian A., O'Hare, Thomas, and Deininger, Michael W.

Abstract

We discovered that the survival and growth of many primary acute myeloid leukemia (AML) samples and cell lines, but not normal CD34+ cells, are dependent on SIRT5, a lysine deacylase implicated in regulating multiple metabolic pathways. Dependence on SIRT5 is genotype agnostic and extends to RAS- and p53-mutated AML. Results were comparable between SIRT5 knockdown and SIRT5 inhibition using NRD167, a potent and selective SIRT5 inhibitor. Apoptosis induced by SIRT5 disruption is preceded by reductions in oxidative phosphorylation and glutamine utilization, and an increase in mitochondrial superoxide that is attenuated by ectopic superoxide dismutase 2. These data indicate that SIRT5 controls and coordinates several key metabolic pathways in AML and implicate SIRT5 as a vulnerability in AML. SIGNIFICANCE: Reducing SIRT5 activity is detrimental to the survival of AML cells regardless of genotype, yet well tolerated by healthy hematopoietic cells. In mouse models, disrupting SIRT5 inhibits AML progression. SIRT5 controls several metabolic pathways that are required for leukemia cell survival. These results identify SIRT5 as a therapeutic target in AML.See related commentary by Li and Melnick, p. 198.

Published
2021

34. SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Author

Yan, Dongqing, primary, Franzini, Anca, additional, Pomicter, Anthony D., additional, Halverson, Brayden J., additional, Antelope, Orlando, additional, Mason, Clinton C., additional, Ahmann, Jonathan M., additional, Senina, Anna V., additional, Vellore, Nadeem A., additional, Jones, Courtney L., additional, Zabriskie, Matthew S., additional, Than, Hein, additional, Xiao, Michael J., additional, van Scoyk, Alexandria, additional, Patel, Ami B., additional, Clair, Phillip M., additional, Heaton, William L., additional, Owen, Shawn C., additional, Andersen, Joshua L., additional, Egbert, Christina M., additional, Reisz, Julie A., additional, D'Alessandro, Angelo, additional, Cox, James E., additional, Gantz, Kevin C., additional, Redwine, Hannah M., additional, Iyer, Siddharth M., additional, Khorashad, Jamshid S., additional, Rajabi, Nima, additional, Olsen, Christian A., additional, O'Hare, Thomas, additional, and Deininger, Michael W., additional

Published
2021
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37. sj-pdf-1-neu-10.1177_1971400920980153 - Supplemental material for Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI

Author

J Scott McNally, Havenon, Adam De, Kim, Seong-Eun, Chuanzhuo Wang, Shuping Wang, Zabriskie, Matthew S, Parker, Dennis L, Hediyeh Baradaran, and Alexander, Matthew D

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-neu-10.1177_1971400920980153 for Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI by J Scott McNally, Adam de Havenon, Seong-Eun Kim, Chuanzhuo Wang, Shuping Wang, Matthew S Zabriskie, Dennis L Parker, Hediyeh Baradaran and Matthew D Alexander in The Neuroradiology Journal

Published
2020
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38. Combining the Allosteric ABL1 Inhibitor Asciminib (ABL001) with Ponatinib Suppresses Emergence of and Restores Efficacy Against Highly Resistant BCR-ABL1 Compound Mutants

Author

Eide, Christopher A., primary, Zabriskie, Matthew S., primary, Savage, Samantha L., primary, Antelope, Orlando, primary, Vellore, Nadeem A., primary, Than, Hein, primary, Reister Schultz, Anna, primary, Clair, Phillip M., primary, Bowler, Amber D., primary, Pomicter, Anthony D., primary, Yan, Dongqing, primary, Senina, Anna V., primary, Wang, Qiang, primary, Kelley, Todd W., primary, Szankasi, Philippe, primary, Heinrich, Michael C., primary, Tyner, Jeffrey W., primary, Rea, Delphine, primary, Cayuela, Jean-Michel, primary, Kim, Dong-Wook, primary, Tognon, Cristina E., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Deininger, Michael W., primary

Published
2019
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39. Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants

Author

Eide, Christopher A., primary, Zabriskie, Matthew S., additional, Savage Stevens, Samantha L., additional, Antelope, Orlando, additional, Vellore, Nadeem A., additional, Than, Hein, additional, Schultz, Anna Reister, additional, Clair, Phillip, additional, Bowler, Amber D., additional, Pomicter, Anthony D., additional, Yan, Dongqing, additional, Senina, Anna V., additional, Qiang, Wang, additional, Kelley, Todd W., additional, Szankasi, Philippe, additional, Heinrich, Michael C., additional, Tyner, Jeffrey W., additional, Rea, Delphine, additional, Cayuela, Jean-Michel, additional, Kim, Dong-Wook, additional, Tognon, Cristina E., additional, O'Hare, Thomas, additional, Druker, Brian J., additional, and Deininger, Michael W., additional

Published
2019
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40. Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI.

Author

McNally, J Scott, Havenon, Adam de, Kim, Seong-Eun, Wang, Chuanzhuo, Wang, Shuping, Zabriskie, Matthew S, Parker, Dennis L, Baradaran, Hediyeh, and Alexander, Matthew D

Abstract

Introduction: Vessel wall magnetic resonance imaging can improve the evaluation of intracranial atherosclerotic disease. However, pathological validation is needed to improve vessel wall magnetic resonance imaging techniques. Human pathology samples are not practical for such analysis, so an animal model is therefore needed. Materials and methods: Watanabe heritable hyperlipidemic rabbits and apolipoprotein E knockout rabbits were evaluated against New Zealand white wild-type rabbits. Evaluation of intracranial arteries was performed with vessel wall magnetic resonance imaging and pathological analysis, rating the presence and severity of disease in each segment. Two-tailed t -tests were performed to compare disease occurrence and severity prevalence among rabbit subtypes. Sensitivity and specificity were calculated to assess the diagnostic accuracy of vessel wall magnetic resonance imaging. Results: Seventeen rabbits (five Watanabe heritable hyperlipidemic, four apolipoprotein E knockout and eight New Zealand white) were analysed for a total of 51 artery segments. Eleven segments (five Watanabe heritable hyperlipidemic and six apolipoprotein E knockout) demonstrated intracranial atherosclerotic disease on pathology. Disease model animals had lesions more frequently than New Zealand white animals (P <0.001). The sensitivity and specificity of vessel wall magnetic resonance imaging for the detection of intracranial atherosclerotic disease were 68.8% and 95.2%, respectively. When excluding mild cases to assess vessel wall magnetic resonance imaging accuracy for detecting moderate to severe intracranial atherosclerotic disease lesions, sensitivity improved to 100% with unchanged specificity. Conclusion: Intracranial atherosclerotic disease can be reliably produced and detected using 3T vessel wall magnetic resonance imaging-compatible Watanabe heritable hyperlipidemic and ApoE rabbit models. Further analysis is needed to characterize better the development and progression of the disease to correlate tissue-validated animal findings with those in human vessel wall magnetic resonance imaging studies. [ABSTRACT FROM AUTHOR]

Published
2021
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41. A novel AGGF1-PDGFRb fusion in pediatric T-cell acute lymphoblastic leukemia

Author

Zabriskie, Matthew S., primary, Antelope, Orlando, additional, Verma, Anupam R., additional, Draper, Lauren R., additional, Eide, Christopher A., additional, Pomicter, Anthony D., additional, Tran, Thai Hoa, additional, Druker, Brian J., additional, Tyner, Jeffrey W., additional, Miles, Rodney R., additional, Graham, James M., additional, Hwang, Jae-Yeon, additional, Varley, Katherine E., additional, Toydemir, Reha M., additional, Deininger, Michael W., additional, Raetz, Elizabeth A., additional, and O’Hare, Thomas, additional

Published
2017
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42. Characterization of the Genomic Landscape of BCR-ABL1 Kinase-Independent Mechanisms of Resistance to ABL1 Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

Author

Eide, Christopher A., primary, Bottomly, Daniel, additional, Savage, Samantha L., additional, White, Libbey, additional, Wilmot, Beth, additional, Reister Schultz, Anna M., additional, Uchida, Kimberly A., additional, Agarwal, Anupriya, additional, Traer, Elie, additional, Beppu, Lan, additional, Sala-Torra, Olga, additional, Radich, Jerald P., additional, Eickelberg, Garrett, additional, Press, Richard D., additional, Loriaux, Marc M., additional, Tantravahi, Srinivas K., additional, Pomicter, Anthony D., additional, Zabriskie, Matthew S., additional, Deininger, Michael W., additional, O'Hare, Thomas, additional, Tyner, Jeffrey W., additional, McWeeney, Shannon K., additional, Tognon, Cristina E., additional, and Druker, Brian J., additional

Published
2016
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43. A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer

Author

Drilon, Alexander, primary, Somwar, Romel, additional, Wagner, Jacob P., additional, Vellore, Nadeem A., additional, Eide, Christopher A., additional, Zabriskie, Matthew S., additional, Arcila, Maria E., additional, Hechtman, Jaclyn F., additional, Wang, Lu, additional, Smith, Roger S., additional, Kris, Mark G., additional, Riely, Gregory J., additional, Druker, Brian J., additional, O'Hare, Thomas, additional, Ladanyi, Marc, additional, and Davare, Monika A., additional

Published
2016
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46. Next Generation Sequencing to Delineate the Mutational Landscape of Chronic Myelomonocytic Leukemia (CMML): Novel Disease Genes and Correlations with Survival

Author

Mason, Clinton C., primary, Khorashad, Jamshid S., additional, Tantravahi, Srinivas K., additional, Kelley, Todd W., additional, Pomicter, Anthony D., additional, Iovino, Anthony J., additional, Reynolds, Kimberly R., additional, Eiring, Anna M., additional, Zabriskie, Matthew S., additional, Kronenberg, Zev, additional, Tyner, Jeffrey W., additional, Dalley, Brian, additional, Dao, Kim-Hien T., additional, O'Hare, Thomas, additional, Yandell, Mark, additional, Druker, Brian J., additional, Gotlib, Jason R., additional, and Deininger, Michael W., additional

Published
2014
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47. BP5-087, a Novel STAT3 Inhibitor, Combines With BCR-ABL1 Inhibition To Overcome Kinase-Independent Resistance In Chronic Myeloid Leukemia

Author

Eiring, Anna M., primary, Kraft, Ira L., additional, Page, Brent D.G., additional, Zhang, Tian Y., additional, Khorashad, Jamshid S., additional, Vellore, Nadeem A., additional, Reynolds, Kimberly R., additional, Pomicter, Anthony D., additional, Senina, Anna V., additional, Zabriskie, Matthew S., additional, Ahmad, Shazia, additional, Mason, Clinton C., additional, Moriggl, Richard, additional, Baron, Riccardo, additional, O'Hare, Thomas, additional, Gunning, Patrick T., additional, and Deininger, Michael W., additional

Published
2013
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48. An Unbiased shRNA Library Screen Identifies Nucleocytoplasmic Transport As a Potential Target For Treatment Of Chronic Myeloid Leukemia

Author

Khorashad, Jamshid Sorouri, primary, Mason, Clinton C., additional, Kraft, Ira L., additional, Reynolds, Kimberly R., additional, Pomicter, Anthony D., additional, Eiring, Anna M., additional, Zabriskie, Matthew S., additional, Iovino, Anthony J, additional, Heaton, William, additional, Tantravahi, Srinivas K., additional, Kauffman, Michael, additional, Schacham, Sharon, additional, Chenchik, Alex, additional, Bonneau, Kyle, additional, O'Hare, Thomas, additional, and Deininger, Michael W., additional

Published
2013
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49. Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis

Author

O'Hare, Thomas, primary, Eide, Christopher A., additional, Agarwal, Anupriya, additional, Adrian, Lauren T., additional, Zabriskie, Matthew S., additional, MacKenzie, Ryan J., additional, LaTocha, Dorian H., additional, Johnson, Kara J., additional, You, Huihong, additional, Luo, Jenny, additional, Riddle, Steven M., additional, Marks, Bryan D., additional, Vogel, Kurt W., additional, Koop, Dennis R., additional, Apgar, John, additional, Tyner, Jeffrey W., additional, Deininger, Michael W., additional, and Druker, Brian J., additional

Published
2013
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50. STAT3 Inhibition Synergizes with BCR-ABL1 Inhibition to Overcome Kinase-Independent TKI Resistance in Chronic Myeloid Leukemia (CML)

Author

Eiring, Anna M., primary, Kraft, Ira L, additional, Page, Brent DG, additional, Anderson, David J, additional, Gu, Zhimin, additional, Khorashad, Jamshid S, additional, Pomicter, Anthony D, additional, Reynolds, Kimberly R, additional, Zabriskie, Matthew S, additional, Moriggl, Richard, additional, Gunning, Patrick T, additional, O'Hare, Thomas, additional, and Deininger, Michael W, additional

Published
2012
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