159 results on '"ZHONGJING WANG"'
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2. Variations in soil microbial communities in different saline soils under typical Populus spp. vegetation in alpine region of the Qaidam Basin, NW China
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Zhenzhong Zhang, Zhongjing Wang, Tan Zhang, Baosi Yin, Runjie Li, Zhuping Sheng, and Shen Li
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Microbial community ,Microbial adaptation ,Soil salinity ,Qaidam basin ,16 S rRNA ,Poplars ,Environmental pollution ,TD172-193.5 ,Environmental sciences ,GE1-350 - Abstract
Salinization is a severe threat to agriculture and the environment in many areas, and the same in Qaidam Basin, Qinghai Province, Northwestern China. Microorganisms have an important influence on regulating the biochemical cycles of ecosystems; however, systematic research exploring microbial diversity and interactions with saline-soil ecosystems’ environmental variables remains scarce. Thus, 16 S rRNA high-throughput sequencing was performed in this paper to characterize microbial diversity under different levels of salinized soils: non-salinized (NS, 2.25 g/L), moderately salinized (MS, 6.14 g/L) and highly salinized (HS, 9.82 g/L). The alpha diversity results showed that the HS soil was significantly different from the NS and MS soils. An analysis of similarity (ANOSIM) and a principal co-ordinates analysis (PCoA) indicated that NS and MS clustered closely while HS separated from the other two. Significant differences in microbial composition were observed at the taxonomic level. Proteobacteria (42.29–79.23 %) were the most abundant phyla in the studied soils. Gammaproteobacteria (52.49 and 66.61 %) had higher abundance in the MS and HS soils at the class level; Methylophaga and Pseudomonas were the predominant bacteria in the HS soil; and Azotobacter and Methylobacillus were abundant in the MS soil. Most genera belonging to Proteobacteria and Actinobacteria were detected via a linear discriminate analysis (LDA) effect size (LEfSe) analysis, which indicated that microbes with the ability to degrade organic matter and accomplish nutrient cycling can be well-adapted to salt conditions. Further analyses (redundancy analysis and Mantel test) showed that the microbial communities were mainly related to the soil salinity, electrical conductivity (EC1:5), total phosphorus (TP) and ammonia nitrogen (NH4+-N). Overall, the findings of the study can provide insights for better understanding the dominant indigenous microbes and their roles in biochemical cycles in different saline soils in the Qaidam Basin, Qinghai Province, China. The researches related to microbial community under typical poplar species should further clarify the mechanism of plant-microbial interaction and benefit for microbial utilization in salt soil remediation.
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- 2024
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3. Neutrophil-to-lymphocyte ratio in type 2 diabetes patients combined with Lower Extremity Peripheral Artery Disease
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Li Li, Mengjie Wang, Ting Jia, Xiaowan Jiang, Fan Yang, Zhongjing Wang, and Xuyan Zhang
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type 2 diabetes mellitus ,lower extremity peripheral artery disease ,neutrophil-to-lymphocyte ratio ,angiography ,stenosis ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
ObjectiveThis study explored the utility of NLR (neutrophil-to-lymphocyte ratio) as a marker to predict Lower Extremity Peripheral Artery Disease (PAD) in the Chinese population, as well as to assess its consistency and diagnostic value with digital subtraction angiography.MethodsPatients were distributed into three groups according to the angiography in lower limb arterial: group L1, plaque with no stenosis; group L2, plaque with luminal stenosis and group L3, total vascular occlusion. Changes in the neutrophil-to-lymphocyte ratio were documented and compared among groups.ResultsCompared to group L1, NLR was significantly increased in L2 (1.76 vs 2.35, p=0.037) and L3 (1.76 vs 3.60, p70%) increased to 2.075 times for every 1 increase in NLR, while it was 46.8% for every 0.1 increase in ABI. The optimal NLR cut-off value to predict severe stenosis in PAD was 2.73. Receiver operating characteristic curve analysis of the inflammatory biomarkers and severe stenosis prediction displayed an area under the curve of 0.81.ConclusionNLR could serve as a new noninvasive and accurate marker in predicting PAD.
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- 2024
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4. Chinese carrier of the HNF1A p.Gln444fs variant exhibits enhanced response to sulfonylureas
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Xiufang Wang, Wenzhuo Cheng, Zhongjing Wang, Chao Liu, Aiping Deng, and Juyi Li
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HNF1A ,MODY3 ,Monogenic diabetes ,Precision therapy ,Whole-exome sequencing ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: We assessed the response to sulfonylureas and the functional characteristics of HNF1A mutations in patients with maturity-onset diabetes of the young type 3 (MODY3). Methods: We recruited a family with suspected MODY in this study, and gene sequencing (whole-exome sequencing) was used to screen germline mutations. Luciferase reporter assays were used to evaluate the activity of the mutated genes. Results: Heterozygous HNF1A variant (NM_000545.8:c.1330_1331del, p.Gln444fs) was identified in the proband and was not found in his father, grandmother, and nonrelated healthy controls. The mutant protein had 552 amino acids, 110 fewer than the wild type protein. Furthermore, the amino acid sequence was completely different between the mutant protein and the wild type protein starting from the 444th amino acid. Luciferase reporter assays revealed that the variant had impaired HNF4A promoter–regulation activity. The patient did not achieve good hypoglycemic effects during long-term treatment with insulin and metformin. The effect of hypoglycemic treatment was highly significant after the addition of sulfonylurea drugs. Conclusions: The HNF1A p.Gln444fs variant associated with MODY3, and most likely a truncated protein, impaired HNF1A transcriptional activity. The variant carrier experienced an enhanced response to sulfonylureas.
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- 2024
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5. Association between a high triglyceride–glucose index and chronic kidney disease in adult patients with latent autoimmune diabetes
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Xiuli Fu, Zihui Xu, Qin Tan, Wei Wei, and Zhongjing Wang
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Triglyceride–glucose index ,Latent autoimmune diabetes in adults ,Insulin resistance ,Chronic kidney disease ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Background Insulin resistance (IR) is one of the risk factors for chronic kidney disease (CKD) and diabetes. The triglyceride–glucose (TyG) index is considered a reliable alternative marker of IR. We investigated the correlation between the TyG index and the severity of CKD in patients with latent autoimmune diabetes in adults (LADA). Methods This cross-sectional study included 288 patients with LADA in the department of endocrinology at our hospital between January 2018 and January 2022. The TyG index was calculated as Ln [TG (mg/dl) × fasting blood glucose (FBG) (mg/dl) / 2]. All individuals were divided into either a LADA + CKD group or a LADA + non-CKD group according to the presence or absence of CKD. A correlation analysis, logistic regression analysis and receiver operating characteristics curve analysis were performed. Results A total of 130 (45.1%) participants were identified as having CKD. Compared with the non-CKD group, the CKD group had a longer disease duration and a higher proportion of smokers; patients were more likely to have hypertension and higher serum creatinine, triglyceride, cholesterol, low-density lipoprotein cholesterol, FBG, uric acid estimated glomerular filtration rates (eGFR) and TyG levels as well as lower high-density lipoprotein cholesterol levels (all P
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- 2023
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6. Exendin-4 ameliorates tau hyperphosphorylation and cognitive impairment in type 2 diabetes through acting on Wnt/β-catenin/NeuroD1 pathway
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Xiaonan Kang, Dan Wang, Lu Zhang, Teng Huang, Siyue Liu, Xiaohui Feng, Yaoyao Guo, Ziyin Zhang, Zhongjing Wang, Huihui Ren, and Gang Yuan
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Type 2 diabetes ,Cognitive impairment ,Tau hyperphosphorylation ,Glucagon-like peptide-1 receptor agonist ,Wnt/β-catenin pathway ,NeuroD1 ,Therapeutics. Pharmacology ,RM1-950 ,Biochemistry ,QD415-436 - Abstract
Abstract Background Type 2 diabetes (T2D) is an independent risk factor for Alzheimer's disease (AD). Exendin-4 (Ex-4), a widely used glucagon-like peptide-1 receptor agonist drug in the treatment of T2D, has been demonstrated the therapeutic effects on diabetic encephalopathy (DE). Especially, the Ex-4 ameliorates the tau hyperphosphorylation and cognitive impairment in DE. And these crucial alterations are also important bridge between T2D and AD. However, its unique mechanism is unclear. Methods The db/db mice, high-fat-diet (HFD) / streptozotocin (STZ)—induced diabetic (HF-diabetic) mice, and high-glucose-damaged (HGD) HT-22 hippocampal cells were enrolled to examine the effects of Ex-4 on AD-like changes in T2D. The Novel object recognition test (NORT) and Morris water maze test (MWMT) were conducted to evaluate the cognitive impairment. The Dickkopf-1 (DKK1) was employed to weaken the activation of the Wnt/β-catenin pathway to explore the mechanism of Ex-4 in protecting the brain functions. The JASPAR was based to predict the interaction between NeuroD1 and the promoter region of Ins2. Moreover, the chromatin immunoprecipitation coupled with quantitative polymerase chain reaction (ChIP-qPCR) and luciferase reporter assays were performed. Results Ex-4 alleviated the tau hyperphosphorylation, increased the brain-derived insulin, and improved the PI3K/AKT/GSK3-β signalling in db/db mice, HF-diabetic mice, and HGD HT-22 hippocampal neuronal cells. The NORT and MWMT indicated that Ex-4 alleviated the learning and memory deficits in HF-diabetic mice. The inhibitor Dickkopf-1 (DKK1) of the Wnt/β-catenin pathway significantly blocked the protective effects of Ex-4. Regarding further molecular mechanisms, NeuroD1 was affected by Ex-4 in vivo and in vitro, and the knockdown or overexpression of NeuroD1 suggested its crucial role in promoting the brain insulin by Ex-4. Meanwhile, the ChIP‒qPCR and luciferase reporter assays confirmed the combination between NeuroD1 and the promoter region of the insulin-encoding gene Ins2. And this interaction could be promoted by Ex-4. Conclusions Our study proposes that Ex-4 alleviates tau hyperphosphorylation and cognitive dysfunction by increasing Ins2-derived brain insulin through the Wnt/β-catenin/NeuroD1 signaling in T2D. And its also show new lights on part of the progress and mechanism on treatment targets for the DE in T2D.
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- 2023
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7. The relationship between red blood cell distribution width and islet β-cell function indexes in patients with latent autoimmune diabetes in adults
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Xiuli Fu, Qin Tan, Wei Wei, Sheng Ding, and Zhongjing Wang
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Latent autoimmune diabetes in adults ,Red blood cell distribution width ,β-cell function ,Glycosylated hemoglobin A1c ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Aims The objective of this study is to explore the relationship between red blood cell distribution and islet β-cell function indexes in patients with Latent Autoimmune Diabetes in Adults. Methods A total of 487 LADA patients were enrolled in this cross-sectional study. Patients were divided into three groups according to RDW tertiles. Clinical and laboratory measurements of age, height, weight, duration of diabetes, blood pressure, RDW, glycosylated hemoglobin A1c (HbA1c), C-peptide and blood lipids were performed. Homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β) were assessed using homeostasis model assessment (HOMA) based on fasting blood glucose (FBG) and fasting C-peptide index (FCP). Correlations and multiple linear regressions were implemented to determine the association of RDW and islet function indexes. Results As the increase of serum RDW level, the presence of β-cell secretion increased(P
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- 2023
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8. The clinical and genetic characteristics of maternally inherited diabetes and deafness (MIDD) with mitochondrial m.3243A > G mutation: A 10‐year follow‐up observation study and literature review
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Shasha Zheng, Juanjuan Wang, Minxian Sun, Pei Wang, Wei Shi, Zhongzhi Zhang, Zhongjing Wang, and Hongmei Zhang
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clinical features ,diagnosis ,genetic testing ,+G+mutation%22">m.3243A > G mutation ,maternally inherited diabetes and deafness (MIDD) ,mitochondrial genes ,Medicine ,Medicine (General) ,R5-920 - Abstract
Key Clinical Message Maternally inherited diabetes and deafness (MIDD) is often caused by the m.3243A > G mutation in mitochondrial DNA. Unfortunately, the characteristics of MIDD, especially long‐term outcomes and heteroplasmic changes, have not been well described previously. The purpose of this study was to describe the clinical and genetic features of a family with MIDD after 10 years of follow‐up.A 33‐year‐old male patient with typical characteristics of MIDD, including early‐onset diabetes, deafness, and low body mass index, was admitted to our department. Further investigation revealed that the vast majority of his maternal relatives suffered from diabetes with or without deafness. A detailed family history was then requested from the patient and a pedigree was constructed. The patient suspected of MIDD was screened for mutations using whole mitochondrial DNA sequencing. Candidate pathogenic variants were then validated in other family members through Sanger sequencing. The patient was diagnosed with MIDD, with inherited m.3243A > G mutation in the mitochondrially encoded tRNA leucine 1 (MT‐TL1) gene, after 10 years of symptom onset. The patient was then treated with insulin and coenzyme Q10 to improve mitochondrial function. During the follow‐up period, his fasting blood glucose and HbA1c levels were improved and the incidence of diabetic ketoacidosis was significantly reduced. Our findings indicate that whole mitochondrial DNA sequencing should be considered for patients suspected of MIDD to improve the efficiency of diagnosis and prognosis.
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- 2024
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9. An Auto-Detection and classification algorithm for identification of sand dunes based on remote sensing images
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Yingfu Tang, Zhongjing Wang, Yunzhong Jiang, Teng Zhang, and Wenjing Yang
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Dune detection ,Dune mapping ,Dune type classification ,Remote sensing ,Convolutional neural network ,Physical geography ,GB3-5030 ,Environmental sciences ,GE1-350 - Abstract
Dunes are among the most abundant aeolian landforms found on Earth and other planets. The automatic mapping of dunes over large-scale areas is crucial for predicting, monitoring, and managing lands threatened by sand encroachment. However, the spectral similarity between dune and inter-dune areas, as well as the diverse presentations of dunes of the same type, have made it challenging to automatically classify and map dunes. In this study, we propose a two-step 'detect-then-classify' framework that enables the automatic identification of heterogeneous dune types. The first step involves dune detection. We introduce a newly developed convolutional neural network called SandUnet, which is adapted from Attention U-Net. This network is designed to preserve uncompressed input signals ensuring that minor differences in the color and texture of the dunes are retained. The second step focuses on dune-type classification. To classify dunes, a fine-tuned MobileNet was constructed to integrate the wealth of knowledge ingrained in MobileNet's pre-trained layers with the adaptations tailored specifically for the sand dune images. Subsequently, each dune image is automatically classified into six different types using this framework. By applying this framework to all the bare sand areas of the Taklamakan (or Taklimakan) Desert using Landsat-8 imagery, the final classification of dune types of the desert was achieved. Testing on randomly selected 10% image patches of whole desert, the overall accuracy of the dune-type classification is 70%. This study presents an automatic and economical solution for identifying dunes in large-scale areas.
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- 2023
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10. Retrospecting the researches and efforts on Lancang-Mekong water issues: a bibliometric perspective
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Wenjia Wang and Zhongjing Wang
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bibliometrics ,citespace ,histcite ,hydropower ,lancang-mekong ,water ,River, lake, and water-supply engineering (General) ,TC401-506 - Abstract
We adopted a spectral clustering algorithm to divide the document co-citation network of 1,776 papers in the field of Lancang-Mekong water, and 14 clusters were identified. For each cluster, the top-cited references construct the knowledge base, and the most-coverage cities are taken as the research frontier. Three indicators, namely betweenness centrality, citation burstness strength, and Sigma, were used to identify the research outputs with pioneering and transformative value. The changes in the research topics and hotspots are closely related to the planning, construction, and operation progress of hydropower engineering, that affected by the gaming results of all parties. The 2009–2010 is an important time boundary, with the original research hotspots including the impact of upstream reservoirs on the hydrological regime and sediment (Clu#3) and arsenic contamination of groundwater in the Lower Mekong (Clu#4) that obtained periodical achievements and reached consensus to some extent around 2008, and the new research boom turns to the Tonle Sap Lake and flood pulse (Clu#2) in short-term characterized literatures with the highest burstness strength mainly concentrated around 2012. HIGHLIGHTS The intellectual bases and research frontiers of 14 identified topics were analyzed based on Document Co-citation Network analysis.; Vietnamese Mekong Delta is the topic with the largest size and arsenic contamination is the cluster with the longest time span.; Evolution of research hotspots is related to the widespread controversy over the planned dams in the Lower Mekong mainstream and the progress of the multi-party games.;
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- 2022
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11. Ecological vulnerability assessment of natural oasis in arid Areas: Application to Dunhuang, China
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Fan Yi, Qi Lu, Yonghua Li, Zhongjing Wang, Bin Yao, Qiankun Yang, and Jing Wang
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Pressure ,Sensitivity ,Resilience ,Vegetation ,Ecology ,QH540-549.5 - Abstract
Oasis vegetation contains a variety of ecological functions and can quickly indicate changes in the environment. According to the vegetation dynamics of natural oasis, this study constructed a natural oasis ecological vulnerability assessment model (NOEV) The model is based on Pressure-Sensitivity-Resilience framework, combined with redundancy analysis, minimum cumulative resistance model, and ecological risk sensitivity index to effectively assess the ecological vulnerability of natural oasis. The results showed that human activities, represented by the expansion of farmland and population growth, were the main factors affecting the vegetation dynamics of natural oasis in the last 30 years, and their contribution to the change of vegetation area is 42.08%. In the temporal dynamics, a serie of economic and environmental policies implemented by the government after the 21st century have promoted the recovery of vegetation. Vulnerability decreased on the whole oasis but increased in some local areas during 2005–2020. In the spatial dynamics, the transition zone of vulnerability from high to low occurred, it a distance of approximately 30 km from an artificial oasis located also in the area. We suggest that the governments should set up an ecological buffer zone in this area and implement different environmental protection policies inside and outside the buffer zone. Few vulnerability assessment models have been constructed for oasis ecosystems, and the NOEV model constructed in this study helps to formulate more direct and effective policy recommendations for the government's ecological protection and restoration work.
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- 2023
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12. The Influence of Sodium Salt on Growth, Photosynthesis, Na+/K+ Homeostasis and Osmotic Adjustment of Atriplex canescens under Drought Stress
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Zhenzhong Zhang, Tan Zhang, Baosi Yin, Zhongjing Wang, Runjie Li, and Shen Li
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Atriplex canescnes ,drought stress ,sodium ion ,osmotic adjustment ,chlorophyll fluorescence ,Agriculture - Abstract
Atriplex canescens is widely cultivated as drought and salt-tolerant fodder in arid regions of Northwest China, which is used for photoremediation of degraded land and soil and water conservation. To explore the growth performance of A. canescens when exposed to drought and salt stress, seedlings were treated with a range of drought stress (WC1: 75 ± 3.6%, WC2: 49 ± 2.9% and WC3: 27 ± 2.5% of soil water content) and the corresponding drought stress with additional sodium salt supplementation (NaCl:Na2SO4 = 1:1 with the total concentration of Na+ set to 150 mM). The findings of this paper indicated that moderate sodium salt could stimulate the growth of A. canescens and effectively alleviate the deleterious impact of drought stress by increasing the turgor potential (ψt) and relative water content (RWC) and decreasing the leaf water osmotic potential (ψs). Furthermore, the photosynthetic capacity was improved and the negative effects of drought stress on photosystem II (PSII) were mitigated. The extra 150 mM sodium salt also markedly increased the contribution of Na+ to ψs and the contribution of betaine to ψs. In summary, these results indicate that A. canescens can adapt to drought stress by accumulating enough Na+ for osmotic adjustment (OA). Additionally, this paper is aimed to provide a fundamental basis for the utilization and cultivation of A. canescens as a favored pasture crop in the Qaidam basin, thus increasing the ecological and environmental benefits for arid regions worldwide.
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- 2023
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13. Model integration methods for hydro-model platform under cloud computing environments
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Ronghua Liu, Jiahua Wei, Zhongjing Wang, Bingyu Zhang, and Chi Zhang
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hydromp ,model integration ,dynamic model management ,cloud computing ,hydraulics ,hydrodynamics ,Environmental sciences ,GE1-350 - Abstract
Computing platforms providing cloud simulation services have raised new challenges on the model integration. Unlike calls to the model programs (components) in traditional simulation software, here the models should be dynamically integrated in the “plug and play” mode regardless of the differences in model type and developer. To this end two integration methods have been proposed, i.e., coarse-grained EXE integration and interactive integration. In an EXE integration method, the simulation program is directly called and thus only a data conversion interface is needed while rewriting of the model source code is not required. In contrast, an interactive integration method wraps the model components using the standard wrapper with communication interfaces, and therefore, it can communicate and exchange data with the platform in a real time. The first method is suitable for the integration of legacy models, while the second one can control the progress of simulation schemes and facilitate the scheduling of computing resources. Examples of the model integration and platform application have been presented in hydraulics/hydrodynamics to demonstrate the effectiveness of the integration method and the cloud computing platform.
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- 2022
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14. Changes in Land Use and Ecosystem Service Values of Dunhuang Oasis from 1990 to 2030
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Fan Yi, Qiankun Yang, Zhongjing Wang, Yonghua Li, Leilei Cheng, Bin Yao, and Qi Lu
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ecosystem service value ,land cover change ,land use simulation ,hyperarid area oasis ,Science - Abstract
Maintaining the integrity and stability of oasis ecosystems is an important topic in the field of ecological research. Assessment of ecosystem services and their changes can provide important support for the sustainable development of oases. This study took the Dunhuang oasis in the hyper-arid area as the research object and used 1990, 2010, and 2020 Landsat series satellite images to complete the land use interpretation by random forest classification. Then we estimated the ecosystem services value (ESV) by using benefit transfer method, and predicted the trend of ecosystem service value changes under three scenarios using the Analytic Hierarchy Process method and the patch generation land use simulation model (AHP-PLUS model). The results showed that the vegetation areas of the Dunhuang Oasis first decreased and then increased during 1990–2020. The decrease was largely due to the expansion of built-up land and farmland, and the increase was mainly contributed by the implementation of ecological protection policies. The path of changes in the ESV of the Dunhuang Oasis during 1990–2020 was well consistent with that of vegetation areas, with a maximum of 9068.15×106 yuan (in 1990) and a minimum of 6271.46×106 yuan (in 2010). Spatial autocorrelation analysis showed that urbanization reduced ESV, and the implementation of ecological policies enhanced ESV. The ESV of the Dunhuang Oasis for the year 2030 under the ecological conservation scenario could reach 7631.07×106 yuan, which is 381.1×106 yuan higher that under the economic development scenario. The ecological conservation scenario is the optimal option to achieve sustainable development of the Dunhuang Oasis. We suggested that the government should continuously enhance the protection of forests and waterbodies, reasonably restrict production and domestic water consumption, and efficiently increase the proportion of ecological water consumption. In addition, this study improved the evaluation method of oasis ESV based on the proportion of Normalized Difference Vegetation Index (NDVI) of grasslands with different coverage, which is important for improving the environment in arid areas.
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- 2023
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15. Accessible Remote Sensing Data Mining Based Dew Estimation
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Ying Suo, Zhongjing Wang, Zixiong Zhang, and Steven R. Fassnacht
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dew estimation ,machine learning ,remote sensing ,Northwest China ,Science - Abstract
Dew has been considered a supplementary water resource as it constitutes an important water supply in many ecosystems, especially in arid and semiarid areas. Remote sensing allows large-scale surface observations, offering the possibility to estimate dew in such arid and semiarid regions. In this study, by screening and combining different remote sensing variables, we obtained a well-performing monthly scale dew yield estimation model based on the support vector machine (SVM) learning method. Using daytime and nighttime land surface temperatures (LST), the normalized difference vegetation index (NDVI), and three emissivity bands (3.929–3.989 µm, 10.780–11.280 µm, and 11.770–12.270 µm) as the model inputs, the simulated site-scale monthly dew yield achieved a correlation coefficient (CC) of 0.89 and a root mean square error (RMSE) of 0.30 (mm) for the training set, and CC = 0.59 and RMSE = 0.55 (mm) for the test set. Applying the model to the Heihe River Basin (HRB), the results showed that the annual dew yield ranged from 8.83 to 20.28 mm/year, accounting for 2.12 to 66.88% of the total precipitation, with 74.81% of the area having an annual dew amount of 16 to 19 mm/year. We expanded the model application to Northwest China and obtained a dew yield of 5~30 mm/year from 2011 to 2020, indicating that dew is a non-negligible part of the water balance in this arid area. As a non-negligible part of the water cycle, the use of remote sensing to estimate dew can provide better support for future water resource assessment and analysis.
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- 2022
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16. China’s Stem Cell Research and Knowledge Levels of Medical Practitioners and Students
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Deng Luo, Zihui Xu, Zhongjing Wang, and Wenzhuo Ran
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Internal medicine ,RC31-1245 - Abstract
Over the last few decades, China has greatly expanded its scope of stem cell research, generating various scientific advances and medical applications. However, knowledge of the extent and characteristics of domestic stem cell development, particularly medical workers’ opinions, is lacking. This study’s purposes were to analyze the growth trends of China’s stem cell community and identify the knowledge and attitudes held by Chinese medical workers regarding stem cell research. We found that there are currently 13 high-quality stem cell research centers with more than 400 PhD-level researchers across Mainland China. These centers feature many high-caliber scientists from the stem cell research community. From 1997 through 2019, the National Natural Science Foundation of China allocated roughly $576 million to 8,050 stem cell programs at Chinese universities and research institutions. China’s annual publications on stem cells increased from less than 0.6% of the world’s total stem cell publications in 1999 to more than 14.1% in 2014. Our survey also revealed that most participants held positive attitudes toward stem cell research, supported further funding, and had high general awareness about stem cells.
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- 2021
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17. Quantifying Water Scarcity in Northern China Within the Context of Climatic and Societal Changes and South‐to‐North Water Diversion
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Yuanyuan Yin, Lei Wang, Zhongjing Wang, Qiuhong Tang, Shilong Piao, Deliang Chen, Jun Xia, Tobias Conradt, Junguo Liu, Yoshihide Wada, Ximing Cai, Zhenghui Xie, Qingyun Duan, Xiuping Li, Jing Zhou, and Jianyun Zhang
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Environmental sciences ,GE1-350 ,Ecology ,QH540-549.5 - Abstract
Abstract With the increasing pressure from population growth and economic development, northern China (NC) faces a grand challenge of water scarcity, which can be further exacerbated by climatic and societal changes. The South‐to‐North Water Diversion (SNWD) project is designed to mitigate the water scarcity in NC. However, few studies have quantified the impact of the SNWD on water scarcity within the context of climatic and societal changes and its potential effects on economic and agricultural food in the region. We used water supply stress index (WaSSI) to quantify water scarcity within the context of environmental change in NC and developed a method to estimate the economic and agricultural impacts of the SNWD. Focuses were put on alleviating the water supply shortage and economic and agricultural benefits for the water‐receiving NC. We find that societal changes, especially economic growth, are the major contributors to water scarcity in NC during 2009–2099. To completely mitigate the water scarcity of NC, at least an additional water supply of 13 billion m3/year (comparable to the annual diversion water by SNWD Central Route) will be necessary. Although SNWD alone cannot provide the full solution to NC's water shortage in next few decades, it can significantly alleviate the water supply stress in NC (particularly Beijing), considerably increasing the agricultural production (more than 115 Tcal/year) and bringing economic benefits (more than 51 billion RMB/year) through supplying industrial and domestic water use. Additionally, the transfer project could have impacts on the ecological environment in the exporting regions.
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- 2020
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18. Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice
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Robert H. Oakley, Matthew J. Campen, Michael L. Paffett, Xin Chen, Zhongjing Wang, Traci L. Parry, Carolyn Hillhouse, John A. Cidlowski, and Monte S. Willis
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MuRF1 ,Hypoxia ,Right heart failure ,Gene expression ,Microarray ,Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1−/− mice exposed to CH are resistant to right ventricular (RV) dysfunction whereas MuRF1 Tg + mice exhibit impaired function indicative of heart failure. The present study was undertaken to understand the underlying transcriptional alterations in the RV of MuRF1−/− and MuRF1 Tg + mice. Methods Microarray analysis was performed on RNA isolated from the RV of MuRF1−/−, MuRF1 Tg+, and wild-type control mice exposed to CH. Results MuRF1−/− RV differentially expressed 590 genes in response to CH. Analysis of the top 66 genes (> 2-fold or 3-fold or
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- 2018
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19. Timely rehabilitation for critical patients with COVID-19: another issue should not be ignored
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Zhen Wang, Zhongjing Wang, Ruixiang Sun, Xiaoye Wang, Shaofei Gu, Xiancui Zhang, and Houbao Huang
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2020
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20. Multi-Year NDVI Values as Indicator of the Relationship between Spatiotemporal Vegetation Dynamics and Environmental Factors in the Qaidam Basin, China
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Junpeng Lou, Guoyin Xu, Zhongjing Wang, Zhigang Yang, and Sanchuan Ni
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Qaidam Basin ,vegetation dynamics ,remote sensing ,artificial neural networks ,machine leaning ,Science - Abstract
The Qaidam Basin is a unique and complex ecosystem, wherein elevation gradients lead to high spatial heterogeneity in vegetation dynamics and responses to environmental factors. Based on the remote sensing data of Moderate Resolution Imaging Spectroradiometer (MODIS), Tropical Rainfall Measuring Mission (TRMM) and Global Land Data Assimilation System (GLDAS), we analyzed the spatiotemporal variations of vegetation dynamics and responses to precipitation, accumulative temperature (AT) and soil moisture (SM) in the Qaidam Basin from 2001 to 2016. Moreover, the contribution of those factors to vegetation dynamics at different altitudes was analyzed via an artificial neural network (ANN) model. The results indicated that the Normalized Difference Vegetation Index (NDVI) values in the growing season showed an overall upward trend, with an increased rate of 0.001/year. The values of NDVI in low-altitude areas were higher than that in high-altitude areas, and the peak values of NDVI appeared along the elevation gradient at 4400–4600 m. Thanks to the use of ANN, we were able to detect the relative contribution of various environmental factors; the relative contribution rate of AT to the NDVI dynamic was the most significant (35.17%) in the low-elevation region (
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- 2021
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21. Assessment of Water Storage Change in China’s Lakes and Reservoirs over the Last Three Decades
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Yu Fang, Huan Li, Wei Wan, Siyu Zhu, Zhongjing Wang, Yang Hong, and Hao Wang
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water storage change ,GEE ,DEM ,geo-statistic ,China ,Science - Abstract
Lakes and reservoirs are essential elements of the hydrological and biochemical cycles, considered sentinels of global climate change. However, comprehensive quantifications of their water storage changes (∆V) at a large spatiotemporal scale are still rare. Here, we integrated a global surface water dataset and SRTM digital elevation models, both available from Google Earth Engine platform at a spatial resolution of 30 m, to evaluate ∆V for a total of 760 lakes and reservoirs across China at an annual timescale since 1984. The results indicated that (1) the aggregated water storage went through a slight increase of 41.5 Gt (1.7 Gt/yr) during 1985−2005, a significant decrease of 100 Gt (−20.6 Gt/yr) during 2005−2009, and then increased by 136.3 Gt (21.3 Gt/yr) during 2009−2015. (2) The increasing trend was largely attributed to lakes and reservoirs in the Tibetan Plateau Lake Zone, and the decreasing trend was mainly due to the North and Northwest Lake Zone, with little variations observed for the Northeast and Southwest Lake Zones. (3) Qinghai lake was associated with the largest increase (18.3 Gt) and Poyang lake presented the largest decline (−9.2 Gt). The results can help advance our understanding of the impact of climate change and improve future projection.
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- 2019
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22. Mapping Areal Precipitation with Fusion Data by ANN Machine Learning in Sparse Gauged Region
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Guoyin Xu, Zhongjing Wang, and Ting Xia
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Qaidam Basin ,remote sensing ,TRMM ,artificial neural network ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Focusing on water resources assessment in ungauged or sparse gauged areas, a comparative evaluation of areal precipitation was conducted by remote sensing data, limited gauged data, and a fusion of gauged data and remote sensing data based on machine learning. The artificial neural network (ANN) model was used to fuse the remote sensing precipitation and ground gauge precipitation. The correlation coefficient, root mean square deviation, relative deviation and consistency principle were used to evaluate the reliability of the remote sensing precipitation. The case study in the Qaidam Basin, northwest of China, shows that the precision of the original remote sensing precipitation product of Tropical Precipitation Measurement Satellite (TRMM)-3B42RT and TRMM-3B43 was 0.61, 72.25 mm, 36.51%, 27% and 0.70, 64.24 mm, 31.63%, 32%, respectively, comparing with gauged precipitation. The precision of corrected TRMM-3B42RT and TRMM-3B43 improved to 0.89, 37.51 mm, −0.08%, 41% and 0.91, 34.22 mm, 0.11%, 42%, respectively, which indicates that the data mining considering elevation, longitude and latitude as the main influencing factors of precipitation is efficient and effective. The evaluation of areal precipitation in the Qaidam Basin shows that the mean annual precipitation is 104.34 mm, 186.01 mm and 174.76 mm based on the gauge data, corrected TRMM-3B42RT and corrected TRMM-3B43. The results show many differences in the areal precipitation based on sparse gauge precipitation data and fusion remote sensing data.
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- 2019
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23. Flow Measurement: An Inverse Problem Formulation.
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Jiwei Li, Lingyun Qiu, Zhongjing Wang, and Hui Yu
- Published
- 2023
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24. Traceability of Water Pollution: An Inversion Scheme Via Dynamic CGO Solutions.
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Lingyun Qiu, Zhongjing Wang, Hui Yu, and Shenwen Yu
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- 2023
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25. A region‐specific modulation of sleep slow waves on interictal epilepsy markers in focal epilepsy
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Cong Chen, Yunling Wang, Lingqi Ye, Jiahui Xu, Wenjie Ming, Xiaochen Liu, Lingli Hu, Hongyi Ye, Cenglin Xu, Yi Wang, Zhongjing Wang, Yao Ding, Junming Zhu, Meiping Ding, Zhong Chen, and Shuang Wang
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Neurology ,Neurology (clinical) - Published
- 2023
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26. A Low Inductance, High Power Density 3L-TNPC Power Module for More-Electric Aircraft Applications
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Zhao Yuan, Asif Imran Emon, Zhongjing Wang, Yang Li, Yalin Wang, and Fang Luo
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Automotive Engineering ,Energy Engineering and Power Technology ,Transportation ,Electrical and Electronic Engineering - Published
- 2022
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27. Canal Controllability Identification Based on Automation Theory to Improve Water Delivery Efficiency in Irrigation Canal Systems
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Zhigang Yang, Zhongjing Wang, Jinlong Liu, Teng Zhang, and Zhilei Zheng
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Agricultural and Biological Sciences (miscellaneous) ,Water Science and Technology ,Civil and Structural Engineering - Published
- 2023
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28. Physical and Economic Determinants on Forecast Horizon for Long-Term Reservoir Operation
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Weisa Meng, Wenhua Wan, Zhongjing Wang, and Jianshi Zhao
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Geography, Planning and Development ,Management, Monitoring, Policy and Law ,Water Science and Technology ,Civil and Structural Engineering - Published
- 2023
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29. Automatic Sand Dune Detection and Classification Framework Using Remote Sensing Images
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Yingfu Tang and Zhongjing Wang
- Abstract
Dune field landscape patterns serve as an important signs of aeolian processes, such as wind conditions, sediment supply, and so on. A novel framework was proposed and evaluated for automatic dune detection and classification with remotely sensed images. The framework consists of two main steps: (1) The first step is to detect sand dunes from remote sensing images by SandUnet, which is firstly proposed in this paper. SandUnet, a Convolutional Neural Network (CNN), has a similar network structure with Attention U-net but modifies its attention gate module. In SandUnet, the input signals' information is not compressed as in the Attention U-net, therefore, the nuanced color and texture information of dunes are preserved. This paper demonstrated that SandUnet has better detection accuracy than other popular CNNs such as FCN, U-net, U-net++, and Attention U-net. (2) The second step is to compute the image similarity scores through MobileNet between each dune detection result image and the representative images of 6 different types of dunes. Then, each dune detection result image is classified into a dune type automatically. This paper applied the proposed framework to Taklimkan Desert in China. The average classification accuracy rate is around 80%, which proves the usefulness of this framework in automatic, no-cost, and accurate sand dune classification.
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- 2023
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30. Optimal Operation Rules for Parallel Reservoir Systems with Distributed Water Demands
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weisa Meng, wenhua Wan, jianshi Zhao, and zhongjing Wang
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Geography, Planning and Development ,Management, Monitoring, Policy and Law ,Water Science and Technology ,Civil and Structural Engineering - Abstract
This paper addresses the doubts regarding the spatial characteristics of the commonly used rules for parallel reservoir system operation. The rules based on aggregation-decomposition determine the system total release first and then assign this release to individual reservoirs, without considering the water demand distribution in the river network. In this paper, a conceptual model for parallel reservoir systems with distributed water demands is proposed. Three specific optimality conditions are derived for determining the optimal analytical solution. A rigorous proof shows that the aggregation-decomposition-based rules are a special case of the derived rules. An efficient algorithm is then developed based on the optimality conditions and shortage allocation index (SAI), in which a larger SAI indicates taking a higher percentage of the system water shortage, as release or storage. Unlike traditional algorithms that modify the violated variables empirically, we propose a criterion in terms of relative deviation indicators to determine the crucial priority of variable modification. This criterion can effectively address constraint violations. The optimal rules along with the solution algorithm are then demonstrated by the operation of a parallel reservoir system in the Shiyang River Basin, China. The results show that the proposed rules and algorithm are more efficient and effective than traditional algorithms and aggregation-decomposition-based rules, especially in dry seasons with more binding constraints.
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- 2023
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31. Mapping of Soils Salinity with Landsat 8 OLI Imagery and Random Forest Algorithm
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Teng Zhang, Zhongjing Wang, Yingfu Tang, and Yujia Shi
- Abstract
Soil salinity mapping is essential for sustainable land development and water resources management. In situ sampling is time-consuming, laborious, and restricted by geographical conditions. Therefore, an efficient and accurate model is necessary to monitor and assess the spatio-temporal dynamic salinization at regional a scale. In this study, Shule River Basin (SLRB) is taken as an example to develop the soil salinity mapping model based on Landsat 8 OLI images using random forest (RF) algorithms. A series of extended soil salinity indexes (ESSIs) were generated by combining any two, three, or four spectral bands were combined in expressions that include one or more of the arithmetic operations: addition, subtraction, multiplication, division, square and rooting form. The features selected from ESSIs outperformed the features selected from soil salinity indexes (SSIs) used in references. The best selected indexes are (B7^2-B5^2)^0.5, (B4^2+B5^2-B6^2)^0.5, (B1*B5-B4*B6/(B1*B5+B4*B6))^0.5,(B2*B6-B3*B7/( B2*B6+B3*B7))^0.5. In addition, three partition sampling methods of the training set and validation set for long-tail distribution problems are compared. The results showed that the resampling method considering the long-tail distribution performs better than systematic resampling and random k-fold cross-validation. The regional soil salinity mapping results showed that most areas are seriously salt-affected in the whole basin, especially along the river and the southeast mountainous area, where the soil salinity classes are highly and even over-extremely saline. This study could have implications for agricultural schemes planning and salinization control.
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- 2023
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32. A Water Resource Allocation Model Based on Coupled Socio-economic-Environment-Ecology-Resources System
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Yujia Shi, Zhongjing Wang, Jiahui Chen, and Jibin Chen
- Abstract
With the ongoing economic development and population growth, the shortage of water resources has become a severe problem which involves conflicts and tradeoffs among society, economy, environment, and ecology. Although previous researches proposed multi-objective optimization models, human-water coupled models, and hydro-economic models to deal with these conflicts and tradeoffs, they still did not address water demands’ integration and lacked future vision of water resource allocation. This paper proposed a Water Resource Allocation Model based on coupled Socio-economic-Environment-Ecology-Resources System (WRAM-SEERS) which considered integrally optimization objectives of socio-economic, environmental, and ecological subsystems under the constraints of water and land resources. The proposed model has the following advantages: (a) It could reflect all the closely related elements of the evolution of human society including urban and ecological space planning, cultivated structure and scale, population structure and size, industrial structure and scale, and so on, (b) It could generate the Pareto frontier surface, which maximized the socio-economic interest while minimizing the adverse externalities reacting in environment and ecology, and (c) It could forecast the future development range of each subsystem under hydrologic uncertainties. We applied WRAM-SEERS to allocate water resources of Yinchuan City in China in 2021-2035 and explained issues related the future perspective of Yinchuan: (a) “what is the lower and upper limits of subsystems’ development targets”, (b) “how to set targets consistent with sustainable development”, and (c) “how to achieve the settled targets”. The above explanations provided a scientific basis and decision-making reference for improving the water safety guarantee ability of Yinchuan's economic and social development and promoting a green, sustainable and high-quality development.
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- 2023
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33. Soil salinity estimation in Shule River Basin using support vector regression model
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Yingfu Tang, Zhongjing Wang, and Teng Zhang
- Subjects
Soil Science ,Environmental Chemistry ,Development ,General Environmental Science - Published
- 2023
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34. Insulation and Switching Performance Optimization for Partial-Discharge-Free Laminated Busbar in More-Electric Aircraft Applications
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Zhao Yuan, Yalin Wang, Zhongjing Wang, Asif Imran Emon, Mustafeez ul-Hassan, Fang Luo, and David Huitink
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020208 electrical & electronic engineering ,0202 electrical engineering, electronic engineering, information engineering ,02 engineering and technology ,Electrical and Electronic Engineering - Published
- 2022
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35. Optimization design for an impeller of the multiphase rotodynamic pump handling gas-liquid two-phase flow
- Author
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Wenwu Zhang, Baoshan Zhu, Zhongjing Wang, and Fujun Wang
- Subjects
Mechanical Engineering ,Energy Engineering and Power Technology - Abstract
The multiphase rotodynamic pump is crucial for the multiphase blending transportation process. However, desigining such pump with high hydraulic performance and good blending transportation ability is quite challenging because of its unique structure. This study constructed a multi-objective optimization design system, which combines the 3D inverse design theory, response surface methodology, genetic algorithm, computational fluid dynamics simulation, and multi-objective optimization strategy, to improve the multiphase pump performance. Five optimization variables, namely the impeller loading parameters ( m1,S, m1,H, kS, kH) and the high-pressure edge angle ( θ), were selected in this study. Furthermore, two optimization objectives were considered at inlet gas void fraction ( IGVF) = 10%, namely the pump efficiency and the gas uniformity at the impeller outlet. The optimization results demonstrated that the pump efficiency and blending transportation ability would improve if the impeller blades had for-loaded loading distribution and the negative high-pressure edge angle. After optimization, the pump efficiency and the gas uniformity for the optimized impeller Opt1 improved by 2.6% and 18.2% at IGVF = 10%, respectively. Moreover, the internal flow pattern in the impeller was improved significantly, resulting in the maximum amplitude of pressure fluctuation in impeller Opt1 being 0.42 times that in the original test impeller.
- Published
- 2022
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36. An analytical model for wicking in porous media based on statistical geometry theory
- Author
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Hui Gao, Guangyu Li, Zhongjing Wang, Nuo Xu, and Zongyu Wu
- Subjects
General Chemical Engineering ,General Chemistry ,Biotechnology - Abstract
In this work, an analytical model describing liquid wicking phenomenon in porous media was constructed, based on the statistical geometry theory and the fractal theory. In the model, a new structure-property relationship, depicted by specific surface, porosity, tortuosity, pore fractal dimension, maximum pore size of the porous media, was introduced into the energy conservation equation. According to the theoretical model, the accumulated imbibition weight in porous media was achieved, and the predictions were verified by available experimental data published in different literatures. Besides, structure parameters influencing the imbibition process upon approaching equilibrium height were discussed. The model and results in this work are useful for the application of porous media in scientific research and industry.
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- 2022
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37. Diagnostic Value of the Combined Measurement of Serum HCY and NRG4 in Type 2 Diabetes Mellitus with Early Complicating Diabetic Nephropathy
- Author
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Sheng Ding, Yi Yang, Yuming Zheng, Jinling Xu, Yangyang Cheng, Wei Wei, Fuding Yu, Li Li, Menglan Li, Mengjie Wang, Zhongjing Wang, and Guangda Xiang
- Subjects
HCY ,NRG4 ,HCY/NRG4 ,diabetes ,DKD ,Medicine (miscellaneous) - Abstract
Purpose: This study aimed to investigate the value of combined detection of HCY and NRG4 in the diagnosis of early diabetic kidney disease (DKD) and to explore the association between the ratio of HCY/NRG4 and DKD. Methods: A total of 140 diabetic patients and 43 healthy people were prospectively enrolled. The plasma HCY level, NRG4 level and HCY/NRG4 of them were measured to compare their differences and analyze the correlation with DKD. The independent influencing factors of patients with DKD were screened, and the nomograph of DKD occurrence was constructed. Results: The levels of HCY and HCY/NRG4 in diabetic patients were significantly increased, while the level of NRG4 was significantly decreased (p < 0.01). The AUCs of HCY/NRG4 predicted for DKD were 0.961. HCY/NRG4 and the course of DM were independent risk factors for DKD. A predictive nomograph of DKD was constructed, and decision curve analysis (DCA) showed good clinical application value. HCY/NRG4 was positively correlated with Scr, UACR, TG, UA, BUN, TCHOL and LDL and negatively correlated with eGFR and HDL (p < 0.05). Conclusions: The level of HCY and NRG4 is closely related to the severity of DM, and combined detection of HCY/NRG4 can identify patients with DKD at an early stage.
- Published
- 2023
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38. Design and Demonstration of a Medium-Voltage Silicon Carbide ANPC Power Stage
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Zhuxuan Ma, Fei Diao, Zhongjing Wang, Yuheng Wu, Mohammad Hazzaz Mahmud, and Yue Zhao
- Published
- 2022
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39. LUCC and its impact on water environment in middle and lower reaches of Liaohe River.
- Author
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Quan Liu, Zhongjing Wang, and Hu Peng
- Published
- 2004
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40. Busbar Design and Optimization for Voltage Overshoot Mitigation of a Silicon Carbide High-Power Three-Phase T-Type Inverter
- Author
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Yuheng Wu, Yue Zhao, Zhongjing Wang, H. Alan Mantooth, Mohammad Hazzaz Mahmud, and Zhao Yuan
- Subjects
Materials science ,business.industry ,Busbar ,020208 electrical & electronic engineering ,Electrical engineering ,Buffer amplifier ,Hardware_PERFORMANCEANDRELIABILITY ,02 engineering and technology ,Decoupling capacitor ,law.invention ,Capacitor ,law ,Hardware_INTEGRATEDCIRCUITS ,0202 electrical engineering, electronic engineering, information engineering ,Snubber ,Inverter ,Equivalent circuit ,Electrical and Electronic Engineering ,business ,Electronic circuit - Abstract
The silicon carbide (SiC) devices have faster switching speed than that of the conventional silicon (Si) devices, which however may cause excessive device voltage overshoot. Larger gate resistance can help to restrain the overshoot, it however slows down the switching speed and increases switching losses. There are other methods that can mitigate the voltage overshoot, e.g., using low-inductance busbars, adding snubber circuits, etc. In this article, the busbar design for a 250-kW SiC three-level T-type inverter is investigated. The current commutation loops (CCLs) are first analyzed using a single-phase equivalent circuit. Then the detailed busbar design methods, especially a 3-D busbar design concept, are proposed to select the optimal stacking order for the multilayer laminated busbar and to address constraints posed by the physical terminal arrangements of SiC modules and dc-link capacitors. The stray inductance in each CCL is extracted via a finite element analysis and validated on the actual inverter busbar prototypes using an impedance analyzer. To further minimize the busbar stray inductance, a hybrid busbar structure with printed circuit board based buffer circuit using high-frequency decoupling capacitors is designed and evaluated in this article. Finally, the effectiveness of the designed busbars as well as the buffer circuit are validated using experimental studies.
- Published
- 2021
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41. The relationship between red blood cell distribution width and islet β-cell function indexes in patients with Latent Autoimmune Diabetes in Adults
- Author
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Xiuli Fu, Qin Tan, Wei Wei, Sheng Ding, and Zhongjing Wang
- Abstract
Aims The objective of this study is to explore the relationship between red blood cell distribution and islet β-cell function indexes in patients with Latent Autoimmune Diabetes in Adults. Methods A total of 487 LADA patients were enrolled in this cross-sectional study. Patients were divided into three groups according to RDW tertiles. Clinical and laboratory measurements of age, height, weight, duration of diabetes, blood pressure, RDW, glycosylated hemoglobin A1c (HbA1c), C-peptide and blood lipids were performed. Homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β) were assessed using homeostasis model assessment (HOMA) based on fasting blood glucose (FBG) and fasting C-peptide index (FCP). Correlations and multiple linear regressions were implemented to determine the association of RDW and islet function indexes. Results As the increase of serum RDW level, the presence of β-cell secretion increased(P
- Published
- 2022
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42. The impact of type 2 diabetes and its management on the prognosis of patients with severe <scp>COVID</scp> ‐19
- Author
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Qingtao Meng, Shuo Wang, Li Wan, Ailin Yu, Ling Gao, Solomon Tesfaye, Lifang Sun, Yingchun Ye, Deng Luo, Zhongjing Wang, and Zihui Xu
- Subjects
Blood Glucose ,Male ,China ,medicine.medical_specialty ,Poor prognosis ,endocrine system diseases ,Coronavirus disease 2019 (COVID-19) ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,03 medical and health sciences ,clinical status ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,Epidemiology ,medicine ,Humans ,Hypoglycemic Agents ,Glucocorticoids ,Aged ,SARS-CoV-2 ,business.industry ,Hazard ratio ,COVID-19 ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Original Articles ,Middle Aged ,Prognosis ,medicine.disease ,Survival Rate ,Diabetes Mellitus, Type 2 ,corona virus disease 2019 (COVID‐19) ,anti‐hyperglycaemic drugs ,Original Article ,glucocorticoid ,Female ,type 2 diabetes ,business ,Biomarkers ,Glucocorticoid ,Follow-Up Studies ,medicine.drug - Abstract
Although type 2 diabetes mellitus (T2DM) patients with coronavirus disease 2019 (COVID-19) develop a more severe condition compared to those without diabetes, the mechanisms for this are unknown. Moreover, the impact of treatment with antihyperglycemic drugs and glucocorticoids is unclear.From 1584 COVID-19 patients, 364 severe/critical COVID-19 patients with clinical outcome were enrolled for the final analysis, and patients without preexisting T2DM but elevated glucose levels were excluded. Epidemiological data were obtained and clinical status evaluation carried out to assess the impact of T2DM and its management on clinical outcomes.Of 364 enrolled severe COVID-19 inpatients, 114 (31.3%) had a history of T2DM. Twenty-seven (23.7%) T2DM patients died, who had more severe inflammation, coagulation activation, myocardia injury, hepatic injury, and kidney injury compared with non-DM patients. In severe COVID-19 patients with T2DM, we demonstrated a higher risk of all-cause fatality with glucocorticoid treatment (adjusted hazard ratio [HR], 3.61; 95% CI, 1.14-11.46; P = .029) and severe hyperglycemia (fasting plasma glucose ≥11.1 mmol/L; adjusted HR, 11.86; 95% CI, 1.21-116.44; P = .034).T2DM status aggravated the clinical condition of COVID-19 patients and increased their critical illness risk. Poor fasting blood glucose (≥ 11.1 mmol/L) and glucocorticoid treatment are associated with poor prognosis for T2DM patients with severe COVID-19.背景: 虽然2019冠状病毒病(COVID-19)合并2型糖尿病(T2DM)患者比未患糖尿病的患者病情更加严重, 但其发病机制尚不清楚。此外, 降糖药和糖皮质激素治疗对COVID-19的影响尚不清楚。 方法: 对我院1584例COVID-19住院患者的临床资料进行回顾性分析。我们排除了既往无T2DM但血糖升高的患者, 得到364例重型/危重型COVID-19患者作为最终分析对象, 收集其流行病学资料和临床转归, 以评估T2DM及其治疗对COVID-19临床预后的影响。 结果: 在364例重型/危重型COVID-19住院患者中, 114例(31.3%)有T2DM病史。27例(23.7%)T2DM患者死亡, 这些患者比非糖尿病患者具有更严重的炎症反应、凝血激活、心肌损伤、肝损伤和肾损伤。在T2DM合并COVID-19重症患者中, 糖皮质激素治疗(校正HR, 3.61;95%CI, 1.14-11.46;P=0.029)和严重高血糖(空腹血糖≥11.1 mmol/L;校正HR, 11.86;95%CI, 1.21-116.44;P=0.034)的全因死亡风险更高。 结论: T2DM加重COVID-19病情并增加其危重症风险。空腹血糖不良(≥11.1mmol/L)和糖皮质激素治疗与重症COVID-19患者预后不良相关。.
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- 2020
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43. Design and Validation of A 250-kW All-Silicon Carbide High-Density Three-Level T-Type Inverter
- Author
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Zhe Zhao, Mohammad Hazzaz Mahmud, Yuheng Wu, H. Alan Mantooth, Zhongjing Wang, and Yue Zhao
- Subjects
Materials science ,Busbar ,medicine.medical_treatment ,Energy Engineering and Power Technology ,Topology (electrical circuits) ,02 engineering and technology ,law.invention ,chemistry.chemical_compound ,law ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Silicon carbide ,0501 psychology and cognitive sciences ,Electrical and Electronic Engineering ,050107 human factors ,Power density ,business.industry ,020208 electrical & electronic engineering ,05 social sciences ,Electrical engineering ,Traction (orthopedics) ,Power (physics) ,Capacitor ,chemistry ,Inverter ,business - Abstract
This article presents a comprehensive design and validation of a compact all-silicon carbide (SiC) 250-kW T-type traction inverter with a power density of 25 kW/l and 98.5% peak efficiency. All the operation modes and switching transitions in a T-type phase leg are analyzed to model the semiconductor power losses over a fundamental cycle. Special attention has been paid to investigate the behavior and losses due to the reverse conduction of the SiC MOSFETs. Then a loss model is built based upon this analysis to calculate the device loss distribution and system efficiency, which is further used to determine the optimal switching frequency. In addition, detailed inverter system design and prototyping procedure, including the selection of SiC modules and dc-link capacitors, and the optimization of a four-layer laminated busbar, are presented. In this article, the T-type phase leg is formed by a normal half-bridge module and a common-source module. The switching performance and losses in this configuration are different from two-level topology that only uses one SiC module. Therefore, the switching performance and the associated switching energy in each switch position are characterized using a custom clamped inductive load (CIL) test setup designed for a T-type phase leg. The performance of the full power traction inverter prototype has been verified experimentally using pulse testing and continuous power testing.
- Published
- 2020
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44. Quantifying the impacts of anthropogenic activity on chemical weathering based on source identification of hydrochemistry: the Liuxi river basin, southern China
- Author
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Zhenglan Xie, Zuobing Liang, Zhongjing Wang, Jianyao Chen, Rui Li, Lei Gao, Shaoheng Li, Zhuowei Wang, Ai-ping Zhu, and Zhigang Yang
- Subjects
China ,Watershed ,010504 meteorology & atmospheric sciences ,Drainage basin ,Fresh Water ,Weathering ,010501 environmental sciences ,Management, Monitoring, Policy and Law ,01 natural sciences ,River water ,Rainwater harvesting ,chemistry.chemical_compound ,Rivers ,Environmental monitoring ,Environmental Chemistry ,Weather ,0105 earth and related environmental sciences ,geography ,geography.geographical_feature_category ,Public Health, Environmental and Occupational Health ,General Medicine ,Silicate ,chemistry ,Southern china ,Environmental chemistry ,Environmental science ,Water Pollutants, Chemical ,Environmental Monitoring - Abstract
The impact of anthropogenic activity on chemical weathering is still an open and significant topic that requires clarification to improve the understanding of watershed evolution. We analyzed river water and rainwater samples to characterize the variation in hydrochemical characteristics and influencing factors. Samples were taken from the Liuxi River Basin (LRB), the only local drinking water supply for Guangzhou, and we studied geochemical parameters, major ions, and Si concentrations. Moreover, elemental ratios of end-members were determined and a modified-forward model was constructed to identify ion sources and estimate the chemical weathering rate (CWR) and anthropogenic input rate (AIR). Finally, we quantified the impacts of anthropogenic activity on the chemical weathering process. The results showed that the dominant hydrochemical type of river water was identified as HCO3-Ca, and rock weathering was the main contributor to river Na+, Mg2+, Ca2+ and HCO3-, whereas anthropogenic activity contributed the most to K+, Cl-, SO42-, and NO3-. The relatively high silicate weathering rate (SWR) (17.8-18.4 t per km2 per year) and AIR (37.8-60.3 t per km2 per year) were mainly attributed to erosion by nitric and sulfuric acid. The contribution rate of these acids to CWR could be regarded as a proxy quantifying the impact of anthropogenic activity on the chemical weathering process. This accounted for approximately 30% of the total SWR in the LRB. Our results demonstrate the effectiveness of hydrochemical source identification for quantifying the impacts of anthropogenic activity on chemical weathering.
- Published
- 2020
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45. Research Progress on Relationship Between Iron Overload and Lower Limb Arterial Disease in Type 2 Diabetes Mellitus
- Author
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Zhongjing Wang, Shu Fang, Sheng Ding, Qin Tan, and Xuyan Zhang
- Subjects
Pharmacology ,Internal Medicine - Abstract
Iron is one of the most important trace elements in life activities. It participates in a variety of important physiological processes in the body through oxidation-reduction reaction. A large number of studies show that iron overload (IO) is closely related to the progression of diabetes and its various chronic complications. However, the mechanism of iron overload in the pathogenesis of diabetes and the mechanism of iron overload in atherosclerosis (AS) are still controversial, and the relationship between iron overload and diabetic lower extremity arterial disease (LEAD) remains still unclear. Some recent reviews and original research articles suggest further studies to explain the complex relationship between iron metabolism and atherosclerosis. This article reviews the relationship between iron overload and diabetes and its relationship with LEAD, and discusses its mechanisms from various aspects, such as lipid peroxidation induced by iron overload, so as to provide clinical diagnosis and treatment ideas for diabetic lower extremity arterial disease. It is hoped that early evaluation, diagnosis and treatment of LEAD will be inspired.
- Published
- 2022
46. Soil Salinity Mapping with Landsat 8 Oli Imagery and Random Forest Algorithm
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Teng Zhang, Zhongjing Wang, Yingfu Tang, Yujia Shi, and Zixiong Zhang
- Subjects
History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
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47. Improving the clinical ability and quality of endocrinology department with diagnosis-related groups tool
- Author
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Sheng Ding, Xiaowan Jiang, Yuming Zheng, Tao Feng, Hong Mao, Zhi Chen, Wei Cai, and Zhongjing Wang
- Subjects
Original Article ,General Medicine - Abstract
BACKGROUND: To evaluate the use of the diagnosis-related groups (DRGs) tool to promote the diagnosis/treatment ability and quality of the endocrinology department under the new policy of grouping payment-related to disease diagnosis. METHODS: We compared the income structure of the endocrinology department in a 3a general hospital between the first half of 2019 and the same period in 2021. We also observed the changes in cost efficiency indexes (CEIs), time efficiency indexes (TEIs), case-mix index (CMI), number of DRGs, risk weight (RW) proportion, and surgery number in the inpatient department. Furthermore, the distribution of inpatients with diabetes of the whole hospital and the improvement of treatment efficiency indexes of the sub-specialty department were analyzed. RESULTS: In the first half of 2021, compared with the same period of 2019, the total revenue of the endocrinology department decreased by 20.05%, the average hospitalization cost decreased by 11.72%, the CEI decreased from 1.31 to 1.06, and the TEI decreased from 0.74 to 0.64. Additionally, the number of DRGs increased from 162 to 176, the average CMI value increased from 0.80 to 0.84, and the proportion of RW 1–5 cases increased. Moreover, the number of surgical cases increased by 60.50%, minimally invasive surgery increased by 53.54%, grade 4 surgery increased by 66.67%, and the proportion of entering the clinical pathway increased from 77.76% to 86.64%. From May to August, 2021, the admission rate of endocrinology sub-specialty increased significantly, the number of DRGs showed an increasing trend, and the CEI and TEI decreased significantly. In the first half of 2021, inpatients with diabetes in the departments of rehabilitation, neurology, nephropathy, ophthalmology, and general administration accounted for 21.99–38.54%. CONCLUSIONS: The DRGs tool can be used to improve the clinical diagnosis and treatment ability of the endocrinology department, as well as optimize the CEI, TEI, CMI, and RW values. It is an effective way to promote the development of the endocrinology department under the new DRGs payment policy, carry out blood glucose management in the hospital, build endocrinology sub-specialties, and improve surgical and operation capacity.
- Published
- 2021
48. System and Component Level Risk Assessment for SiC MOSFET Based Inverter for Traction Application at High Coolant Temperatures and Off-Road Mission Profile
- Author
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Yuheng Wu, Yue Zhao, Bakhtiyar Mohammad Nafis, Mohammad Hazzaz Mahmud, David Huitink, and Zhongjing Wang
- Subjects
Computer science ,medicine.medical_treatment ,Traction (orthopedics) ,Automotive engineering ,Computer Science Applications ,Electronic, Optical and Magnetic Materials ,Coolant ,Reliability (semiconductor) ,Mechanics of Materials ,Component (UML) ,MOSFET ,medicine ,Inverter ,Electrical and Electronic Engineering ,Risk assessment - Abstract
Monitoring and predicting temperatures at critical locations of a power electronic system is important for safety, reliability, and efficiency. As the market share of vehicles with electric powertrains continues to increase, there is also an important economic cost of failing electronic components. For inverters present in such a drive system, exceeding the temperature limit for certain critical components, such as DC-link capacitors and Silicon carbide MOSFETs, can lead to failure of the system. In such an application, extracting the temperatures using sensors from locations such as dies and capacitors require expensive modifications and poses technical challenges. It is therefore necessary to create a thermal model for the inverter system to estimate the temperature at various components in order to ensure operation within temperature limits. The model approach is also suitable for predicting the effect on the component temperature and reliability of boundary conditions such as coolant, ambient temperature, and mission profile. This study assesses the reliability of a 250 kW liquid cooled inverter system designed for traction application. The critical failure areas are the DC-link capacitors, and the SiC MOSFET dies, which are rated at 175 °C. The system is modeled as a compact system by reasonably considering each component as a lumped capacitance and estimating the thermal resistance using physical dimensions. Results from the model are then compared against experimental data from constant power testing, and good agreement is observed for the cold plate and gate driver temperatures. With the model fidelity established, the model is then used to implement drive cycles from the Environmental Protection Agency for nonroad applications. The resulting temperature profile for each component is a series of temperature peaks and troughs that contribute to damage and failure. Rainflow counting algorithm is then used to quantify the damage per mini-cycles and used to estimate the predicted life for each component based on their manufacturer provided reliability qualification, and the mission profile is executed on the test bench for validation. The results are then used to generate a system risk matrix that relates the failure risk associated with a certain mission profile and the cooling scheme. It therefore demonstrates that an automotive inverter with SiC switching devices can be credibly assessed for failure risk using a compact model that is independent of boundary conditions, in combination with established reliability correlations and techniques.
- Published
- 2021
- Full Text
- View/download PDF
49. Oasis Change Characteristics and Influencing Factors in the Shiyang River Basin, China
- Author
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Yu Fang, Xulian Wang, Yufei Cheng, and Zhongjing Wang
- Subjects
Renewable Energy, Sustainability and the Environment ,oasis evolution ,natural factor ,human interference ,Shiyang River Basin ,Geography, Planning and Development ,Building and Construction ,Management, Monitoring, Policy and Law - Abstract
The variability of the natural environment and the complexity of human activities result in dynamic changes in oasis areas, which is directly related to the sustainable development of arid and semi-arid areas. In order to better balance economic development and environmentally sustainable development, based on land use data and social and economic data from 1980 to 2015, this paper analyzed the oasis change characteristics under natural and human factors in the Shiyang River Basin in Northwest China. The results indicated that the oasis in the Shiyang River Basin showed an expansion trend from 1980 to 2015, with the expansion mainly occurring in the diluvial and alluvial fan, and along the middle and lower reaches of the river. The oasis changed actively in areas at an elevation of 1350 m, with a slope of 2°, at the distance of 1500 m to rivers, and with precipitation of 120 mm and temperature of 15 °C. Furthermore, the oasis mainly evolved towards gentler slopes and lower altitudes, and migrated closer to rivers before 1992 and farther away from rivers afterwards. Population growth and economic development were the important inducers of oasis change, and government policies on agricultural benefits and ecological conservation also influenced the oasis change, especially after 2000. The evolution patterns of oasis distribution revealed in this study can provide a reference for promoting oasis ecological restoration and sustainable development.
- Published
- 2022
- Full Text
- View/download PDF
50. System and Component Level Risk Assessment for SiC MOSFET Based Inverter for Traction Application
- Author
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Yuheng Wu, Yue Zhao, Bakhtiyar Mohammad Nafis, David Huitink, Zhongjing Wang, and Mohammad Hazzaz Mahmud
- Subjects
Computer science ,medicine.medical_treatment ,Traction (orthopedics) ,Capacitance ,Automotive engineering ,law.invention ,Capacitor ,Reliability (semiconductor) ,law ,visual_art ,Component (UML) ,MOSFET ,Electronic component ,visual_art.visual_art_medium ,medicine ,Inverter - Abstract
Monitoring and predicting temperatures at critical locations of a power electronic system is important for safety, reliability and efficiency. As the market share of vehicles with electric powertrains continue to increase, there is also an important economic cost of failing electronic components. For inverters present in such a drive system, exceeding the temperature limit for certain critical components, such as DC-link capacitors and Silicon carbide MOSFETs, can lead to failure of the system. In such an application, extracting the temperatures using sensors from locations such as dies and capacitors require expensive modifications and poses technical challenges. It is therefore necessary to create a thermal model for the inverter system to estimate the temperature at various components in order to ensure operation within temperature limits. The model approach is also suitable for predicting the effect on the component temperature and reliability of boundary conditions such as coolant, ambient temperature and mission profile. This study assesses the reliability of a 250 kW liquid cooled inverter system designed for traction application. The critical failure areas are the DC-link capacitors, and the SiC MOSFET dies which are rated at 175 degrees C. The system is modeled as a compact system by reasonably considering each component as a lumped capacitance and estimating the thermal resistance using physical dimensions. Results from the model are then compared against experimental data from constant power testing, and good agreement is observed for the cold plate and gate driver temperatures. With the model fidelity established, the model is then used to implement drive cycles from the Environmental Protection Agency for nonroad applications. The resulting temperature profile for each component are a series of temperature peaks and troughs that contribute to damage and failure. Rainflow counting algorithm is then used to quantify the damage per mini-cycles, and used to estimate the predicted life for each component based on their manufacturer provided reliability qualification and the mission profile is executed on the test bench for validation. The results are then used to generate a system risk matrix that relates the failure risk associated with a certain mission profile and the cooling scheme. It therefore demonstrates that an automotive inverter with SiC switching devices can be credibly assessed for failure risk using a compact model that is independent of boundary conditions, in combination with established reliability correlations and techniques.
- Published
- 2021
- Full Text
- View/download PDF
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