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The application of NiCuZn ferrites (NCZFs) in high-power communication systems is constrained by their nonlinear excitation. To reduce nonlinear effects, it is essential for ferrite materials to possess a relatively high spin-wave linewidth (ΔHk). Doping with ions such as cobalt and rare-earth (RE) ions with fast relaxation has proven effective in increasing ΔHk of ferrites. However, the regulatory mechanism of doping NCZFs with RE ions with larger ionic radii remains unclear. In this study, Ho3+-substituted NCZFs were synthesized via a solid-state reaction route. The spatial distribution and substitution amount of the Ho3+ ions were carefully investigated via elemental and phase composition analysis, revealing the limited solid solubility of the Ho3+ ions in NCZFs. Some of the Ho3+ ions enter the lattice and occupy the octahedral sites, accelerating relaxation and increasing ΔHk to a maximum value of 2.63 kA·m−1. Insoluble Ho3+ ions combine with Fe3+ ions to form a HoFeO3 heterogeneous phase with Fe3+ ions at the grain boundaries, leading to iron deficiency within NCZF crystals and significantly reducing the dielectric loss tangent at microwave frequencies. These results reveal the great potential of Ho3+-substituted NCZFs for high-power, low-loss microwave applications.

BackgroundIn recent years, the incidence of endometrial cancer (EC) has been rising. This meta-analysis aims to clarify the prognostic significance of serum CA-125 levels in EC.MethodsArticles up to March 1, 2024, were systematically searched in EMBASE, Cochrane Library, PubMed, and Web of Science. This analysis pooled hazard ratios (HR) and 95% confidence intervals (CI) from qualifying studies to evaluate the association of CA-125 levels with overall survival (OS), progression-free survival (PFS), disease-free/relapse-free survival (DFS/RFS), and disease-specific survival (DSS).Results25 studies involving 7,716 patients were included. The analysis revealed that elevated CA-125 levels correlate with poorer OS (HR = 1.848, 95% CI: 1.571-2.175, p < 0.001). This association persisted across various study regions and sample sizes, and was notably strong in subgroups with a CA-125 cut-off value of less than 35 (HR = 2.07, 95% CI: 1.13-3.80, p = 0.019) and equal to 35 (HR = 2.04, 95% CI: 1.49-2.79, p < 0.001), and among type II pathology patients (HR = 1.72, 95% CI: 1.07-2.77, p = 0.025). Similarly, high CA-125 levels were linked to reduced PFS, particularly in subgroups with a CA-125 cut-off value less than 35 (HR = 1.87, 95% CI: 1.15-3.04, p = 0.012) and equal to 35 (HR = 4.94, 95% CI: 2.56-9.54, p < 0.001), and in endometrioid endometrial cancer patients (HR = 2.28, 95% CI: 1.18-4.40, p = 0.014). Elevated CA-125 levels were also indicative of worse DFS/RFS (HR = 2.17, 95% CI: 1.444-3.262, p < 0.001) and DSS (HR = 2.854; 95% CI: 1.970-4.133, p < 0.001).ConclusionSerum CA-125 levels before treatment was highly associated with prognosis of EC patients.

BackgroundCervical spondylotic amyotrophy (CSA) is a special type of cervical spondylosis based on cervical degeneration, which is mainly manifested by weakness and atrophy of upper limb muscles without obvious sensory impairment. Various diagnostic and treatment strategies used; however, discrepancies exist. We tried to discuss diagnosing and treating CSA.Methods15 patients with CSA were diagnosed in the Orthopedics Department of the First Affiliated Hospital of Zhengzhou University, aged 42–70 years old. The duration of preoperative symptoms of amyotrophy was 6 to 240 months. 12 patients received surgical treatment, and 3 patients received conservative treatment. The patients were divided into two groups according to the site of preoperative amyotrophy. The manual muscle test was used to evaluate the patients' muscle strength pre-and postoperatively.ResultsDuring postoperative follow-up, the muscle strength of 12 patients improved to different degrees compared to before surgery. The improvement effect was excellent in 2 cases, good in 6, and moderate in 4. There was no decrease in postoperative muscle strength compared with that before surgery. The satisfaction rate of the effect was 66.7%. The two groups had no statistically significant difference in preoperative muscle strength. The postoperative muscle strength of the proximal group was significantly better than that of the distal group.ConclusionThe surgical effect of CSA of the proximal type is significantly better than that of the distal type. The recovery effect of amyotrophy after surgery for distal type CSA is poor; thus, surgical treatment should be carefully considered.

Abstract Objectives To propose a surface reconstruction algorithm based on a differential manifold (a space with local Euclidean space properties), which can be used for processing of clinical images and for modeling of the atlantoaxial joint. To describe the ideal anatomy of the lateral atlantoaxial articular surface by measuring the anatomical data. Methods Computed tomography data of 80 healthy subjects who underwent cervical spine examinations at our institution were collected between October 2019 and June 2022, including 46 males and 34 females, aged 37.8 ± 5.1 years (28–59 years). A differential manifold surface reconstruction algorithm was used to generate the model based on DICOM data derived by Vision PACS system. The lateral mass articular surface was measured and compared in terms of its sagittal diameter, transverse diameter, articular surface area, articular curvature and joint space height. Results There was no statistically significant difference between left and right sides of the measured data in normal adults (P > 0.05). The atlantoaxial articular surface sagittal diameter length was (15.83 ± 1.85) and (16.22 ± 1.57) mm on average, respectively. The transverse diameter length of the articular surface was (16.29 ± 2.16) and (16.49 ± 1.84) mm. The lateral articular surface area was (166.53 ± 7.69) and (174.48 ± 6.73) mm2 and the curvature was (164.03 ± 5.27) and (153.23 ± 9.03)°, respectively. The joint space height was 3.05 ± 0.11mm, respectively. There is an irregular articular space in the lateral mass of atlantoaxial, and both upper and lower surfaces of the articular space are concave. A sagittal plane view shows that the inferior articular surface of the atlas is mainly concave above; however, the superior articular surface of the axis is mainly convex above. In the coronal plane, the inferior articular surface of the atlas is mostly concave above, with most concave vertices located in the medial region, and the superior articular surface of the axis is mainly concave below, with most convex vertices located centrally and laterally. Conclusion A differential manifold algorithm can effectively process atlantoaxial imaging data, fit and control mesh topology, and reconstruct curved surfaces to meet clinical measurement applications with high accuracy and efficiency; the articular surface of the lateral mass of atlantoaxial mass in normal adults has relatively constant sagittal diameter, transverse diameter and area. The distance difference between joint spaces is small, but the shape difference of articular surfaces differs greatly.

In this study, a combined system consisting of an anaerobic membrane bioreactor (AnMBR) and flow-through biofilm reactor/CANON (FTBR/CANON) was developed to simultaneously remove carbon and nitrogen from synthetic livestock wastewater. The average removal efficiencies of total nitrogen (TN) were 64.2 and 76.4% with influent ammonium (NH4+-N) concentrations of approximately 200 and 500 mg/L, respectively. The COD removal efficiencies were higher than 98.0% during the entire operation. Mass balance analysis showed that COD and TN were mainly removed by the AnMBR and FTBR/CANON, respectively. The anammox process was the main nitrogen removal pathway in the combined system, with a contribution of over 80%. High functional bacterial activity was observed in the combined system. Particularly, an increase in the NH4+-N concentration considerably improved the anammox activity of the biofilm in the FTBR/CANON. 16S rRNA high-throughput sequencing revealed that Methanosaeta, Candidatus Methanofastidiosum, and Methanobacterium were the dominant methanogens in the AnMBR granular sludge. In the CANON biofilm, Nitrosomonas and Candidatus Kuenenia were identified as aerobic and anaerobic ammonium-oxidizing bacteria, respectively. In summary, this study proposes a combined AnMBR and FTBR/CANON process targeting COD and nitrogen removal, and provides a potential alternative for treating high-strength wastewater.

Abstract The physical states and chemical components of bulk sludge determine the occurrence and development of membrane fouling in membrane bioreactors. Thus, regulation of sludge suspensions can provide new strategies for fouling control. In this study, we used “top-down” enrichment to construct a synthetic anti-fouling consortium (SAC) from bio-cake and evaluate its roles in preventing membrane fouling. The SAC was identified as Massilia-dominated and could almost wholly degrade the alginate solution (1,000 mg/L) within 72 h. Two-dimensional Fourier transformation infrared correlation spectroscopy (2D-FTIR-CoS) analysis demonstrated that the SAC induced the breakage of glycosidic bond in alginates. The co-cultivation of sludge with a low dosage of SAC (ranging from 0 to 1%) led to significant fouling mitigation, increased sludge floc size, and decreased unified membrane fouling index value (0.55 ± 0.06 and 0.11 ± 0.05). FTIR spectra and X-ray spectroscopy analyses demonstrated that the addition of SAC decreased the abundance of the O-acetylation of polysaccharides in extracellular polymeric substances. Secondary derivatives analysis of amide I spectra suggested a strong reduction in the α-helix/(β-sheet + random coil) ratio in the presence of SAC, which was expected to enhance cell aggregation. Additionally, the extracellular secretions of SAC could both inhibit biofilm formation and strongly disperse the existing biofilm strongly during the biofilm incubation tests. In summary, this study illustrates the feasibility and benefits of using SAC for fouling control and provides a new strategy for fouling control.

ObjectiveA method involving derivatization combined with liquid chromatography-tandem mass spectrometry was developed for the determination of vitamin D in infant formula food.MethodsThe samples were treated with enzymolysis， saponification， liquid-liquid extraction， and 4-phenyl-1，2，4-triazoline-3，5-dion derivatization. Chromatographic separation was performed using an Atlantis® T3 column， and gradient elution was performed using the methanol-5 mmol/L ammonium format solution as the mobile phase. The method applied positive electrospray ionization and multiple reaction monitoring mode and was quantified with the isotope internal standard method.ResultsA good linearity was obtained with a correlation coefficient above 0.99. The average recovery levels from three different ranged from 92.3% to 94.2%， and the relative standard deviations were between 3.03% and 5.34% （n=6）. The limit of quantification was 1 μg/kg.ConclusionThis method is simple， accurate with high sensitivity and high selectivity， and suitable for the determination of vitamin D in infant formula food.

Developing novel catalysts with high activity and high stability for the methanol oxidation reaction (MOR) is of great importance for the ever-broader applications of methanol fuel cells. Herein, we present a facile technique for synthesizing Au10Pt1@MnO2 catalysts using a wet chemical method and investigate their catalytic performance for the MOR. Notably, the Au10Pt1@MnO2-M composite demonstrated a significantly high peak mass activity of 15.52 A mg(Pt)−1, which is 35.3, 57.5, and 21.9 times greater than those of the Pt/C (0.44 A mg(Pt)−1), Pd/C (0.27 A mg(Pt)−1), and Au10Pt1 (0.71 A mg(Pt)−1) catalysts, respectively. Comparative analysis with commercial Pt/C and Pd/C catalysts, as well as Au10Pt1 HSNRs, revealed that the Au10Pt1@MnO2-M composite exhibited the lowest initial potential, the highest peak current density, and superior CO anti-poisoning capability. The results demonstrate that the introduction of MnO2 nanosheets, with excellent oxidation capability, not only significantly increases the reactive sites, but also promotes the reaction kinetics of the catalyst. Furthermore, the high surface area of the MnO2 nanosheets facilitates charge transfer and induces modifications in the electronic structure of the composite. This research provides a straightforward and effective strategy for the design of efficient electrocatalytic nanostructures for MOR applications.

BackgroundThe primary heat exchanger (PHX) used in the 10 MWt Molten Salt Reactor Experiment (MSRE) at Oak Ridge National Laboratory (ORNL), is a U-tube heat exchanger, where the shell side (hot side) contains the fuel salt from the primary loop and the tube side (cold side) carries the coolant salt from the secondary loop.PurposeThis study aims to deepen the understanding and mastery of the operational characteristics of molten salt heat exchangers, and to accumulate experience in their design and operation within molten salt reactors.MethodsFirstly, based on the design parameters, the MSRE-PHX was modeled, and theoretical calculations for shell and tube hear exchanger were conducted using the Kern method and the Bell-Delaware method. Then, software simulations were performed using HTRI Xchanger Suite, and computational fluid dynamics (CFD) simulations were also carried out with Ansys Fluent. Finally, critical performance metrics, such as the heat transfer coefficient, the pressure drop, and the heat transfer power, were obtained and compared to the MSRE operation data.ResultsThe comparison results indicate that the discrepancies from theoretical calculations, HTRI software, and CFD simulations, are all within acceptable margins to the experimental data. Notably, the greatest variance is found with the Kern method, which showed a deviation in heat transfer quantity of about 15%, while the smallest discrepancy is observed in the overall heat transfer coefficient calculated using HTRI software, differing by merely 0.16% from the experimental data.ConclusionsAll of the methods are suitable and applicable for designing and studying a molten salt shell and tube heat exchanger. Moreover, the CFD simulation can provide fine localized details of the heat transfer and flow of the molten salt fluid. This offers substantial theoretical support and practical guidance for the future design and improvement of molten salt heat exchangers.

Abstract Background Odd-skipped related 1 (OSR1) has been reported as a tumor suppressor gene in various malignant tumors. The mechanism through which OSR1 regulates ovarian cancer (OC) progression remains unclear. Materials and methods Immunohistochemistry was utilized to evaluate OSR1 expression in patients with ovarian cancer. We investigated the association between clinicopathological parameters and OSR1 expression in OC patients and the influence of OSR1 expression on patient survival and prognosis. OC cells with OSR1 overexpression or knockdown were established and validated using Western blot and Quantitative reverse-transcription polymerase chain reaction (qRT-PCR). The influence of OSR1 on the NF-κB pathway was examined by analyzing the p-IκBα, IκBα, p65, and p-p65 protein expression. In vitro assays, such as cell cycle assay, Cell Counting Kit-8 (CCK-8), transwell invasion assay, wound healing migration assay, enzyme-linked immunoassay (ELISA), and Annexin V/PI flow cytometry apoptosis assay, were conducted to explore the effect of OSR1 knockdown or dual inhibition of OSR1 and the NF-κB pathway on OC malignant biological behavior. Results OSR1 expression was downregulated in OC tissues, with significant associations observed between its expression and The International Federation of Gynecology and Obstetrics (FIGO) stage and tissue differentiation. Low OSR1 expression in OC patients correlated with reduced overall survival (OS) rates and poor prognosis. In vitro, experiments confirmed a negative correlation between OSR1 expression and NF-κB pathway activity. OSR1 knockdown facilitated OC cell malignant biological behavior, while the NF-κB pathway inhibitor (Bay 11-0782) reversed the impacts of OSR1 knockdown on cell proliferation, migration, invasion, and apoptosis. Conclusion Our findings indicate that OSR1 is downregulated and associated with OC prognosis. OSR1 suppresses NF-κB pathway activity and inhibits OC progression by targeting the NF-κB pathway.

Objective To investigate the role and mechanism of fibrinogen-like protein 2 (Fgl2) in acute kidney injury induced by rhabdomyolysis (RM-AKI). Methods Wild-type mice (WT) and Fgl2 gene knockout mice (Fgl2 KO) with the same background, were randomly divided into 4 groups respectively, that is WT+saline, WT+Gly, Fgl2 KO+saline, Fgl2 KO+Gly (n=5). The mice of the RM-AKI group were given 50% glycerol (10 μL/g) and those of the control groups were given same amount of normal saline into the hind leg by intramuscular injection. In 48 h later, the serum samples were collected to detect the levels of Scr and BUN. HE staining was employed to assess and score the severity of renal injury. qRT-PCR was used to detect the mRNA levels of Fgl2, IL-6, MCP-1, TNF-α, IL-1β and IL-10. The expression of Fgl2 and F4/80 was observed with immunohistochemical staining (IHC). TUNEL assay and Western blotting were applied to measure cell apoptosis and expression of apoptosis-related proteins, respectively. Results Fgl2 expression in renal tissue was significantly elevated in glycerol-treated WT mice compared with saline-treated WT mice. When compared with WT mice, Fgl2 deficiency significantly alleviated renal dysfunction and renal histopathological injury, with statistically lower renal injury score (P < 0.05). Moreover, the expression of pro-inflammatory factors, IL-6, MCP-1, TNF-α and IL-1β in renal tissues was decreased, while that of anti-inflammatory factor IL-10 was increased (P < 0.05). The infiltration of macrophages and apoptosis of renal cells were reduced in the Fgl2 KO mice than the WT mice. The expression of apoptosis-related proteins, Bax, cleaved Caspase-3, and cleaved Caspase-9 was reduced, while that of Bcl2 showed no significant difference. Conclusion Knockout of Fgl2 inhibits inflammatory response and reduces apoptosis in renal cells, and exerts a protective effects on RM-AKI mice.

Ovarian cancer (OC) is the fifth leading cause of death in females. This study aims to identify new prognostic genes of OC through bioinformatics analysis. Based on two datasets from the NCBI GEO public database, we constructed two WGCNA networks. We then selected and intersected two key modules and 177 key genes were identified. The GO, KEGG and PPI network were determined based on the screened genes. According to the LASSO analysis and KM plotter, three hub genes were associated with the overall survival. GEPIA and IHC staining showed that CCDC80 expression level was lower while FBXO16 expression level was higher in OC tissues than in normal ovarian tissues. The relationship between hub genes and clinical characteristics was evaluated and the prognostic significance was validated in 60 clinical patients with OC. CIBERSORT shows that both CCDC80 and FBXO16 were significantly correlated with the immune cell content. Drug sensitivity analysis shows that CCDC80 affected the IC50 value of Gefitinib, and FBXO16 affected the IC50 value of Cisplatin and Docetaxel. CCDC80 and FBXO16 were identified as two robust prognostic factors in OC that could be explored further with respect to the diagnosis and treatment of OC patients.

Abstract The continuous emergence of SARS-CoV-2 variants highlights the need of developing vaccines with broad protection. Here, according to the immune-escape capability and evolutionary convergence, the representative SARS-CoV-2 strains carrying the hotspot mutations were selected. Then, guided by structural and computational analyses, we present a mutation-integrated trimeric form of spike receptor-binding domain (mutI-tri-RBD) as a broadly protective vaccine candidate, which combined heterologous RBDs from different representative strains into a hybrid immunogen and integrated immune-escape hotspots into a single antigen. When compared with a homo-tri-RBD vaccine candidate in the stage of phase II trial, of which all three RBDs are derived from the SARS-CoV-2 prototype strain, mutI-tri-RBD induced significantly higher neutralizing antibody titers against the Delta and Beta variants, and maintained a similar immune response against the prototype strain. Pseudo-virus neutralization assay demonstrated that mutI-tri-RBD also induced broadly strong neutralizing activities against all tested 23 SARS-CoV-2 variants. The in vivo protective capability of mutI-tri-RBD was further validated in hACE2-transgenic mice challenged by the live virus, and the results showed that mutI-tri-RBD provided potent protection not only against the SARS-CoV-2 prototype strain but also against the Delta and Beta variants.

Background The rapid increase in the detection rate of thyroid cancer over the past few decades has caused some unexpected economic burdens. However, that of papillary thyroid carcinoma (PTC) seems to have had the opposite trend, which is worthy of further comprehensive exploration. Methods The Surveillance, Epidemiology, and End Results 18 database was used to identify patients with PTC diagnosed during 2003-2017. The incidence trends were analyzed using joinpoint analysis and an age-period-cohort model. Results The overall PTC incidence rate increased from 9.9 to 16.1 per 100 000 between 2003 and 2017. The joinpoint analysis indicated that the incidence growth rate began to slow down in 2009 (annual percentage change [APC] = 3.1%, 95% confidence interval [CI] = 1.9%–4.4%). After reaching its peak in 2015, it began to decrease by 2.8% (95% CI = −4.6% to −1.0%) per year. The stratified analysis indicated that the incidence patterns of different sexes, age groups, races, and tumor stages and sizes had similar downward trends, including for the localized (APC = −4.5%, 95% CI = −7% to −1.9%) and distant (APC = −1.3%, 95% CI = −2.7% to −.1%) stages, and larger tumors (APC = −4%, 95% CI = −12% to 4.7%). The age-period-cohort model indicated a significant period effect on PTC, which gradually weakened after 2008-2012. The cohort effect indicates that the risk of late birth cohorts is gradually stabilizing and lower than that of early birth cohorts. Conclusion The analysis results of the recent downward trend and period effect for the incidence of each subgroup further support the important role of correcting overdiagnosis in reducing the prevalence of PTC. Future research needs to analyze more-recent data to verify these downward trends.

BackgroundSurvival rates are usually used to evaluate the effect of cancer treatment and prevention. This study aims to analyze the 5-year relative survival of non-Hodgkin lymphoma (NHL) in United States using population-based cancer registry data.MethodsA period analysis was used to evaluate the improvement in long-term prognosis of patients with NHL from 2004 to 2018, and a generalized linear model was developed to predict the 5-year relative survival rates of patients during 2019–2023 based on data from the SEER database stratified by age, sex, race and subtype.ResultsIn this study, relative survival improved for all NHL, although the extent of improvement varied by sex, age group and lymphoma subtype. Survival improvement was also noted for NHL subtypes, although the extent varied, with marginal-zone lymphoma having the highest 5-year relative survival rate (92.5%) followed by follicular lymphoma (91.6%) and chronic lymphocytic leukemia/small lymphocytic lymphoma (87.3%). Across all subtypes, survival rates were slightly higher in females than in males. Survival rates are lower in the elderly than in the young. Furthermore, the study demonstrated that black patients had lower NHL survival rates than white patients. Survival rates for NHL were higher in rural areas than in urban areas. Patients with extra-nodal NHL had a higher survival rate than patients with nodal NHL.ConclusionOverall, patient survival rates for NHL gradually improved during 2004–2018. The trend continues with a survival rate of 75.2% for the period 2019–2023. Analysis by NHL subtype and subgroups indicating that etiology and risk factors may differ by subtype. Identification of population-specific prevention strategies and treatments for each subtype can be aided by understanding these variations.

Evaluating cardiac function from magnetic resonance images requires segmentation of the right ventricle (RV). The traditional segmentation methods, however, are often ineffective due to the complex structure of RV. Herein, a dense and multi-scale U-net (DMU-net) method is proposed to segment RV. Fifty six datasets were preprocessed, and the steps included normalization, enhancement and region of interest (ROI) extraction. Then a DMU-net was constructed by combining multi-scale aggregation with nested dense connection. The preprocessed datasets were then used to train and verify the DMU-net for predicting the results in 15 datasets with ROI extraction only. The mean of Dice index and Hausdorff distance obtained with the proposed method were 0.862 and 4.44 mm, respectively, which were better than those obtained with the conventional methods. Correlation coefficients of the endo-diastolic volume, endo-systolic volume, ejection fraction and stroke volume estimated were 0.992, 0.960, 0.987 and 0.982, respectively. The results demonstrated that the segmentation method based on the DMU-net has better relevance and consistency compared to manual segmentation, providing a promising tool the diagnosis of cardiac diseases.

Abstract Background Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcripts and increased the metastatic potential of colon cancer cells in vitro and in vivo. This study aims to explore the mechanisms through which transgelin participates in the metastasis of colon cancer cells. Methods Immunofluorescence and immunoblotting analysis were used to determine the cellular localization of endogenous and exogenous transgelin in colon cancer cells. Co-immunoprecipitation and subsequently high-performance liquid chromatography/tandem mass spectrometry were performed to identify the proteins that were potentially interacting with transgelin. The 256 downstream transcripts regulated by transgelin were analyzed with bioinformatics methods to discriminate the specific key genes and signaling pathways. The Gene-Cloud of Biotechnology Information (GCBI) tools were used to predict the potential transcription factors (TFs) for the key genes. The predicted TFs corresponded to the proteins identified to interact with transgelin. The interaction between transgelin and the TFs was verified by co-immunoprecipitation and immunofluorescence. Results Transgelin was found to localize in both the cytoplasm and nucleus of the colon cancer cells. Approximately 297 proteins were identified to interact with transgelin. The overexpression of TAGLN led to the differential expression of 184 downstream genes. Network topology analysis discriminated seven key genes, including CALM1, MYO1F, NCKIPSD, PLK4, RAC1, WAS and WIPF1, which are mostly involved in the Rho signaling pathway. Poly (ADP-ribose) polymerase-1 (PARP1) was predicted as the unique TF for the key genes and concurrently corresponded to the DNA-binding proteins potentially interacting with transgelin. The interaction between PARP1 and transgelin in human RKO colon cancer cells was further validated by immunoprecipitation and immunofluorescence assays. Conclusions Our results suggest that transgelin binds to PARP1 and regulates the expression of downstream key genes, which are mainly involved in the Rho signaling pathway, and thus participates in the metastasis of colon cancer.

The inseparable internet requirements and the endless stream of cyber-attacks have led to strong demand for trusted IP addresses. However, the existing collaborative DNS security schemes have the defects of low credibility and imperfect incentive mechanism. Enlightened by the Consortium blockchain technology, we propose a novel DNS Cache Resources Trusted Sharing Model, which can improve the credibility of DNS resolution results by establishing a complete chain of trust. Firstly, the consortium blockchain is introduced as the carrier of the peer-to-peer network to reduce the impact of illegal access and complicity tampering on the DNS cache credibility; Secondly, the evaluation index of the node credibility in the DNS cache sharing model is proposed, and the trust-based incentive mechanism is designed to reduce the impact of free-riding behavior and on the trusted performance of the system. The two indicators of node abnormal behavior similarity and roundtrip time between nodes are used to comprehensively evaluate the degree of recommendation of the node and serve as the basis for dynamic scheduling; Finally, we use the stochastic distributed decentralized storage mechanism to solve the problem of low efficiency in the consortium blockchain. The simulation results show that the model has certain advantages in ensuring the credibility of domain name resolution results, and maintains the ideal efficiency while ensuring trust.

The traditional kernel correlation filter (KCF) algorithm has poor tracking results in complex scenes with severe occlusion, deformation, and low resolution and cannot achieve long-term tracking. To improve the accuracy of the tracking algorithm in complex scenes, an adaptive kernel correlation filter algorithm is proposed. First, a multifeature complementary scheme is proposed that linearly weights the responses of the histogram of oriented gradient (HOG) features and color features and learns a target position estimation model to realize target position estimation. Then, an adaptive scale model for estimating the scale transformation of the target is learned by extracting the HOG features of the object. Finally, according to occlusion judgment criteria, the Kalman filter is introduced to correct the position of the tracking target. The accuracy and success rate of the proposed algorithm are verified by simulation analysis on TC-128/OTB2015 benchmarks. Extensive experimental results illustrate that the proposed tracker achieves competitive performance compared with state-of-the-art trackers. The distance precision rate and overlap success rate of the proposed algorithm on OTB2015 are 0.899 and 0.635, respectively. The proposed algorithm effectively solves the long-term object tracking problem in complex scenes. This study provides references for computer vision processing, such as image retrieval, behavior analysis, and intelligent driving.

The fiber orientation is playing an important performance indexed for glass fiber reinforced polypropylene for water-assisted injection molding. Based on the viscoelastic constitutive equation (White-Metzner) and the fiber orientation model (iARD-RPR), the effects of fiber mass content, water injection delay time, water injection pressure, and melt temperature, which are on the fiber orientation along the flow direction and shear rate distribution of the melt, were investigated. Studies found that the orientation degree of the fiber along the flow direction was reduced with the increase of the fiber mass content, the extension of the water injection delay time, and the improvement of the melt temperature and that the orientation degree of the fiber along the flow direction was raised with the increase of the water injection pressure flow in the laminar flow state, but it was reduced with the increase in the turbulent state. It can be further learned from the shear rate distribution that decreasing fiber mass content, reducing the water injection delay time, lower melt temperature, and increasing water injection pressure in laminar flow conditions will increase the shear rate in the channel layer and the shear rate gradient along the thickness direction of the melt, while the water injection pressure in the turbulent state is on the contrary.

Excellent gyromagnetic properties of textured, bulk Ba-hexaferrite samples are required for low-loss, self-biased applications for microwave and millimeter-wave (MMW) devices. However, conventionally processed bulk Ba-hexaferrite ceramics typically demonstrate low remanent magnetization values, 4πMr, of 2.0~3.0 kG, and relatively large ferromagnetic resonance (FMR) linewidths, ΔHFMR, of 0.8~2 kOe. These properties lead to the development of high-performance, practical devices. Herein, crystallographically textured Ba-hexaferrite samples, of the composition Ba0.8La0.2Fe11.8Cu0.2O19, having excellent functional properties, are proposed. These materials exhibit strong anisotropy fields, Ha, of ~14.6 kOe, high remanent magnetization, 4πMr, of 3.96 kGs, and a low ΔHFMR of 401 Oe at zero-bias field at the Q-band. Concomitantly, the broadband millimeter-wave transmittance was utilized to determine the complex permeability, μ*, and permittivity, ε*, of textured hexaferrites. Based on Schlöemann’s theory of complex permeability, μ*, the remanent magnetization, 4πMr, anisotropy field, Ha, and effective linewidth, ΔHeff, were estimated; these values agree well with measured values.

C40H28N4O10Co, monoclinic, C2/c (no. 15), a = 29.686(3) Å, b = 6.2315(4) Å, c = 21.0994(15) Å, β = 114.727(8)°, V = 3545.3(5) Å3, Z = 4, Rgt(F) = 0.0386, wRref(F2) = 0.0897, T = 293(2) K.

Right ventricle (RV) segmentation is essential for assessing cardiac function in patients with pulmonary hypertension, tetralogy of Fallot, and so on. However, it remains difficult due to the complex structure of heart, thin myocardium and large variability of the RV, as well as the interferences from the fat nearby. Due to its high temporal and spatial resolution, cardiac cine magnetic resonance imaging is widely used for functional evaluation of the heart. This article reviews the commonly-used methods for RV segmentation from the cardiac cine magnetic resonance images. The traditional algorithms are described first, followed by the novel multi-atlas and deep learning methods. Lastly, the evaluation standards for RV segmentation are introduced. It is concluded that the deep learning-based segmentation methods may have the potential to become the method of choice in clinical settings due to their high efficiency and accuracy in the diagnosis and prognosis of the heart-related diseases.

Abstract Background To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway. Methods Thirty-seven paired colon cancer and its adjacent samples from The Cancer Genome Atlas (TCGA) were analyzed. Chip Analysis Methylation Pipeline (ChAMP) analysis was employed for differential methylated points (DMPs) and the differential methylation regions (DMRs) screening. The HOXD10 mRNA expression and DNA methylation levels were detected by RT-PCR. The Cell proliferation, migration, invasion and apoptosis were respectively measured by MTT assay, transwell assay, wound healing assay and flow cytometry assay in carcinoma cell lines after treated with 5-aza-2′-deoxycytidine (5-Aza-dC) or transfected with HOXD10-expressing plasmid. The expression of HOXD10 and RHOC was revealed by immunohistochemistry in disparate differentiation colon carcinoma tissues, and the dephosphorylation of AKT and MAPK pathways were detected by RT-PCR and western blot. Results The bioinformatics analysis demonstrated that HOXD10 was hypermethylated and low-expressed in colorectal cancer tissues. The detection of RT-PCR indicated the similar results in colorectal cancer cell lines and tissues. The induction of demethylation was recovered by treatment with 5-Aza-dC and the HOXD10 in colorectal cancer cell lines was re-expressed by transfection with a HOXD10 expression vector. The demethylation or overexpression of HOXD10 suppressed proliferation, migration, invasion and promoted apoptosis in colorectal cancer cells. HXOD10 suppressed the tumor growth and detected an opposite trend of protein RHOC. AKT and MAPK pathways were notably inactivated after the dephosphorylation due to the overexpression of HOXD10. Conclusions HOXD10 was suppressed in colon adenocarcinoma cells, which down-regulated RHOC/AKT/MAPK pathway to enhance colon cancer cells apoptosis and constrain the proliferation, migration and invasion.

Compared with water penetration condition of short-shot water-assisted injection molding with or without overflow cavity, it can be known from theory and common knowledge that short-shot water-assisted injection molding with overflow cavity has many advantages, such as it can save materials and energy. Then, the effects of melt short shot size, water injection delay time, melt temperature and water injection pressure on the penetration of water after penetration, and the orientation distribution of short fibers during water-assisted injection molding of the overflow cavity short-shot method were studied. It is found that the melt short shot size had the greatest influence on it, followed by water injection pressure, water injection delay time, and finally, melt temperature. With the increase of the melt short shot size, the thickness of the residual wall of the whole main cavity becomes thinner, the orientation of short fiber along the melt flow direction becomes higher, and the degree of fiber orientation changes becomes lower. In the front half of the main cavity, with the decrease of water injection pressure, the delay time of water injection, and the melt temperature, in the front part of the main cavity, the residual wall thickness becomes thinner, the fiber orientation along the melt flow direction becomes lower, and the fiber orientation changes degree becomes higher; in the latter half of the main cavity, the influence of the water penetration and the orientation distribution of short fibers along the melt flow direction are not significant.

This work demonstrates the dependence between magnetic properties and the thickness of NiFe thin films. More importantly, a quantitative study of the surface composition of NiFe thin film exposed to atmospheric conditions has been carried out employing angle-resolved X-ray photoelectron spectroscopy (ARXPS). In this study, we fabricated Ni81Fe19 (NiFe) thin films on Si (100) substrate using electron beam evaporation and investigated their surface morphologies, magnetic properties, and the thickness of the surface oxide layer. The coexistence of metallic and oxidized species on the surface are suggested by the depth profile of ARXPS spectra. The thickness of the oxidized species, including NiO, Ni(OH)2, Fe2O3, and Fe3O4, are also estimated based on the ARXPS results. This work provides an effective approach to clarify the surface composition, as well as the thickness of the oxide layer of the thin films.