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Abstract Background Organophosphate-Induced Delayed Neuropathy (OPIDN) is a rare neurological disorder triggered by exposure to organophosphorus compounds. These compounds exert their neurotoxic effects by impacting the nervous system, leading to systemic manifestations. Urinary system symptoms are infrequently observed in clinical settings. Currently, effective therapeutic interventions for OPIDN-related urinary symptoms are lacking. Sacral nerve modulation therapy, an FDA-approved approach for managing lower urinary tract symptoms, presents as a promising option. Herein, we present a case of OPIDN-induced lower urinary tract obstruction successfully treated with sacral nerve modulation therapy, resulting in substantial symptom relief. Case report A 27-year-old male patient presented with severe bilateral hydronephrosis, attributed to low bladder compliance and accompanied by a fever persisting for 6 days. The patient’s medical history revealed accidental ingestion of organophosphate pesticide (Dimethoate) with no concomitant underlying diseases. In consideration of the potential for OPIDN, surgical intervention in the form of sacral neuromodulation (phase I) was undertaken. Subsequent evaluation one month post-surgery revealed notable improvements in both bladder compliance and bilateral hydronephrosis, necessitating sacral neuromodulation (phase II). Presently, following a 5-month follow-up period, the patient remains asymptomatic and in favorable health. Conclusion This patient achieved long-term relief using sacral neuromodulation.

Abstract Type 2 diabetes mellitus (T2DM) is a complicated disease related to metabolism that results from resistance to insulin and sustained hyperglycemia. Traditional antidiabetic drugs cannot meet the demand of different diabetes patients for reaching the glycemic targets; thus, the identification of new antidiabetic drugs is urgently needed for the treatment of T2DM to enhance glycemic control and the prognosis of patients suffering from T2DM. Recently, glucokinase (GK) has attracted much attention and is considered to be an effective antidiabetic agent. Glucokinase activators (GKA) represented by dorzagliatin could activate GK and mimic its function that triggers a counter‐regulatory response to blood glucose changes. Dorzagliatin has shown great potential for glycemic control in diabetic patients in a randomized, double‐blind, placebo‐controlled Phase 3 trial (SEED study) and had a favorable safety profile and was well tolerated (DAWN study). In the SEED study, dorzagliatin significantly reduced glycosylated hemoglobin (HbA1c) by 1.07% and postprandial blood glucose by 2.83 mol/L, showing the great potential of this drug to control blood glucose in diabetic patients, with good safety and good tolerance. An extension of the SEED study, the DREAM study, confirmed that dorzagliatin monotherapy significantly improved 24‐h glucose variability and increased time in range (TIR) to 83.7% over 46 weeks. Finally, the clinical study of dorzagliatin combined with metformin (DAWN study) confirmed that dorzagliatin could significantly reduce HbA1c by 1.02% and postprandial blood glucose by 5.45 mol/L. The current review summarizes the development of GK and GKA, as well as the prospects, trends, applications, and shortcomings of these treatments, especially future directions of clinical studies of dorzagliatin.

BackgroundRecent an observational study has suggested a potential connection between gut microbiota (GM) and peptic ulcer diseases (PUDs), particularly gastric ulcer (GU) and duodenal ulcer (DU). However, the causal connection remains unsure.MethodsA two-sample Mendelian randomization (MR) is carried out to explore the connection between the GM and DU or GU. Data on the GM comes from the MiBioGend database, and GU or DU data are based on the FinnGen database. One group of single nucleotide polymorphisms (SNPs) (P < 5 × 10−8) are served as instrumental variables (IVs). To obtain a more comprehensive conclusion, the other SNPs (P < 1 × 10−5) are selected as IVs. Inverse variance weighting (IVW) is used to determine the causal relationship.ResultsAt the level of P < 1 × 10−5, the IVW analysis suggests that Clostridiaceae1, Butyriccoccus, and Peptcoccus have harmful effects on GU, while LachnospiraceaeUCG004 and MollicutesRF9 have beneficial effects on GU. Then, in the case of DU, the IVW analysis suggested that Lentisphaeria, Negativicutes, Clostridiaceae1, ClostridiumseMnsustricto1, ErysipelotrichaceaeUCG003, LachnospiraceaeNC2004group, Selenomonadale, Victivallales, and Lentisphaerae have harmful effects, while Catenibacterium, Escherichia.Shigella, LachnospiraceaeUCG008, and Sutterella have beneficial effects. When P < 5 × 10−8, IVW analysis suggests that GM has no significant influence on GU or DU.ConclusionThis two-sample MR indicates a causal relationship between GM and GU or DU.

The seismic performance of isolated girder bridges is accurately investigated and addressed by considering the theoretical foundation of seismic isolation, taking into account the operational period’s service state and changes in relevant performance indicators of vulnerable components. The analysis encompasses a comprehensive parameter analysis of seismic performance during the operational period, utilizing finite element analysis software, which involves comparing and analyzing structural deflections, deformation performance, and damage performance of seismically isolated girder bridges under varying parameters. The research findings indicate that, in terms of evaluating the damage state of the member, the displacement of the girder end of the main girder is primarily influenced by the interface friction coefficient of the isolation device, followed by the post-yield stiffness of the bearing. Conversely, abutment lateral stiffness has a relatively minor influence. Moreover, it is observed that the mechanical properties of the bearing (friction coefficient and post-yield stiffness) exert a significant impact on the structural seismic response. Therefore, more attention should be paid to the functional condition and the variation of mechanical performance parameters of the seismic isolation bearing during the operational phase.

Abstract Background Sini Decoction (SND), a classic Chinese medicine prescription, has been proved to have a good effect on heart failure (HF), whereas its underlying mechanism is still unclear. In order to explore the therapeutic mechanism of SND, we combined with 16S rRNA gene sequencing to analyze the composition of gut microflora in rats with HF. Material and methods Twenty Sprague–Dawley (SD) rats were divided into four groups (n = 5): normal group, model group, SND treatment group (SNT group), and metoprolol (Met) treatment group (Meto group). All the rats except the normal group were intraperitoneally injected with doxorubicin (concentration 2 mg/mL, dose 0.15 mL/100 g) once a week to induce HF. After successfully modeling, SND and Met were gavaged to rats, respectively. After the treatment period, blood was collected for hematological analyses, myocardial tissue and colon tissues were collected for Hematoxylin–Eosin (H&E) staining, and mucosal scrapings were collected for Illumina Miseq high-throughput sequencing. Results Echocardiographic results suggested that both left ventricular ejection fraction (LVEF) and left ventricular fraction shortening (LVFS) in Model rats decreased compared with normal rats. The results of H&E staining showed that compared with the model group, the structures of myocardial tissue and colon tissue in the SNT group and Meto group showed a recovery trend. Alpha results showed that the model group had higher species diversity and richness compared with the normal group. After treatment, the richness and diversity of intestinal bacteria in the SNT group were significantly restored, and Met also showed the effect of adjusting bacterial diversity, but its effect on bacterial richness was not ideal. At the Family level, we found that the number of several bacteria associated with HF in the model group increased significantly. Excitingly, SND and Met had shown positive effects in restoring these HF-associated bacteria. Similarly, the results of Linear discriminant analysis (LDA) showed that both SND and Met could reduce the accumulation of bacteria in the model group caused by HF. Conclusion Collectively, SND can improve HF by regulating the intestinal flora. This will provide new ideas for the clinical treatment of patients with HF.

Debiased recommender models have recently attracted increasing attention from the academic and industry communities. Existing models are mostly based on the technique of inverse propensity score (IPS). However, in the recommendation domain, IPS can be hard to estimate given the sparse and noisy nature of the observed user–item exposure data. To alleviate this problem, in this paper, we assume that the user preference can be dominated by a small amount of latent factors, and propose to cluster the users for computing more accurate IPS via increasing the exposure densities. Basically, such method is similar with the spirit of stratification models in applied statistics. However, unlike previous heuristic stratification strategy, we learn the cluster criterion by presenting the users with low ranking embeddings, which are future shared with the user representations in the recommender model. At last, we find that our model has strong connections with the previous two types of debiased recommender models. We conduct extensive experiments based on real-world datasets to demonstrate the effectiveness of the proposed method.

The quantitative evaluation of the ecological security can reflect the changes in the quality of ecological environment and provide a scientific basis for the formulation of land-use policy and for the construction of the ecological environment. In this study, we selected Xilingol League in Inner Mongolia, China, as the research area, and established the driving force-pressure-state-impact-response-management (DPSIRM) model to evaluate grassland ecological security. The results were as follows: (1) During 2005–2015, the overall trend of ecological security level in the study area increased, with the western region being relatively ecologically insecure and the eastern region being more secure. (2) The spatial distribution trend of ecological security level from west to east was “ very serious alerts ” → “ serious alerts ” → “ moderate alerts ” → “ light alerts ”→ “ no alert ”. (3) The “ very serious alerts ” and “ serious alerts ” are mainly concentrated in Sonid Left Banner and Sonid Right Banner, but from the perspective of spatial migration of ecological security, unsafe and less safe tend to shift to the northeast. This study provides a new idea for grassland ecological security evaluation research, has important practical significance for understanding the ecological security level of Xilingol grassland area, and will guide the reasonable development and utilization of Xilingol grassland.

The local series system with typical common plate rubber support/pier in highway reinforced concrete girder bridge is the object of the current research. The finite element numerical simulation method is used to study sensitive parameters – the mechanical properties of the series system under the horizontal load. The simulated results show that the interface bonding strength between the bearing and adjacent structure is reduced; the equivalent shear deformation and the horizontal force of bearing under horizontal load change insignificantly with the increase of horizontal displacement. However, the total shear deformation and equivalent shear deformation increase with the increase of the axial compression ratio. In addition, the top horizontal force and displacement of the pier significantly decrease with reduction of the connection strength at both ends of the bearing. Therefore, adjusting the axial compression ratio of the pier and interfacial connection mode can obviously affect the mechanical properties of the support and adjacent structure, even the failure mode of the local structure. This approach can help estimate the mechanical properties of the existing bridge and determine the reasonable maintenance plan.

Purpose: Based on self-determination theory, this study sought to clarify the internal mechanism of the impact of proactive personality and career calling on job performance from both personality traits and intrinsic motivation perspectives, highlight the important role of job crafting as an individual’s proactive behaviour, and demonstrate the supporting role of organisational embeddedness as an external environmental factor. Design/methodology/approach: Hierarchical regression analysis and bootstrap-based path analysis were used to test the above hypotheses on 292 employees in China. Findings/results: The results show that proactive personality and career calling had significant positive effects on employees’ job performance, and job crafting was a full mediator in both paths, with significantly different mediation effects. Organisational embeddedness moderated this mediating effect. Practical implications: This study provides references for employees and organisations to continuously improve their job performance. Organisations need to address job crafting behaviours and create related supporting atmospheres. Originality/value: This study explored the mechanisms that affect career outcomes from both personality traits and intrinsic motivation aspects. The theoretical model verifies the value of individual intrinsic motivation and autonomous behaviour, and confirms the theory of self-determination. The study also extends the existing career theory by breaking through the one-sidedness of the previous theory that emphasises only the role of the organisation, but highlights the crucial importance of employees’ subjective initiatives.

By using urea linked porous organic polymers as template, a new nano palladium catalyst with low Pd loading can be easily prepared (1.0 wt% Pd only). Although such less amount of Pd was contained in this new catalyst, it is still an effective catalyst for the Suzuki-Miyaura coupling of aryl iodines and aryl boric acids, affording biphenyl products in excellent yields with outstandingly enhanced turnover numbers (up to 10,536) under green solvent (water). Keywords: Nanoparticles, Porous materials, Palladium, Porous organic polymers, Suzuki Cross coupling

A facile and practical heterogeneous copper nanoparticles catalyst (Cu@AEPOP) was prepared by the incorporation of Cu(OAc)2 to amide and ether functionalized porous organic polymers (AEPOP) that were efficiently prepared by condensation of 4,4′-diaminodiphenyl ether with 1,3,5-benzenetricarbonyl chloride. The prepared AEPOP and Cu@AEPOP were characterized by SEM, BET, TEM, ICP, FT-IR and XRD. With TBHP (70 wt% in water) as oxidant and solvent, Cu@AEPOP showed excellent catalytic activity for the selective oxidation of benzylic C–H bonds. Among the oxidation of alkyl benzenes to ketones, secondary alcohols to ketones, and primary alcohols to acids, the copper catalyst exhibited remarkable selectivity and reactivity for a broad range of substrates in excellent yields. Furthermore, the experimental operation was very facile and the heterogeneous catalyst could be easily recovered by filtration separation.

We, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article:Hanyu Shi, Zhenhua Dong & Haiqing Gao (2019) LncRNA TUG1 protects against cardiomyocyte ischaemia reperfusion injury by inhibiting HMGB1. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 3511–3516, DOI: 10.1080/21691401.2018.1556214It has come to our attention that the full authorship list and affiliations for this manuscript were changed after the article was submitted. We have contacted the authors for an explanation, but we have not received a response within the requested timeframe. As determining authorship is core to the integrity of published work, we are therefore retracting the article. The authors listed in this publication have been sent notification.We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.

The novel palladium nanoparticles (Pd@POPs) were successfully prepared with controllable sizes and dispersity through the introduction of H2PdCl4 into urea-linked porous organic polymers (POPs) in an aqueous environment followed by reducing Pd(II) to Pd(0) by NaBH4. The newly prepared Pd@POPs were thoroughly characterized by FT-IR, ICP-AES, BET, XRD, SEM and TEM. Furthermore, the catalytic reactivities of this novel Pd@POPs were investigated via Heck, Suzuki-Miyaura cross-coupling reaction and nitroarene reduction, and they exhibited superior catalytic performances in all these three reactions, producing the corresponding products in up to quantitative yields. Additionally, the Pd@POPs had excellent recyclability in both Heck and Suzuki-Miyaura cross-coupling reactions with the repeating time up to four times and ten times, respectively, along with no obvious decrease of catalytic reactivities.

This paper’s purpose is to test the employability paradox by adopting a combined linear and non-linear approach based on the conservation of resource (COR) theory and the prospect theory and further to discuss it in two groups of employees with different seniority following the career timetable perspective. A total of 623 pairs of matched employee and manager surveys was collected from 27 Chinese enterprises in two waves. Hierarchical regression analysis was used to test the hypotheses. The results show no paradox that perceived employability promotes both an employee’s turnover intention and performance. Specifically, perceived employability has a significant inverted U-shaped effect on turnover intention but no direct influence on job performance. Seniority is a moderator, showing the curvilinear relationship only exhibits for employees with shorter work seniority (≤3 years), and a positive linear relationship between perceived employability and job performance only exists for employees with longer seniority (>3 years). This study emphasizes the value of employability for employers and proposes who is more suitable and what timetable should be followed for employability enhancement in practice. In addition, the study provides an enlightening finding of the inverted U-shaped relationship between perceived employability and turnover intention, applies the COR theory and the prospect theory to explain the non-linear relationship, validates the effect of too much of a good thing (TMGT), and negates the paradox from the perspective of the perceived general employability and career timetable.

Abstract Background α-Linolenic acid (ALA) is a plant-derived omega-3 unsaturated fatty acid that is rich in flaxseed oil (FO). The effect of FO on bone health is controversial. This study aims to evaluate the effect of FO on bone damage induced by a high-fat diet (HFD) and to explore the possible mechanism. Methods Male Sprague-Dawley rats were fed a normal control diet (NC, 10% fat), FO diet (NY, 10% fat), HFD (60% fat), or HFD containing 10% FO (HY, 60% fat) for 22 weeks. Micro CT and three-point bending tests were conducted to evaluate bone microstructure and biomechanics. Serum was collected for the detection of ALP, P1NP, and CTX-1. Rat primary osteoblasts (OBs) were treated with different concentrations of ALA with or without palmitic acid (PA) treatment. The ALP activity, osteogenic-related gene and protein expression were measured. Results Rats in the HFD group displayed decreased biomechanical properties, such as maximum load, maximum fracture load, ultimate tensile strength, stiffness, energy absorption, and elastic modulus, compared with the NC group (p

In the context of climate change, the remote sensing identification of crops is extremely important for the rapid development of agricultural economy and the detailed assessment of the agro-meteorological disasters. The Jilin Province is the main grain production area in China, with a reputation of being a “golden corn belt”. The main crops in the Jilin Province are rice, corn, and soybean. A large amount of remote sensing data and programming codes from the Google Earth engine (GEE) platform allow for large-area farmland recognition. However, the substantial amount of crop sample information hinders the mapping of crop types over large farmland areas. To save costs and quickly and accurately map the crop types in a study area, multi-source remote sensing data and historical crop labels based on the GEE platform were used in this study, together with the random forest classification method and optimal feature selection to classify farming areas in the Jilin Province. The research steps were as follows: (1) select samples based on the historical crop layer of the farmland; and (2) obtain the classification characteristics of rice, corn, and soybean using multi-source remote sensing data, calculating the feature importance scores. Using different experimental combinations, an optimal classification method was then selected to classify crops in the Jilin Province. The results indicated variable impacts of vegetation indices (of different periods) on crop classification. The normalized difference vegetation index (NDVI), green normalized difference vegetation index (GNDVI), and green chlorophyll vegetation index (GCVI) in June exerted a significant impact on the classification of rice, corn, and soybean, respectively. The overall accuracy of crop classification during different periods based on historical crop labels reached 0.70, which is acceptable in crop classification research. The study results demonstrated that the proposed method has promising potential for mapping large-scale crop areas.

Palladium immobilized on an amide and ether functionalized porous organic polymer (Pd@AEPOP) is reported to be an effective heterogeneous catalyst for the Heck cross-coupling reaction of aryl iodides with styrene for the synthesis of diphenylethene derivatives. Excellent yields can be obtained using a 0.8 mol% Pd catalyst loading under the optimized reaction condition. The heterogeneous Pd@AEPOP catalyst can also be applied on the Suzuki reaction and the reduction of nitroarene.

In this paper, we selected Xilingol League in Inner Mongolia, China, as the research area, based on the land-use data of five Landsat remote sensing images taken between 1980 and 2015. Then, we calculated the complex network eigenvalues, such as the average shortest path, betweenness centrality, and degree, to identify the key land-use types, stability, and ecological environment change regularity from the perspective of the land-use system. Finally, we used the Canonical Correspondence Analysis (CCA) method to explore the main driving forces behind changes in the land-use system, to provide scientific support for the study of changing trends in land-use, and regional grassland ecological management. The findings are shown below. First, in the last 35 years, grasslands have always been the major type of change in land-use transfer matrices. Grasslands play a controlling role in the whole land-use system. Second, grassland and cultivated land are the major “transfer out” type of land in the Xilingol area, while construction land and water area belong to the major “transfer in” type of land. Third, the average shortest path values of four transition matrix networks were all less than 1.5, indicating that the land-use system becomes less stable, but the average shortest path values of these four networks present an increasing trend, leading to a more stable development of the land-use system. However, on the whole, it shows an upward trend, and the land-use system is moving in a stable direction. Fourth, the average annual rainfall, population, topographic factors, GDP, and distance from settlements play a prominent role in determining the spatial distribution of change in land-use in Xilingol.

Debris flow events often pose significant damage and are a threat to infrastructure and even livelihoods. Recent studies have mainly focused on determining the susceptibility of debris flow using deterministic or heuristic/probabilistic models. However, each type of model has its own significant advantages with some irreparable disadvantages. The random forest model, which is sensitive to the region where the terrain conditions are suitable for the occurrence of debris flow, was applied along with the steady-state infinite slope method, which is capable of describing the initiation mechanism of debris flow. In this manner, a random-forest-based steady-state infinite slope method was used to conduct susceptibility assessment of debris-flow at Changbai mountain area. Results showed that the assessment accuracy of the proposed random-forest-based steady-state infinite slope method reached 90.88%; however, the accuracy of just the random forest model or steady-state infinite slope method was only 88.48% or 60.45%, respectively. Compared with the single-model assessment results, the assessment accuracy of the proposed method improved by 2.4% and 30.43%, respectively. Meanwhile, the debris-flow-prone area of the proposed method was reduced. The random-forest-based steady-state infinite slope method inherited the excellent diagnostic performance of the random-forest models in the region where the debris flow disaster already occurred; meanwhile, this method further refined the debris-flow-prone area from the suitable terrain area based on physico-mechanical properties; thus, the performance of this method was better than those of the other two models.

The effect of vehicle loads on reinforced concrete plate-girders was evaluated using the current Chinese specifications. Repeated loading performance tests with loading amplitudes of 77 kN, 97 kN, and 121 kN, which correspond to the standard vehicle load, 1.25 times overload, and 1.6 times overload proportions effect were carried out on three full-scale simply-supported reinforced concrete plate-girders. Our research results indicate that the development of cracks in reinforced concrete beams can be divided into three stages: rapid development, stability, and failure. During the entire process, the strain of steel and concrete did not reach their yield strain. The most severe damage done to the concrete beams was the brittle fractures caused by the fatigue fracturing of the rebar. When in a stable condition, the extent to which the vehicle was overloaded had a significant effect on the fatigue performance of the beam, and the corresponding residual deflection and residual strain increased with the rise in the overload proportion. In addition, as the overload proportion increased, the stiffness degradation and the cumulative damage that occurred under the same loading cycle was more significant. The test beam reached failure after being subjected to 350,000 and 670,000 repeated loading cycles, when the load was 1.6 times and 1.25 times of the standard load effect. With a standard vehicle load effect, the test beam was able to endure 2,000,000 repeated load cycles with no significant degradation in stiffness and bearing capacity.

Composite materials that combine the unique properties of zeolitic imidazolate frameworks (ZIFs) and carbon nanotubes (CNTs) can give rise to novel applications. Here, ZIF-8/CNT composites were successfully prepared with and without the addition of an agent template. The size of the ZIF-8 crystals in the composite materials was controlled by varying the template, feeding order, and concentration of reactants. Thus, ZIF-8 crystals with a wide variety of sizes (from nano- to micrometer size, which is range that differs by a factor of 10) were obtained, depending on the conditions. This size-controllable synthesis of ZIF-8 was achieved by modifying the number of nucleation sites on the CNTs, as revealed by density functional theory (DFT) calculations. This work provides an efficient method for preparing ZIF-8/CNT composites with controllable size and can pave the way for the synthesis of other metal-organic framework (MOF)/CNT composite materials.

Transcutaneous electrical nerve stimulation (TENS) is commonly used in clinical practice for alleviating pains and physiological disorders. It has been reported that TENS could counteract the ischemic injury happened in some vital organs. To determine the protective effect of TENS on internal organs during CH in dogs, target hypotension was maintained for 60 min at 50% of the baseline mean arterial pressure (MAP). The perfusion to the brain, liver, stomach, and kidney was recorded and apoptosis within these organs was observed. Results showed that when arriving at the target MAP, and during the maintaining stage for 10 min, perfusion to the stomach and liver in the CH+TENS group was much higher than in the CH group (P

Drought has an important influence on the hydrological cycle, ecological system, industrial and agricultural production, and social life. Based on the different time scales of characteristics of drought variability, the standardized precipitation evapotranspiration index (SPEI), a multi-timescale index with consideration of evaporation, was used in this study to estimate the spatial and temporal variability characteristics of drought. Climatic data from 15 meteorological stations across Horqin Sandy Land during 1964–2013 were used to calculate the SPEI of 1, 3, 6, and 12 months. In order to examine the relationship between droughts and other variables, 10 extreme climate indices were calculated based on the daily precipitation and maximum/mean/minimum temperature data of 15 meteorological stations, and linkages between SPEI-12 and atmosphere indices were established using by the cross wavelet transform method. The results indicated that the climate of Horqin Sandy Land had a tendency towards drought conditions, which is particularly apparent from the year 2000 onwards. During the study period, drought events were frequent in the region. Mild drought occurred in a quarter of the month, with that of moderate, severe, and extreme drought accounting for 0.11, 0.05, and 0.02 of the total months. The spatial trend of multi-timescale drought revealed that there was an increase in the severity of drought throughout Horqin Sandy Land, among which the magnitude in southern parts was larger than that of northern parts. The results also showed that the short time scale drought negatively correlated with precipitation extremes and positively correlated with temperature extremes. Furthermore, the long time scale drought (SPEI-12) was associated with atmosphere indices. Significant resonance periods were found between El Nino southern oscillation (ENSO), the East Asian summer monsoon index (EASMI), and SPEI-12.