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Background Successful aging can help to alleviate the aging process, but may be affected by household income. Objective To explore the impact of household income on successful aging and provide fundamental data for improving health equity for the elderly in China. Methods Data from the 2018 China Health and Retirement Longitudinal Study (CHARLS) were used to select participants aged 60 and above. The older adults were categorized into the high-income (≤33.33%) , middle-income (33.34%-66.66%) , and low-income (≥66.67%) groups based on the annual household income levels within each province. Successful aging was measured based on the Rowe and Kahn models and the multivariate Logistic regression was conducted to identify the effects of different levels of household income on successful aging. Results A total of 7 741 subjects were finally included with 2 192 (28.32%) , 2 680 (34.62%) and 2 869 (37.06%) in the low-income group, middle-income group and high-income group, respectively. The proportion of successful aging was 15.55% (1 204/7 741) among Chinese older adults in 2018, with 21.02% (603/2 869) for high-income group, 13.62% (365/2 680) for middle-income group, and 10.77% (236/2 192) for low-income group (P0.05) . The results of multivariate Logistic regression analysis showed that after controlling for demographic characteristics (age, gender, ethnicity, education level, and region of residence) , the proportion of successful aging in the middle-income and high-income groups was 1.226 times (OR=1.226, 95%CI=1.028-1.463) and 1.721 times (OR=1.721, 95%CI=1.450-2.044) as high as those in the low-income group; after controlling for health status and behavioral factors (night sleep duration, accidental falls, hospitalization in the past year, hearing, and masticatory function) , the proportion of successful aging in the high-income group was 1.559 times higher than that in the low-income group (OR=1.559, 95%CI=1.300-1.882) ; after controlling for home living environment (bathing facilities, home hygiene) , the proportion of successful aging in the high-income group was 1.461 times higher than that in the low-income group (OR=1.461, 95%CI=1.207-1.770) (P

Objective(s): The present study aims to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks.Materials and Methods: Chronic migraine (CM) model rats were divided into 3 groups, and intragastrically administered alcoholic drinks (sample A, B, or C) to simulate hangover headache attacks. The withdrawal threshold for the hind paw/face and the thermal latency of hind paw withdrawal were detected after 24 hr. Serum was collected from the periorbital venous plexus of rats in each group, and enzymatic immunoassays were used to determine the serum levels of calcitonin gene-related peptide (CGRP), substance P (SP), and nitric oxide (NO).Results: Compared with the control group, the mechanical hind paw pain threshold was significantly lower in rats administered Samples A and B after 24 hr; however, no significant difference was observed across groups for the thermal pain threshold. The mechanical threshold for periorbital pain was only significantly reduced in rats administered Sample A. Immunoassays further indicated that serum levels of SP in the group administered Sample A were significantly higher than those in the control group; the serum levels of NO and CGRP were significantly higher in the group of rats receiving Sample B.Conclusion: We successfully developed an effective and safe rat model for investigating alcohol drink induced hangover headaches. This model could be used to investigate the mechanisms associated with hangover headaches for the development of novel and promising candidates for the future treatment or prophylaxis of hangover headaches.

Objective To analyze the level of intestinal flora in uterine myoma patients and normal women, and to explore the correlation between intestinal flora and uterine myoma. Methods We selected 70 female patients with uterine myoma treated in our hospital from June 2015 to July 2017 as the study subjects, and 70 healthy women as control group. The feces of two groups were collected to extract their DNA and measure the number of intestinal flora. The levels of intestinal microflora were compared between the two groups, and the correlation between intestinal flora and the occurrence of uterine myoma was analyzed. Results Compared with the control group, total bacterial count and lactobacillus levels were significantly higher, and the levels of bifidobacterium, bacteroidetes, fusobacterium and proteus species were significantly lower in uterine myoma group (all P < 0.05). Total number of bacteria, bifidobacterium and lactobacillus were positively correlated, while bacteroides, clostridium and proteus were negatively correlated with the occurrence of uterine myoma (all P < 0.05). Conclusion There is correlation of the number and species of intestinal flora with the occurrence of uterine myoma.

Numerical analysis software based on linear finnite element method and statistical damage theory concrete material has been adopted in this study. Dynamic numerical model of twin fibers pullout test of concrete matrix have been created by considering the meso-heterogeneity of concrete material. The whole process from micro-cracks initiation, propagation to crack penetration has been simulated. The influence of stress wave loading peak and loading rate on twin fibers pull-out test of concrete matrix under dynamic load has, therefore, been scrutinized. Results show that loading rate has effect on failure mode and crack propagation along interface of the twin fibers pull-out specimens. With increasing loading rates, the rate of interface crack propagation and damage area increase either.