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Objective To explore the application value of functional movement screening (FMS) and targeted physical fitness training in military training for armored troops in cold area. Methods A total of 160 male new recruits were selected from an armored synthetic brigade by random number table method, and then divided into the experimental group and the control group (n=80). The common subjects in the military training program were given to the control group. Besides the common subjects, the experimental group were also given targeted physical fitness training, including core strength training and targeted movement correction training. Before and in 6 months after training, FMS test was carried out for the 2 groups. The occurrence of training injuries were observed and recorded in 2 groups during the 6 months of new training. Results Before the new training, there was no statistical difference in the FMS score between the experimental group and the control group (15.64±2.95 vs 15.67±3.42, P>0.05). After 6 months of training, the FMS score of the experimental group was 18.33±2.67, which was significantly higher than that of the control group (16.75±3.31, P < 0.05). The overall incidence of training injury was 12.50% in the experimental group, which was significantly lower than that in the control group, but no significant difference. In both groups, the incidence of training injury was significantly higher in those with FMS score < 14 than those with the score ≥14 from the same group (P < 0.05). The incidence in the experimental group with FMS score < 14 was 23.53% (4/17), significantly lower than that in the control group with FMS score < 14 [64.29% (9/14), P < 0.05]. Conclusion Application of FMS is conducive to understanding and judging the fundamental movements in officers and soldiers, and targeted physical fitness correction training can enhance their own physical quality and reduce the occurrence of training injuries.

[Objective] In order to enrich the data for the study of micropyle closure in gymnosperms and to provide a reference for the phylogenetic study of gymnosperms, micropyle closure of Platycladus orientalis Franco was investigated. [Methods] Female cones of P . orientalis were sampled and examined using morphological techniques, including paraffin section and scanning electron microscopy. In addition, cluster analysis of the mode of micropyle closure was conducted for Bennettitales. [Results] (1) After pollen enters the ovule, the innermost two cell layers of the integument began to grow radially inward until the micropyle was completely closed. (2) During the micropyle closure, the innermost cells of the integument were elongated and became conical in shape, with the cell layers typically increased to 4 to 6 layers. (3) The micropyle closure of gymnosperms could be divided into four clades: One for Cycas and Ginkgo, one for Pinus and Podocarpaceae, a separate group for Bennettitales, and a cluster of P . orientalis and other species. [Conclusion] The micropyle closure of P . orientalis differs from Ginkgo and cycads, which is similar to Pinus and Bennettitales. This study suggests that there is an evolutionary relationship in micropyle closure between Bennettitales and existing conifers, providing novel morphological evidence for the understanding of evolution of the reproductive systems of gymnosperms.

In order to decode the difference between audiovisual bimodal and unimodal responses of the human brain in semantic context, this study designed a related task paradigm and applied a new generation magnetoencephalogram combined with the machine learning model to analyze the collected signals from three perspectives: behavioral response, event-related field (ERF) and single-trial detection. Results show that the unimodal semantic response was mainly concentrated in the occipital cortex, while the bimodal semantic response was mainly concentrated in the parietal cortex. At the same time, respondents' response rate and the detection accuracy of single-trial in bimodal mode were significantly higher than that in unimodal mode. Moreover, the support vector machine (SVM) showed the best classification performance among the four machine learning models, with an average classification accuracy of 75.16% for within-subject classification and 80.56% for between-subject classification. This research concludes that the combination of optically pumped magnetometer-magnetoencephalography (OPM-MEG) and machine learning model provides an efficient approach to decode the difference between audiovisual bimodal and unimodal responses of the human brain in semantic context.

In December 2023, the Chinese Center for Disease Control and Prevention published National and subnational trends in cancer burden in China, 2005-2020: an analysis of national mortality surveillance data.on Lancet Public Health, covering the mortality rate and average years of life lost from 23 specific tumor sites in people in 31 provinces and cities across the country. The analysis suggests that in 2020, the number of deaths from cancer in China was 2.3978 million, with a mortality rate of 170.80/100 000. The top 10 tumor deaths cases are as follows: lung cancer 761,000, liver cancer 367,700, stomach cancer 291,200, colorectal cancer 182,400, esophageal cancer 173,300, pancreatic cancer 100,400, breast cancer 57,100, leukemia 54,900, cranial nerve cancer 54,200, cervical cancer 44,800, accounting for 32.0%, 15.3%, 12.1%, 7.6%, 7.2%, 4.2%, 2.4%, 2.3%, 2.3%, 1.9% of the total number of deaths due to tumors, respectively. The mortality rates were 54.57/100 000, 26.19/100 000, 20.74/100 000, 13.00/100 000, 12.34/100 000, 7.15/100 000, 4.06/100 000, 3.91/100 000, 3.86/100 000 and 3.19/100 000, respectively. In 2020, the average years of life lost (AYLL) due to cancer in China was 23.60 years, which was 3.74 years lower than that in 2015. Among them, leukemia caused an AYLL of 37.35 years, with a decrease of 13.36 years from the AYLL of 50.71 years caused by leukemia in 2005, but it was still the tumor that caused the most life loss. Prostate cancer was the tumor that caused the least AYLL. The composition of China’s cancer spectrum is changing to those in developed countries. Lung cancer, breast cancer and colorectal cancer, which are highly prevalent in developed countries, are showing an increasing disease burden trend in China. In 2020, the mortality rates of lung cancer, breast cancer and colorectal cancer all increased during this period, increasing by 78.98%, 19.41% and 47.56% respectively compared with those in 2005. GLOBOCAN2022 suggests that the top 10 cancer incidence rates in China in 2020 are lung cancer (40.8/100 000), breast cancer (33.0/100 000), thyroid cancer (24.6/100 000), liver cancer (20.1/100 000), cervical cancer (15.0/100 000), gastric cancer (13.8/100 000), prostate cancer (13.7/100 000), esophageal cancer (9.7/100 000), uterine cancer (8.7/100 000) and ovarian cancer (6.8/100 000). Five of the top 10 common cancer in China and the United States overlap, and lung cancer is the leading cause of death in both countries. Changes in the spectrum of tumor diseases have made the promotion and implementation of proven tumor prevention and control measures more urgent.

In the traditional sharing mode, the risk information of food full-process and all-information is sensitive and easy to leak, the self-interest and complete autonomy of centralized servers and malicious nodes easily give rise to malicious behaviors, cross-link interactions are difficult to deal with, and the single purposes causes low utilization of data. In view of these problems, this paper proposes a trusted sharing model for risk information of food full-process and all-information based on blockchain and federated learning. First, based on analysis of the information sharing needs of food companies and regulatory agencies, federal learning was integrated into a hierarchical blockchain architecture, and the relay concept was used to construct the trusted sharing model. Next, the federated learning process was divided into horizontal and vertical federated learning processes based on the characteristics and categories of risk information, and two federated learning aggregation algorithms were used to achieve the aggregation of data. Then, in response to the different needs of sharing risk information within and between enterprises, and between enterprises and regulatory agencies, homomorphic encryption algorithms and zero-knowledge proof were utilized for hierarchical encryption and targeted trusted sharing of risk information with different sensitivities. Finally, this model was validated by applying it to food safety risk assessment based on the food risk information disclosure dataset and open-source platforms. The results showed that the trusted sharing model could meet the different risk information sharing needs of enterprises and regulatory agencies, and achieve the full utilization as well as safe, credible, efficient and accurate sharing of risk information, thereby strengthening the determination of food enterprises and regulatory agencies to share data, and promoting the development of trusted data sharing and food safety digitalization in the food industry.

We demonstrate a technique for flexibly controlling subwavelength focusing and scanning, by using the Fourier translation property of a topology-preserved flat lens. The Fourier transform property of the flat lens enables converting an initial phase shift of light into a spatial displacement of its focus. The flat lens used in the technique exhibits a numerical aperture of 0.7, leading to focusing the incident light to a subwavelength scale. Based on the technique, we realize flexible control of the focal positions with arbitrary incident light, including higher-order structured light. Particularly, the presented platform can generate multifocal spots carrying optical angular momentum, with each focal spot independently controlled by the incident phase shift. This technique results in a scanning area of 10 μm × 10 μm, allowing to realize optical scanning imaging with spatial resolution up to 700 nm. This idea is able to achieve even smaller spatial resolution when using higher-numerical-aperture flat lens and can be extended to integrated scenarios with smaller dimension. The presented technique benefits potential applications such as in scanning imaging, optical manipulation, and laser lithography.

Currently, research and practice on roadway floor heave mainly explore the deformation mechanism and control technology of roadway floor. The mechanical analysis of floor before and after roof cutting and pressure relief in gob-side entry retaining is not comprehensive. In order to solve the above problem, mechanical models of the surrounding rock and floor of the roadway before and after roof cutting are constructed based on the features of coal partition failure. The effects of solid coal, roadway support, and goaf on the floor are analyzed. The analytical solutions for the floor heave of the roadway before and after roof cutting are obtained. The conclusion is drawn that the elastic-plastic zone of the coal wall beside the roadway, the support structure of the roadway, and the load on the floor of the subsidence zone jointly affect the magnitude of the roadway floor heave. Numerical simulation is used to verify the features of rock mass failure, stress distribution, and changes in floor heave in gob-side entry retaining before and after roof cutting and pressure relief. The results show that roof cutting and pressure relief technology can effectively reduce the damage area on the solid coal side and top of the roadway, and maintain the stability of the roadway rock mass structure. The maximum stress of the roadway floor, the resistance of the roadway side support, and the amount of roadway floor heave all decrease, with an average decrease of 25.78%, 56.14%, and 54.07%, respectively. The on-site application results show that the amount of floor heave of thick hard top in gob-side entry retaining is reduced from 709.345 1 mm to 320.965 8 mm. The roof cutting and pressure relief technology can optimize the stress structure of the surrounding rock of the roadway, suppress the floor heave of the roadway, and effectively improve the floor damage.

The constant strain rate compression experiment of powder metallurgy Mo–14Re alloys was carried out by Gleeble 1500 thermal simulation tester. The effects of deformation temperature (1100~1400 ℃) and strain rate (0.100~0.001 s−1) on the flow stress and microstructure evolution were analyzed. The constitutive equation of Mo–14Re alloys was established by hyperbolic sinusoidal Arrhenius model. The results show that, the flow stress of powder metallurgy Mo–14Re alloys decreases with the increase of deformation temperature or the decrease of strain rate during the thermal deformation, and the true stress-true strain curve shows the obvious work hardening and dynamic softening phenomenon. The dynamic softening behavior is mainly attributed to the dynamic recrystallization of Mo–14Re alloys at low strain rate (0.010 s−1 and 0.001 s−1) or high deformation temperature (>1200 ℃) during the thermal compression. The nucleation mode is grain boundary protruding nucleation. With the decrease of strain rate or the increase of temperature, the degree of recrystallization continues to increase, the grains continue to grow, and the Mo–14Re alloys are completely recrystallized at 1400 ℃ with the strain rate of 0.001 s−1.

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple system involvements. The number of SLE patients in China is large, and patients suffer more severe condition, with low remission rate ，high recurrence rate ，and high risk of infection.The situation of diagnosis and treatment for SLE is still serious. Relevant research released in 2023 shows that there are about 3.41 million cases of SLE patients in the world,and the number of patients in China amounts to 700 000-1 000 000, ranking the first in the world. The average onset age of SLE patients in China is 30.7 years old, and the incidence ratio of women to men is 12∶1.Organ involvement is more common in China, with 45.02% of renal involvement and 37.2% of haematological involvement, which are significantly higher than those in European patients with SLE (27.9% of renal involvement and 18.2% of haematological involvement). The clinical remission rate of SLE patients in China is 2.47%，while the relief rate reported internationally is 22.9%. Currently, the short-term survival rate of SLE patients in China is basically in line with that in the world (5-year survival rate reach 94%), but the long-term survival rate is still not optimistic, declining sharply, with a 25-30 year survival rate of only 30%. In China, 84.13% of SLE patients receive glucocorticoid（GC）therapy, while 42.6% SLE patients receive GC in the world. Infection is the leading cause of death for SLE patients in China, while in western countries, the main causes of death for SLE patients are cardiovascular disease and tumors With the proposal of new classification standards, the introduction of the concept of up-to-date treatment, as well as the use of new treatment methods, the development of SLE diagnosis and treatment will be greatly promoted, and it is expected to further improve the prognosis of patients in China.

[Objective] To improve the drying quality of pumpkins. [Methods] This study conducted experiments on hot air drying, vacuum drying, and combined hot air-vacuum drying, these drying characteristics were evaluated and compared based on unit energy consumption, rehydration ratio, and color difference indicators. Combining BP neural network model with genetic algorithm, combined with entropy weight and weighted scoring method, a multi-objective comprehensive optimization was carried out for the combined hot air-vacuum drying of pumpkins. [Results] Under the same conditions, the highest drying efficiency was hot air drying; And the findings revealed that at drying temperatures was 55 ℃, with a moisture content transition point of 30%, the combined drying method reduced the drying time by 52.63%, compared to vacuum drying. The lowest unit energy consumption was vacuum drying; The worst rehydration performance was hot air drying. The best color was vacuum drying. The optimal drying parameters determined by the genetic algorithm combined with a BP neural network model were a hot air drying temperature of 65 ℃, conversion point moisture content of 50%, and vacuum drying temperature of 56.050 9 ℃. Verification experiments demonstrated that the average relative errors between the genetic algorithm optimized values and the experimental values for unit energy consumption, rehydration ratio, and color difference were 2.5%, 5.53%, and 4.84%, respectively, all lower than 6%. [Conclusion] The combined hot air-vacuum drying of pumpkin integrates the advantages of both hot air drying and vacuum drying, and combined with BP neural network genetic algorithm model can optimize the process parameters for pumpkin hot air vacuum drying.

Background: Adenylyl cyclase (AC) isoforms played a key role in the multiple cancer pathology, However, the expression, prognostic value and function of ADCY5 in Glioblastoma (GBM) have not been reported yet. This research intends to discover the expression, epigenetic alteration and biological function of ADCY5 in GBM and its value on patients' prognosis. Methods: ① Transcriptional level, epigenetic alteration, prognostic value and molecular network of ADCY5 were analyzed by using of public online datasets. ② The mRNA expression profile of ADCY5 was explored by using GEPIA database and protein expression levels were detected by HPA Database. ③ The prognostic value of ADCY5 was determined by Kaplan-Meier Plotter, GEPIA and CGGA database. ④ The epigenetic characteristics of ADCY5 were determined by DiseaseMeth database. ⑤ Identification of genes co-expressed with ADCY5 and potential mechanism analyses were performed by using DAVID cBioPorta and STRING. ⑥ Reverse transcription-polymerase chain reaction (RT-PCR), cell counting kit-8 (CCK-8), colony formation, wound-healing scratch and transwell assay were applied to detect relative mRNA expression and biological function of ADCY5 in GMB cells. Results: ADCY5 mRNA and protein were downregulated in GBM compared with normal tissues. Analysis of the genetics and epigenetics of ADCY5 suggested that its expression was negatively correlated with DNA methylation. High expression of ADCY5 was significantly associated with age, grade, IDH mutation, 1p19q_codeletion, radiotherapy and chemotherapy and acted as an independent prognostic factor in GBM. ADCY5 mRNA also down-expressed in GBM cell lines and re-expressed of ADCY5 could inhibit cell proliferation, viability, migration/invasion and epithelial-mesenchymal transition (EMT) in vitro. In the analysis of genes co-expressed with ADCY5, we found that cAMP/AKT pathway, cGMP-PKG pathway, Wnts pathway were dissimilarly enriched. Conclusion: Our study indicated that ADCY5 could act as an epigenetic biomarker in GBM, as well as a prognosis target in patients with GBM.

C21H19BrO3, orthorhombic, P212121 (no. 19), a = 6.011(2) Å, b = 11.630(2) Å, c = 25.165(5) Å, V = 1759.3(7) Å3, Z = 4, Rgt (F) = 0.0163, wRref (F 2) = 0.0420, T = 100(2) K.

C22H20O5, orthorhombic, P212121 (no. 19), a = 5.8585(3) Å, b = 16.2727(10) Å, c = 18.4886(11) Å, V = 1762.59(18) Å3, Z = 4, Rgt (F) = 0.0276, wRref (F 2) = 0.0700, T = 100(2) K.

Objective To explore the possibility of rhabdomyolysis and related organ damage in new recruits training in high temperature and high humidity environment by comparing the effects of different training environments on the laboratory indicators and electrocardiogram. Methods A total of 250 new recruits from a unit in Beijing and another 250 ones from a unit in Hainan were recruited and assigned into conventional environment group and high temperature and high humidity environment group, respectively. All of them were male, with an average age of 21.36±2.59 years. Before and in 4 weeks after training in the same subjects, their general information, blood and urine indicators, and electrocardiogram were collected. All data were statistically analyzed. Results The incidences of inflammatory reaction, myocardial injury, muscle injury, liver injury, and kidney injury were 45.76%, 3.39%, 12.71%, 25.42%, and 12.71%, respectively, in the high temperature and high humidity environment group, which were all significantly higher than those in the conventional environment group (P < 0.05). The former group had an incidence rate of 6.78%, 5.93%, 8.47%, 6.78%, and 2.54%, respectively, in sinus bradycardia, atrial premature beats, unspecific ST-T changes, left ventricular hypertension and short PR interval, and all of the rates were higher than those of the conventional environment group (P < 0.05). Conclusion The incidences of inflammatory reaction, myocardial injury, muscle injury, liver injury, kidney injury, and ECG abnormalities are more common in new recruits after military training in high temperature and high humidity environment.

The treatment of tritiated water(HTO) produced during the operation of nuclear power plants involves the challenging process of H2O/HTO separation, for which non-radioactive H2O/HDO separation is usually used as a research model in laboratories. Recently, membrane distillation processes based on multi-layered graphene oxide membranes showed good performance for H2O/HDO separation, but further improvement still need developing novel membrane materials or structures. In view of this, mono-layered graphene oxide nanoplatelets with different lateral sizes were utilized to prepare PTFE supported graphene oxide composite membranes for H2O/HDO separation in membrane distillation:(1) two types of mono-layered graphene oxide nanoplatelets with different lateral sizes were chosen to investigate the impact of lateral size of mono-layered graphene oxide nanoplatelets on the performance of H2O/HDO separation. The graphene oxide membrane based on GO nanoplatelets with the smaller lateral size gives the permeation flux of 0.944 L/(m2·h) and the separation factor of 1.043, and its overall separation performance is higher than that of graphene oxide membrane obtained with the larger lateral size of graphene oxide nanoplatelets; (2) mono-layered graphene oxide nanoplatelets with different lateral sizes were mixed in various mass ratios for the combination of their structural characteristics to prepare composite membranes. When the mixing mass ratio of the two sizes of graphene oxide nanoplatelets is 1:1, the resultant graphene oxide membrane exhibits permeation flux of 0.806 L/(m2·h), higher than that of the graphene oxide membrane prepared with the larger lateral size, and the separation factor of these two membranes is similar; (3) mono-layered graphene oxide nanoplatelets with the larger lateral size were etched to introduce in-plane pores. The resulted GO membrane gave enhanced H2O/HDO separation performance. These results demonstrate that the lateral size of mono-layered graphene oxide nanoplatelets can affect the performance of corresponding membranes for the separation of H2O/HDO in membrane distillation, and the membranes based on mono-layered graphene oxide nanoplatelets with smaller lateral size or mono-layered graphene oxide nanoplatelets with different lateral sizes mixed in a certain ratio has better performance for the separation of H2O/HDO in membrane distillation. Moreover, the separation performance of H2O/HDO in membrane distillation can also be improved by introducing in-plane pores to graphene oxide nanoplatelets. Therefore, this work can guide the development of novel membrane materials or structures to achieve better H2O/HDO separation performance in membrane distillation and provide solutions for the treatment of radioactive wastewater containing tritiated water.

The brain, heart, liver, kidney, and other organs are susceptible to the harmful effects of ischemia-reperfusion injury (IRI), where the excessive production of reactive oxygen species (ROS) following IRI contributes to tissue damage and ensuing inflammation. In recent years, researchers have designed various nanoparticles that are responsive to ROS for the treatment of IRI. Empagliflozin (EMPA), an inhibitor of the sodium-glucose cotransporter-2 commonly used in type 2 diabetes mellitus, shows promise in mitigating IRI. However, its water-insolubility and low bioavailability present challenges in fully realizing its therapeutic efficacy. To tackle this issue, we formulated EMPA-loaded nanomicelles designed to respond to ROS, aiming to prevent renal damage caused by ischemia-reperfusion. Extensive characterization confirmed the effectiveness of the formulated nanomicelles. Through simulations and release studies, we observed structural modifications in the micelles leading to the release of EMPA upon encountering ROS (H2O2). In animal studies, rats treated with EMPA-loaded micelles showed normal renal tissue architecture, with only some remaining tubular swelling. Molecular assessments revealed that IRI triggered cell apoptosis through mechanisms involving hypoxia, metabolic stress, ROS, and TNF-α elevation. EMPA treatment reversed this process by upregulating B-cell lymphoma protein 2 and reducing levels of associated X (BAX) protein, Caspase 3, and Caspase 8. These results indicate that ROS-responsive micelles could act as a spatially targeted delivery system, effectively transporting EMPA directly to the ischemic kidney. This offers a promising therapeutic strategy for alleviating the impact of renal IRI.

Tooth surface twisting is a kind of processing error generated when the spiral herringbone gear is formed and grinded. In order to reduce the tooth surface distortion and improve the grinding accuracy, a gear reverse twisting processing calculation method is proposed based on reverse thinking to reduce the processing error caused by the tooth surface distortion. According to the meshing coordinate system of the shaping and grinding herringbone gear space, the contact line at multiple positions of the standard gear tooth surface, tooth surface twisting and tooth surface anti-twisting is solved, and the reverse distortion model of the tooth surface of the herringbone gear is established by calculating the curvature of the tooth surface method and the amount of spiral modification. The contact line optimization of the gears before and after the shaping is combined with the Monte Carlo method; and the transmission error of the tooth surface anti-twisting and the tooth surface twisting; and also the tooth surface contact stress are analyzed by the finite element method. Finally, the dynamic characteristics of the tooth surface twist and the tooth surface anti-twist after the shape are compared. The results show that the tooth surface anti-twisting machining can effectively reduce the error of the tooth surface processing principle of the herringbone gear and improve the grinding accuracy of the herringbone gear.

Objective·To explore the relationship of screen time and dietary behaviors with depressive symptoms in junior high school students in 5 provinces in China.Methods·A total of 1 067 junior high school students were selected from Zhejiang and Guangdong in the eastern region, Jiangxi in the central region, Sichuan and Guizhou in the western region of China by using stratified random cluster sampling method for a questionnaire survey, which included general demographic characteristics, health behaviors, diatery behaviors, and depressive symptoms. Univariate analysis was used to analyze the report rates of depressive symptoms, daily screen time and dietary behaviors of the students with variant demographic characteristics, and Logistic regression analysis was used to analyze the relationship of daily screen time and dietary behaviors with depressive symptoms and the interaction effects as well.Results·The report rate of depressive symptoms was 12.9% in the junior high school students in 5 provinces. The students who were in the western region, were not only children, had a weekly allowance of over 100 yuan, had smoked or consumed alcohol, had daily screen time≥2 h, or had unhealthy dietary behaviors, had higher reporting rates of depressive symptoms (P

Chloroprene rubber was vulcanized with 1,2-ethylenethiourea as accelerator, zinc oxide and magnesium oxide as vulcanizing agents. The non-isothermal vulcanization kinetics of chloroprene rubber was studied by differential scanning calorimetry, the kinetic parameters of vulcanization reaction were calculated by Kissinger and Crane equations, and the kinetics of isothermal vulcanization reaction was studied by vulcanizer method and the apparent activation energy at the thermal vulca-nization stage was calculated. The results showed that the n-order kinetic model could describe the non-isothermal vulcanization process of chloroprene rubber effectively. The apparent activation energy of the vulcanization reaction was 92.78 kJ/mol and the reaction order was 0.93. The isothermal vulcanization process of chloroprene rubber could be divided into 3 stages: scorching stage, thermal vulcanization stage and flat vulcanization stage. The thermal vulcanization stage followed the first-order reaction kinetics and the apparent activation energy of the thermal vulcanization stage was 53.38 kJ/mol.

ObjectiveTo investigate the high-risk detection rate and aggregation of cardiovascular diseases（CVD） in 8 districts of Shanghai and influencing factors， and to provide scientific references for prevention and control of CVD.MethodsBased on the Cardiovascular Disease Screening and Management Program in Shanghai from 2016 to 2021， 104 685 participants aged 35 to 75 in 8 districts of Shanghai were selected for analysis. χ2 test and multivariate logistic regression were used for statistical analysis of the influencing factors of CVD and aggregation of CVD.ResultsThe proportion of high-risk CVD individuals in the population was 19.17%， including the high-risk individuals with hypertension （8.65%）， dyslipidemia （6.33%）， CVD history （5.58%）， and WHO assessed risk ≥20% types （2.69%）， respectively. Old age， overweight and obesity， central obesity， smoking， drinking， farmers， unmarried， and low family income were the risk factors of CVD， while high education level was the protective factor. In the participants， 16 323 people （81.34%） were classified as CVD high-risk groups； The number of aggregation of 1， 2 and ≥3 high risk types of CVD were 16 323（81.34%）， 3 236（16.13%）， 509（2.54%）， respectively. Old age， low education level， low annual family income， farmers， unmarried， smoking， drinking， overweight， obesity and central obesity were associated with the risk of aggregation of high risk types of CVD， and the correlation strength increased with the increase of aggregation types.ConclusionThe prevention and control of CVD in Shanghai should focus on the hypertension， elderly， overweight， obesity， central obesity， smoking， drinking， low educated， low family income， farmers and unmarried people， and targeted intervention measures should be taken to reduce the risk of CVD among residents.

For a better understanding of the difference in functional components and functions among different parts of highland barley bran, the contents of protein, β-glucan and polyphenol, antioxidant activity, and alkyl radical intensity in highland barley bran with various milling rates were compared. The results showed that the contents of total protein, albumin, globulin, glutenin, free polyphenol, bound polyphenol, free flavone, bound flavone and condensed tannin first increased and then decreased with increasing milling rate. Protein mainly existed in bran flour with a milling rate of 17.74% and 19.22%. Bran flour with 9.7% milling rate had the highest phenol content, and the trend in antioxidant activity was consistent with that in the content of phenols. The contents of β-glucan and gliadin increased from outside to inside, and reached the highest value at a milling rate of 25.99%. Alkyl radical intensity was significantly higher at 1.54%–5.84% milling rates than at 7.67%–25.99% milling rates, indicating a higher susceptibility to oxidation. The findings of this study provide a theoretical basis for the deep processing of different layers of highland barley bran.

Mass spectrometry has become an invaluable tool for real-time reaction monitoring and capturing highly reactive intermediates, significantly contributing to the understanding of various chemical reactions mechanisms. Recent studies involving the capture of elusive carbocations from different reactions within water microdroplets have drawn considerable attention. Inspired by George Olah's pioneering works on carbocations and superacid chemistry, they attributed the stabilization of transient carbocations to the acidic environment spontaneously formed on the surface of microdroplets, as per microdroplets' intriguing feature. In this work, the electrospray ionization mass spectrometry (ESI-MS) was used to determine a variety of carbocation precursor molecules mentioned. It's important to note that commercial ESI sources are typically unaffected by microdroplet effects due to the short lifespan of the droplets, resulting from an extremely short flight distance and immediate evaporation facilitated by the drying gas. Surprisingly, even in the absence of the ultra-acidic environment considered necessary for the stabilization of carbocations, the carbocation signals are able to be detected under specific analytical conditions. By studying the mass spectra of the same analytes when changing the inlet capillary temperature and switching tube lens voltage, it was revealed that the precursor species might undergo in-source fragmentation due to the combined effects of the inlet capillary's high temperature and the high tube lens voltage. Tube lenses, designed to improve the ion transport efficiency, were located at the entrance from the first to the second pumping stage, where the remaining pressure could be around 133 Pa. The voltage was applied here right after the ions flow out of the inlet capillary. Therefore, the temperature and tube lens voltage might interact with each other, and together with the remaining pressure in this rough vacuum region, the ions could potentially collide with gaseous molecules, leading to the production of carbocation fragments. These fragments, which were in consistent with those generated from collision-induced disassociation (CID) of the precursor species, could possibly be misinterpreted as intermediates of some certain reactions, thereby misleading our understanding of the reaction mechanism. Through the detailed investigation of instrument parameters, and a closer look at the structure of the atmospheric pressure interface was achieved, this work highlights the importance of carefully considering various instrument parameters when mass spectrometry is used for reaction monitoring and intermediate capture studies, to ensure the accuracy of the results, and avoid such pitfalls.

Platelet elevation is a rare manifestation in the peripheral blood of patients with chronic myeloid leukemia (CML). In this paper, we report for the first time a case of CML combined with cerebral hemorrhage manifested by abnormally elevated platelets. The patient had elevated platelets in the peripheral blood, showed normal coagulation function, and underwent intracranial hematoma removal due to cerebral hemorrhage. After the operation, bleeding from the operated area and other systems occurred, and the patient was diagnosed as having accelerated CML after combining bone marrow biopsy and genetic testing. His condition was controlled after administration of flumatinib through a jejunal tube. Based on this patient's experience, the feasibility ofadministering flumatinib via a jejunostomy tube was determined, which is the first report of its kind in China and abroad.This article summarizes the diagnosis and treatment process of this patient, with the aim of providing a warning and reference for clinicians.

In order to improve the quality and reduce the loss of the nutritional content of camellia oil with the traditional press, this paper studied the process of pressing Camellia Oleifera Seeds with 10t/d Twin-Screw Oil Press. The results demonstrated that the best conditions for this article were: 9% moisture content of Camellia Oleifera seed kernels and 8% content of Camellia oleifera seed shell. The oil content of Camellia oleifera seed cake was reduced to 2.49%, and the produced camellia oil could meet the standard of first -class oil. In comparison to the camellia oil sold on the market, the retention rate of α-tocopherol in the camellia oil obtained through this process was higher, and the nutritional value of camellia oil has been further improved, which could provide technical guidance for the high-value processing of camellia oil in China.

Abstract Currently, a standardized design and calculation specification for suction drum foundations has yet to exist in China. The engineering design currently depends mainly on the subjective understanding and engineering experience of the designers, which can be considered somewhat blind and subjective. In this paper, we utilize the offshore wind power project in Yangjiang City, Guangdong Province, as our case study. Building upon domestic and international research results, relevant investigations, design specifications, and engineering applications in related fields, we conduct a systematic study on the design calculation and construction control technology of the suction drum foundation. The document presents the design calculation and inspection of the suction drum foundation. Building on this foundation, we propose a sinking feasibility analysis method and a parameter value method for the suction drum foundation calculation. We also examine the suction drum foundation construction process, examining its control parameters, technology, and standards. Finally, based on the measured data from six four-barrel guided frame platform suction drum foundations that were successfully installed, the proposed design and control method are evaluated, and their effectiveness is verified. The results of this study can provide valuable references for the design and construction of similar suction drum foundation platforms.

Mo−14Re and Mo−42Re alloy bars were prepared by powder metallurgy and hot press working. The microstructure, phase composition, and tensile properties at room and high temperature were observed and tested, and the fracture mechanism of Mo−Re alloys was analyzed, combined with the fracture morphology. The results show that, after the hot press working, the Mo−Re alloy grains change from equiaxed to elongated fibrous, and the relative density of alloy bars is more than 99.6%. The solid solution of Re in Mo reduces the lattice constant of Mo−Re alloy from 3.1384 Å of Mo−14Re to 3.1304 Å of Mo−42Re, leading to the increase of lattice distortion. The room and high temperature strength of Mo−Re alloys are greatly improved with the increase of Re mass fraction from 14% to 42%. With the increase of test temperature, the strength of Mo−Re alloys decreases, the elongation of Mo−14Re alloys decreases slightly, while that of Mo−42Re increases. The room temperature fracture of Mo−14Re alloys exhibits a wood-grain tearing fracture, the fracture at 1100~1300 ℃ is dimple, and the plastic deformation is mainly caused by grain boundary slip at 1500 ℃. The room temperature fracture of Mo−42Re alloys shows a transgranular fracture, the fracture at 1100~1500 ℃ is completely dimpled, and the plastic deformation at high temperature is provided by the non-uniform deformation produced by dimple.

ObjectiveTo develop an ultrahigh-performance liquid chromatography-tandem mass spectrometry （UHPLC-MS/MS） analytical method for the determination of cyanuric acid in the outer packaging of imported cold-chain food.MethodsA 50% aqueous acetonitrile solution was used as an extraction solvent. The extraction was performed by shaking the samples. The sample was centrifuged， and the supernatant was transferred for injection. Cyanuric acid was separated using a Waters ACQUITY BEH HILIC （2.1×100 mm， 1.7 μm）. The mobile phase consisted of acetonitrile and a 10 mmol/L aqueous ammonium acetate solution. An isocratic elution was also performed. Cyanuric acid was detected using UHPLC-MS/MS.ResultsGood linearity was achieved， with a correlation coefficient above 0.999 0. The limit of detection and limit of quantitation of the method were 5.0-20.0 and 20.0-50.0 μg/kg， respectively. The mean recoveries at low， middle， and high spiked levels were 80.0%-96.6%. The intra- and inter-day relative standard deviations were

Objective Evaluate the effect of an integrated teaching model of oral preclinical practice based on endodontic-restorative sequential treatment to provide a reference for the exploration of the teaching mode of the stomatology specialty. Methods This retrospective study was reviewed and approved by the Ethics Committee. The study was divided into 2 groups. There were 450 2018-grade and 2019-grade students in the discipline integration teaching method (DIT) group, and a preclinical practice course (root canal therapy and fixed prosthetic treatments were integrated into an endodontic-restorative sequential treatment) using the DIT method was applied. There were 443 2016-grade and 2017-grade students in the traditional teaching method (TT) group, and a TT preclinical practice course (root canal therapy and fixed prosthetic treatments training courses were taught separately) was applied. Both groups were taught by the same two teachers. The scores of clinical skills examination and treatment planning were compared between the two groups. In addition, students in the two groups were asked to complete the questionnaires about the teaching methods, and students in Group DIT and their teachers were asked to complete the questionnaires on their degree of satisfaction with the DIT method in the preclinical course. Results Students in the DIT group had an average score of 90.2 ± 4.16 in the practical skill evaluation, which was higher than that of the TT group (86.3±3.57) (P = 0.001). In the case analysis, 91.8% (413/450) of the students in the DIT group successfully planned the treatment, compared to a significantly lower rate in the TT group of 74.7% (331/443) (P = 0.001). The questionnaire results showed that recognition degrees of cultivated clinical thinking, improved indication analysis ability, improved operational skills, stimulated enthusiasm for learning, and improved autonomous learning were higher in the DIT group than in the TT group, and both teachers (2/2) and 98.4% (443/450) of students recognized the DIT method. Conclusions The DIT method significantly improved students’ learning quality and ability, proved effective in the endodontic-restorative sequential treatment practice course and was more acceptable to teachers and students. The DIT method is more effective than the TT method in improving students’ clinical thinking and operation ability.

C20H18ClNO3, monoclinic, P21 (no. 4), a = 6.3252(4) Å, b = 7.3424(5) Å, c = 17.8513(12) Å, β = 90.902(2)°, V = 828.95(10) Å3, Z = 2, Rgt (F) = 0.0223, wRref (F 2) = 0.0593, T = 100(2) K.

Unmanned aerial vehicle (UAV) array InSAR is a new type of single-flight 3D SAR imaging system with the advantages of high coherence and resolution. However, due to the low altitude of the platform, the elevation ambiguity of the system is smaller than the maximal terrain elevation. Since the spatial phase unwrapping is conducted based on the assumption of phase continuity, the inappropriate ambiguity will cause significant unwrapping errors. In this work, a 3D phase unwrapping algorithm assisted by image segmentation is proposed to address this issue. The Markov random field (MRF) is utilized for image segmentation. The optimal spatial phase unwrapping network is achieved based on the segmentation results. The asymptotic 3D phase unwrapping is adopted to get the refined 3D reconstruction. Results based on the real airborne array-InSAR data show that the proposed method effectively improves the elevation ambiguity.

The low cycle fatigue（LCF） properties of DD6 single crystal superalloy were investigated at 700 ℃ and R of 0.05. SEM was used to study the fracture surface and fracture microstructure. The results show that the LCF life of the alloy decreases with the increase of strain amplitude. LCF properties of the alloy are excellent under asymmetrical cyclic loading. The alloy has no transition fatigue life during LCF tests at all total strain amplitudes. LCF fatigue damage can be dominantly contributed to elastic damage and the plastic deformation is very minimal. The plastic damage increases with the increase of total strain amplitude. The crack initiation site, the fatigue crack propagation area and the final fracture zone can be observed in the fracture surface and all specimens is similar to quasi-cleavage fracture. The fatigue cracks are initiated from the micro-pores on the surface, sub-surface or far from the surface. Far from the surface crack fractures have fish-eye feature. The fatigue crack propagates perpendicularly to main stress at first and then along {111} plane. Typical fatigue striation, cleavage steps and river pattern characteristic are formed on fatigue crack propagation zone. The cleavage plane, slip band and tearing ridge are seen in the final fracture zone. Fracture microstructure analysis shows that the γ′ phase morphology far from the fracture surface still maintains cubic shape， and the slip bands are visible seen near the fracture surface， and secondary cracks are formed along slip bands.

Objective To summarize the clinical manifestations and histopathological characteristics of skeletal muscle in scleromyositis patients with positive anti‑Ku or anti‑PM‑Scl antibodies. Methods and Results Retrospective collection of clinical data from 70 scleromyositis patients diagnosed at Peking University First Hospital from January 2010 to March 2023, analysis showed the average onset age of patients was 36.00 (20.75, 51.25) years old. The initial symptoms of 77.14% (54/70) patients was mainly in the proximal limbs myasthenia [74.29% (52/70)], mild to moderate [77.14% (54/70)], and 52.86% (37/70) patients had systemic symptoms such as fatigue or skin involvement during the course of the disease. The serum creatine kinase (CK) level was 2775.00 (995.50, 4995.75) U/L. About 32.86% (23/70) were positive for anti‑Ku antibody, 65.71% (46/70) were positive for anti‑PM‑Scl antibody, 1.43% (1/70) were both positive, and 27.14% (19/70) could also had increased level of other myositis antibodies. The main histopathological changes were inflammatory [41.43% (29/70)] or necrotic [24.29% (17/70)] myopathic pathological changes, presenting as muscle fiber atrophy [91.43% (64/70)], necrosis [68.57% (48/70)] or regeneration [85.71% (60/70)]. Comparison of symptoms, signs and histopathological characteristics of skeletal muscle between patients with positive anti‑Ku antibody and with positive anti‑PM ‑Scl antibody, female proportion (χ2 = 4.381, P = 0.036) and C5b9 deposition damage (χ2 = 4.725, P = 0.030) were higher in the former than those in the latter. Conclusions Scleromyositis patients with positive anti‑Ku or anti‑PM‑Scl antibodies mostly started in young and middle age, mainly manifesting as mild to moderate myasthenia in the proximal limbs, and skeletal muscle inflammatory or necrotic myopathic lesions as characteristic pathological changes. Compared with positive anti ‑ PM ‑ Scl antibody patients, positive anti ‑ Ku antibody scleromyositis patients were mainly female, and skeletal muscle complement deposition was more notable.

Glioma, the most prevalent primary malignant tumor of the adult central nervous system, is highly malignant. Despite the current clinical treatment options including surgical resection, radiotherapy and chemotherapy, the survival period of patients is still relatively short, which poses a serious threat to patients' lives and health. In recent years, the research on glioma has made great progress, and the study on the mechanism of glioma development and the characteristics of the immune microenvironment has also deepened. At the same time, researches on molecular pathological typing of glioma, comprehensive clinical diagnostic and therapeutic programs, novel drug delivery systems and big data clinical translation are also steadily underway. This article reviews the research progress in the field of glioma in China in 2022, with the hope of providing reference for clinical diagnosis and treatment.

The magnetic resonance image segmentation of glioma is significant in disease diagnosis, surgical planning, and determination of treatment plans such as radiotherapy. In response to the problem of low segmentation accuracy, inaccurate edge segmentation, and prone to false positives in existing brain tumor segmentation algorithms, an improved Unet model based on multi-head self-attention and deformable convolution is proposed. The model replaces the standard convolution of the original Unet framework with residual modules to prevent vanishing gradient during model training. Multi-head self-attention modules based on Transformer are added in the bottleneck layer to extract local features and global context information for better exploration of correlations between pixels. Deformable convolution is used at cross-layer connections to enhance the model's sensitivity to shape perception and improve the ability to extract tumor edge features. Experimental results show that the segmentation evaluation metrics of the proposed algorithm are higher than those of other comparative literature and models using the same dataset, with more precise segmentation of tumor edges. This indicates that the algorithm proposed in this paper is an effective automatic glioma segmentation algorithm.

Xanthoxyletin is a vital plant-derived bioactive coumarin. It has been shown to exhibit anticancer effects against different human cancers. Nonetheless, the anticancer effects of xanthoxyletin against human pancreatic cancer cells have not been evaluated. Against this backdrop, the present study was designed to evaluate the anticancer effects of xanthoxyletin in human pancreatic cancer cells and to decipher the underlying molecular mechanisms. The results revealed a significant (p < 0.05) upregulation of receptor activator of NF-kappaB (RANK), receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG) in human pancreatic tissues and cell lines at both transcriptional and translational levels. The administration of pancreatic cancer cells with xanthoxyletin diminished the viability of Capan-2 cells in a concentration-dependent manner and led to a significant decline in RANK, RANKL, and OPG expression. Silencing of RANK and xanthoxyletin treatment declined the viability of Capan-2 pancreatic cancer cells via induction of apoptosis. However, pancreatic cancer cells overexpressing RANK could rescue the growth inhibitory effects. Collectively, xanthoxyletin targets the RANK/RANKL signaling pathway in pancreatic cancer cells to induce cell apoptosis and may prove to be an important lead molecule.

Objective To explore the regulatory role and molecular mechanism of sodium butyrate (NaB) in lipopolysaccharide (LPS) induced inflammatory phenotype in BV2 microglia cells and the molecular mechanism. Methods BV2 cells were treated with different concentrations of NaB alone or combined with LPS.CCK8 assay was used to detect the change of cell viability and to screen the optimal concentration of the drug.Then the BV2 cells were divided into control, LPS group, low-and high-dose NaB groups (0.125 and 0.25 mmol/L).An inflammatory model of BV2 cells were established by pretreatment with NaB for 17 h followed by LPS treatment for 24 h.Griess assay was used to measure the NO content in the supernatant, and ELISA was employed to determine the contents of IL-1β, TNF-α and IL-10 in culture medium.The mRNA levels of iNOS and CD206 were detected by RT-qPCR.Immunofluorescence staining was used to observe the expression of iNOS and CD206.The protein levels of TLR4, NF-κB p65m, IKB-α and p-IKB-α were detected by Western blotting.Cytoplasmic and nuclear proteins were isolated to detect the nuclear translocation of NF-κB p65. Results Griess assay showed that the secretion of NO in the high-and low-dose NaB groups were lower than that in the LPS group (P < 0.05).ELISA results indicated that the high-and low-dose NaB groups had lower secretion levels of IL-1β and TNF-α, but high secretion level of IL-10 than the LPS model group (all P < 0.05).RT-qPCR revealed that high-and low-dose NaB treatment significantly decreased the mRNA expression of iNOS (M1 phenotypic marker) and promoted that of CD206(M2 phenotypic marker)(both P < 0.05).Immunofluorescence staining presented similar results as RT-qPCR (P < 0.05).Western blot results displayed that high-and low-dose NaB resulted in significantly inhibited protein expression of TLR4, NF-κB p65 and p-IKB-α as well as nuclear translocation of NF-κB p65 when compared with the LPS group (P < 0.05). Conclusion NaB significantly reduces LPS-induced neuroinflammatory responses in BV2 cells, which might be associated with its inhibition of TLR4/NF-κB signaling pathway and promotion of BV2 cells shifting from M1 to M2 phenotype.

The variant aircraft can change its shape to adapt to different flight states and improve aerodynamic properties of aircraft. Aiming at a new hypersonic vehicle concept machine, the applicability of the wing variable sweep design on this hypersonic aircraft is discussed, and the influence of the deformation design of directly extending the trailing edge of the wing on the aerodynamics of the aircraft is studied. Firstly, the 3D model of the hypersonic vehicle with different deformable wings is obtained. Then, based on the k-ε turbulence model, the numerical simulation of the external flow field around the hypersonic vehicle is carried out respectively. Finally, the aerodynamic characteristics of the hypersonic vehicle under different angles of attack and different wing deformation schemes are analyzed. The research results show that the variable-sweep wing scheme cannot achieve the goal of improving the liftto-drag ratio under the design conditions of the hypersonic vehicle, and the deformation design of directly extending the wing can improve the aerodynamic characteristics of the hypersonic vehicle under the design conditions. The research results can provide reference for the design of hypersonic variant aircraft, and have certain practical value.

ObjectiveTo investigate the diagnostic value of trimethylamine N-Oxide （TMAO） and serum amyloid A （SAA） levels in peripheral blood of patients with chronic cerebral hypoperfusion （CCH）. MethodsThe patients attending the Department of Neurology of Sichuan Provincial Peoples Hospital from February 2022 to June 2022 were divided into CCH group （n=55） and control group （n=42） based on the results of magnetic resonance arterial spin labeling （ASL）. The levels of TMAO and SAA were detected by ELISA and their diagnostic value for CCH were anaylzed by ROC curve. ResultsThe levels of TMAO （47.24±8.84 vs 40.81±8.33, t=3.639, P＜0.05） and SAA （14.04±2.70 vs 12.20±2.30, t=3.542, P＜0.05） in CCH group were significantly higher than those in control group. High levels of TMAO and SAA and history of primary hypertension were independent risk factors for the occurrence of CCH （P＜0.05）. The areas under ROC curve （AUC） of TMAO and SAA for diagnosing CCH were 0.701 （95%CI: 0.594-0.809） respectively and 0.675 （95%CI: 0.565-0.786）. The combined detection of TMAO and SAA achieved the highest AUC of 0.765 （95%CI: 0.667-0.863）. ConclusionBoth TMAO and SAA are related to the occurrence of CCH and can be used as auxiliary diagnostic indicators for CCH.

【Objective】 Soil water in the field experiences spatiotemporal variation due to irrigation and rainfall evens, but its impact on crop growth is unclear. Using millet as a model plant, this paper investigates the effect of temporal soil moisture fluction on its water use efficiency. 【Method】 Experiments were conducted in pots with two soil water treatments: keeping the soil water content stable (SW), or temporally fluctuating it (FW). The former was achieved by keeping the pressure of irrigation water negative (NPI), and the latter by manual irrigation. In both treatments, the average soil water content was kept at 24.94%~25.61% (W1) or 21.12%~22.60%. The changes in growth, photosynthesis, stomatal characteristics, biomass allocation and physiological traits of the millet were measured in each treatment. 【Result】 ① Keeping soil water content stable significantly promoted crop growth. 60 days after start of the experiment, keeping soil water content stable in the range of 24.94%~25.61% (SW1) increased plant height, stem diameter and leaf area by 33.0%, 13.04% and 127.36%, respectively, compared to FW1, while SW2 increased plant height, stem diameter and leaf area by 51.94%, 144.70% and 13.91%, respectively, compared to FW2. ② Compared to FW, SW increased photosynthesis, dry matter accumulation and water use efficiency. During the experimental period, the photosynthetic traits of the millet in SW were significantly higher than those in FW. ③ In addition, SW1 increased fresh biomass and water use efficiency by 222.45% and 200.00%, respectively, compared to FW1, while SW2 increased the fresh biomass and water use efficiency by 352.54% and 260.00%, respectively, compared to FW2. On average, SW increased length and width of leaf stomata while reducing leaf stomatal density. SW and FW treatments did not show significant influence on root malondialdehyde (MDA), root antioxidant enzymes (SOD, POD, CAT), leaf malondialdehyde (MDA), leaf proline (Pro), leaf superoxide dismutase (SOD) and leaf catalase (CAT) contents, but impacted root pro, leaf POD and leaf abscisic acid contents significantly. 【Conclusion】 The broomcorn millet responded differently to stable and fluctuating soil water content, with stable soil water content being more favorable to growth, photosynthesis and water use efficiency of the crop.

The surface potential signals induced by the deformation and failure of coal and rock contain key information on damage evolution. It has been widely studied in the field of coal and rock dynamic disaster monitoring. However, most of these studies focus on the fluctuation features of potential time series signals in a single time dimension. There is a lack of in-depth research on the nonlinear and multiscale feature changes of the time series signals. To solve this problem, a monitoring system for the potential of coal and rock failure is built, and the potential time series signals of raw coal and gabbro samples are synchronously tested. Through the multiscale multifractal analysis (MMA) method, the nonlinear features of potential signals at multiple scales are studied in depth. The singularity index, singularity dimension, local Hurst index and other parameters of the potential time series signals are obtained. The Hurst surface is quantified by the L2 norm. The experimental results show that the overall potential signals of raw coal and gabbro show multiscale multifractal features, and the potential multifractal maps before and after crack initiation show some differences. Compared with gabbro, the positive and negative trends of the singularity index difference Δα of the potential signals of the coal samples at different positions in the pre-loading and post-loading phases show different features. It indicates a stronger non-linear evolution of the coal samples. The L2 norm of the local Hurst index at multiple scales better reflects the long-range correlation between different channel potential signals of the sample. It can quantify the nonlinear evolution features of the sample time series signals, thereby achieving the prediction of coal rock instability and failure.

The effects of heat treatment temperatures on the microstructure and mechanical properties of Mo–14Re alloy tubes after the vacuum annealing were studied in this paper. The results show that, the grains of Mo–14Re alloy tubes after rolling are elongated along the rolling direction, showing the obvious fiber structure, and the grains are locally widened after the heat treatment at 1100 ℃. With the increase of heat treatment temperature, the grains of Mo–14Re alloy tubes are completely recrystallized at 1300 ℃. The Mo–14Re alloy tubes show the excellent combination of strength and plasticity at 1100 ℃ for 1 h, the tensile strength is 710 MPa, and the elongation is 36.5%. In the fracture analysis, it is found that the Mo–14Re alloy tubes have the wood grain tearing fracture at the annealing temperature below 1100 ℃, showing the obvious plastic deformation characteristics. However, when the heat treatment temperature is increased to 1300 ℃, the fracture is quasi-cleavage due to the recrystallization, and the plastic deformation is mainly caused by grain boundary slip. Comprehensive analysis shows that the optimal heat treatment temperature of Mo–14Re alloy rolling tubes should be controlled between 1100 ℃ and 1300 ℃.

This paper proposes an operation control technology based on modular design, to address challenges involved in the train operation control and automatic loading or unloading between sky trains and the automated guided vehicles (AGVs) in the automatic control process of air rail collection and distribution systems. An information processing mechanism is created with independent modules connected to the corresponding external systems, to ensure a clear business information processing flow for each module. Shared information is processed in a unified and centralized manner through a common resource management module, allowing for the global visibility of the shared information. The proposed technology for operation control has been applied in a 655-meter-long demonstration line and underwent a three-month operational test. The system achieved a full-automatic fulfillment rate of waybills not less than 98%. The application results indicate the proposed technology can resolve the two core issues of air rails,including automatic operation control and automatic loading and unloading. The air rail collection and distribution system equipped with this technological solution has been operated smoothly in its official operation stage.

In order to increase the wear and corrosion resistance of the surface of the steel structures, four kinds of CoCrMnNiMox (x=0.1, 0.2, 0.3, 0.4) high entropy alloy (HEA) coatings with different compositions were prepared on N80 steel substrate by laser cladding. The effect of Mo content on microstructure, wear resistance and corrosion resistance of HEA coating was studied. Results showed that the CoCrMnNiMox coating structure was a single FCC phase. With the increase of Mo content, the coating hardness increased. The average Vickers hardness of the CoCrMnNiMo0.4 HEA coating was up to 628 HV, which was 3.8 times higher than that of N80 steel substrate (165 HV). The friction coefficient decreased first and then increased, reaching the lowest (0.38) at Mo content of 0.3, which reduced by 0.40 compared to that of N80 substrate. The wear mechanism of clad layer changed from adhesive wear to abrasive wear and the wear resistance increased. The dynamic corrosion and static corrosion of clad layer reached the optimum at Mo content of 0.3. Compared with the substrate, the dynamic corrosion potential increased by 0.2 V at Mo content of 0.3, and the corrosion current density decreased by one order of magnitude. However, the corrosion resistance of the clad layer was greatly reduced compared with the static corrosion due to the promoting effect of wear on corrosion. The corrosion wear coupling test results showed that with the increase of Mo content, the potential first gradually increased and then decreased. The potential reached the highest (-0.28 V) at Mo content of 0.3. The corrosion resistance under friction condition was the best, which was 0.22 V higher than that of N80 substrate (-0.50 V). The wear and corrosion resistance of the substrate surface were well improved. The friction coefficient of the sample under corrosion increased first and then decreased. Except for the high friction coefficient at Mo content of 0.2, the friction coefficient of the other samples was low in the stable run-in stage, and the wear resistance under corrosion condition was relatively good.

BackgroundPsychological problems such as depression and anxiety are common in pregnant women， and many studies have found that body image disturbance is closely related to depression and anxiety symptoms. Still， there is large variability in previous findings.ObjectiveTo review the researches on the relation of body image disturbance to depression and anxiety in pregnant women， and to provide a reference for interventions targeting maternal body image disturbance and depression and anxiety symptoms.MethodsOn January 10， 2023， well qualified literature focusing on the relationship between body image disturbance and depression and anxiety symptoms in pregnant women were searched in PubMed， Embase， CINAHL， Web of Science， China National Knowledge Infrastructure （CNKI）， VIP databases， Wanfang Data Database and China Biology Medicine disc （CBMdisc） from inception to January 1， 2023. The research content， factors influencing body image disturbance and relevant findings were extracted and summarized for analysis.ResultsA total of 14 articles were included in this review. The body image disturbance in pregnant women was manifested predominantly by an excessive concern about body weight and shape， and was affected by demographic characteristics， sociocultural factors， obstetric factors and other factors. Furthermore， body image disturbance significantly predicted the occurrence of depression， and proved a close relationship with anxiety symptoms.ConclusionBody image disturbance seriously affects the physical functioning and psychological status of pregnant women and may further exacerbate the symptoms of depression and anxiety.

The conveyor belt and driving device are the main components of the belt conveyor and are the high-risk areas for faults. Taking conveyor belt faults and driving device faults as the starting point, this paper analyzes the mechanisms of conveyor belt deviation, slipping, damage, stacking and scattering, as well as the faults of the driving device roller, idler and reducer. It focuses on the research progress of knowledge-driven and data-driven fault diagnosis methods for belt conveyors. Based on the knowledge processing technology, the knowledge-driven method realizes the unification of symbol processing and numerical processing, the unification of reasoning process and algorithm process. It mainly includes expert system and fault tree analysis. The data-driven method uses machine learning and data mining techniques to analyze and process historical data. It establishes diagnostic models, and achieves fault diagnosis purposes. It mainly includes support vector machines (SVM), comparison method, and diagnosis methods based on sound and vision. This paper analyzes the current challenges and future development trend of belt conveyor fault diagnosis methods. ① The historical fault data and real-time data should be combined to infer equipment health. The early minor faults should be predicted so as to remind the staff to carry out predictive maintenance. ② The correlation between coupling faults of belt conveyors should be revealed. The emerging technologies such as artificial intelligence should be used to study joint diagnosis methods for coupling faults. ③ The multimodal machine learning technology should be utilized to study the mechanism of multimodal information fusion and utilization of belt conveyors. Fault diagnosis methods for multimodal information fusion of belt conveyors needs to develop. ④ The fault knowledge graph and the belt conveyor domain knowledge should be combined to realize the belt conveyor equipment fault tracking and fault early warning. Through the knowledge query, knowledge reasoning and auxiliary decision-making functions, the capability of fault handling and precise mining of potential fault risks of equipment can be improved.

With the rapid development of urbanization and the continuous growth of population, the design and planning of high-rise residential buildings have become increasingly important. The purpose of this study is to explore the space optimization design method of high-rise residential buildings based on genetic algorithm(GA), focusing on the comparative analysis between traditional GA and Adaptive genetic algorithm(AGA). In this paper, AGA is used to establish the spatial optimization model of high-rise residential buildings. By dynamically adjusting the parameters of the algorithm, AGA makes the algorithm better adapt to the characteristics of the problem and improves the search efficiency. The results show that AGA is superior to traditional GA in global convergence probability, especially when the population size is large. AGA improves the adaptability and robustness of the algorithm by dynamically adjusting the crossover and mutation probability. AGA has better flexibility and adaptability in the design of high-rise residential buildings and is expected to provide more optimized solutions for solving complex design problems. The findings of this study provide a useful reference for innovation and sustainable development in the field of high-rise building design and also provide practical methods and tools for the application of GA.

This paper studies and analyzes the theoretical value of the college English education course Civics based on fuzzy set theory and explores the optimization path of its teaching mode. The article uses literature analysis, case studies, and multiple linear regression models. In colleges and universities, Civics and Politics curriculum is instrumental in promoting excellent culture and enhancing students’ comprehensive quality and moral cultivation. Implementing the WITS model makes the teaching process more efficient and encourages students’ active participation and deep thinking. The students ‘English reading level significantly improved after integrating the elements of civics and politics into the teaching process. After analyzing 220 questionnaires, it was found that factors such as course content and communication environment in the teaching process significantly impacted the teaching effect, in which teaching activities and course themes related to Civics and Politics made the most significant contribution to the teaching effect. The research in this paper proposes suggestions for optimizing teaching, such as improving teachers’ civic and political literacy and innovating teaching contents and methods. After studying and analyzing the curriculum, Civic and Political has an essential theoretical and practical value in English education in colleges and universities. Optimizing the teaching mode can improve students’ English proficiency and ideological and political quality.

This paper explores the process of traditional voiceprint recognition, analyzes the traditional GMM recognition algorithm, and proposes a GE2E-based voiceprint recognition algorithm by combining it with the deep neural network. It firstly uses the Bi-GRU network to replace the LSTM network to prevent the lack of semantic information, then adds the SGD algorithm to optimize the speech features, and finally improves the stability and accuracy of recognition by the GE2E loss function. On this basis, a voiceprint recognition system based on GE2E is designed, and the overall performance of the system is tested. Additionally, a voiceprint recognition system is being explored for fault localization. The results show that the recognition accuracy of male voiceprints in the test is at [0.89,0.95], and the recognition accuracy of female voiceprints is at [0.88,0.96], and there is not much difference in the voiceprint recognition accuracy of the voiceprint recognition system for both male and female students, and the overall recognition accuracy is greater than 0.9. When applied in fault location, the error between the measured distance and the actual fault distance is within 0.1 meters, enabling fault location.

Taking a new type of 35 pumping unit suitable for deep well mining as the research object, the mechanical analysis of its gear long ring rack transmission mechanism is carried out to solve the problems of short operation cycle and high energy consumption in deep well mining with electric submersible pump. The mechanical model of the transmission mechanism is established and the force variation law of the gear long ring rack is obtained in the process of reversing. Based on the dynamic simulation of the pumping unit operation process using Adams, the dynamic characteristics of the transmission mechanism and rollers are studied and the influence of dynamic on the pumping unit operation state is analyzed. The results show that the force of the transmission mechanism changes with the gear position in the process of commutation. During the up and down stroke, the size and direction of the force on the long ring rack are different. The rack box is overturned around its own x, y and z axes. The pneumatic counterweight of 7 t is the best counterweight of the pumping unit. The research results can provide a theoretical reference for the further improvement and optimization of the pumping unit parts.