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In the process of data connection of each system in fully mechanized working face, it is necessary to perform frequent correspondence between the data point table and the semantics, which leads to the surge of system interconnection and data sharing cost of fully mechanized working face. An information model of intelligent fully mechanized working face based on OLE for process control unified architecture(OPC UA) is proposed. According to the physical composition, functional modules and the information flow requirements between modules of intelligent fully mechanized working face, the information model architecture of intelligent fully mechanized working face is proposed by using object-oriented method. On the basis of this architecture, the physical objects and mining process data in fully mechanized working face are digitized and modeled to form a face-level information model. The static attribute set and process attribute set of basic component, monitoring component set and functional component set objects in information model are introduced in detail. The information model of the intelligent fully mechanized working face is instantiated by adopting the combined modeling mode of the OPC UA and the unified modeling language(UML). The UML class diagram is used to assist in the description of the information model structure, and then converted into the OPC UA information model XML description file. The information model structure data and attribute data are mapped to the OPC UA address space model, and the OPC UA server is started. The practical application results show that each system of fully mechanized working face can access the server address space, and successfully obtain the structure of intelligent fully mechanized working face information model and object data semantics, so as to complete the data collection, storage and update quickly. In order to verify the application effect of the information model, based on the OPC UA server, the information management and integrated analysis platform of fully mechanized working face is developed. The field application test show that the monitoring data displayed by the platform is consistent with the actual operation results (the background data are all from the address space information model), thus verifying the feasibility of the information model combined with the OPC UA protocol to realize the information interconnection of fully mechanized working face.

Campus loans have become a part of the lives of Chinese college students. While such loans are convenient for students, they can also create considerable difficulties. In the context of unbalanced economic development between Western and Eastern China, this study aimed to understand the factors affecting the campus loan behaviors of college students in Western China. A sample of 568 undergraduate and graduate students from four universities in Western China was taken as the research object. Binary logistic regression and orderly logistic regression were used to study campus loan consumption factors. Students without state-subsidized loans were found to have stronger campus loan consumption intention and higher loan amounts, and recreational consumption was the main loan purpose. The factors affecting campus loan consumption included students' family structure, parents' education level, peer students' consumption status, grade level, relationship status, and ability to assess loan risk. Based on the findings, suggestions are made for managing campus loan behavior from the perspectives of the individual, family, school, and government. This study can provide guidance for standardizing campus loans and adjusting college students' consumption attitudes and behaviors.

Photobiomodulation (PBM) using 830 nm light‐emitting diode (LED) benefits tissue regeneration, wound healing and neural stimulation. However, there is not much exploration of its effect on melanocytes and ex vivo skin model. This study aims to investigate the mechanism behind the anti‐melanogenic activity of 830 nm LED and provides evidence for its activity in human ex vivo skin model. Our results showed that 830 nm LED at fluences ranging from 5 to 20 J/cm2 inhibited melanosome maturation and reduced melanin content, tyrosinase activity and melanogenesis‐related proteins. 830 nm LED inhibited the phosphorylation of AKT and its downstream FOXO3a, leading to nuclear translocation of FOXO3a. Furthermore, FOXO3a knockdown and AKT activator like SC79 could reverse the melanogenesis inhibition phenotype induced by 830 nm LED. In human ex vivo skin model, Fontana–Masson staining revealed a decrease in epidermal basal pigmentation after 830 nm LED irradiation. Taken together, 830 nm LED demonstrated the anti‐melanogenic activity via FOXO3a. [ABSTRACT FROM AUTHOR]

Aquaculture, the world's fastest-growing food production sector, is critical for addressing food security concerns because of its potential to deliver high-quality, nutrient-rich supplies by 2050. This review assesses the effectiveness of CRISPR/Cas9 genome editing technology in enhancing desirable traits in fish species, including growth rates, muscle quality, disease resistance, pigmentation, and more. It also focuses on the potential effectiveness of the technology in allowing precise and targeted modifications of fish DNA to improve desirable characteristics. Many studies have reported successful applications of CRISPR/Cas9, such as knocking out reproductive genes to control reproduction and sex determination, enhancing feed conversion efficiency, and reducing off-target effects. Additionally, this technology has contributed to environmental sustainability by reducing nitrogen-rich waste and improving the nutritional composition of fish. However, the acceptance of CRISPR/Cas9 modified fish by the public and consumers is hindered by concerns regarding public perception, potential ecological impacts, and regulatory frameworks. To gain public approval and consumer confidence, clear communication about the editing process, as well as data on the safety and environmental considerations of genetically modified fish, are essential. This review paper discusses these challenges, provides possible solutions, and recommends future research on the integration of CRISPR/Cas9 into sustainable aquaculture practices, focusing on the responsible management of genetically modified fish to enable the creation of growth and disease-resistant strains. In conclusion, this review highlights the transformative potential of CRISPR/Cas9 technology in improving fish traits, while also considering the challenges and ethical considerations associated with sustainable and responsible practices in aquaculture. [ABSTRACT FROM AUTHOR]

Hyperuricemia (HUA), or elevated uric acid in the blood, has become more prevalent in recent years. Polyphenols, which are known to have good inhibitory activity on xanthine oxidoreductase (XOR), are effective in uric acid reduction. In this review, we address the structure–activity relationship of flavonoids that inhibit XOR activity from two perspectives: the key residues of XOR and the structural properties of flavonoids. Flavonoids' inhibitory effect is enhanced by their hydroxyl, methoxy, and planar structures, whereas glycosylation dramatically reduces their activity. The flavonoid structure–activity relationship informed subsequent discussions of the changes that occur in polyphenols' XOR inhibitory activity during their extraction, processing, gastrointestinal digestion, absorption, and interactions. Furthermore, gastrointestinal digestion and heat treatment during processing can boost the inhibition of XOR. Polyphenols with comparable structures may have a synergistic effect, and their synergy with allopurinol thus provides a promising future research direction. [ABSTRACT FROM AUTHOR]

Background: Noninvasive energy‐based device (NI‐EBD) aesthetic procedures has recently gained widespread usage for treating various skin conditions, enhancing skin texture and performing rejuvenation‐related procedures. However, practically all NI‐EBD procedures result in variable degrees of damage to the skin barrier, inducing pathological and physiological processes such as oxidative stress and inflammation, and only a small percentage of individuals possess the innate ability to restore it. Objective: To introduce the concept of integrated skincare and establish standardized operational procedures for perioperative integrated skincare, and furnish a theoretical basis for clinical diagnosis and treatment performed by professional medical aestheticians. Methods: The author leveraged domestic and international guidelines, clinical practice expertise and evidence‐based research, adapting them to suit the specific circumstances in China. Results: The consensus were provided four parts, including concept and essence of integrated skincare, integrated skincare significance during the perioperative phase of NI‐EBD procedures, active ingredients and functions of effective skincare products, standardized perioperative skincare procedure for NI‐EBD procedures and precautions. For the standardized perioperative skincare procedure, four recommendations were listed according to different stages during NI‐EBD procedures. Conclusion: These recommendations create the 'Expert Consensus on Perioperative Integrated Skincare for Noninvasive Energy‐Based Device Aesthetic Procedures in Clinical Practice in China'. [ABSTRACT FROM AUTHOR]

Integrated skincare combines clinically proven skincare products with professional medical aesthetics to provide a comprehensive solution for beauty pursuers. Studies have demonstrated that a combination of medical aesthetic procedures and maintenance therapies is more effective than either treatment alone. This review outlines the current applications of integrated skincare, including different regimens of energy‐based aesthetic devices and active ingredients in cosmeceuticals or chemical peels. Additionally, the benefits and limitations of integrated skincare are discussed. Lastly, this review highlights the potential for improved satisfaction and long‐term maintenance of the desired outcomes through appropriate integrated skincare procedures. [ABSTRACT FROM AUTHOR]

The Common Black Carp Strain (Cyprinus carpio var. baisenensis), known for its black skin, is commonly cultured in the integrated rice-agriculture (IRA) system in Guangxi province, China. This study aimed to compare the genetic diversity of three common carp strains/populations (Common Black Carp Strain, Huanghe, and Songpu) using resequencing data. The genome-based method reveals a significant difference (p < 0.05) in identified loci and SNP frequency (p < 1 × 10−6) between the Songpu (Sp) or mirror carp and Huanghe (Hh) new strain. Additionally, the Common Black Carp Strain (Bk) exhibits a higher number of Tajima's D values, possibly due to its population size and mutations within its entire genome. The average value of population nucleotide diversity (π) for the Bk is 1.706 × 10−4 while the mean number for the Hh and Sp strains is 1.691 × 10−4 Heterozygosity analysis results indicate that the Bk has the highest F coefficient compared to the Sp and Hh hybrids. This suggests that the isolated population of the Bk may have experienced a decrease in population size as a result of environmental disturbances in the IRA system. PCA results further reveal that all individuals of the Bk, except for one, are clustered together, while individuals of the Hh form a separate group. On the other hand, Sp displays a distinct distribution pattern. The comparative study of the genetic diversity of the Bk provides baseline data on its genome makeup. Assessing genetic diversity and genetic structure is critical for fisheries management and the conservation of critically endangered fish species. [ABSTRACT FROM AUTHOR]

In order to study the oil-gas two-phase flow characteristics in the bearing chamber of an aeroengine and improve the oil return effect of lubricating oil,an embedded improvement scheme was proposed for the ventilation structure of the bearing chamber.A two-phase flow solution model for the bearing chamber based on the Euler-Euler method was established,and the flow characteristics and oil return characteristics of conventional bearing chamber and embedded improvement bearing chamber under different operating conditions were analyzed.The results show that after the embedded improvement of the ventilation structure of the conventional bearing chamber,the lubricating oil is blocked by the embedded ventilation wall.Under the action of air shear force and gravity, the lubricating oil on the right side of the ventilation port moves downstream through the ventilation port,reducing the amount of lubricating oil flowing out of the ventilation port and increasing the amount of lubricating oil flowing out of the return port,thus significantly improving the return oil efficiency .As the embedding depth increases, the lubricating oil flowing out of the vent is further suppressed, the volume fraction of the lubricating oil in the chamber further increases,and the return oil efficiency is further improved.Compared with conventional bearing cavities,when the oil flow rate is 200 L/h and the rotation speed is 15 000 r/min,the embedded improvement scheme has the most significant improvement in oil return efficiency,and the oil return efficiency is increased by 16.72%, 18.80%, and 20.19% respectively for the improved schemes with embedded depths of 8 mm, 10 mm,and 12 mm. [ABSTRACT FROM AUTHOR]

Background: There is no standardized and effective treatment modality for Riehl's melanosis. Aims: To compare the efficacy and safety of oral tranexamic acid (TXA) combined with intense pulsed light (IPL) versus TXA alone in the treatment of refractory Riehl's melanosis. Methods: A prospective study of 28 subjects with refractory Riehl's melanosis and Fitzpatrick Skin Types III or IV was conducted. All subjects received oral TXA 500 mg daily and 11 of them were treated in combination with monthly IPL therapy for 6 months. The primary outcome measure was mean melanin index (MI), erythema index (EI) and acquired dermal macular hyperpigmentation area and severity index (DPASI). The Physician Global Assessment (PGA) and patient satisfaction scale were documented. Results: After treatment, DPASI, mean MI, and EI were significantly reduced in both groups. The group treated with combination therapy showed better improvement according to MI (p = 0.0032) and DPASI (p = 0.00468). PGA and patient satisfaction scale showed superior efficacy in the combination group. No significant difference was observed in treatment‐related side effects. Conclusion: The combination of oral TXA and IPL proves to be a safe and satisfactory treatment strategy for refractory Riehl's melanosis. [ABSTRACT FROM AUTHOR]

Rosacea is a chronic inflammatory skin disease that affects a patient's appearance and quality of life. It mainly affects the midface region and presents as erythema, flushing, telangiectasia, papules, pustules, and rhinophyma. Despite its prevalence, the precise pathophysiology of rosacea remains unknown, and novel pharmacological therapies are currently under investigation. Tranexamic acid (TA) is a synthetic, lysine-like compound that competitively inhibits fibrinogen production by synthesizing fibrinolytic enzymes. In addition to its popular application in hemorrhage treatment, TA has been used to manage a number of skin conditions, including melasma, chronic urticaria, and angioedema. TA is a better option for melasma treatment. However, the role of TA in treating rosacea has not yet been systematically elucidated. In this study, we reviewed all available literature on the use of TA for rosacea treatment. The included articles examined the therapeutic effects of TA in patients with rosacea, including traditional methods such as oral and topical administration and more novel approaches such as intradermal injections, microneedling, and laser-assisted delivery. Several recent clinical studies demonstrated that TA alleviates rosacea symptoms by restoring the permeability barrier, ameliorating the immune reaction, and inhibiting angiogenesis. In this review, we summarized the function and potential application of TA in rosacea treatment, aiming to facilitate the implementation of clinical applications. [ABSTRACT FROM AUTHOR]