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Concerns has been raised in improving the quality of adaptive design randomized trials reports. Based on the CONSORT 2010 (Consolidated Standards of Reporting Trials), The Adaptive designs CONSORT Extension (ACE) has developed items and reporting specifications for adaptive design trials. This paper presents a brief explanation of the extension and new items of ACE and introduces the applications of ACE checklist with examples.如何提高适应性设计随机对照试验报告质量成为目前的关注热点。使用适应性设计的随机对照试验研究报告规范（adaptive designs CONSORT Extension，ACE）在CONSORT 2010声明基础上进行了针对适应性设计随机对照试验的拓展，为规范适应性设计随机对照试验报告提供了指导。本文将重点对ACE拓展和新增的条目进行解读，同时结合实例说明ACE条目清单在实际中的应用。.

OBJECTIVE: To investigate the expectations of patients for total knee arthroplasty (TKA), and to analyze its influencing factors. METHODS: Experimental design: Single center, retrospective, multiple regression analysis. The data including the age, height, and weight of 108 patients undergoing unilateral TKA due to end-stage osteoarthritis were obtained. The patients' preoperative Hospital for Special Surgery (HSS) knee arthroplasty expectation score, the Western Ontario and McMaster Universities (WOMAC) score, Knee Society score (KSS), the MOS 36-item short-from health survey (SF-36) score, and visual analogue scale (VAS) were evaluated, and the 30-second chair-stand test (30-CST), 40-meter fast-paced walk test (40-FPWT), 12-level stair-climb test (12-SCT), 3-meter timed up-and-go test (TUG), 6-minute walk test (6-MWT), and recorded daily steps for 7 consecutive days were performed. The SPSS 22.0 software was used for statistical analysis. The observed values of various data were described. Pearson correlation analysis was used to evaluate the correlation between various parameters, and the multi-factor linear regression analysis was used to investigate the influencing factors of the patients preoperative expectation scores. RESULTS: The average expectation score of this group of patients was 58.98±5.44. In the Pearson correlation analysis, the patient's preoperative expectation had a weak correlation to the result of the patient's 12-SCT, TUG, 6-MWT, KSS function score, and SF-36 mental component score (correlation coefficient 0.1-0.3). The patient's preoperative expectation had a moderate correlation to the patient's daily average steps, 30-CST, 40-FPWT, KSS, WOMAC and its pain, stiffness, function scores, SF-36 physical functioning, role-physical, bodily pain, vitality, and physical component score (correlation coefficient 0.3-0.6). In the multivariate linear regression analysis, only the results of 30-CST and the role-physical, bodily pain and vitality in the SF-36 scale were related to the patient's expectation score (P < 0.05). CONCLUSION: The estimated expectation score of patients before TKA is not high. Patients with more severe preoperative pain, worse physical function, and lower overall health are more eager to improve after surgery. Thus surgeons must communicate fully with patients with unrealistic expectations before surgery in order to obtain more satisfactory results postoperatively.

Neuroendocrine neoplasms (NEN) are rare neoplasms originating from all major systems, in which gastric neuroendocrine neoplasms (G-NEN) is rarely malignant neoplasm originated in stomach. In 2019, the 5th WHO classification of digestive system tumors updated the classification of G-NEN and solved several naming problems. Since the classification of G-NEN has become more specific and more scientific, the surgical treatment of G-NEN is becoming more individual and more precise. Generally, endoscopic resection is often recommended for the treatment of type I gastric neuroendocrine tumors (NET). Type II gastric NET is mostly secondary to gastrinoma originating from the duodenum or pancreas, and thus surgical treatment of primary gastrinoma deserves enough attention. The decision of operation for type III gastric NET needs comprehensive consideration of tumor size, invasive depth and lymph node metastasis. For gastric neuroendocrine carcinomas without distant metastasis, aggressive surgery should be performed, and the resection range of primary site and lymph nodes can refer to the standard of gastric adenocarcinoma. For locally advanced gastric NEC, it has not been reported whether neoadjuvant chemotherapy or neoadjuvant chemoradiotherapy could reduce tumor stage and improve radical resection rate. In addition, for functional gastric NEN with distant metastasis, radical resection or palliative surgery can be performed to control hormone secretion and may improve the survival. In general, it is an important principle to thoroughly consider biological behavior, extent of primary and metastatic sites, resectability and function of tumor before surgery of gastric neuroendocrine neoplasm, and thus multi-disciplinary treatment (MDT) is recommended.神经内分泌肿瘤（NEN）是一类可发生于全身的罕见肿瘤，胃NEN则是胃部罕见恶性肿瘤之一。2019年WHO第5版消化系统NEN分类标准更新了胃NEN的分型和若干命名问题。对胃NEN更加精准、科学的分型，也使得胃NEN的外科治疗更加个体化、精准化。一般来说，Ⅰ型胃神经内分泌瘤（NET）常可考虑内镜下切除；Ⅱ型胃NET多因发生于十二指肠或胰腺的胃泌素瘤而产生，需重视原发胃泌素瘤的外科治疗；Ⅲ型胃NET需根据肿瘤大小、浸润深度及淋巴结转移情况综合考虑手术方式；而对于无远处转移的胃神经内分泌癌（NEC），应积极行外科手术治疗，其手术切除范围及淋巴结清扫范围可参照胃腺癌标准。对于局部进展期胃NEC，能否行新辅助化疗或新辅助放化疗以充分降期及提高根治性切除率，目前尚未见文献报道。此外，已有远处转移的功能性胃NEN亦可选择根治性切除及姑息性减瘤手术控制激素分泌，改善患者生存。在充分的多学科讨论基础上，综合考虑肿瘤的生物学行为、原发灶及转移灶的范围、可切除性和功能性是胃NEN外科治疗的重要原则。.

Gastrointestinal stromal tumor (GIST) is the most common soft tissue sarcoma in the gastrointestinal tract. Biological behavior of GIST is varied. It is very important to accurately assess the risk of recurrence and metastasis after resection of primary tumor in order to guide adjuvant therapy and predict prognosis. With increasing understanding of the biological behavior of GIST, the risk stratification criterion has undergone continuous reform and improvement since its introduction. In the early stage, clinical parameters such as tumor size and mitotic rate were formulated as risk stages, and then tumor site, tumor rupture and other factors were included to form a more accurate AFIP standard and modified NIH risk stratification. Recently, more researches have used new statistical methods such as nomogram and contour maps, which more accurately predict risk of recurrence and better guide adjuvant treatment. Thus, individualized treatment of GIST becomes possible.胃肠间质瘤（GIST）是胃肠道最常见的软组织肉瘤，它的生物学行为多种多样。制定准确的危险度分级、评估原发肿瘤切除术后的复发转移危险、指导辅助治疗以及预测患者预后，具有重要的临床意义。GIST危险度分级标准自面世以来，随着对GIST疾病逐渐深入地了解，不断地经历了变革和完善。初期主要是根据肿瘤大小、核分裂象计数等临床参数制定危险度分级；中期再把肿瘤部位、肿瘤破裂等因素纳入而形成较为完善的美军病理研究所（AFIP）标准以及改良美国国立卫生研究院（NIH）分级；近期更有研究使用新的统计学方法如列线图、等高线图等，使得预测患者复发风险更为精准，由此让GIST个体化治疗变成可能。.

EAST tokamak has complicated supercritical helium loops for cooling the superconducting magnets and other thermal loads. When failures occur in these load devices, such as magnet quench or vacuum failure, a large amount of helium evaporated in the cryogenic circuits returns to the cryogenic distribution system, which makes the pressures rise and the helium returning to the refrigerator increases. The refrigerator will run in a supercooling state and the turbine protection shutdown will be triggered with probability, which further affects the operation of the cryogenic system. This paper analyzes the archive data of this undesired phenomenon, the EAST cryogenic system model based on EcosimPro is used to simulate the dynamic process during the failure. A split-range control scheme to stabilize the pressures in the distribution system under failure state is proposed. the control module is developed in EcosimPro, simulation results show that it could achieve a satisfactory control performance and reduce the impact caused by the failure.

China Fusion Engineering Test Reactor (CFETR) is the next magnetic confinement fusion device to demonstrate fusion energy. To test the cryogenic performance of CFETR Toroidal Field (TF) superconducting magnet, a large-scale helium cryogenic system was under construction to provide Supercritical Helium (SHe), supported by Comprehensive Research Facility for Fusion Technology (CRAFT). In this paper, heat loads of TF magnet and the dedicated distribution system were analysed to define the scale. Process flow of the helium refrigerator has been designed considering the various operation phases. Preliminary thermodynamic cycle of the helium refrigerator have been calculated with the capacity of 4kW@4.5K+20g/s@50K. This 4kW@4.5K helium refrigerator was not only a test facility for CFETR superconducting magnets, but also a prototype of CFETR helium refrigerator.

EAST (Experimental Advanced Superconducting Tokamak) cryogenic system has participated in the physical experimental campaigns over 15 years since the first cool-down experiment in 2006. Some fault of the heat exchanger blocking due to the purification of gas helium has occurred several times during the cryogenic system’s operation since 2017, which caused the system warmed up to deal with the malfunction. Therefore, the helium gas purification system including the oil-removal system after the oil-injected screw compressors, the adsorbers inside the cold-box and two sets of external purifiers as well as the control system has been redesigned and reconstructed from 2019 to 2020, and put into operation in the 18th cool-down experiment of EAST cryogenic system at the beginning of 2021. The process flow of new helium purification system and the equipment parameters together with the reconstruction process will be presented in detail in this paper. Meanwhile, the commissioning operation results will be illustrated to show the purification performance good and the reconstruction successful.

The nonlinear load of electric vehicle AC charging pile brings harmonic pollution to the power system, which seriously affects the safe and stable operation of the power system. In this paper, the AC charging pile of an electric vehicle is taken as the research object, and the system simulation and harmonic analysis are carried out. And APF is used to compensate and suppress the harmonic of the simulation model of electric vehicle charging. The simulation results show that the charger mainly increases the 5th and 7th harmonics to the power grid. After adding APF to the power grid side, the harmonics of the power grid side are suppressed, and the influence of the charging pile on the DC power grid is greatly reduced.

The lasing characteristics of InAs/InP(1 0 0) quantum dot lasers grown by gas source molecular beam epitaxy were carefully studied by varying cavity length and stripe width. With the increase of injection current, the lasers having a longer cavity length and a wider stripe width exhibited simultaneously two-lasing peaks or/three-lasing peaks. The high-energy peak undergoes continuous buleshift, while the low-energy peaks are somewhat fixed. At the same times, the injection current density decreased as the stripe width increase. When the lasers were applied to external cavity system, the shorter cavity length of InAs/InP quantum dot laser had a wider tunable range.

The comprehensive research facility for key systems of fusion reactors was included in the “13th Five-Year Plan” priority project in China. In order to meet the requirements of cryogenic testing of large superconducting magnets, it is proposed to build a 3kW@4.5K refrigerator and carry out research on 3kW@4.5K superfluid helium cryogenic system. In order to evaluate the reliability of the 3kW refrigerator, the FMECA analysis was performed on the helium refrigerator. The refrigerator system is divided into three subsystems: the compressor system, the monitoring and control system and the cold box, to identify the failure mode and the impact on the refrigerator system related functions. The critical value is calculated and the critical matrix is drawn by the severity and the occurrence of the rating criteria. Identify the parts with high and medium risks and propose corresponding risk mitigation measures.

The subcooled helium cryogenic testing platform with cold compressors has been operated successfully in the end of 2018 at the Institute of Plasma Physics, Chinese Academy of Sciences (CASIPP). It is the first subcooled helium cryogenic system based on the cryogenic decompression technique in China, which has been designed and constructed over two years by our own team. The subcooled helium cryogenic testing platform was designed to provide the 4.5 K supercritical helium for the helium forced-flow cooling with one helium circulating pump, and provide the 3 K subcooled helium with two cold compressors in series. It consists of one 2.5 kW@4.5 K helium refregeator and one distribution valve box where the helium circulating pump and the cold compressors installed on it. This paper will present the process control flow of the distribution system and the design parameters of two cold compressors. During the commissioning, the startup and stop control flow of the two cold compressors have been determined. And their operation and control were performed within the safe operation area in the performance map. The testing result shows the lowest temperature and pressure of the saturated helium bath, and indicates the subcooled helium system has an equivalent refrigeration power greater than the design value of 700 W@3 K. The commissioning experience will help the reconstruction of the subcooled helium system for EAST Tokamak in future to enhance the cryogenic stability in higher magnetic field.

In order to increase the magnetic field and temperature margin of superconducting magnets, a test facility for a 700 W@3 K sub-cooled helium refrigerator was proposed to decrease the operation temperature from 4.5 K down to 3 K. The process flow of the 3 K sub-cooled helium test facility has been designed with two cold compressors arranged in series to pump the vapour pressure from 120 kPa to 24 kPa. This 3 K sub-cooled unit has been constructed and operated successfully to decompress the 4.5 K saturated helium to 3 K sub-cooled helium. The preliminary commissioning results indicated that this 3K sub-cooled helium unit could achieve more than 700 W capacity at 3 K sub-cooled helium. Thermodynamic parameters and performances of this 3 K sub-cooled helium unit were introduced and compared with the designed values in good agreement. The rotation speeds, pressures and temperatures of cold compressors during the transient state and the steady state were also analysed.

Pre-cooling of helium with liquid nitrogen is a good alternative to large scale helium refrigerators for initial cool-down from room temperature to about 80 K due to high exergy efficiency, high cooling capacity, and low demand of heat exchanger area. However, during the initial cool-down, two problems have to be faced for an improper liquid nitrogen pre-cooling stage arrangement. The temperature difference between helium and nitrogen at the cold end of the first heat exchanger became very large, which leaded to high thermal stress and potential damage. The outlet temperature of the nitrogen stream of the heat exchanger is lower than room temperature, thus the efficiency decreases and more liquid nitrogen is consumed. In this paper, the performance of a liquid nitrogen pre-cooling stage for the EAST 2kW/4.5K helium refrigerator during cool-down phase will be analyzed. Then a new arrangement will be sought to avoid a larger temperature difference and underutilization of nitrogen cold energy. The current work may help to design, optimize and operate the liquid nitrogen pre-cooling stage for large scale helium refrigerators.

To observe the effects of pretreatment with dimethyloxalylglycine (DMOG) on the survival of multi-territory perforator flap and the vessels of choke zone (CZ) 2 in rat, and to explore related mechanism.Sixty adult SD rats were divided into group DMOG and normal saline group (NS) according to the random number table, with 30 rats in each group. Perforator flap with three angiosomes was made on the right dorsal side of rat, including deep iliac circumflex artery perforator, intercostal artery perforator, thoracodorsal artery perforator, as well as CZ 1 and CZ 2. Rats in group DMOG were intraperitoneally injected with 2 mL NS containing DMOG (40 mg/kg) 2 days before operation, 2 hours before operation, and 2 days after operation. Rats in group NS were intraperitoneally injected with equivalent volume of NS at the same time point. On post operation day (POD) 7, gross observation was conducted, and the survival rate of flap was calculated. On POD 7, the vascularity in CZ 2 and potential zone of flap was observed using angiography. On POD 7, new vessel in CZ 2 of flap was observed with HE staining, and the microvessel density (MVD) was calculated. On POD 7, the expression of vascular endothelial growth factor (VEGF) in CZ 2 of flap was detected by immunohistochemistry and Western blotting (respectively denoted as integral absorbance values and ratio of gray value), and blood flow volume of vessel in CZ 2 of flap was examined by laser Doppler perfusion imager. The sample number of each index was 6 in each group. Data were processed with t test.(1) On POD 7, rats in two groups all survived, and the flaps were not infected. In group DMOG, the necrotic area of flaps of rats with dark yellow crust and soft texture was observed approximately at the distal end of skin entry point of thoracodorsal artery perforator. In group NS, the necrotic area of flaps of rats with brownish black crust and hard texture was observed approximately at the distal end of CZ 2. The survival rate of flap of rats in group DMOG was (88±3) %, which was significantly higher than that in group NS [(82±3) %, t=3.38, P0.01]. (2) On POD 7, there were clear vascular structure and many new vessels in CZ 2 of flaps of rats in group DMOG, with intact vascular structure in potential zone. On POD 7, there were unclear vascular structure and few new vessels in CZ 2 of flaps of rats in group NS, with disorder vascular structure in potential zone. (3) On POD 7, MVD in CZ 2 of flaps in rats of group DMOG was (29.2±2.2)/mm(2,) which was significantly higher than that of group NS [(20.3±3.6)/mm(2,) t=5.10, P0.01]. (4) On POD 7, the expressions of VEGF in CZ 2 of flaps in rats of group DMOG detected by immunohistochemistry and Western blotting were 5 060±432 and 0.48±0.04 respectively, which were significantly higher than those of group NS (2 811±382 and 0.26±0.06, with t values respectively 9.54 and 5.67, P values below 0.01). (5) On POD 7, blood flow volume of vessel in CZ 2 of flaps in rats of group DMOG was (58±4) perfusion units (PU), which was significantly more than that of group NS [(46±4) PU, t=5.20, P0.01].DMOG can increase the survival rate of multi-territory perforator flap through promoting angiogenesis in CZ 2 of flap on the back of rat and improving blood supply of flap.

To collect comprehensive data of the physical function of the end-stage osteoarthritis (OA) patients, and compare it with patients with mild OA. To evaluate the correlations among pain, self-reported questionnaire, performance based physical function and actual daily life activity level.In this prospective study, the comprehensive physical function parameters of 87 end stage OA patients waiting for total knee replacement, and that of 60 patients with mild OA [Kellgren-Lawrence (K-L) grade 0-2] were collected. The comprehensive physical function parameters including: age, height, body weight, 30 s chair stand test (30-CST), 40 m fast-paced walk test (40-FPWT), 12 steps stair climb test (12-SCT), timed upgo test (TUG), 6 minutes walk test (6-MWT), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), knee society score (KSS), visual analogue scale (VAS) pain scale, and everyday steps counts for continuous 7 days. The data were analyzed with the soft ware SPSS 22.0. The descriptive report of all the parameters was made. Because the Kolmogorv-Smirnov test results for all the parameters were negative for normal distribution, nonparative Mann-Whitney test was used to analysis the differences between the two groups, as well as the Spearman test for the correlations.All the parameters of the mild OA group were better than those of the end stage group, and the differences were significant (P0.05). In the mild OA group, there were no correlations or weak correlations between all the physical function test and questionnaire, however, in the end stage group, the correlations were weak, moderate, or strong.The usage of lots of different physical parameters from Chinese OA patients were reported in this study. The results showed that there are no good correlations among performance based physical function test, actual daily activity level, self reported questionnaires, and the pain scales. More comprehensive evaluation for the OA patients needs to be made, in order to make better decision for arthroplasty.

We reported on growth conditions of InAs/GaAs quantum dots laser grown by gas source molecular beam epitaxy. It was found that the uniformity and size of dots had a close collection with growth temperature and thicknesses of InAs layer. As the increase of growth temperature, the emission wavelength kept red shift and line width of emission spectra also increased. Good uniformity of QD could be easily obtained with a relative lower growth temperature of 425 °C. At a higher growth temperature of 500 °C, a wider tunable region of 129.9 nm was observed by adjusting the thicknesses of InAs layers. Comparison with a normal capping process, the growth interruption of capping materials would not lead to the formed dots collapse. An available growth temperature of 425 °C was obtained to achieve good performances of InAs/GaAs quantum dot laser, which had one facet power more than 103 mW under continuous wave mode.

EAST is the first full superconducting fusion device. The plasma is confined by the magnetic fields generated from a large set of superconducting magnets which are made of cable in-conduit conductor (CICC). In operation, these magnets suffer heat loads from thermal and nuclear radiation from the surrounding components and plasma as well as the eddy currents and the AC losses generated within the magnets, together with the heat conduction through supports and the resistive heat generated at the current lead transiting to room temperature. The cryogenic system of our EAST consists of a 2kW/4K helium refrigerator and a distribution system for the cooling of poloidal field (PF) and toroidal field (TF) coils, structures, thermal shields, buslines and current leads. Pulsed heat load is the main difference between the cryogenic system of a full superconducting Tokamak system and other large scale cryogenic systems. The cryogenic system operates in a pulsed heat loads mode requiring the helium refrigerator to remove periodically large heat loads in time. At the same time, the cryogenic system parameters such as helium cooling superconducting magnets, helium refrigerator and helium distribution system are changing. In this paper, the variation range of the parameters of superconducting magnets and refrigerator has been analyzed in the typical plasma discharge mode. The control scheme for the pulsed loads characteristics of the cryogenic system has been proposed, the implementation of which helps to smooth the pulse loads and to improve the stability of the operation of the cryogenic system.

The cryogenic control system for EAST (Experimental Advanced Superconducting Tokamak) was designed based on DeltaV DCS of Emerson Corporation. The automatic control of the cryoplant warm compressors has been implemented. However, with ever-degrading performance of critical equipment, the cryoplant operation in the partial design conditions makes the control system fluctuate and unstable. In this paper, the warm compressor control system was optimized to eliminate the pressure oscillation based on the expert PID theory.

The hydrodynamic stability of a liquid column resting on a gas in a vertical tube with its upper end closed is analyzed. The maximum height above which the interface is unstable is given as a function of the Bond number and the density ratio. The instability is shown to be monotonic, i.e., nonoscillatory.

The absolute and convective instability of a jet of an inviscid compressible fluid emanating into another inviscid compressible fluid is investigated. It is shown that the compressibility of the ambient fluid, as well as the surface tension, tends to promote absolute instability. The absolute instability can be reduced to the convective one by reducing the surface tension and/or increasing the compressibility of the jet fluid, depending on the flow parameters.

To study the pathological changes of nasopharyngeal carcinoma cases after the treatment of stereotactic radiosurgery.15 cases with recurrent or residual squamous cell carcinoma of nasopharynx diagnosed as T1-4 N0M0 were selected, which had undergone previous radiotherapy. The patients were treated by Gamma Knife while the isodose curve was 50% and the margin dose was 20 Gy. The nasopharynx biopsy was performed before the treatment and 1, 3, 6, 12 months after the treatment. The biopsy specimen was taken to make a pathological examination.1. Before the Gamma Knife treatment, carcinoma cell could be seen in the tissue; 2. 1-3 months after the treatment, cell necrosis and acute inflammation cell infiltration could be seen in the target; 3. 6-12 months after the treatment, infiltration of chronic inflammation cell, proliferation of fibrous tissue and capillary could be found in the target.This research implies that the short-term pathological changes after the treatment of stereotactic radiosurgery can be defined as two phases: The first phase occurs from 1 to 3 months after the treatment called necrosis period. The second phase occurs from 6 to 12 months after the Gamma Knife treatment named as absorption period.

the effect of compressibili ty of fluids on the atomization of a liquid jet emanating from a nozzle into the ambient gas is investigated by use of linear stability analysis. An increase in the compressibility of the liquid gas is shown to promote the generation of smaller droplets, although at a slower rate. It is shown that in some parameter ranges, a small change in compressibility may result in a qualitative change of the mechanism of atomization. TOMIZATION is a process of breaking up a liquid jet into droplets of diameter much smaller than the jet di- ameter. This process is widely used in industrial applications including fuel injections in internal combustion engines. A good knowledge of the fundamental mechanism of atomiza- tion is essential for raising the combustion efficiency and re- ducing the environmental pollution. Our understanding of atomization is not yet complete. A concise review of experimental and theoretical work on atomization was given by Reitz and Bracco.1-2 A more ex- tensive exposition of the subject can be found in the work of Lefebvre.3 The atomization process as the consequence of the aerodynamic instability of a jet emanated into ambient gas was investigated by Taylor,4 Levich,5 and others. They con- sidered instability with respect to temporally growing dis- turbances. Atomization as the consequence of convective in- stability caused by spatially growing disturbances was studied by Lin and Kang,6 Lin and Lian,7 and Lin and Creighton.8 In all of the theoretical works mentioned above, the fluids are assumed to be incompressible. On the other hand in many applications, the jet speed is such that the Mach number of the ambient gas relative to the jet may reach transonic. For future applications it may even reach supersonic. Therefore, the compressibility of the fluids must be taken into account. Here, we investigate the effects of compressibility on atom- ization. The problem of instability of an inviscid compressible jet emanating into an inviscid compressible gas is formulated in the next section. The disturbance is allowed to grow both tem- porally and spatially. The results of the solution to the formu- lated problem are used to demonstrate that the compressibility brings about not only quantitative but also qualitative differences in the mechanism of atomization at its onset.

101 children of anorexia with Spleen deficiency were divided randomly into two groups, the invigorating Spleen(IS) group of 58 cases treated by modified Yi-Gong-San, and the replenishing zinc(RZ) group of 43 cases treated by 0.2% zinc sulphate syrup. One course of treatment was 3 months.the clinical effects of IS group were notable in promoting appetite, increasing body weight and height, eliminating polyhidrosis, preventing common cold and tracheitis etc. The total effective rate was 96.6% in IS group which was significantly better than 72.1% in the RZ group (P less than 0.01). The effect of examination showed that the levels of hair zinc after treatment were markedly increased in both groups (P less than 0.01). The average increased value of hair zinc was 62.2 +/- 9.1 (ppm) in IS group which was higher than 42.1 +/- 7.2 (ppm) in RZ group (P less than 0.05). Moreover excretion rate and Hb after treatment in the IS group were markedly higher those in the RZ group (P less than 0.01). Chemical analysis showed that the concentration of zinc in modified Yi-Gong-San was very slight (0.73 mg/pack). It indicated that arising hair zinc in IS group was not simply supply of zinc but also the treatment in appetite, digestion and absorption, with which the body was supplied enough zinc naturally by food taken.