1. Endometrium in in-vitro fertilization cycles: morphological and functional differentiation in the implantation phase
- Author
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Mourad W. Seif, John D. Aplin, P.L. Matson, J.M. Pearson, C.H. Buckley, P. Buck, Z. H. Z. Ibrahim, and Brian A. Lieberman
- Subjects
endocrine system ,medicine.medical_specialty ,Menotropins ,Secretory component ,Biopsy ,medicine.medical_treatment ,media_common.quotation_subject ,Fertilization in Vitro ,Luteal phase ,Biology ,Endometrium ,Buserelin ,Chorionic Gonadotropin ,Internal medicine ,Follicular phase ,medicine ,Humans ,Embryo Implantation ,Ovulation ,Progesterone ,reproductive and urinary physiology ,media_common ,In vitro fertilisation ,Estradiol ,Rehabilitation ,Antibodies, Monoclonal ,Obstetrics and Gynecology ,Immunohistochemistry ,Embryo transfer ,Endocrinology ,medicine.anatomical_structure ,Reproductive Medicine ,Keratan Sulfate ,Female - Abstract
Secretory differentiation of endometrium after multiple follicular stimulation using gonadotrophin releasing hormone and human menopausal gonadotrophin has been studied both histologically and immunohistochemically in 30 women undergoing in-vitro fertilization treatment. None had embryo transfer. Patients were randomly allocated to receive luteal phase support with a single dose of human chorionic gonadotrophin. The latter failed to produce any significant enhancement of endometrial structure or secretions. Appropriate glandular morphology was present in a greater proportion of those who were successfully stimulated than those who responded poorly. However, defective secretion of the cycle-dependent component studied, using monoclonal antibody D9B1, was demonstrated in two-thirds of cases regardless of the ovarian response. Early vascular maturation in the stroma was a common finding, and was thus considered as a feature of structural modulation of these endometria.
- Published
- 1992
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