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3. The Angers CT Score is a Risk Factor for the Failure of the Conservative Management of Adhesive Small Bowel Obstruction: A Prospective Observational Multicentric Study

Author

Paisant, Anita, Burgmaier, Jeanne, Calame, Paul, Loison, Mélanie, Molière, Sébastien, Brigand, Cécile, Belabbas, Dihia, Duchalais, Emilie, Regimbeau, Jean-Marc, Yzet, Thierry, Alves, Arnaud, Fohlen, Audrey, Bergeat, Damien, Vauclair, Estelle, Pellegrini, Julie, Ragot, Emilia, Lansier, Alexandre, Abet, Emeric, Nevot, Alexandre, Rousset, Pascal, Ouaissi, Mehdi, Besson, Marie, Ronot, Maxime, Giacca, Massimo, Girard, Edouard, Tessier, Yann, Massalou, Damien, Poirier, Florent, Lakkis, Zaher, Aubé, Christophe, Hamel, Jean Francois, Passot, Guillaume, and Venara, Aurélien

Published
2023
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7. FRI-456 Characterization of the intratumoral immune microenvironment of hepatocellular carcinoma before selective intrahepatic radiation therapy (SIRT) and study of its prognostic value on response to treatment

Author

Franzè, Maria Stella, primary, Vigneron, Paul, additional, Caruso, Stefano, additional, Regnault, Hélène, additional, Sessa, Anna, additional, Maille, Pascale, additional, Bouda, Yasmine, additional, Iavarone, Massimo, additional, Canova, Lorenzo, additional, Maggioni, Marco, additional, Khac, Eric Nguyen, additional, Sarba, Ruxandra, additional, Yzet, Thierry, additional, Heurgue-berlot, Alexandra, additional, Kianmanesh, Reza, additional, Rhaiem, Rami, additional, Nault, Jean Charles, additional, Soussan, Michael, additional, Sutter, Olivier, additional, Allaire, Manon, additional, Lequoy, Marie, additional, Bouattour, Mohamed, additional, Beaufrère, Aurélie, additional, Burgio, Marco Dioguardi, additional, Raffaele, Brustia, additional, Sommacale, Daniele, additional, Luciani, Alain, additional, Tacher, Vania, additional, Pawlotsky, Jean-Michel, additional, Leroy, Vincent, additional, Calderaro, Julien, additional, and Amaddeo, Giuliana, additional

Published
2024
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8. Health-related quality of life in locally advanced hepatocellular carcinoma treated by either radioembolisation or sorafenib (SARAH trial)

Author

Assenat, Eric, Delhom-Christol, Elisabeth, Fourcade, Marjolène, Guiu, Boris, Ilonca, Alina Diana, Lonjon, Julie, Pageaux, Georges-Philippe, Abdel-Rehim, Mohamed, Allaham, Wassim, Bouattour, Mohamed, Castera, Laurent, Dieudonné, Arnaud, Lebtahi, Rachida, Ronot, Maxime, Sibert, Annie, Vilgrain, Valérie, Chor, Hélène, Devictor, Julie, Barraud, Hélène, Bazin, Christophe, Bronowicki, Jean-Pierre, Imbert, Laetitia, Laurent, Valérie, Mathias, Elodie, Chagneau-Derrode, Carine, Gallais, Christelle, Perdrisot, Rémy, Silvain, Christine, Tasu, Jean Pierre, Borentain, Patrick, Farman, Bardia, Gerolami, René, Mundler, Olivier, Seitz, Jean-Francois, Vidal, Vincent, Aubé, Christophe, Bouchet, Francis, Bouvier, Antoine, Couturier, Olivier, Oberti, Frédéric, Vervueren, Laurent, Brenot-Rossi, Isabelle, Darreon, Julien, Raoul, Jean Luc, Sarran, Anthony, Chalaye, Julia, Costentin, Charlotte, Itti, Emmanuel, Kobeiter, Hicham, Luciani, Alain, Masset, Hélène, Adam, René, Lewin, Maïté, Samuel, Didier, Edeline, Julien, Garin, Etienne, Laffont, Sophie, Rolland, Yan, Archambeaud, Isabelle, Carlier, Thomas, Eugene, Thomas, Frampas, Eric, Cassinotto, Christophe, Guyot, Martine, Hiriart, Jean-Baptiste, Lapuyade, Bruno, Tendero, Karine, Vergniol, Julien, Bachellier, Philippe, Détour, Julien, Duclos, Bernard, Greget, Michel, Habersetzer, Francois, Imperiale, Alessio, Enderlin, Elise, Merle, Philippe, Rode, Agnès, Morvan, Julie, Nguyen-Khac, Eric, Talbot, Antoine, Yzet, Thierry, Baudin, Guillaume, Chevallier, Patrick, Mahamat, Abakar, Maurel, Fabien, Piche, Thierry, Razzouk, Micheline, Hillon, Patrick, Loffroy, Romaric, Toubeau, Michel, Vincent, Julie, Vrigneaud, Jean-Marc, Barabino, Gabriele, Bouarioua, Nadia, Cuilleron, Muriel, Ecochard, Marie, Prevot-Bitot, Nathalie, Rousset, Evelyne, Leroy, Vincent, Reboulet, Ghislaine, Roux, Julie, Sengel, Christian, Bourcier, Valérie, Ganne-Carrie, Nathalie, Seror, Olivier, Costo, Sylvie, Dao, Thông, Desmonts, Cédric, Pelage, Jean-Pierre, Defez, Didier, Dumortier, Jérôme, Giammarile, Francesco, Valette, Pierre-Jean, Bernardini, Michela, Ghazar, Nadia, Pellerin, Olivier, Taieb, Julien, Weinmann, Pierre, Heurgue-Berlot, Alexandra, Marcus, Claude, Sommacale, Daniele, Castilla-Lièvre, Maria-Angéla, Forbes, Aurélie, Maitre, Sophie, Marthey, Lysiane, Pereira, Helena, Burgio, Marco D., Grégory, Jules, and Chatellier, Gilles

Published
2021
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9. Cost-Utility Analysis of Transarterial Radioembolization With Yttrium-90 Resin Microspheres Compared With Sorafenib in Locally Advanced and Inoperable Hepatocellular Carcinoma

Author

Assenat, Eric, Delhom-Christol, Elisabeth, Guiu, Boris, Ilonca, Alina D., Lonjon, Julie, Pageaux, Georges-Philippe, Abdel-Rehim, Mohamed, Al-laham, Wassim, Bouattour, Mohamed, Castera, Laurent, Dieudonné, Arnaud, Lebtahi, Rachida, Ronot, Maxime, Sibert, Annie, Vilgrain, Valérie, Barraud, Hélène, Bazin, Christophe, Bronowicki, Jean-Pierre, Laurent, Valérie, Mathias, Elodie, Chagneau-Derrode, Carine, Perdrisot, Rémy, Silvain, Christine, Tasu, Jean-Pierre, RenéGerolami, Patrick Borentain, Mundler, Olivier, Seitz, Jean-Francois, Vidal, Vincent, Aubé, Christophe, Bouvier, Antoine, Couturier, Olivier, Oberti, Frédéric, Vervueren, Laurent, Brenot-Rossi, Isabelle, Raoul, Jean-Luc, Sar-ran, Anthony, Chalaye, Julia, Costentin, Charlotte, Itti, Emmanuel, Kobeiter, Hicham, Luciani, Alain, Adam, René, Lewin, Maïté, Samuel, Didier, Edeline, Julien, Garin, Etienne, Rolland, Yan, Archambeaud, Isabelle, Eugene, Thomas, Frampas, Eric, Cassinotto, Christophe, Guyot, Martine, Hiriart, Jean-Baptiste, Lapuyade, Bruno, Vergniol, Julien, Bachellier, Philippe, Detour, Julien, Duclos, Bernard, Greget, Michel, Habersetzer, Francois, Imperiale, Alessio, Merle, Philippe, Rode, Agnès, Morvan, Julie, Nguyen-Khac, Eric, Yzet, Thierry, Baudin, Guillaume, Chevallier, Patrick, Mahamat, Abakar, Piche, Thierry, Razzouk, Micheline, Hillon, Patrick, Loffroy, Romaric, Toubeau, Michel, Vincent, Julie, Barabino, Gabriele, Bouarioua, Nadia, Cuilleron, Muriel, Ecochard, Marie, Prevot-Bitot, Nathalie, Leroy, Vincent, Roux, Julie, Sengel, Christian, Bourcier, Valérie, Carrie, Nathalie Ganne, Seror, Olivier, Costo, Sylvie, Dao, Thông, Pelage, Jean-Pierre, Dumortier, Jérôme, Giammarile, Francesco, Valette, Pierre-Jean, Ghazzar, Nadia, Pellerin, Olivier, Taieb, Julien, Weinmann, Pierre, Berlot, Alexandra Heurgue, Marcus, Claude, Sommacale, Daniele, Castilla-Lièvre, Maria-Angéla, Maitre, Sophie, Marthey, Lysiane, Zarca, Kevin, Mimouni, Maroua, Pereira, Helena, Chatellier, Gilles, and Durand-Zaleski, Isabelle

Published
2021
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11. Acute pancreatitis and computed tomography: Interest of portal venous phase alone in the initial phase.

Author

Ansel-Wallois, Wilfried, Assako, Parfait, Yzet, Thierry, and Bouzerar, Roger

Subjects
NECROTIZING pancreatitis, COMPUTED tomography, PANCREATITIS, SYMPTOMS, IRRADIATION
Abstract

Background: There are no guidelines in the literature for the use of a computed tomography (CT) protocol in the initial phase of acute pancreatitis (AP). Purpose: To evaluate the contribution of single portal venous phase CT compared to triple-phase CT protocol, performed in the initial phase of AP for severity assessment. Material and Methods: In this retrospective study, a total of 175 patients with acute pancreatitis who underwent initial triple-phase CT protocol (non-contrast, arterial phase, and portal venous phase) between D3 and D7 after the onset of symptoms were included. Analysis of AP severity and complications was independently assessed by two readers using three validated CT severity scores (CTSI, mCTSI, EPIC). All scores were applied to the triple-phase CT protocol and compared to the single portal venous phase. Inter-observer analyses were also performed. Results: No significant difference whatever the severity score was observed after analysis of the single portal venous phase compared with the triple-phase CT protocol (interstitial edematous pancreatitis: CTSI: 2 vs. 2, mCTSI: 2 vs. 2, EPIC: 1 vs. 1; necrotizing pancreatitis: CTSI: 6 vs. 6, mCTSI: 8 vs. 8, EPIC: 5 vs. 5). Inter-observer agreement was excellent (ICC = 0.96–0.99), whatever the severity score. Conclusion: A triple-phase CT protocol performed at the initial phase of AP was no better than a single portal venous for assessing the severity of complications and could lead to a 63% reduction in irradiation. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Hépatite alcoolique aiguë sévère

Author

Nguyen-Khac, Eric, Dejour, Valérie, Sarba, Ruxandra, Yzet, Thierry, Chatelain, Denis, Marcq, Ingrid, Chivot, Cyril, Papillon, Charles Antoine, Attencourt, Christophe, and Houchi, Hakim

Published
2018
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17. Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial

Author

Assenat, Eric, Delhom - Christol, Elisabeth, Guiu, Boris, Ilonca, Alina D, Lonjon, Julie, Pageaux, Georges-Philippe, Abdel-Rehim, Mohamed, Allaham, Wassim, Bouattour, Mohamed, Castera, Laurent, Dieudonné, Arnaud, Lebtahi, Rachida, Ronot, Maxime, Sibert, Annie, Vilgrain, Valérie, Barraud, Hélène, Bazin, Christophe, Bronowicki, Jean-Pierre, Laurent, Valérie, Mathias, Elodie, Chagneau-Derrode, Carine, Perdrisot, Rémy, Silvain, Christine, Tasu, Jean-Pierre, Borentain, Patrick, Gerolami, René, Mundler, Olivier, Seitz, Jean-Francois, Vidal, Vincent, Aubé, Christophe, Bouvier, Antoine, Couturier, Olivier, Oberti, Frédéric, Vervueren, Laurent, Brenot-Rossi, Isabelle, Raoul, Jean-Luc, Sarran, Anthony, Chalaye, Julia, Costentin, Charlotte, Itti, Emmanuel, Kobeiter, Hicham, Luciani, Alain, Adam, René, Lewin, Maïté, Samuel, Didier, Edeline, Julien, Garin, Etienne, Rolland, Yan, Archambeaud, Isabelle, Eugene, Thomas, Frampas, Eric, Cassinotto, Christophe, Guyot, Martine, Hiriart, Jean-Baptiste, Lapuyade, Bruno, Vergniol, Julien, Bachellier, Philippe, Detour, Julien, Duclos, Bernard, Greget, Michel, Habersetzer, Francois, Imperiale, Alessio, Merle, Philippe, Rode, Agnès, Morvan, Julie, Nguyen-Khac, Eric, Yzet, Thierry, Baudin, Guillaume, Chevallier, Patrick, Mahamat, Abakar, Piche, Thierry, Razzouk, Micheline, Hillon, Patrick, Loffroy, Romaric, Toubeau, Michel, Vincent, Julie, Barabino, Gabriele, Bouarioua, Nadia, Cuilleron, Muriel, Ecochard, Marie, Prevot-Bitot, Nathalie, Leroy, Vincent, Roux, Julie, Sengel, Christian, Bourcier, Valérie, Ganne-Carrie, Nathalie, Seror, Olivier, Costo, Sylvie, Dao, Thông, Pelage, Jean-Pierre, Dumortier, Jérôme, Giammarile, Francesco, Valette, Pierre-Jean, Ghazzar, Nadia, Pellerin, Olivier, Taieb, Julien, Weinmann, Pierre, Heurgue-Berlot, Alexandra, Marcus, Claude, Sommacale, Daniele, Castilla-Lièvre, Maria-Angéla, Maitre, Sophie, Marthey, Lysiane, Pereira, Helena, Ilonca, Alina Diana, Dinut, Aurelia, and Chatellier, Gilles

Published
2017
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19. Use of water-soluble contrast medium (gastrografin) does not decrease the need for operative intervention nor the duration of hospital stay in uncomplicated acute adhesive small bowel obstruction? A multicenter, randomized, clinical trial (Adhesive Small Bowel Obstruction Study) and systematic review

Author

Scotté, Michel, Mauvais, Francois, Bubenheim, Michael, Cossé, Cyril, Suaud, Leslie, Savoye-Collet, Celine, Plenier, Isabelle, Péquignot, Aurelien, Yzet, Thierry, and Regimbeau, Jean Marc

Published
2017
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21. Robotically assisted deployment of flow diverter stents for the treatment of cerebral and cervical aneurysms.

Author

Chivot, Cyril, Bouzerar, Roger, Peltier, Johann, Lefranc, Michel, and Yzet, Thierry

Subjects
INTRACRANIAL aneurysm surgery, SURGICAL robots, CEREBRAL angiography, PATIENT safety, THERAPEUTIC embolization, ENDOVASCULAR surgery, SURGICAL stents, TREATMENT effectiveness, RETROSPECTIVE studies
Abstract

Background Despite the growing sophistication of robot-assisted surgery, it is necessary to demonstrate that robots can reliably perform complex procedures on site and then remotely. Although a flow diverter stent is one of the most effective and widely used devices, its placement is sometimes challenging. Objective To evaluate the feasibility and safety of the CorPath GRX robotic platform for the embolization of cerebral and cervical aneurysms using flow diverter stents. Methods We performed a single-center technical study of the first 10 flow diverter stent deployments with the CorPath GRX Robotic System (Corindus Inc, Waltham, Massachusetts, USA) for the treatment of cerebral aneurysms between April and October 2022. Results Ten patients underwent robot-assisted embolization with flow diverter stents: there were nine intracranial aneurysms (paraclinoid n=6; posterior communicating artery aneurysm n=1; anterior communicating artery n=2) and one cervical aneurysm. Four procedures were performed with coils plus a flow diverter stent, one was performed with woven endobridge plus a flow diverter stent and four were performed with flow diverter stents alone. Of these procedures, two were performed with telescoping flow diverters. All flow diverter stents were deployed with robotic assistance, with only one partial conversion to a manual technique (caused by guidewire torquability limitations). No perioperative complications were observed. Conclusion Robot-assisted flow diverter stent deployment using the CorPath GRX platform is feasible and appears to be safe. Larger, in-depth studies of the technique's safety and benefits are now warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Right portal vein ligation is still relevant for left hemi-liver hypertrophy: results of a comparative study using a propensity score between right portal vein ligation and embolization.

Author

Werey, Fabien, Dembinski, Jeanne, Michaud, Audrey, Sabbagh, Charles, Mauvais, François, Yzet, Thierry, and Regimbeau, Jean-Marc

Subjects
PORTAL vein surgery, PORTAL vein, COLORECTAL liver metastasis, HYPERTROPHY
Abstract

Background: In two-stage hepatectomy for bilobar liver metastases from colorectal cancer, future liver remnant (FLR) growth can be achieved using several techniques, such as right portal vein ligation (RPVL) or right portal vein embolization (RPVE). A few heterogeneous studies have compared these two techniques with contradictory results concerning FLR growth. The objective of this study was to compare FLR hypertrophy of the left hemi-liver after RPVL and RPVE. Study design: This was a retrospective comparative study using a propensity score of patients who underwent RPVL or RPVE prior to major hepatectomy between January 2010 and December 2020. The endpoints were FLR growth (%) after weighting using the propensity score, which included FLR prior to surgery and the number of chemotherapy cycles. Secondary endpoints were the percentage of patients undergoing simultaneous procedures, the morbidity and mortality, the recourse to other liver hypertrophy procedures, and the number of invasive procedures for the entire oncologic program in intention-to-treat analysis. Results: Fifty-four consecutive patients were retrospectively included and analyzed, 18 in the RPVL group, and 36 in the RPVE group. The demographic characteristics were similar between the groups. After weighting, there was no significant difference between the RPVL and RPVE groups for FLR growth (%), respectively 32.5% [19.3–56.0%] and 34.5% [20.5–47.3%] (p = 0.221). There was no significant difference regarding the secondary outcomes except for the lower number of invasive procedures in RPVL group (median of 2 [2.0, 3.0] in RPVL group and 3 [3.0, 3.0] in RPVE group, p = 0.001)). Conclusion: RPVL and RPVE are both effective to provide required left hemi-liver hypertrophy before right hepatectomy. RPVL should be considered for the simultaneous treatment of liver metastases and the primary tumor. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Correction: Endoscopic treatment of large gastric leaks after gastrectomy using the combination of double pigtail drains crossing a covered stent

Author

Yzet, Clara, primary, Hakim, Sami, additional, Pioche, Mathieu, additional, Le Mouel, Jean-Phillippe, additional, Deschepper, Constance, additional, Lafeuille, Pierre, additional, Delcenserie, Richard, additional, Yzet, Thierry, additional, Nguyen-Khac, Eric, additional, Fumery, Mathurin, additional, and Brazier, Franck, additional

Published
2022
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34. Efficacy of adalimumab in patients with Crohnʼs disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study

Author

Bouhnik, Yoram, Carbonnel, Franck, Laharie, David, Stefanescu, Carmen, Hébuterne, Xavier, Abitbol, Vered, Nachury, Maria, Brixi, Hedia, Bourreille, Arnaud, Picon, Laurence, Bourrier, Anne, Allez, Matthieu, Peyrin-Biroulet, Laurent, Moreau, Jacques, Savoye, Guillaume, Fumery, Mathurin, Nancey, Stephane, Roblin, Xavier, Altwegg, Romain, Bouguen, Guillaume, Bommelaer, Gilles, Danese, Silvio, Louis, Edouard, Zappa, Magaly, Mary, Jean-Yves, Arrive, Lionel, Aubourg, Alexandre, Baillon, Audrey, Baudin, Guillaume, Beaugerie, Laurent, Bolivar, Julie, Brun, Vanessa, Buisson, Anthony, Cadiot, Guillaume, Chevalier, Patrick, Colombel, Jean Frédéric, Cuilleron, Muriel, Dupas, Jean Louis, Filippi, Jérôme, Flourié, Bernard, Frampas, Eric, Gayet, Mathilde, Gornet, Jean Marc, Hordonneau, Constance, Lapuyade, Bruno, Laurent, Valérie, Leroy, Christophe, Lewin, Maïté, Otal, Philippe, Oudjit, Ammar, Panis, Yves, Pariente, Benjamin, Scotto, Béatrice, Simon, Marion, Treton, Xavier, Valette, Pierre-Jean, Yzet, Thierry, and Zagdanski, Anne Marie

Published
2018
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36. Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography

Author

UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiologie, Bouhnik, Yoram, Le Berre, Catherine, Zappa, Magaly, Lewin, Maïté, Boudiaf, Mourad, Zagdanski, Anne Marie, Frampas, Eric, Oudjit, Ammar, Scotto, Béatrice, Tissier, Muriel, Annet, Laurence, Aufort, Sophie, Yzet, Thierry, Cuilleron, Muriel, Baudin, Guillaume, Abitbol, Vered, Cosnes, Jacques, Bourreille, Arnaud, Mary, Jean Yves, Simon, Marion, Dupas, Jean Louis, Marteau, Philippe, Picon, Laurence, Pelletier, Anne Laure, Altwegg, Romain, Dewit, Olivier, Filippi, Jérome, Roblin, Xavier, Stéfanescu, Carmen, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiologie, Bouhnik, Yoram, Le Berre, Catherine, Zappa, Magaly, Lewin, Maïté, Boudiaf, Mourad, Zagdanski, Anne Marie, Frampas, Eric, Oudjit, Ammar, Scotto, Béatrice, Tissier, Muriel, Annet, Laurence, Aufort, Sophie, Yzet, Thierry, Cuilleron, Muriel, Baudin, Guillaume, Abitbol, Vered, Cosnes, Jacques, Bourreille, Arnaud, Mary, Jean Yves, Simon, Marion, Dupas, Jean Louis, Marteau, Philippe, Picon, Laurence, Pelletier, Anne Laure, Altwegg, Romain, Dewit, Olivier, Filippi, Jérome, Roblin, Xavier, and Stéfanescu, Carmen

Abstract

Background The severity of small bowel (SB) inflammation in Crohn’s disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS). Methods Each gastroenterologist/radiologist pair in 13 centers selected MREs from 6 patients with SB-CD stratified on their perceived MRE inflammation severity. The 78 blinded MREs were allocated through balanced incomplete block design per severity stratum to these 13 pairs for rating the presence/severity of 13 preselected items for each SB 20-cm diseased segment. Global inflammation severity was evaluated using a 100-cm visual analog scale. Reproducibility of recorded items was evaluated. The CDMRIS was determined through linear mixed modeling as a combination of the numbers of segments with lesions highly correlated to global inflammation severity. Results Four hundred and forty-two readings were available. Global inflammation severity mean ± SD was 21.0 ± 16.2. The independent predictors explaining 54% of the global inflammation severity variance were the numbers of segments with T1 mild–moderate and severe intensity of enhancement, deep ulceration without fistula, comb sign, fistula, and abscess. Unbiased correlation between CDMRIS and global inflammation severity was 0.76. Conclusions The CDMRIS is now available to evaluate the severity of SB-CD inflammation. External validation and sensitivity-to-change are mandatory next steps.

Published
2022

37. Portal Vein Pulsatility Index as a Potential Risk of Venous Congestion Assessed by Magnetic Resonance Imaging: A Prospective Study on Healthy Volunteers

Author

Abou-Arab, Osama, primary, Beyls, Christophe, additional, Moussa, Mouhamed Djahoum, additional, Huette, Pierre, additional, Beaudelot, Elodie, additional, Guilbart, Mathieu, additional, De Broca, Bruno, additional, Yzet, Thierry, additional, Dupont, Hervé, additional, Bouzerar, Roger, additional, and Mahjoub, Yazine, additional

Published
2022
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38. Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography

Author

Bouhnik, Yoram, Le Berre, Catherine, Zappa, Magaly, Lewin, Maïté, Boudiaf, Mourad, Zagdanski, Anne Marie, Frampas, Eric, Oudjit, Ammar, Scotto, Béatrice, Tissier, Muriel, Annet, Laurence, Aufort, Sophie, Yzet, Thierry, Cuilleron, Muriel, Baudin, Guillaume, Abitbol, Vered, Cosnes, Jacques, Bourreille, Arnaud, Mary, Jean Yves, Simon, Marion, Dupas, Jean Louis, Marteau, Philippe, Picon, Laurence, Pelletier, Anne Laure, Altwegg, Romain, Dewit, Olivier, Filippi, Jérome, Roblin, Xavier, Stéfanescu, Carmen, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Centre du cancer, and UCL - (SLuc) Service de radiologie

Subjects
MRE, Gastroenterology, CDMRIS, macromolecular substances, crohn, Small bowel
Abstract

Background The severity of small bowel (SB) inflammation in Crohn’s disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS). Methods Each gastroenterologist/radiologist pair in 13 centers selected MREs from 6 patients with SB-CD stratified on their perceived MRE inflammation severity. The 78 blinded MREs were allocated through balanced incomplete block design per severity stratum to these 13 pairs for rating the presence/severity of 13 preselected items for each SB 20-cm diseased segment. Global inflammation severity was evaluated using a 100-cm visual analog scale. Reproducibility of recorded items was evaluated. The CDMRIS was determined through linear mixed modeling as a combination of the numbers of segments with lesions highly correlated to global inflammation severity. Results Four hundred and forty-two readings were available. Global inflammation severity mean ± SD was 21.0 ± 16.2. The independent predictors explaining 54% of the global inflammation severity variance were the numbers of segments with T1 mild–moderate and severe intensity of enhancement, deep ulceration without fistula, comb sign, fistula, and abscess. Unbiased correlation between CDMRIS and global inflammation severity was 0.76. Conclusions The CDMRIS is now available to evaluate the severity of SB-CD inflammation. External validation and sensitivity-to-change are mandatory next steps.

Published
2022

40. Health-related quality of life in locally advanced hepatocellular carcinoma treated by either radioembolisation or sorafenib (SARAH trial)

Author

Pereira, Helena, primary, Bouattour, Mohamed, additional, Burgio, Marco D., additional, Assenat, Eric, additional, Grégory, Jules, additional, Bronowicki, Jean-Pierre, additional, Chatellier, Gilles, additional, Vilgrain, Valérie, additional, Delhom-Christol, Elisabeth, additional, Fourcade, Marjolène, additional, Guiu, Boris, additional, Ilonca, Alina Diana, additional, Lonjon, Julie, additional, Pageaux, Georges-Philippe, additional, Abdel-Rehim, Mohamed, additional, Allaham, Wassim, additional, Castera, Laurent, additional, Dieudonné, Arnaud, additional, Lebtahi, Rachida, additional, Ronot, Maxime, additional, Sibert, Annie, additional, Chor, Hélène, additional, Devictor, Julie, additional, Barraud, Hélène, additional, Bazin, Christophe, additional, Imbert, Laetitia, additional, Laurent, Valérie, additional, Mathias, Elodie, additional, Chagneau-Derrode, Carine, additional, Gallais, Christelle, additional, Perdrisot, Rémy, additional, Silvain, Christine, additional, Tasu, Jean Pierre, additional, Borentain, Patrick, additional, Farman, Bardia, additional, Gerolami, René, additional, Mundler, Olivier, additional, Seitz, Jean-Francois, additional, Vidal, Vincent, additional, Aubé, Christophe, additional, Bouchet, Francis, additional, Bouvier, Antoine, additional, Couturier, Olivier, additional, Oberti, Frédéric, additional, Vervueren, Laurent, additional, Brenot-Rossi, Isabelle, additional, Darreon, Julien, additional, Raoul, Jean Luc, additional, Sarran, Anthony, additional, Chalaye, Julia, additional, Costentin, Charlotte, additional, Itti, Emmanuel, additional, Kobeiter, Hicham, additional, Luciani, Alain, additional, Masset, Hélène, additional, Adam, René, additional, Lewin, Maïté, additional, Samuel, Didier, additional, Edeline, Julien, additional, Garin, Etienne, additional, Laffont, Sophie, additional, Rolland, Yan, additional, Archambeaud, Isabelle, additional, Carlier, Thomas, additional, Eugene, Thomas, additional, Frampas, Eric, additional, Cassinotto, Christophe, additional, Guyot, Martine, additional, Hiriart, Jean-Baptiste, additional, Lapuyade, Bruno, additional, Tendero, Karine, additional, Vergniol, Julien, additional, Bachellier, Philippe, additional, Détour, Julien, additional, Duclos, Bernard, additional, Greget, Michel, additional, Habersetzer, Francois, additional, Imperiale, Alessio, additional, Enderlin, Elise, additional, Merle, Philippe, additional, Rode, Agnès, additional, Morvan, Julie, additional, Nguyen-Khac, Eric, additional, Talbot, Antoine, additional, Yzet, Thierry, additional, Baudin, Guillaume, additional, Chevallier, Patrick, additional, Mahamat, Abakar, additional, Maurel, Fabien, additional, Piche, Thierry, additional, Razzouk, Micheline, additional, Hillon, Patrick, additional, Loffroy, Romaric, additional, Toubeau, Michel, additional, Vincent, Julie, additional, Vrigneaud, Jean-Marc, additional, Barabino, Gabriele, additional, Bouarioua, Nadia, additional, Cuilleron, Muriel, additional, Ecochard, Marie, additional, Prevot-Bitot, Nathalie, additional, Rousset, Evelyne, additional, Leroy, Vincent, additional, Reboulet, Ghislaine, additional, Roux, Julie, additional, Sengel, Christian, additional, Bourcier, Valérie, additional, Ganne-Carrie, Nathalie, additional, Seror, Olivier, additional, Costo, Sylvie, additional, Dao, Thông, additional, Desmonts, Cédric, additional, Pelage, Jean-Pierre, additional, Defez, Didier, additional, Dumortier, Jérôme, additional, Giammarile, Francesco, additional, Valette, Pierre-Jean, additional, Bernardini, Michela, additional, Ghazar, Nadia, additional, Pellerin, Olivier, additional, Taieb, Julien, additional, Weinmann, Pierre, additional, Heurgue-Berlot, Alexandra, additional, Marcus, Claude, additional, Sommacale, Daniele, additional, Castilla-Lièvre, Maria-Angéla, additional, Forbes, Aurélie, additional, Maitre, Sophie, additional, and Marthey, Lysiane, additional

Published
2021
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44. Cost-Utility Analysis of Transarterial Radioembolization With Yttrium-90 Resin Microspheres Compared With Sorafenib in Locally Advanced and Inoperable Hepatocellular Carcinoma

Author

Zarca, Kevin, primary, Mimouni, Maroua, additional, Pereira, Helena, additional, Chatellier, Gilles, additional, Vilgrain, Valérie, additional, Durand-Zaleski, Isabelle, additional, Assenat, Eric, additional, Delhom-Christol, Elisabeth, additional, Guiu, Boris, additional, Ilonca, Alina D., additional, Lonjon, Julie, additional, Pageaux, Georges-Philippe, additional, Abdel-Rehim, Mohamed, additional, Al-laham, Wassim, additional, Bouattour, Mohamed, additional, Castera, Laurent, additional, Dieudonné, Arnaud, additional, Lebtahi, Rachida, additional, Ronot, Maxime, additional, Sibert, Annie, additional, Barraud, Hélène, additional, Bazin, Christophe, additional, Bronowicki, Jean-Pierre, additional, Laurent, Valérie, additional, Mathias, Elodie, additional, Chagneau-Derrode, Carine, additional, Perdrisot, Rémy, additional, Silvain, Christine, additional, Tasu, Jean-Pierre, additional, RenéGerolami, Patrick Borentain, additional, Mundler, Olivier, additional, Seitz, Jean-Francois, additional, Vidal, Vincent, additional, Aubé, Christophe, additional, Bouvier, Antoine, additional, Couturier, Olivier, additional, Oberti, Frédéric, additional, Vervueren, Laurent, additional, Brenot-Rossi, Isabelle, additional, Raoul, Jean-Luc, additional, Sar-ran, Anthony, additional, Chalaye, Julia, additional, Costentin, Charlotte, additional, Itti, Emmanuel, additional, Kobeiter, Hicham, additional, Luciani, Alain, additional, Adam, René, additional, Lewin, Maïté, additional, Samuel, Didier, additional, Edeline, Julien, additional, Garin, Etienne, additional, Rolland, Yan, additional, Archambeaud, Isabelle, additional, Eugene, Thomas, additional, Frampas, Eric, additional, Cassinotto, Christophe, additional, Guyot, Martine, additional, Hiriart, Jean-Baptiste, additional, Lapuyade, Bruno, additional, Vergniol, Julien, additional, Bachellier, Philippe, additional, Detour, Julien, additional, Duclos, Bernard, additional, Greget, Michel, additional, Habersetzer, Francois, additional, Imperiale, Alessio, additional, Merle, Philippe, additional, Rode, Agnès, additional, Morvan, Julie, additional, Nguyen-Khac, Eric, additional, Yzet, Thierry, additional, Baudin, Guillaume, additional, Chevallier, Patrick, additional, Mahamat, Abakar, additional, Piche, Thierry, additional, Razzouk, Micheline, additional, Hillon, Patrick, additional, Loffroy, Romaric, additional, Toubeau, Michel, additional, Vincent, Julie, additional, Barabino, Gabriele, additional, Bouarioua, Nadia, additional, Cuilleron, Muriel, additional, Ecochard, Marie, additional, Prevot-Bitot, Nathalie, additional, Leroy, Vincent, additional, Roux, Julie, additional, Sengel, Christian, additional, Bourcier, Valérie, additional, Carrie, Nathalie Ganne-, additional, Seror, Olivier, additional, Costo, Sylvie, additional, Dao, Thông, additional, Pelage, Jean-Pierre, additional, Dumortier, Jérôme, additional, Giammarile, Francesco, additional, Valette, Pierre-Jean, additional, Ghazzar, Nadia, additional, Pellerin, Olivier, additional, Taieb, Julien, additional, Weinmann, Pierre, additional, Berlot, Alexandra Heurgue-, additional, Marcus, Claude, additional, Sommacale, Daniele, additional, Castilla-Lièvre, Maria-Angéla, additional, Maitre, Sophie, additional, and Marthey, Lysiane, additional

Published
2021
Full Text
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