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921 results on '"Yuzefpolskaya, Melana"'

3. Added prognostic value of visually estimated coronary artery calcium among heart transplant recipients

Author

Clerkin, Kevin J., Sewanan, Lorenzo, Griffin, Jan M., DeFilippis, Ersilia M., Peng, Boyu, Chernovolenko, Margarita, Harris, Erin, Prasad, Nikil, Colombo, Paolo C., Yuzefpolskaya, Melana, Fried, Justin, Raikhelkar, Jayant, Topkara, Veli K., Castillo, Michelle, Lam, Elaine Y., Latif, Farhana, Takeda, Koji, Uriel, Nir, Sayer, Gabriel, and Einstein, Andrew J.

Published
2024
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4. Alterations in the sarcopenia index are associated with inflammation, gut, and oral microbiota among heart failure, left ventricular assist device, and heart transplant patients

Author

Yuzefpolskaya, Melana, Bohn, Bruno, Ladanyi, Annamaria, Pinsino, Alberto, Braghieri, Lorenzo, Carey, Matthew R., Clerkin, Kevin, Sayer, Gabriel T., Latif, Farhana, Koji, Takeda, Uriel, Nir, Nandakumar, Renu, Uhlemann, Anne-Catrin, Colombo, Paolo C., and Demmer, Ryan T.

Published
2024
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5. A comparison of quality-adjusted life years in older adults after heart transplantation versus long-term mechanical support: Findings from the SUSTAIN-IT study

Author

Grady, Kathleen L., Dew, Mary Amanda, Pagani, Francis D., Spertus, John A., Hsich, Eileen, Yuzefpolskaya, Melana, Lampert, Brent, Kirklin, James K., Petty, Michael, Kao, Andrew, Yancy, Clyde, Hartupee, Justin, Pamboukian, Salpy V., Johnson, Maryl, Murray, Margaret, Wu, Tingqing, and Andrei, Adin-Cristian

Published
2024
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8. Nitrite Generating and Depleting Capacity of the Oral Microbiome and Cardiometabolic Risk: Results from ORIGINS

Author

Goh, Charlene E, Bohn, Bruno, Marotz, Clarisse, Molinsky, Rebecca, Roy, Sumith, Paster, Bruce J, Chen, Ching‐Yuan, Rosenbaum, Michael, Yuzefpolskaya, Melana, Colombo, Paolo C, Desvarieux, Moïse, Papapanou, Panos N, Jacobs, David R, Knight, Rob, and Demmer, Ryan T

Subjects
Dental/Oral and Craniofacial Disease, Genetics, Human Genome, Clinical Research, Infection, Adult, Bacteria, Cardiovascular Diseases, Female, Humans, Male, Microbiota, Nitrates, Nitric Oxide, Nitrites, Nitrogen, Nitrogen Dioxide, RNA, Ribosomal, 16S, 16S rNA sequencing, blood pressure, epidemiology, insulin resistance, metagenomics, nitric oxide, oral microbiome, Cardiorespiratory Medicine and Haematology
Abstract

Background The enterosalivary nitrate-nitrite-nitric oxide (NO3-NO2-NO) pathway generates NO following oral microbiota-mediated production of salivary nitrite, potentially linking the oral microbiota to reduced cardiometabolic risk. Nitrite depletion by oral bacteria may also be important for determining the net nitrite available systemically. We examine if higher abundance of oral microbial genes favoring increased oral nitrite generation and decreased nitrite depletion is associated with a better cardiometabolic profile cross-sectionally. Methods and Results This study includes 764 adults (mean [SD] age 32 [9] years, 71% women) enrolled in ORIGINS (Oral Infections, Glucose Intolerance, and Insulin Resistance Study). Microbial DNA from subgingival dental plaques underwent 16S rRNA gene sequencing; PICRUSt2 was used to estimate functional gene profiles. To represent the different components and pathways of nitrogen metabolism in bacteria, predicted gene abundances were operationalized to create summary scores by (1) bacterial nitrogen metabolic pathway or (2) biochemical product (NO2, NO, or ammonia [NH3]) formed by the action of the bacterial reductases encoded. Finally, nitrite generation-to-depletion ratios of gene abundances were created from the above summary scores. A composite cardiometabolic Z score was created from cardiometabolic risk variables, with higher scores associated with worse cardiometabolic health. We performed multivariable linear regression analysis with cardiometabolic Z score as the outcome and the gene abundance summary scores and ratios as predictor variables, adjusting for sex, age, race, and ethnicity in the simple adjusted model. A 1 SD higher NO versus NH3 summary ratio was inversely associated with a -0.10 (false discovery rate q=0.003) lower composite cardiometabolic Z score in simple adjusted models. Higher NH3 summary score (suggestive of nitrite depletion) was associated with higher cardiometabolic risk, with a 0.06 (false discovery rate q=0.04) higher composite cardiometabolic Z score. Conclusions Increased net capacity for nitrite generation versus depletion by oral bacteria, assessed through a metagenome estimation approach, is associated with lower levels of cardiometabolic risk.

Published
2022

11. Experimentally Induced Peripheral Venous Congestion Exacerbates Inflammation, Oxidative Stress, and Neurohormonal and Endothelial Cell Activation in Patients With Systolic Heart Failure

Author

COLOMBO, PAOLO C., CASTAGNA, FRANCESCO, ONAT, DUYGU, WONG, KA YUK, HARXHI, ANTE, HAYASHI, YACKI, FRIEDMAN, RICHARD A., PINSINO, ALBERTO, LADANYI, ANNAMARIA, MEBAZAA, ALEXANDER, JELIC, SANJA, ARRIGO, MATTIA, LEJEMTEL, THIERRY H., PAPAPANOU, PANOS, SABBAH, HANI N., SCHMIDT, ANN MARIE, YUZEFPOLSKAYA, MELANA, and DEMMER, RYAN T.

Published
2024
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12. Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS

Author

Marotz, Clarisse, Molinsky, Rebecca, Martino, Cameron, Bohn, Bruno, Roy, Sumith, Rosenbaum, Michael, Desvarieux, Moïse, Yuzefpolskaya, Melana, Paster, Bruce J, Jacobs, David R, Colombo, Paolo C, Papapanou, Panos N, Knight, Rob, and Demmer, Ryan T

Subjects
Microbiology, Biological Sciences, Ecology, Clinical Research, Diabetes, Infectious Diseases, Dental/Oral and Craniofacial Disease, Metabolic and endocrine, Oral and gastrointestinal, Good Health and Well Being, Bacteria, Cardiovascular Diseases, Humans, Microbiota, Periodontitis, Saliva
Abstract

Periodontitis affects up to 50% of individuals worldwide, and 8.5% are diagnosed with diabetes. The high-comorbidity rate of these diseases may suggest, at least in part, a shared etiology and pathophysiology. Changes in oral microbial communities have been documented in the context of severe periodontitis and diabetes, both independently and together. However, much less is known about the early oral microbial markers of these diseases. We used a subset of the ORIGINS project dataset, which collected detailed periodontal and cardiometabolic information from 787 healthy individuals, to identify early microbial markers of periodontitis and its association with markers of cardiometabolic health. Using state-of-the-art compositional data analysis tools, we identified the log-ratio of Treponema to Corynebacterium bacteria to be a novel Microbial Indicator of Periodontitis (MIP), and found that this MIP correlates with poor periodontal health and cardiometabolic markers early in disease pathogenesis in both subgingival plaque and saliva.

Published
2022

18. Pulsatility and flow patterns across macro- and microcirculatory arteries of continuous-flow left ventricular assist device patients

Author

Stöhr, Eric J., Ji, Ruiping, Mondellini, Giulio, Braghieri, Lorenzo, Akiyama, Koichi, Castagna, Francesco, Pinsino, Alberto, Cockcroft, John R., Silverman, Ronald H., Trocio, Samuel, Zatvarska, Oksana, Konofagou, Elisa, Apostolakis, Iason, Topkara, Veli K., Takayama, Hiroo, Takeda, Koji, Naka, Yoshifumi, Uriel, Nir, Yuzefpolskaya, Melana, Willey, Joshua Z., McDonnell, Barry J., and Colombo, Paolo C.

Published
2023
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19. Caregiver burden before heart transplantation and long-term mechanical circulatory support: Findings from the sustaining quality of life of the aged: Transplant or mechanical support (SUSTAIN-IT) study

Author

Okwuosa, Ike S., Anderson, Allen, Petty, Michael, Wu, Tingqing, Andrei, Adin-Cristian, Kao, Andrew, Spertus, John A., Pham, Duc T., Yancy, Clyde W., Dew, Mary Amanda, Hsich, Eileen, Cotts, William, Hartupee, Justin, Pamboukian, Salpy, Pagani, Francis, Lampert, Brent, Johnson, Maryl, Murray, Margaret, Tekeda, Koji, Yuzefpolskaya, Melana, Kirklin, James K., and Grady, Kathleen L.

Published
2023
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29. Change in Caregiver Health-Related Quality of Life From Before to Early After Surgery: SUSTAIN-IT Study

Author

Chuzi, Sarah, Wilcox, Jane E., Kao, Andrew, Spertus, John A., Hsich, Eileen, Dew, Mary Amanda, Yancy, Clyde W., Pham, Duc T., Hartupee, Justin, Petty, Michael, Cotts, William, Pamboukian, Salpy V., Pagani, Francis D., Lampert, Brent, Johnson, Maryl, Murray, Margaret, Takeda, Koji, Yuzefpolskaya, Melana, Silvestry, Scott, Kirklin, James K., Wu, Tingqing, Andrei, Adin-Cristian, Baldridge, Abigail, and Grady, Kathleen L.

Published
2023
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31. CAV Trajectories Among Patients With No or Mild CAV at 10 Years Posttransplant.

Author

Harris, Erin, Prasad, Nikil, Skoll, Devin, Kumar, Sambhavi Sneha, Fried, Justin, Topkara, Veli, Raikhelkar, Jayant K., DeFilippis, Ersilia M., Latif, Farhana, Yuzefpolskaya, Melana, Colombo, Paolo C., Uriel, Nir, Takeda, Koji, Sayer, Gabriel T., and Clerkin, Kevin J.

Subjects
HEART transplantation, CORONARY artery disease, CARDIOVASCULAR diseases, VASCULAR diseases, ANGIOGRAPHY
Abstract

Cardiac allograft vasculopathy (CAV) is a major cause of morbidity and mortality following heart transplantation (HT). Prior studies identified distinct CAV trajectories in the early post‐HT period with unique predictors, but the evolution of CAV in later periods is not well‐described. This study assessed the prevalence of late CAV progression and associated risk factors in HT recipients with ISHLT CAV 0/1 at 10 years post‐HT. Consecutive adult patients who underwent HT from January 2000 to December 2008 were evaluated and grouped by CAV trajectories into progressors (developed ISHLT CAV 2/3) or nonprogressors (remained ISHLT CAV 0/1). A total of 130 patients were included with a median age at angiography of 61.7 years and a median follow‐up time of 4.8 years. 8.5% progressed to CAV 2/3, while the remaining 91.5% were nonprogressors. Progression was not associated with death or retransplantation (27.3% [progressor] vs. 21.0% [nonprogressor], p = 0.70). These data may inform shared decision‐making about late CAV screening. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Unplanned hospital readmissions following HeartMate 3 implantation: Readmission rates, causes, and impact on survival.

Author

Shih, Hueyjong, Mondellini, Giulio M., Kurlansky, Paul A., Sun, Jocelyn, Ning, Yuming, Feldman, Vivian R., Tiburcio, Melie, Maguire, Conor W., Ladanyi, Annamaria, Clerkin, Kevin, Naka, Yoshifumi, Sayer, Gabriel T., Uriel, Nir, Colombo, Paolo C., Takeda, Koji, and Yuzefpolskaya, Melana

Subjects
HEART assist devices, PATIENT readmissions, ACADEMIC medical centers, QUALITY of life, OVERALL survival
Abstract

Background: Hospital readmissions following left ventricular assist device (LVAD) remain a frequent comorbidity, associated with decreased quality of life and increased resources utilization. This study sought to determine causes, predictors, and impact on survival of hospitalizations during HeartMate 3 (HM3) support. Methods: All patients implanted with HM3 between November 2014 to December 2019 at Columbia University Irving Medical Center were consecutively enrolled in the study. Demographics and clinical characteristics from the index admission and the first outpatient visit were collected and used to estimate 1‐year and 900‐day readmission‐free survival and overall survival. Multivariable analysis was performed for subsequent readmissions. Results: Of 182 patients who received a HM3 LVAD, 167 (92%) were discharged after index admission and experienced 407 unplanned readmissions over the median follow up of 727 (interquartile range (IQR): 410.5, 1124.5) days. One‐year and 900‐day mean cumulative number of all‐cause unplanned readmissions was 0.43 (95%CI, 0.36, 0.51) and 1.13 (95%CI, 0.99, 1.29). The most frequent causes of rehospitalizations included major infections (29.3%), bleeding (13.2%), device‐related (12.5%), volume overload (7.1%), and other (28%). One‐year and 900‐day survival free from all‐cause readmission was 38% (95%CI, 31–46%) and 16.6% (95%CI, 10.3–24.4%). One‐year and 900‐day freedom from 2, 3, and ≥4 readmissions were 60.7%, 74%, 74.5% and 26.2%, 33.3%, 41.3%. One‐year and 900‐day survival were unaffected by the number of readmissions and remained >90%. Male sex, ischemic etiology, diabetes, lower serum creatinine, longer duration of index hospitalization, and a history of readmission between discharge and the first outpatient visit were associated with subsequent readmissions. Conclusions: Unplanned hospital readmissions after HM3 are common, with infections and bleeding accounting for the majority of readmissions. Irrespective of the number of readmissions, one‐year survival remained unaffected. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Presence of Intracardiac Thrombus at the Time of Left Ventricular Assist Device Implantation Is Associated With an Increased Risk of Stroke and Death

Author

Bravo, Claudio A., Fried, Justin A., Willey, Joshua Z., Javaid, Azka, Mondellini, Giulio M., Braghieri, Lorenzo, Lumish, Heidi, Topkara, Veli K., Kaku, Yuji, Witer, Lucas, Takayama, Hiroo, Takeda, Koji, Sayer, Gabriel, Uriel, Nir, Demmer, Ryan T., Naka, Yoshifumi, Yuzefpolskaya, Melana, and Colombo, Paolo C.

Published
2021
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35. Medium-Term Outcomes of Concomitant Aortic Valve Repair in Patients with Continuous-Flow Left Ventricular Assist Device

Author

Hynds, Melissa A., primary, Hayashi, Hideyuki, additional, Kurlansky, Paul, additional, Zhao, Yanling, additional, Vinogradsky, Alice V., additional, Yuzefpolskaya, Melana, additional, Colombo, Paolo C., additional, Sayer, Gabriel T., additional, Uriel, Nir, additional, Naka, Yoshifumi, additional, and Takeda, Koji, additional

Published
2024
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36. Alterations in Sarcopenia Index are Associated with Inflammation, Gut and Oral Microbiota among Heart Failure, Left Ventricular Assist Device and Heart Transplant Patients.

Author

Yuzefpolskaya, Melana, primary, Bohn, Bruno, additional, Ladanyi, Annamaria, additional, Pinsino, Alberto, additional, Braghieri, Lorenzo, additional, Carey, Matthew R., additional, Clerkin, Kevin, additional, Sayer, Gabriel T., additional, Latif, Farhana, additional, Koji, Takeda, additional, Uriel, Nir, additional, Nandakumar, Renu, additional, Uhlemann, Anne-Catrin, additional, Colombo, Paolo C., additional, and Demmer, Ryan T., additional

Published
2024
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37. Dietary nitrate intake and net nitrite-generating capacity of the oral microbiome interact to enhance cardiometabolic health: Results from the Oral Infections Glucose Intolerance and Insulin Resistance Study (ORIGINS)

Author

Goh, Charlene E., primary, Bohn, Bruno, additional, Genkinger, Jeanine M., additional, Molinsky, Rebecca, additional, Roy, Sumith, additional, Paster, Bruce J., additional, Chen, Ching-Yuan, additional, Yuzefpolskaya, Melana, additional, Colombo, Paolo C., additional, Rosenbaum, Michael, additional, Knight, Rob, additional, Desvarieux, Moïse, additional, Papapanou, Panos N., additional, Jacobs, David R., additional, and Demmer, Ryan T., additional

Published
2024
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38. Utility of a fusion protein T‐cell co‐stimulation blocker Belatacept in heart transplant recipients: Real world experience from a high volume center

Author

Oren, Daniel, primary, Uriel, Matan, additional, Moeller, Cathrine M., additional, Valledor, Andrea Fernandez, additional, DeFilippis, Ersilia M., additional, Lotan, Dor, additional, Colombo, Paolo C., additional, Yuzefpolskaya, Melana, additional, Topkara, Veli K., additional, Clerkin, Kevin J., additional, Raikhelkar, Jayant K., additional, Fried, Justin A., additional, Oh, David (Kyung Taek), additional, Bae, David, additional, Lin, Eddie, additional, Theodoropoulos, Kleanthis, additional, Naka, Yoshifumi, additional, Takeda, Koji, additional, Choe, Jason, additional, Jennings, Douglas L., additional, Majure, David, additional, Latif, Farhana, additional, Sayer, Gabriel, additional, and Uriel, Nir, additional

Published
2024
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41. Right Ventricular Pressure–Volume Analysis During Left Ventricular Assist Device Speed Optimization Studies: Insights Into Interventricular Interactions and Right Ventricular Failure

Author

Brener, Michael I., Hamid, Nadira B., Fried, Justin A., Masoumi, Amirali, raikhelkar, Jayant, Kanwar, Manreet K., Pahuja, Mohit, Mondellini, Giulio M., Braghieri, Lorenzo, Majure, David T., Colombo, Paolo C., Yuzefpolskaya, Melana, Sayer, Gabriel T., Uriel, Nir, and Burkhoff, Daniel

Published
2021
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44. Driveline Infection in Left Ventricular Assist Device Patients: Effect of Standardized Protocols, Pathogen Type, and Treatment Strategy

Author

Lumish, Heidi S., Cagliostro, Barbara, Braghieri, Lorenzo, Bohn, Bruno, Mondellini, Giulio M., Antler, Karen, Feldman, Vivian, Kleet, Audrey, Murphy, Jennifer, Tiburcio, Melie, Fidlow, Kathryn, Jennings, Douglas, Sayer, Gabriel T., Takeda, Koji, Naka, Yoshifumi, Demmer, Ryan T., Aaron, Justin G., Uriel, Nir, Colombo, Paolo C., and Yuzefpolskaya, Melana

Published
2022
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47. Pre‐operative pectoralis muscle area index is associated with biomarkers of inflammation and endotoxemia and predicts clinical outcomes after left ventricular assist device implantation: A cohort study.

Author

Carey, Matthew R., Ladanyi, Annamaria, Nishikawa, Mia, Bordon, Abraham, Leb, Jay S., Pinsino, Alberto, Driggin, Elissa, Latif, Farhana, Sayer, Gabriel T., Clerkin, Kevin J., Takeda, Koji, Uriel, Nir, Colombo, Paolo C., and Yuzefpolskaya, Melana

Subjects
PECTORALIS muscle, HEART assist devices, COMPUTED tomography, ENDOTOXEMIA, GASTROINTESTINAL hemorrhage, SARCOPENIA
Abstract

Background: Pre‐left ventricular assist device (LVAD) pectoralis muscle assessment, an estimate of sarcopenia, has been associated with postoperative mortality and gastrointestinal bleeding, though its association with inflammation, endotoxemia, length‐of‐stay (LOS), and readmissions remains underexplored. Methods: This was a single‐center cohort study of LVAD patients implanted 1/2015–10/2018. Preoperative pectoralis muscle area was measured on chest computed tomography (CT), adjusted for height squared to derive pectoralis muscle area index (PMI). Those with PMI in the lowest quintile were defined as low‐PMI cohort; all others constituted the reference cohort. Biomarkers of inflammation (interleukin‐6, adiponectin, tumor necrosis factor‐α [TNFα]) and endotoxemia (soluble (s)CD14) were measured in a subset of patients. Results: Of the 254 LVAD patients, 95 had a preoperative chest CT (median days pre‐LVAD: 7 [IQR 3–13]), of whom 19 (20.0%) were in the low‐PMI cohort and the remainder were in the reference cohort. Compared with the reference cohort, the low‐PMI cohort had higher levels of sCD14 (2594 vs. 1850 ng/mL; p = 0.04) and TNFα (2.9 vs. 1.9 pg/mL; p = 0.03). In adjusted analyses, the low‐PMI cohort had longer LOS (incidence rate ratio 1.56 [95% confidence interval 1.16–2.10], p = 0.004) and higher risk of 90‐day and 1‐year readmissions (subhazard ratio 5.48 [1.88–16.0], p = 0.002; hazard ratio 1.73 [1.02–2.94]; p = 0.04, respectively). Conclusions: Pre‐LVAD PMI is associated with inflammation, endotoxemia, and increased LOS and readmissions. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Abstract 13537: The Difference Between Cystatin C- and Creatinine-Based Kidney Function Assessment is Associated With Clinical Outcomes, Quality of Life and Frailty in Patients With Heart Failure and Reduced Ejection Fraction: Insights From PARADIGM-HF

Author

Pinsino, Alberto, Carey, Matthew R, Syed, Husain A, Jennings, Douglas L, Mohan, Sumit, Takeda, Koji, Naka, Yoshifumi, Sayer, Gabriel T, Uriel, Nir, Demmer, Ryan T, Colombo, Paolo C, and Yuzefpolskaya, Melana

Published
2022
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