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Abstract Inspired by the scar‐free wound healing in infants, an anti‐scar strategy is proposed by accelerating wound healing using silicate bioactive materials. Bioglass/alginate composite hydrogels are applied, which significantly inhibit scar formation in rabbit ear scar models. The underlining mechanisms include stimulation of Integrin Subunit Alpha 2 expression in dermal fibroblasts to accelerate wound healing, and induction of apoptosis of hypertrophic scar fibroblasts by directly stimulating the N‐Acylsphingosine Amidohydrolase 2 expression in hypertrophic scar fibroblasts, and indirectly upregulating the secretion of Cathepsin K in dermal fibroblasts. Considering specific functions of the bioactive silicate materials, two scar treatment regimes are tested. For severe scars, a regenerative intervention is applied by surgical removal of the scar followed by the treatment with bioactive hydrogels to reduce the formation of scars by activating dermal fibroblasts. For mild scars, the bioactive dressing is applied on the formed scar and reduces scar by inducing scar fibroblasts apoptosis.

Regenerating skin nerves in deep burn wounds poses a significant clinical challenge. In this study, we designed an electrospun wound dressing called CuCS/Cur, which incorporates copper-doped calcium silicate (CuCS) and curcumin (Cur). The unique wound dressing releases a bioactive Cu2+-Cur chelate that plays a crucial role in addressing this challenge. By rebuilding the “factory” (hair follicle) responsible for producing nerve cells, CuCS/Cur induces a high expression of nerve-related factors within the hair follicle cells and promotes an abundant source of nerves for burn wounds. Moreover, the Cu2+-Cur chelate activates the differentiation of nerve cells into a mature nerve cell network, thereby efficiently promoting the reconstruction of the neural network in burn wounds. Additionally, the Cu2+-Cur chelate significantly stimulates angiogenesis in the burn area, ensuring ample nutrients for burn wound repair, hair follicle regeneration, and nerve regeneration. This study confirms the crucial role of chelation synergy between bioactive ions and flavonoids in promoting the regeneration of neuralized skin through wound dressings, providing valuable insights for the development of new biomaterials aimed at enhancing neural repair.

A nanocomposite microneedle (ZCQ/MN) patch containing copper/zinc dual-doped mesoporous silica nanoparticles loaded with quercetin (ZCQ) was developed as a combination therapy for androgenic alopecia (AGA). The degradable microneedle gradually dissolves after penetration into the skin and releases the ZCQ nanoparticles. ZCQ nanoparticles release quercetin (Qu), copper (Cu2+) and zinc ions (Zn2+) subcutaneously to synergistically promote hair follicle regeneration. The mechanism of promoting hair follicle regeneration mainly includes the regulation of the main pathophysiological phenomena of AGA such as inhibition of dihydrotestosterone, inhibition of inflammation, promotion of angiogenesis and activation of hair follicle stem cells by the combination of Cu2+ and Zn2+ ions and Qu. This study demonstrates that the systematic intervention targeting different pathophysiological links of AGA by the combination of organic drug and bioactive metal ions is an effective treatment strategy for hair loss, which provides a theoretical basis for development of biomaterial based anti-hair loss therapy.

Limited load capacity is the bottleneck for the practical application of mobile multi-joint legged robots. And improving the efficiency of the drive system is a key factor in improving the load capacity. To improve the efficiency of mobile robots, in this paper, a new kind of actuator that imitates the driving mechanism of human muscles is innovatively designed and validated through experiments. The proposed actuator consists of a single power source and multiple plunger pistons, and imitates the configuration of a human muscle, to improve the efficiency and load capacities. The design proposed here represents a new class of driving methods. The actuator selects the most appropriate combination of the effective areas of plunger pistons like the human muscles, to ensure that the maximal output force aligns with the load force. To validate that the new actuator can improve the efficiency of hydraulic systems of mobile robots, a robotic arm incorporating a prototype of the new actuator was designed. The proposed system was validated through a series of experiments. The experiments show that the bionic actuator can adjust the flow rate of the system input by adjusting the number and size of the motion units involved in the work, and with the change in load force, it changes the output force by recruiting different motion units, which indicates good controllability. The results reported herein reveal that the application of bionics to the design of robotic actuator can significantly improve the efficiency and overall performance of the robots, and this biomimetic approach can be applied to a variety of robots.

Stable, quiet, and efficient propulsion methods are essential for underwater robots to complete their tasks in a complex marine environment. However, with a single propulsion method, such as propeller propulsion and bionic propulsion, it is difficult to achieve high efficiency and high mobility at the same time. Based on the advantages of the high-efficiency propulsion of a bionic undulating fin and the stable control of the propeller, an underwater robot based on the hybrid propulsion of a quadrotor and undulating fin is proposed in this paper. This paper first introduces the mechanical implementation of the underwater robot. Then, based on kinematic modeling and theoretical derivation, the underwater motion and attitude of the robot are analyzed and the 6-DOF dynamic equation of the robot is established. Finally, the underwater motion performance of the robot is verified through field experiments. The experimental results show that the robot can realize the heave motion, surge motion, and in-situ steering motion independently and can hover stably. When the undulating frequency is 6 Hz, the maximum propulsion speed of the robot can reach up to 1.2 m/s (1.5 BL/s).

Abstract To improve the heat extraction efficiency from the wellbore fluids to the stratum in the geothermal well, thermal insulation cement, which contains of waste glass powder as a heat-insulating material, is proposed to apply in geothermal well’s middle and upper sections in the paper. Effect of such glass powers on mechanic and thermal property of thermal insulation cement was then investigated. Various tests were carried out to measure compressive strength, thermal conductivity, microstructure porosity etc. parameters of the thermal insulation cement. Results showed that the waste glass powder would enhance its the compressive strength and improve its the thermal insulation performance. Correlation study between contents of the added waste glass powder in geothermal cements and its mechanic and thermal property was conducted. It was found that thermal insulation cement exhibited its optimum performance when the added content of glass powers was 20% in weight. Analysis of the microstructure porosity with SEM found that the pores in thermal insulation cement with added waste glass powders were mostly closed, tiny and even, and therefore contributed to the compressive strength of the thermal insulation cement; such pores would be also beneficial to improving its thermal insulation performance.

To contribute to the goal of carbon neutralization, the closed-loop borehole heat exchanger system is widely applied to use geothermal energy for building cooling and heating. In this work, a new type of medium-shallow borehole heat exchanger (MSBHE) is proposed, which is coaxial type and has a depth range between 200 m to 500 m. To investigate the long-term performance of MSBHE in the area with unbalanced cooling and heating load of buildings and the sustainable load imbalance ratio under different design parameters, a comprehensive numerical model is established. The results show that the drilling depth significantly influences the sustainable load imbalance ratio of MSBHE. As the drilling depth is increased from 200 m to 500 m, the load imbalance ratio of the MSBHE increases from 20.76% to 60.29%. In contrast, the load imbalance ratio is always kept at the same level with different inlet velocities and operation modes. Furthermore, in a 9-MSBHE array system, the heat exchanger located in the middle of the array has the lowest load imbalance ratio of 48.97%, which is 15.98% lower than the borehole in the edge location. This is caused by the significant influence of the shifted-load phenomenon among MSBHEs in an array system. The findings of the work imply that this newly proposed MSBHE can sustain a notable load imbalance ratio, which is particularly applicable to the areas with a strong imbalance of annual building load.