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1. Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus

Author

Tomotaka Okamura, Yuya Shimizu, Masamitsu N. Asaka, Tomohiro Kanuma, Yusuke Tsujimura, Takuya Yamamoto, Kazuhiro Matsuo, and Yasuhiro Yasutomi

Subjects
Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract The use of an adjuvant in vaccination is thought to be effective for enhancing immune responses to various pathogens. We genetically constructed a live attenuated simian human immunodeficiency virus (SHIV) to express the adjuvant molecule Ag85B (SHIV-Ag85B). SHIV-Ag85B could not be detected 4 weeks after injection in cynomolgus macaques, and strong SHIV-specific T cell responses were induced in these macaques. When the macaques in which SHIV-Ag85B had become undetectable were challenged with pathogenic SHIV89.6P at 37 weeks after SHIV-Ag85B had become undetectable, SHIV89.6P was not detected after the challenge. Eradication of SHIV89.6P was confirmed by adoptive transfer experiments and CD8-depletion studies. The SHIV-Ag85B-inoculated macaques showed enhancement of Gag-specific monofunctional and polyfunctional CD8+ T cells in the acute phase of the pathogenic SHIV challenge. The results suggest that SHIV-Ag85B elicited strong sterile immune responses against pathogenic SHIV and that it may lead to the development of a vaccine for AIDS virus infection.

Published
2021
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12. A Case of Topical Ofloxacin-Induced Otomycosis and Literature Review

Author

Yuya Shimizu, Rima Zakzuk Alshahni, Koichi Makimura, Takashi Tamura, Ryuichi Fujisaki, Chiaki Yamanishi, and Mohamed Mahdi Alshahni

Subjects
Ofloxacin, medicine.medical_specialty, medicine.drug_class, Veterinary (miscellaneous), Secondary infection, Antibiotics, Otomycosis, Candida parapsilosis, Applied Microbiology and Biotechnology, Microbiology, Medical microbiology, medicine, Humans, Malassezia, integumentary system, biology, business.industry, Fungi, Otitis Externa, Isolation (microbiology), biology.organism_classification, medicine.disease, Dermatology, business, Agronomy and Crop Science, medicine.drug
Abstract

The prevalence of fungal otitis externa, or otomycosis, has been increasing in recent decades. Fungi may act as primary pathogens in this condition, or they may occur as secondary infections after prolonged ototopical treatment with antibiotics, which alters the flora of the external auditory canal (EAC) and enables overgrowth of its fungal inhabitants. We report here a case of otomycosis by Candida parapsilosis, Malassezia obtusa, and Malassezia furfur as a secondary infection following prolonged otic ofloxacin treatment. To the best of our knowledge, although isolation of C. parapsilosis and M. furfur from the EAC is not uncommon, the recovery of M. obtusa has not yet been reported. We also conducted a literature review of the searchable data on PubMed concerning the isolation of Malassezia species from the human EAC.

Published
2021
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13. A murine model of eosinophilic chronic rhinosinusitis using the topical application of a vitamin D3 analog

Author

Ryoji Kagoya, Tatsuya Yamasoba, Kenji Kondo, Shu Kikuta, Yuya Shimizu, and Megumi Kishimoto-Urata

Subjects
0301 basic medicine, Thymic stromal lymphopoietin, Immunology, Mucous membrane of nose, Basophil, Mice, 03 medical and health sciences, Nasal Polyps, 0302 clinical medicine, Eosinophilia, Eosinophilic, Animals, Immunology and Allergy, Medicine, Sinusitis, CCL11, Cholecalciferol, Rhinitis, business.industry, respiratory system, Eosinophil, Eosinophils, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, 030228 respiratory system, Chronic Disease, Cytokines, business, CCL24, Olfactory epithelium, hormones, hormone substitutes, and hormone antagonists
Abstract

Background Eosinophilic chronic rhinosinusitis (ECRS) is a chronic inflammatory disease, characterized by eosinophilic infiltration, T-helper type 2 (Th2-type) response, and olfactory dysfunction. A master regulator of Th2-type inflammation, thymic stromal lymphopoietin (TSLP), is important for basophil activation. TSLP-elicited basophils are a key factor in the pathogenesis of ECRS. Methods In order to elucidate the mechanisms of ECRS in humans, we aimed to establish a murine model of ECRS based on TSLP production in response to the topical application of MC903 (a vitamin D3 analog) and the subsequent TSLP-induced basophil activation. Histological analyses were performed to assess immune cell infiltration into the nasal mucosa and to explore the impact of eosinophilic inflammation on the olfactory epithelium. The status of Th2-type inflammation was evaluated by quantitative real-time PCR and enzyme-linked immunosorbent assay (ELISA). Results Eosinophils, basophils, and M2 macrophages increased significantly in the nasal mucosa of the mice treated with MC903 and ovalbumin (OVA), compared to those treated with OVA alone or the controls. Quantitative real-time PCR and ELISA revealed elevated expression of interleukin (IL)-4, IL-5, IL-13, TSLP, the chemokine CCL11, and CCL24 in the nasal mucosa of the ECRS mice. In parallel, thinned olfactory epithelium and decreased mature olfactory sensory neurons were observed in the ECRS mice. Conclusions Our model of ECRS displayed Th2-type inflammation in the sinonasal region, including both eosinophil infiltration and basophil infiltration. Additionally, olfactory epithelium turned out to be affected by eosinophilic inflammation. These features are consistent with the characteristics of the human ECRS.

Published
2020
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17. Angular analysis of the rare decay B-s(0) -> phi mu(+)mu(-)

Author

B. Schmidt, C. Santamarina Rios, Thomas Grammatico, P. K Resmi, Ivan Belyaev, M. van Veghel, G. Martellotti, V. Bellee, Jan-Marc Basels, A. Artamonov, Marie Bachmayer, R. Santacesaria, W. D. Hulsbergen, Aidan Richard Wiederhold, Konstantinos Petridis, J. A. Rodriguez Lopez, L. Garrido, Michal Kazimierz Mazurek, J. García Pardiñas, Mick Mulder, A. Brossa Gonzalo, P. Gironella Gironell, Hans Dembinski, R. Le Gac, Felicia Carolin Volle, V. Franco Lima, J. A. de Vries, D. Wiedner, F. Blanc, M. Patel, Anastasiia Kharisova, Federico Lazzari, N. K. Watson, T. J. V. Bowcock, Anthony Gavin Downes, Julien Cogan, Daniel Foulds-Holt, Tabitha Halewood-leagas, Roberto Ribatti, M. Shapkin, Jonathan Edward Davies, A. Pereiro Castro, Hendrik Jage, A. Dzyuba, A. Petrolini, Marco Petruzzo, R. Lefèvre, R. Matev, M. Witek, B. Rachwal, Victor Egorychev, P. Gandini, T. T. H. Pham, M. Needham, Brij Kishor Jashal, Lorenzo Pica, R. McNulty, A. Palano, Tomasz Szumlak, Adam Davis, Alessandro Scarabotto, Y. Zhou, Marian Stahl, Veronique Puill, Samuel Belin, Aleksei Andreianov, Naomi Veronika Raab, A. Romero Vidal, Jana Crkovská, Constantin Weisser, P. Krokovny, Eduardo Rodrigues, Matteo Barbetti, Victor Renaudin, M. Senghi Soares, Da Yu Tou, Tai-hua Lin, Marie Helene Schune, G. Graziani, Sandra Amato, A. Bondar, James Vincent Mead, H. Li, R. Jacobsson, Rafal Dominik Krawczyk, K. Belous, Jolanta Brodzicka, F. Teubert, F. Goncalves Abrantes, Olli Lupton, Ettore Zaffaroni, Biljana Mitreska, J. Lomba Castro, P. Vazquez Regueiro, K. Wyllie, S. G. Weber, B. Pietrzyk, D. De Simone, Viacheslav Matiunin, Cheryl Pappenheimer, Marco Cattaneo, Y. H. Zheng, Xiaolong Hu, C. J. G. Onderwater, Alexander Inglessi, Elena Graverini, Hannah Louise Pullen, M. Korolev, J. He, Mateusz Rafal Kmiec, Surapat Ek-In, Sune Jakobsen, Ivan Solovyev, W. Baldini, Laurent Dufour, Nicola Neri, Ouail Kitouni, Johannes Albrecht, Malcolm John, N. G. Polukhina, Roberto Calabrese, P. Durante, K. O. Padeken, M. Vieites Diaz, Lucio Anderlini, S. Easo, Miroslaw Firlej, Lauren Emma Yeomans, P. Campana, Paolo Carniti, Meril Reboud, Daniel Vieira, Alexander Berezhnoy, Alexander Mclean Marshall, M. Gandelman, Matthew Birch, Igor Kostiuk, Valeriia Lukashenko, Valeriia Zhovkovska, Cameron Thomas Dean, B. Souza De Paula, E. Gushchin, Ling-Yun Dai, Nathan Allen Grieser, S. Li, P. Spradlin, Konstantin Gizdov, Wiktor Byczynski, M. Martinelli, Xiaotao Huang, Eluned Smith, P. Billoir, Mark Hatch, C. M. Costa Sobral, Johannes Heuel, Sebastian Schulte, Jonas Rademacker, Gary Robertson, Sergey Gromov, Ilia Belov, Louis Henry, Nikolay Bondar, Jozef Tomasz Borsuk, Wojciech Kucewicz, Yiduo Shang, Stephen M. Stahl, Quan Zou, O. Maev, Ina Carli, Tommaso Colombo, Louis Lenard Gerken, Stephan Escher, Abhijit Mathad, N. Neufeld, C. A. Chavez Barajas, Patrick Koppenburg, R. Schwemmer, Tomasz Skwarnicki, Niall Thomas Mchugh, B. D. C. Westhenry, Ross John Hunter, Ph. Ghez, Imanol Corredoira, J. M. Otalora Goicochea, Piera Muzzetto, Sofia Kotriakhova, Sebastian Bachmann, Basem Khanji, Y. Xie, Thomas Blake, Jake Lewis Amey, Julian Alexander Boelhauve, Tengiz Kvaratskheliya, Michael Becker, Dmitry Golubkov, D. Galli, H. Schindler, Matthew George Chapman, Olivier Deschamps, Marko Milovanovic, Ming Zeng, Marco Santimaria, Xiaofeng Zhu, C. Remon Alepuz, A. Papanestis, Marek Idzik, Thomas Hadavizadeh, A. Grecu, L. Sun, B. R. Gruberg Cazon, J. Marks, Antje Mödden, Mauro Morandin, Marco Adinolfi, R. Currie, M. Straticiuc, Seophine Stanislaus, A. Fernandez Prieto, Emmy Gabriel, Alessandro Minotti, Benedetto Gianluca Siddi, Jascha Peter Grabowski, V. Obraztsov, M. Lucio Martinez, Stephan Eisenhardt, M. van Beuzekom, Scott Ely, Gediminas Sarpis, Maria Elena Stramaglia, G. Valenti, Martino Borsato, Kuzma Ivshin, X. Cid Vidal, Benjamin Audurier, Joan Mauricio, Philipp Ibis, P. Garcia Moreno, Andrey Ustyuzhanin, S. Hansmann-Menzemer, Gerd Joachim Kunde, Jordy Sebastiaan Butter, J. J. Back, Fabio Ferrari, Marcin Kucharczyk, Maximilien Chefdeville, Simon Nieswand, Bernardo Adeva, Annarita Buonaura, Valery Zhukov, Giulia Frau, Lishuang Ma, D. R. Johnson, Maciej Witold Majewski, S. Mariani, C. R. Jones, Matthew Scott Rudolph, D. Zhang, V. Shevchenko, Yiheng Luo, Deepanwita Dutta, Sandro Cadeddu, John Gordon Smeaton, M. Veltri, G. Haefeli, Lex Marinus Greeven, Niklas Stefan Nolte, H. V. Cliff, A. Schopper, Oleksander Kot, Stefano Petrucci, Federico Alessio, Marcel Merk, G. Manca, O. Schneider, H. R. Qi, M. Xu, R. Mountain, Jennifer Clare Smallwood, L. Calero Diaz, D. Melnychuk, S. Simone, Agnieszka Oblakowska-Mucha, N. Valls Canudas, Yawen Wang, Christopher Betancourt, Sebastian Neubert, A. Satta, Fidan Suljik, Sara Celani, Ivan Polyakov, Yuyue Gan, Anatoly Butkevich, Thomas Peter Jones, Rui Wang, Matteo Salomoni, Kenenbek Arzymatov, F. Maciuc, Davide Zuliani, Aleksandr Terentev, Andrea Lampis, Patrick Mackowiak, Bo Fang, Qiang Xu, M. Van Dijk, Floris Keizer, D. Pinci, Jihyun Bhom, R. Nandakumar, Daniel Cervenkov, Karol Hennessy, L. G. Scantlebury Smead, M. Charles, Minaugas Sarpis, T. Lesiak, Ulrik Egede, Svende Braun, Valery Pugatch, M. T. Tran, Igor Slazyk, Martina Ferrillo, Xiao-Rui Lyu, Aravindhan Venkateswaran, Alexandru Ene, E. Thomas, Martha Hilton, F. Archilli, Francesco Dettori, O. Steinkamp, A. Alfonso Albero, X. Han, G. Wormser, A. Sergi, Vladimir Chulikov, Mariia Poliakova, E. Vilella Figueras, I. A. Monroy, T. E. Latham, Thomas Ackernley, Tianwen Zhou, Elisabet Golobardes, S. Perazzini, M. Franco Sevilla, Alexey A. Petrov, C. Satriano, A. Contu, Bhagyashree Pagare, Joseph David Shupperd, Cynthia Nunez, Yuya Shimizu, Vladimir Romanovskiy, L. Zhang, Michael Alexander, D. Lucchesi, Thomas Henry Hancock, Matteo Bartolini, Yue Pan, Carmelo D'Ambrosio, Jean François Marchand, L. Kravchuk, Oleg Stenyakin, Tara Shears, Alex Daniel Fernez, Marco Pizzichemi, R. I. Rabadan Trejo, Ryan Calladine, Olivier Leroy, Polina Kravchenko, M. Brodski, T. J. Gershon, C. Haen, A. Zhelezov, S. Farry, Alessandro Cardini, Elie Aslanides, Chishuai Wang, J. M. De Miranda, L. R. Madhan Mohan, Lesya Shchutska, M. Tobin, Mika Vesterinen, S. Ferreres Sole, Artem Maevskiy, V. Gibson, C. B. Van Hulse, B. Malecki, Dawid Gerstel, J. Baptista Leite, G. Wilkinson, Hangyi Wu, Dominik Stefan Mitzel, Anton Poluektov, Lorenzo Sestini, C. A. Aidala, L. Del Buono, Roman Litvinov, Krzysztof Swientek, Ning Qin, Harald Viemann, Eliane Epple, Olga Madejczyk, Franco Bedeschi, Davide Fazzini, Jinqing Yu, G. Punzi, Hilbrand Steffen Kuindersma, Gennady Panshin, E. Cogneras, Peilian Li, Gianfranco Morello, Pawel Kopciewicz, Claudio Gotti, Andrea Villa, G. Carboni, K. Carvalho Akiba, Alexander Vagner, Anna Danilina, Harris Conan Bernstein, E. Dall’Occo, Sergey Didenko, C. Bozzi, Simone Bifani, Thomas Boettcher, Malte Hecker, T. Ruf, Y. Li, Almagul Kondybayeva, L. De Paula, Baasansuren Batsukh, Dominik Müller, D. Hynds, Marina Artuso, Blaise Delaney, Oleg Yushchenko, Laura Promberger, D. E. Hutchcroft, Pascal Vincent, Simone Capelli, Marcel Materok, Alex Seuthe, M. Poli Lener, G. Lanfranchi, M.-N. Minard, Z. Xiang, S. A. Wotton, Alessio Sarti, John Jake Lane, Fabrice Desse, Rudolf Oldeman, A. Falabella, Anton Philippov, Nicola Serra, Vlad-George Dedu, Maksim Karpov, Felix Johannes Kress, Shantam Taneja, D. Vom Bruch, Andrew Beiter, Ahmed Sameh Wagih Abdelmotteleb, Alina Zharkova, Edoardo Franzoso, Rizwaan Adeeb Mohammed, J. Maratas, Ifan Williams, Marko Petrič, R. J. Barlow, Stephane T'Jampens, A. Vorobyev, F. Dordei, V. Vagnoni, Biagio Saitta, Stanislav Luchuk, Eleonora Luppi, A. Bertolin, S. H. Lee, Sevda Esen, U. Marconi, Anja Beck, Mark Richard James Williams, M. J. Bradley, S. H. Kalavan Kadavath, A. Di Cicco, E. L. Gkougkousis, Mikhail Zavertyaev, Marta Calvi, Massimiliano Fiorini, Nicola Skidmore, Ilaria Neri, Vasyl Dobishuk, Dmitrii Pereima, Fedor Ratnikov, Renato Quagliani, A. Gallas Torreira, Jingxu Wang, Luca Tomassetti, Sergei Popov, Vitalii Lisovskyi, M. Pepe Altarelli, Thomas Harrison, Luciano Pappalardo, Martin Duy Tat, Nikolai Voropaev, Stanislav Poslavskii, Jake Alexander Ward, Daniel Berninghoff, David Gerick, J. Ruiz Vidal, M. Palutan, L. Dieste Maronas, Tomasz Fiutowski, Jakub Moron, Kurt Rinnert, C. Göbel, E. Spadaro Norella, Kodassery Prasanth, Vlad-Mihai Placinta, Chenzhi Dong, X. K. Zhou, Jennifer Brigitta Zonneveld, Salvatore Aiola, Philip Ilten, Milosz Zdybal, A. Leflat, William Barter, Martina Pili, V. V. Gligorov, Luca Minzoni, Dylan Jaide White, Michela Garau, G. Mancinelli, Conor Fitzpatrick, Claudia Bertella, Edward James Millard, Marco Gersabeck, Aristeidis Fkiaras, Roger Forty, Alexander Battig, Angelo Carbone, Jaap Velthuis, Dana Bobulska, P. Collins, E. Santovetti, Gabriele Simi, Lukas Witola, A. Brea Rodriguez, Dmitrii Ilin, Hongjie Mu, Yang Yang, A. Lai, Aleksandra Snoch, Sigrid Scherl, Sara Elizabeth Mitchell, Shakhzod Dadabaev, Andrea Mauri, Wenbin Qian, Marco Guarise, Y. Zhang, Roberta Cardinale, S. Malde, Jonas Nathanael Eschle, Z. Mathe, Veronika Chobanova, Jan Langer, Liupan An, D. Torres Machado, F. Stagni, Phoebe Meredith Hamilton, B. Dey, Y. G. Gao, Y. Sun, Halime Sazak, I. V. Gorelov, K. Müller, Giovanni Bassi, Holger Stevens, Hang Yin, O. Boente Garcia, Serhii Koliiev, Alexandre Boyer, D. Websdale, B. Couturier, Aodhan Tomas Burke, E. Ben-Haim, Jan Buytaert, Maxime Schubiger, Alessandro Pastore, Zhenzi Wang, Veronica Soelund Kirsebom, R. A. Fini, M. Plo Casasus, O. De Aguiar Francisco, A. F. Campoverde Quezada, Ignacio Bediaga, Desmond Mzamo Shangase, Mateusz Goncerz, Barbara Sciascia, Miroslav Saur, Paul Nathaniel Swallow, C. Abellán Beteta, Tamaki Holly Mcgrath, Zhihong Shen, S. Schael, Jordan Daniel Roth, A. Lusiani, Giovanni Cavallero, Hossein Afsharnia, R. Silva Coutinho, Ryan Newcombe, Dmitry Popov, Simon Akar, Evgenii Shmanin, Gerwin Meier, T. Gys, Kevin Heijhoff, Lorenzo Capriotti, Niladribihari Sahoo, Fionn Caitlin Ros Bishop, Frederic Machefert, Sheldon Stone, Nico Kleijne, P. Naik, Mauricio Féo, Carmen Giugliano, Silvia Borghi, A. Jawahery, M. Karacson, Qundong Han, Serena Maccolini, P. Di Nezza, Saliha Bashir, S. Klaver, J. J. Saborido Silva, Mario Edgardo Olivares, Henryk Karol Giemza, M. Schmelling, Z. A. Zhu, Dong Xiao, S. Kandybei, J. A. B. Coelho, Jan Patrick Hammerich, M. Pappagallo, C. Chen, M. De Cian, M. Rama, F. Fontanelli, Preema Rennee Pais, Michele Veronesi, S. Meloni, Alexandra Paige Rollings, John Leslie Cobbledick, Zakariya Aliouche, Alexsei Chubykin, Camille Normand, S. Zucchelli, Fanghua Jiang, Adam Benjamin Morris, Razvan Daniel Moise, T. Kirn, Kimberley Vos, Alastair Roger Tanner, Ekaterina Govorkova, A. Bay, Georgios Chatzikonstantinidis, F. J. P. Soler, Samuel Maddrell-Mander, A. Hicheur, T. Mombächer, A. Bursche, Zhao Yang, A. Dziurda, Jixing Qin, I. Longstaff, Claire Prouve, Neville Harnew, F. Martinez Vidal, M. De Serio, D. Lacarrere, C. L. Da Silva, M. McCann, Carina Trippl, Lucia Grillo, Yuezhe Yao, S. Ricciardi, Ekaterina Trifonova, l. Soares Lavra, Christoph Frei, Anna Lupato, Aleksandr Solovev, C. Matteuzzi, Lucian Cojocariu, A. McNab, Tjeerd Ketel, Mark Smith, P. Alvarez Cartelle, S. Monteil, George Holger Lovell, J. Fu, Shinichi Okamura, C. Vázquez Sierra, F. Reiss, Manuel Schiller, Lauren Douglas, B. T. Meadows, G. Raven, D. Decamp, Roland Bernet, P. Roloff, Aleksei Chernov, Christoph Hasse, G. Passaleva, Christopher James Pawley, Lukas Calefice, Andrea Valassi, Tara Nanut, Wojciech Krupa, Sergey Legotin, A. Golutvin, Sebastian Schmitt, Christopher Burr, L. Ferreira Lopes, L. M. Garcia Martin, F. L. Souza De Almeida, Matthew Kenzie, S. Filippov, Daria Strekalina, Xavier Vilasis-Cardona, V. Vorobyev, H. Cai, M. Romero Lamas, M. Ferro-Luzzi, P. Camargo Magalhaes, M. D. Sokoloff, E. Grauges, Amanda May Donohoe, William Parker, Ying Lu, F. Polci, Ryunosuke Hugo O'Neil, Mark Wilkinson, Roland Waldi, A. G. Morris, Artur Ishteev, Jakub Ryzka, Timothy Evans, C. Parkes, Silvia Gambetta, Timofei Maltsev, Davide Brundu, Colm Harold Murphy, C. Patrignani, V. Tisserand, M. Andreotti, Matthieu Marinangeli, S. J. Chen, Christoph Langenbruch, Gianluigi Casse, Angelo Loi, M. R. J. Williams, C. Sanchez Gras, Naomi Cooke, Anna Ossowska, Nathan Jurik, E. Jans, Daniel Joachim Unverzagt, Srishti Bhasin, M. S. Rangel, R. Vazquez Gomez, S. Lopez Solino, Sara Sellam, Diego Alejandro Milanes, M. J. Morello, P. Perret, Sergey Barsuk, Ruiting Ma, Daniel James David Thompson, François Fleuret, B. Leverington, D. Yang, M. Chrzaszcz, Dustin Michael Keller, L. Giubega, A. Oyanguren, Loris Martinazzoli, Ao Xu, Mara Senghi Soares, Jakob Haimberger, R. Lindner, Elisabeth Maria Niel, Sonia Amina Bouchiba, Adam Dendek, B. Garcia Plana, Anastasia Smetkina, D. Martinez Santos, J. Z. Fan, Mark Whitehead, Shulei Zhang, Tommaso Pajero, Lucas Mcconnell, L. Bian, C. Marin Benito, Konrad Klimaszewski, Anatoly Konoplyannikov, Jakub Jacek Malczewski, Guillaume Pietrzyk, Danila Saranin, Andrii Usachov, Alexander Leon Gilman, Chiara Lucarelli, Markus Frank, J. J. Xu, Sophie Elizabeth Hollitt, Luca Giambastiani, Alexander Semennikov, Kevin Heinicke, Kara Renee Mattioli, M. Cruz Torres, S. Vecchi, Yasmine Amhis, Matteo Giovannetti, Alexey Boldyrev, U. Uwer, Liliana Congedo, R. A. Ruiz Fernandez, Adam Szabelski, A. Ukleja, Antonio Pellegrino, F. Redi, E. Polycarpo, Tatsuya Nakada, G. Bencivenni, A. Lobo Salvia, Richard Lane, Michele Atzeni, G. Liu, Moran Wang, N. Tuning, Alessandra Gioventù, M. Rotondo, Serhii Cholak, Renata Kopecna, Patrick Owen, C. Gaspar, Alex Pearce, Viacheslav Duk, J. H. Lopes, Daniele Marangotto, V. Balagura, Wenhua Hu, Youen Kang, S. Blusk, Z. Xu, Vukan Jevtic, K. M. Fischer, Fedor Baryshnikov, Donal Hill, Chung Nguyen-Mau, Gregory Ciezarek, Xingyu Tong, G. H. Gong, Jeremy Dalseno, Artem Ryzhikov, Franz Muheim, Nis Meinert, Alison Tully, Paolo Ciambrone, Michal Kreps, B. Jost, Mikhail Mikhasenko, Andrea Bizzeti, Petr Andreevich Gorbounov, Ph. Charpentier, Hanna Malygina, Edward Brendan Shields, Alexander Malinin, Yuqing Fan, G. Alkhazov, S. L. Yang, Jonathan Plews, Mikhail Hushchyn, P. De Simone, A. B. Rodrigues, David Anthony Friday, B. Spaan, S.I. Eidelman, J. Closier, A. Massafferri, Xuhao Yuan, Jiayin Sun, Zhuyin Ren, Stefano Cali, George Coombs, Sophie Katharina Kretzschmar, M. Calvo Gomez, Maciej Wojciech Dudek, G. Corti, Roel Aaij, Vadym Denysenko, E. van Herwijnen, Martin Stefan Bieker, Marco Clemencic, Mikkel Bjørn, F. A. Garcia Rosales, Mark Slater, Daniel Charles Craik, Tatiana Ovsiannikova, Marianna Fontana, Arthur Marius Hennequin, L. Buonincontri, Vladislav Belavin, Heather Mckenzie Wark, Abbie Jane Chadwick, L. Shekhtman, A. Bitadze, Patrick Robbe, P. Baladron Rodriguez, M. Ramos Pernas, Flavio Pisani, Lars Eklund, Leon David Carus, Maciej Pawel Szymanski, Jiangqiao Hu, Ziad Ajaltouni, Xixin Liang, Quentin Fuehring, Chun-wei Gu, Phillip John Marshall, F. F. Wilson, Wojciech Krzemien, Gianluca Zunica, A. Gomes, Federico Betti, L. A. Granado Cardoso, Michele Piero Blago, Dillon Scott Fitzgerald, E. R. R. Rodriguez Rodriguez, Robbert Erik Geertsema, Eduard Ursov, Evelina Gersabeck, Barbara Passalacqua, Andreas Güth, Peter Svihra, Thomas Oeser, T. D. Nguyen, Maria Flavia Cicala, Victor Coco, Mauro Piccini, Denis Derkach, F. Ferreira Rodrigues, Giulia Tuci, Sergei Kholodenko, N. Sagidova, O. Zenaiev, Zhuoming Li, W. Huang, Li Xu, S. De Capua, Emilie Maurice, V. Kudryavtsev, Donal Murray, A. Casais Vidal, L. Meyer Garcia, Ia. Bezshyiko, Nikolay Nikitin, S. Gomez Fernandez, D. Savrina, Philippe d'Argent, B. Quintana, P. E. L. Clarke, Sebastien Ponce, Kayleigh Anne Thomson, Tatiana Gaintseva, Daniele Manuzzi, A. C. dos Reis, John Matthew Durham, K. De Bruyn, Andrea Merli, Jacopo Cerasoli, Dmitrii Maisuzenko, Hans Dijkstra, Maxim Borisyak, Vladimir Macko, I. Nasteva, C. Agapopoulou, Yury Guz, Shuaiyi Liu, A. Dovbnya, J. J. Walsh, Davide Lancierini, Daniel Patrick O'Hanlon, O. Lantwin, Paul Andre Günther, G. D. Lafferty, Ivan Shchemerov, Houkang Liu, W. Wislicki, The LHCb collaboration, Aaij, R., Abdelmotteleb, A.S.W., Abellán Beteta, C., Ackernley, T., Adeva, B., Adinolfi, M., Afsharnia, H., Agapopoulou, C., Aidala, C.A., Aiola, S., Ajaltouni, Z., Akar, S., Albrecht, J., Alessio, F., Alexander, M., Alfonso Albero, A., Aliouche, Z., Alkhazov, G., Alvarez Cartelle, P., Amato, S., Amey, J.L., Amhis, Y., An, L., Anderlini, L., Andreianov, A., Andreotti, M., Archilli, F., Artamonov, A., Artuso, M., Arzymatov, K., Aslanides, E., Atzeni, M., Audurier, B., Bachmann, S., Bachmayer, M., Back, J.J., Baladron Rodriguez, P., Balagura, V., Baldini, W., Baptista Leite, J., Barbetti, M., Barlow, R.J., Barsuk, S., Barter, W., Bartolini, M., Baryshnikov, F., Basels, J.M., Bashir, S., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I., Beiter, A., Belavin, V., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Berninghoff, D., Bernstein, H.C., Bertella, C., Bertolin, A., Betancourt, C., Betti, F., Bezshyiko, Ia., Bhasin, S., Bhom, J., Bian, L., Bieker, M.S., Bifani, S., Billoir, P., Birch, M., Bishop, F.C.R., Bitadze, A., Bizzeti, A., Bjørn, M., Blago, M.P., Blake, T., Blanc, F., Blusk, S., Bobulska, D., Boelhauve, J.A., Boente Garcia, O., Boettcher, T., Boldyrev, A., Bondar, A., Bondar, N., Borghi, S., Borisyak, M., Borsato, M., Borsuk, J.T., Bouchiba, S.A., Bowcock, T.J.V., Boyer, A., Bozzi, C., Bradley, M.J., Braun, S., Brea Rodriguez, A., Brodski, M., Brodzicka, J., Brossa Gonzalo, A., Brundu, D., Buonaura, A., Buonincontri, L., Burke, A.T., Burr, C., Bursche, A., Butkevich, A., Butter, J.S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Calefice, L., Calero Diaz, L., Cali, S., Calladine, R., Calvi, M., Calvo Gomez, M., Camargo Magalhaes, P., Campana, P., Campoverde Quezada, A.F., Capelli, S., Capriotti, L., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carli, I., Carniti, P., Carus, L., Carvalho Akiba, K., Casais Vidal, A., Casse, G., Cattaneo, M., Cavallero, G., Celani, S., Cerasoli, J., Cervenkov, D., Chadwick, A.J., Chapman, M.G., Charles, M., Charpentier, Ph., Chatzikonstantinidis, G., Chavez Barajas, C.A., Chefdeville, M., Chen, C., Chen, S., Chernov, A., Chobanova, V., Cholak, S., Chrzaszcz, M., Chubykin, A., Chulikov, V., Ciambrone, P., Cicala, M.F., Cid Vidal, X., Ciezarek, G., Clarke, P.E.L., Clemencic, M., Cliff, H.V., Closier, J., Cobbledick, J.L., Coco, V., Coelho, J.A.B., Cogan, J., Cogneras, E., Cojocariu, L., Collins, P., Colombo, T., Congedo, L., Contu, A., Cooke, N., Coombs, G., Corredoira, I., Corti, G., Costa Sobral, C.M., Couturier, B., Craik, D.C., Crkovská, J., Cruz Torres, M., Currie, R., Da Silva, C.L., Dadabaev, S., Dai, L., Dall'Occo, E., Dalseno, J., D'Ambrosio, C., Danilina, A., d'Argent, P., Davies, J.E., Davis, A., De Aguiar Francisco, O., De Bruyn, K., De Capua, S., De Cian, M., De Miranda, J.M., De Paula, L., De Serio, M., De Simone, D., De Simone, P., de Vries, J.A., Dean, C.T., Decamp, D., Dedu, V., Del Buono, L., Delaney, B., Dembinski, H.-P., Dendek, A., Denysenko, V., Derkach, D., Deschamps, O., Desse, F., Dettori, F., Dey, B., Di Cicco, A., Di Nezza, P., Didenko, S., Dieste Maronas, L., Dijkstra, H., Dobishuk, V., Dong, C., Donohoe, A.M., Dordei, F., dos Reis, A.C., Douglas, L., Dovbnya, A., Downes, A.G., Dudek, M.W., Dufour, L., Duk, V., Durante, P., Durham, J.M., Dutta, D., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., Eisenhardt, S., Ek-In, S., Eklund, L., Ely, S., Ene, A., Epple, E., Escher, S., Eschle, J., Esen, S., Evans, T., Falabella, A., Fan, J., Fan, Y., Fang, B., Farry, S., Fazzini, D., Féo, M., Fernandez Prieto, A., Fernez, A.D., Ferrari, F., Ferreira Lopes, L., Ferreira Rodrigues, F., Ferreres Sole, S., Ferrillo, M., Ferro-Luzzi, M., Filippov, S., Fini, R.A., Fiorini, M., Firlej, M., Fischer, K.M., Fitzgerald, D.S., Fitzpatrick, C., Fiutowski, T., Fkiaras, A., 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A., Gushchin, E., Guth, A., Guz, Y., Gys, T., Hadavizadeh, T., Haefeli, G., Haen, C., Haimberger, J., Halewood-leagas, T., Hamilton, P.M., Hammerich, J.P., Han, Q., Han, X., Hancock, T.H., Hansmann-Menzemer, S., Harnew, N., Harrison, T., Hasse, C., Hatch, M., He, J., Hecker, M., Heijhoff, K., Heinicke, K., Hennequin, A.M., Hennessy, K., Henry, L., Heuel, J., Hicheur, A., Hill, D., Hilton, M., Hollitt, S.E., Hu, J., Hu, W., Hu, X., Huang, W., Huang, X., Hulsbergen, W., Hunter, R.J., Hushchyn, M., Hutchcroft, D., Hynds, D., Ibis, P., Idzik, M., Ilin, D., Ilten, P., Inglessi, A., Ishteev, A., Ivshin, K., Jacobsson, R., Jage, H., Jakobsen, S., Jans, E., Jashal, B.K., Jawahery, A., Jevtic, V., Jiang, F., John, M., Johnson, D., Jones, C.R., Jones, T.P., Jost, B., Jurik, N., Kalavan Kadavath, S.H., Kandybei, S., Kang, Y., Karacson, M., Karpov, M., Keizer, F., Keller, D.M., Kenzie, M., Ketel, T., Khanji, B., Kharisova, A., Kholodenko, S., Kirn, T., Kirsebom, V.S., Kitouni, O., Klaver, S., 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[Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), LHCb, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Aaij, R, Abdelmotteleb, A, Abellan Beteta, C, Ackernley, T, Adeva, B, Adinolfi, M, Afsharnia, H, Agapopoulou, C, Aidala, C, Aiola, S, Ajaltouni, Z, Akar, S, Albrecht, J, Alessio, F, Alexander, M, Alfonso Albero, A, Aliouche, Z, Alkhazov, G, Alvarez Cartelle, P, Amato, S, Amey, J, Amhis, Y, An, L, Anderlini, L, Andreianov, A, Andreotti, M, Archilli, F, Artamonov, A, Artuso, M, Arzymatov, K, Aslanides, E, Atzeni, M, Audurier, B, Bachmann, S, Bachmayer, M, Back, J, Baladron Rodriguez, P, Balagura, V, Baldini, W, Baptista Leite, J, Barbetti, M, Barlow, R, Barsuk, S, Barter, W, 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Subjects
FCNC Interaction, 13000 GeV-cms, B physic, B/s0: semileptonic decay, K-ASTERISK(0)MU(+)MU(-), rare decay [B/s0], 01 natural sciences, Square (algebra), B physics, Subatomär fysik, Flavor physics, Hadron-Hadron scattering (experiments), Subatomic Physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], scattering [p p], Physic, Invariant mass, Nuclear Experiment, Physics, 8000 GeV-cms, (muon+ muon-) [mass spectrum], Luminosity (scattering theory), Particle physics, Observable, dimuon: mass spectrum, muon: pair production, CERN LHC Coll, Hadron collider, angular distribution [decay], 7000 GeV-cms, +Phi%281020%29+muon%2B+muon%22">B/s0 --> Phi(1020) muon+ muon, mass spectrum [dimuon], LHC, Particles and field, Nuclear and High Energy Physics, p p: scattering, data analysis method, COLLISIONS, Hadrons, Standard Model, NO, PE2_2, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, 0103 physical sciences, B-0, decay: angular distribution, ddc:530, pair production [muon], SDG 7 - Affordable and Clean Energy, 010306 general physics, Large Hadron Collider (France and Switzerland), 010308 nuclear & particles physics, semileptonic decay [B/s0], Phi(1020), Gran Col·lisionador d'Hadrons, Collision, LHC-B, HEP, mass spectrum: (muon+ muon-), LHCb, Rare decay, Flavor physic, High Energy Physics::Experiment, Física de partícules, Experiments, B/s0: rare decay, experimental results
Abstract

An angular analysis of the rare decay$$ {B}_s^0 $$Bs0→ ϕμ+μ−is presented, using proton-proton collision data collected by the LHCb experiment at centre-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 8.4 fb−1. The observables describing the angular distributions of the decay$$ {B}_s^0 $$Bs0→ ϕμ+μ−are determined in regions ofq2, the square of the dimuon invariant mass. The results are consistent with Standard Model predictions.

Published
2021
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18. Observation of a $$ {\varLambda}_b^0 $$ − $$ {\overline{\varLambda}}_b^0 $$ production asymmetry in proton-proton collisions at $$ \sqrt{s} $$ = 7 and 8 TeV

Author

B. Pietrzyk, Thomas Peter Jones, Cheryl Pappenheimer, Andrea Lampis, G. Carboni, Y. H. Zheng, Xiaolong Hu, C. J. G. Onderwater, X. Han, Alexander Inglessi, M. Brodski, Elena Graverini, D. E. Hutchcroft, Pascal Vincent, L. Zhang, Christoph Hasse, G. Passaleva, Christopher James Pawley, Lukas Calefice, Eliane Epple, Harris Conan Bernstein, S. Ferreres Sole, Marcel Materok, Valeriia Lukashenko, Christopher Burr, L. M. Garcia Martin, Alina Zharkova, Rizwaan Adeeb Mohammed, V. Gibson, C. Bozzi, Davide Fazzini, K. Carvalho Akiba, T. Ruf, Sevda Esen, Anton Philippov, Nicola Serra, Xiao-Rui Lyu, Dmitry Popov, Simon Akar, Vitalii Lisovskyi, Dawid Gerstel, P. Spradlin, Malte Hecker, Almagul Kondybayeva, D. Hynds, Marina Artuso, Vladimir Macko, Jake Alexander Ward, Y. Li, G. Lanfranchi, M.-N. Minard, A. Vorobyev, F. Dordei, D. Vom Bruch, Andrew Beiter, U. Marconi, R. J. Barlow, E. L. Gkougkousis, L. Garrido, Marta Calvi, Hans Dembinski, E. Grauges, I. Nasteva, Yury Guz, A. Bay, Chenzhi Dong, X. K. Zhou, Jake Lewis Amey, Julian Alexander Boelhauve, Marco Adinolfi, A. Fernandez Prieto, Emmy Gabriel, Alessandro Minotti, Ph. Charpentier, Daniel Berninghoff, R. Nandakumar, R. Silva Coutinho, B. T. Meadows, Ryan Newcombe, G. Raven, D. Decamp, Kevin Heijhoff, Lorenzo Capriotti, Alexander Malinin, Marie Bachmayer, Yang Yang, G. Mancinelli, Conor Fitzpatrick, A. Brea Rodriguez, Dmitrii Ilin, A. Lai, A. Golutvin, M. D. Sokoloff, Andrea Mauri, Wenbin Qian, P. Gandini, Luca Minzoni, Dylan Jaide White, Michela Garau, Ryunosuke Hugo O'Neil, A. G. Morris, Shuaiyi Liu, A. Dovbnya, J. J. Walsh, Davide Lancierini, Claudia Bertella, Aleksandra Snoch, Y. G. Gao, Benedetto Gianluca Siddi, Jascha Peter Grabowski, V. Shevchenko, Yiheng Luo, Deepanwita Dutta, Stefano Petrucci, W. Wislicki, Adam Davis, Alessandro Scarabotto, Aleksei Andreianov, Lingzhu Bian, Evgenii Shmanin, R. Santacesaria, S. Perazzini, M. Franco Sevilla, Alexey A. Petrov, Joseph David Shupperd, A. 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Thomas, Anna Danilina, Angelo Loi, Mario Edgardo Olivares, G. D. Lafferty, Ivan Shchemerov, M. Palutan, Aodhan Tomas Burke, C. A. Chavez Barajas, Jana Crkovská, R. McNulty, P. Krokovny, Eduardo Rodrigues, Yawen Wang, L. Dieste Maronas, Samuel Belin, A. Romero Vidal, Sebastian Neubert, Da Yu Tou, F. Teubert, Maciej Witold Majewski, S. Mariani, C. R. Jones, Matthew Scott Rudolph, Z. A. Zhu, E. Spadaro Norella, Jozef Tomasz Borsuk, Patrick Robbe, P. Baladron Rodriguez, G. Wilkinson, Hangyi Wu, Ross John Hunter, Jakub Jacek Malczewski, Li Xu, Michael Becker, Dmitry Golubkov, R. Le Gac, Felicia Carolin Volle, D. Galli, Stephen M. Stahl, V. Franco Lima, J. A. de Vries, N. Neufeld, A. Lobo Salvia, Richard Lane, Martha Hilton, F. Archilli, A. Alfonso Albero, Tatiana Ovsiannikova, G. Wormser, A. Sergi, Vladimir Chulikov, D. Wiedner, Constantin Weisser, Quentin Fuehring, Phillip John Marshall, A. Dzyuba, M. Tobin, Guillaume Pietrzyk, M. Senghi Soares, M. Witek, Tara Shears, Alex Daniel Fernez, Ivan Solovyev, Sergey Didenko, W. Baldini, Cynthia Nunez, Simone Bifani, Anton Poluektov, Lorenzo Sestini, Edoardo Franzoso, Dana Bobulska, H. Li, Danila Saranin, Matteo Bartolini, B. Malecki, Aristeidis Fkiaras, R. Schwemmer, Roger Forty, Alexander Battig, E. Santovetti, Alex Seuthe, Harald Viemann, C. Chen, N. Tuning, M. De Cian, M. Rama, F. Fontanelli, E. Jans, Daniel Joachim Unverzagt, Gabriele Simi, Lukas Witola, Marko Petrič, M. Needham, Krzysztof Swientek, Ning Qin, Dmitrii Pereima, Fedor Ratnikov, Olga Madejczyk, Franco Bedeschi, Andrii Usachov, J. van Tilburg, Wojciech Krzemien, Arthur Marius Hennequin, S. De Capua, Alessandra Gioventù, M. Rotondo, Serhii Cholak, Renata Kopecna, Michele Veronesi, S. Meloni, Robbert Erik Geertsema, Eduard Ursov, Evelina Gersabeck, Barbara Passalacqua, Simon Nieswand, Sofia Kotriakhova, Davide Zuliani, Patrick Mackowiak, Bo Fang, Annarita Buonaura, Valery Zhukov, Ouail Kitouni, Johannes Albrecht, Floris Keizer, D. Pinci, Malcolm John, Tai-hua Lin, Olli Lupton, Jihyun Bhom, Luca Tomassetti, Liupan An, D. Torres Machado, Eleonora Luppi, N. G. Polukhina, Blaise Delaney, B. Dey, Paul Seyfert, Simone Capelli, Matthew Birch, Igor Kostiuk, Ia. Bezshyiko, Nikolay Nikitin, S. Gomez Fernandez, Mauro Morandin, Srishti Bhasin, X. Cid Vidal, Alessandro Pastore, Zhenzi Wang, Veronica Soelund Kirsebom, Salvatore Aiola, Philip Ilten, M. S. Rangel, Zakariya Aliouche, Camille Normand, S. Zucchelli, M. Gandelman, Mauro Piccini, L. Kravchuk, Y. Zhang, F. Stagni, Mariia Poliakova, Laura Promberger, Denis Derkach, R. Vazquez Gomez, E. Gushchin, Phoebe Meredith Hamilton, D. Savrina, Alessandro Cardini, Philippe d'Argent, Jan Buytaert, M. Pepe Altarelli, Thomas Harrison, Edward James Millard, Marco Gersabeck, Chishuai Wang, J. M. De Miranda, S. Simone, J. M. Otalora Goicochea, Piera Muzzetto, G. Punzi, F. Ferreira Rodrigues, Giulia Tuci, E. Vilella Figueras, Christopher Betancourt, A. Satta, Ling-Yun Dai, Xiaotao Huang, Eluned Smith, Jakub Moron, Wolfgang Funk, Roberta Cardinale, Mark Richard James Williams, Kodassery Prasanth, A. Leflat, John Gordon Smeaton, M. Veltri, G. Haefeli, Mikhail Zavertyaev, S. Li, M. R. J. Williams, Naomi Cooke, Konstantin Gizdov, Wiktor Byczynski, M. Martinelli, Nikolai Voropaev, I. V. Gorelov, K. Müller, Giovanni Bassi, P. E. L. Clarke, Niklas Stefan Nolte, Jennifer Clare Smallwood, L. Calero Diaz, Yuyue Gan, Anatoly Butkevich, Luciano Pappalardo, Tamaki Holly Mcgrath, Roberto Ribatti, S. Lopez Solino, M. Shapkin, Patrick Owen, Z. Xiang, Alessio Sarti, Mika Vesterinen, M. Vieites Diaz, Jonathan Edward Davies, Mark Hatch, Lucio Anderlini, G. Manca, O. Schneider, Giovanni Cavallero, Sebastien Ponce, C. M. Costa Sobral, Anja Beck, Kayleigh Anne Thomson, Johannes Heuel, Sebastian Schulte, Ulrik Egede, J. Baptista Leite, Gennady Panshin, Svende Braun, M. Poli Lener, M. Plo Casasus, Daniele Manuzzi, Brij Kishor Jashal, Lorenzo Pica, A. C. dos Reis, Minaugas Sarpis, P. Billoir, Fabrice Desse, Fionn Caitlin Ros Bishop, Dominik Stefan Mitzel, Loris Martinazzoli, Marco Guarise, Sara Sellam, Valery Pugatch, P. Naik, Yunyun Fan, Ryan Calladine, Gianfranco Morello, A. Palano, Tomasz Szumlak, Mauricio Féo, Pawel Kopciewicz, Nicola Skidmore, Tommaso Colombo, Vasyl Dobishuk, Stephane T'Jampens, Ina Carli, Vlad-Mihai Placinta, Stanislav Poslavskii, Saliha Bashir, Imanol Corredoira, Basem Khanji, Y. Xie, Kimberley Vos, Nikolay Bondar, O. Maev, Abhijit Mathad, Thomas Blake, Jennifer Brigitta Zonneveld, F. J. P. Soler, C. Satriano, Matthew George Chapman, A. Contu, Marko Milovanovic, Xiaofeng Zhu, C. Remon Alepuz, A. Papanestis, Ao Xu, Mara Senghi Soares, Jakob Haimberger, R. Lindner, Elisabeth Maria Niel, Yuya Shimizu, R. Jacobsson, Rafal Dominik Krawczyk, Adam Benjamin Morris, Ph. Ghez, Georgios Chatzikonstantinidis, Sonia Amina Bouchiba, Mateusz Goncerz, G. Alkhazov, Claudio Gotti, Andrea Villa, Martino Borsato, Diego Alejandro Milanes, Barbara Sciascia, Vladimir Romanovskiy, A. Zhelezov, Henryk Karol Giemza, M. Schmelling, M. J. Morello, Dong Xiao, Dominik Müller, H. Schindler, Marek Idzik, P. Garcia Moreno, M. Xu, Thomas Hadavizadeh, Samuel Maddrell-Mander, V. V. Gligorov, A. Grecu, L. Sun, Karol Hennessy, R. I. Rabadan Trejo, L. G. Scantlebury Smead, M. Charles, Andrey Ustyuzhanin, J. J. Back, Jordan Daniel Roth, David Gerick, J. Ruiz Vidal, M. Pappagallo, Hossein Afsharnia, Tomasz Skwarnicki, G Falmagne, Sebastian Bachmann, Mikhail Hushchyn, M. van Beuzekom, Scott Ely, Gediminas Sarpis, Maria Elena Stramaglia, S.I. Eidelman, A. Hicheur, Kurt Rinnert, V. Obraztsov, M. De Serio, L. R. Madhan Mohan, Lesya Shchutska, M. Lucio Martinez, Stephan Eisenhardt, Heather Mckenzie Wark, Olivier Leroy, Giulia Frau, Lishuang Ma, Tengiz Kvaratskheliya, B. R. Gruberg Cazon, D. Lacarrere, C. L. Da Silva, Polina Kravchenko, T. Mombächer, A. Bursche, Bernardo Adeva, Lex Marinus Greeven, P. Perret, Sergey Barsuk, Xuhao Yuan, Jiayin Sun, Adam Dendek, B. Garcia Plana, Anastasia Smetkina, H. B. Liu, Sune Jakobsen, Preema Rennee Pais, E. Cogneras, Peilian Li, Ruiting Ma, E. Dall’Occo, M. McCann, Carina Trippl, Lucia Grillo, S. Ricciardi, D. Martinez Santos, Aleksandr Solovev, S. A. Wotton, J. Z. Fan, Sophie Katharina Kretzschmar, M. Calvo Gomez, Alexsei Chubykin, J. Marks, Antje Mödden, M. Straticiuc, J. García Pardiñas, Mick Mulder, F. Blanc, Halime Sazak, H. V. Cliff, Milosz Zdybal, Federico Alessio, Maciej Wojciech Dudek, G. Corti, C. Matteuzzi, Daniel James David Thompson, A. McNab, V. Vagnoni, Roland Bernet, Christoph Frei, Abbie Jane Chadwick, A. Bitadze, R. Lefèvre, Martin Stefan Bieker, Mark Whitehead, Shulei Zhang, Tommaso Pajero, Lucas Mcconnell, François Fleuret, D. Zhang, B. Leverington, D. Yang, M. Chrzaszcz, Fanghua Jiang, Hannah Louise Pullen, M. Korolev, Daniel Charles Craik, J. He, Mateusz Rafal Kmiec, Surapat Ek-In, Aleksandr Terentev, Marcel Merk, Alexandre Boyer, A. F. Campoverde Quezada, Fidan Suljik, Sara Celani, Ivan Polyakov, F. Maciuc, John Jake Lane, Rudolf Oldeman, Roberto Calabrese, P. Durante, Louis Lenard Gerken, Stephan Escher, G. Graziani, S. Easo, Miroslaw Firlej, Massimiliano Fiorini, Ilaria Neri, Lauren Emma Yeomans, P. Campana, L. Giubega, A. Oyanguren, A. Gallas Torreira, M. Ramos Pernas, Paolo Carniti, Meril Reboud, A. Bertolin, Qiang Xu, M. T. Tran, J. Lomba Castro, P. Vazquez Regueiro, D. De Simone, Igor Slazyk, I. A. Monroy, Patrick Koppenburg, Viacheslav Matiunin, Lars Eklund, William Barter, Martina Pili, B. D. C. Westhenry, Sandro Cadeddu, Alexander Berezhnoy, Alexander Mclean Marshall, Flavio Pisani, Leon David Carus, Marco Cattaneo, Ziad Ajaltouni, Valeriia Zhovkovska, Cameron Thomas Dean, Francesco Dettori, Yue Pan, T. J. Gershon, Angelo Carbone, Gianluca Zunica, D. Melnychuk, M. Van Dijk, Peter Griffith, Elie Aslanides, B. Souza De Paula, Michele Piero Blago, N. Valls Canudas, Nathan Allen Grieser, Dillon Scott Fitzgerald, Andreas Güth, Aravindhan Venkateswaran, Jaap Velthuis, Peter Svihra, Thomas Ackernley, T. D. Nguyen, F. F. Wilson, Sara Elizabeth Mitchell, Michael Alexander, D. Lucchesi, Sergei Kholodenko, N. Sagidova, O. Zenaiev, Thomas Henry Hancock, A. Falabella, Biagio Saitta, Stanislav Luchuk, Shakhzod Dadabaev, S. Malde, Jonas Nathanael Eschle, A. Gomes, Federico Betti, L. A. Granado Cardoso, Z. Mathe, Veronika Chobanova, Jan Langer, E. R. R. Rodriguez Rodriguez, Serhii Koliiev, Alexandra Paige Rollings, John Leslie Cobbledick, E. Ben-Haim, Maxime Schubiger, Maria Flavia Cicala, Petr Andreevich Gorbounov, Ekaterina Govorkova, O. De Aguiar Francisco, Miroslav Saur, Paul Nathaniel Swallow, A. Lusiani, Lucian Cojocariu, Jonathan Plews, P. De Simone, Ignacio Bediaga, Desmond Mzamo Shangase, B. Spaan, Ilia Belov, Louis Henry, J. Closier, A. Massafferri, Zhuyin Ren, Wojciech Kucewicz, Yiduo Shang, Mark Smith, Roel Aaij, Vadym Denysenko, P. Roloff, Aleksei Chernov, J. H. Lopes, V. Balagura, T. Gys, Wenhua Hu, Youen Kang, S. Blusk, Z. Xu, P. Di Nezza, Vukan Jevtic, K. M. Fischer, Fedor Baryshnikov, Donal Hill, Quan Zou, S. Klaver, J. J. Saborido Silva, Chung Nguyen-Mau, Gregory Ciezarek, G. H. Gong, Jeremy Dalseno, Amanda May Donohoe, William Parker, F. Polci, Carmelo D'Ambrosio, Jean François Marchand, Paolo Ciambrone, Oleg Stenyakin, Mikhail Mikhasenko, Andrea Bizzeti, Marco Santimaria, R. Currie, C. A. Aidala, L. Del Buono, S. Hansmann-Menzemer, Gerd Joachim Kunde, A. Schopper, Roman Litvinov, Jakub Ryzka, Oleksander Kot, Timothy Evans, R. Mountain, S. H. Lee, Rui Wang, Davide Brundu, Colm Harold Murphy, C. Patrignani, T. Lesiak, Renato Quagliani, C. Göbel, V. Tisserand, M. Andreotti, Adam Szabelski, A. Ukleja, Antonio Pellegrino, F. Redi, E. Polycarpo, Tatsuya Nakada, G. Bencivenni, M. Patel, Anastasiia Kharisova, Federico Lazzari, N. K. Watson, Marie Helene Schune, Michele Atzeni, James Vincent Mead, F. Goncalves Abrantes, G. Liu, Olivier Deschamps, Moran Wang, Ying Lu, Mark Wilkinson, Roland Waldi, Timofei Maltsev, S. Vecchi, Matthieu Marinangeli, S. J. Chen, Yasmine Amhis, C. Sanchez Gras, Matteo Giovannetti, Alexey Boldyrev, Mark Slater, Vladislav Belavin, Anna Ossowska, Nathan Jurik, Jixing Qin, I. Longstaff, L. Shekhtman, Maciej Pawel Szymanski, U. Uwer, Jiangqiao Hu, Xixin Liang, Chun-wei Gu, F. Martinez Vidal, Tjeerd Ketel, Victor Coco, Zhuoming Li, Liliana Congedo, P. Alvarez Cartelle, W. Huang, J. Fu, Emilie Maurice, Andrea Valassi, Tara Nanut, V. Kudryavtsev, Donal Murray, A. Casais Vidal, L. Meyer Garcia, Markus Frank, Matthew Kenzie, Daria Strekalina, Xavier Vilasis-Cardona, B. Quintana, J. J. Xu, Sophie Elizabeth Hollitt, Tatiana Gaintseva, Alexander Semennikov, John Matthew Durham, Kevin Heinicke, Kara Renee Mattioli, M. Cruz Torres, K. De Bruyn, Andrea Merli, Jacopo Cerasoli, Dmitrii Maisuzenko, Hans Dijkstra, Maxim Borisyak, C. Gaspar, Jing Wang, Alex Pearce, Viacheslav Duk, Daniele Marangotto, Artem Ryzhikov, Franz Muheim, Nis Meinert, Alison Tully, Michal Kreps, B. Jost, Hanna Malygina, Edward Brendan Shields, Marco Clemencic, Mikkel Bjørn, F. A. Garcia Rosales, Sergey Legotin, L. Ferreira Lopes, F. L. Souza De Almeida, S. Filippov, V. Vorobyev, H. Cai, M. Romero Lamas, M. Ferro-Luzzi, P. Camargo Magalhaes, Yuezhe Yao, Ekaterina Trifonova, l. Soares Lavra, Anna Lupato, S. Monteil, George Holger Lovell, Shinichi Okamura, C. Vázquez Sierra, F. Reiss, Manuel Schiller, Lauren Douglas, Wojciech Krupa, Gary Robertson, Sergey Gromov, Bhagyashree Pagare, Hilbrand Steffen Kuindersma, A. Di Cicco, Tomasz Fiutowski, P. Collins, Y. Sun, Gerwin Meier, Serena Maccolini, S. Kandybei, J. A. B. Coelho, Jan Patrick Hammerich, T. Kirn, A. Dziurda, Claire Prouve, Neville Harnew, Ettore Zaffaroni, K. Wyllie, and S. G. Weber

Subjects
Physics, Semileptonic decay, Nuclear and High Energy Physics, Particle physics, Luminosity (scattering theory), Hard scattering, Proton, 010308 nuclear & particles physics, Keywords: Hadron-Hadron scattering (experiments), media_common.quotation_subject, 01 natural sciences, Asymmetry, B physics, Keywords: Hadron-Hadron scattering (experiments), Heavy quark production, proton- proton scattering, Hard scattering, B physics, Baryon, Heavy quark production, proton- proton scattering, 0103 physical sciences, CP violation, Production (computer science), Rapidity, 010306 general physics, media_common
Abstract

This article presents differential measurements of the asymmetry between $$ {\varLambda}_b^0 $$ Λ b 0 and $$ {\overline{\varLambda}}_b^0 $$ Λ ¯ b 0 baryon production rates in proton-proton collisions at centre-of-mass energies of $$ \sqrt{s} $$ s = 7 and 8 TeV collected with the LHCb experiment, corresponding to an integrated luminosity of 3 fb−1. The $$ {\varLambda}_b^0 $$ Λ b 0 baryons are reconstructed through the inclusive semileptonic decay $$ {\varLambda}_b^0 $$ Λ b 0 → $$ {\varLambda}_c^{+} $$ Λ c + μ−$$ \overline{\nu} $$ ν ¯ μX. The production asymmetry is measured both in intervals of rapidity in the range 2.15 < y < 4.10 and transverse momentum in 2 < pT< 27 GeV/c. The results are found to be incompatible with symmetric production with a significance of 5.8 standard deviations for both $$ \sqrt{s} $$ s = 7 and 8 TeV data, assuming no CP violation in the decay. There is evidence for a trend as a function of rapidity with a significance of 4 standard deviations. Comparisons to predictions from hadronisation models in Pythia and heavy-quark recombination are provided. This result constitutes the first observation of a particle-antiparticle asymmetry in b-hadron production at LHC energies.

Published
2021
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19. Metabolism of Odorant Molecules in Human Nasal/Oral Cavity Affects the Odorant Perception

Author

Yusuke Ihara, Hidehiko Wakabayashi, Ayumi Nagashima, Yoshihito Niimura, Yasuko Nogi, Sayoko Ihara, Kenji Kondo, Chiori Ijichi, Yuya Shimizu, Shingo Sugiyama, and Kazushige Touhara

Subjects
0301 basic medicine, Saliva, Physiology, Raspberry ketone, Olfaction, Receptors, Odorant, Hexanal, 03 medical and health sciences, Behavioral Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Physiology (medical), Humans, Mouth, Mucus, Sensory Systems, Benzyl acetate, Nasal Mucosa, 030104 developmental biology, chemistry, Odor, Biochemistry, Odorants, Nasal Cavity, psychological phenomena and processes, 030217 neurology & neurosurgery, Hexanol
Abstract

In this study, we examined the mode of metabolism of food odorant molecules in the human nasal/oral cavity in vitro and in vivo. We selected 4 odorants, 2-furfurylthiol (2-FT), hexanal, benzyl acetate, and methyl raspberry ketone, which are potentially important for designing food flavors. In vitro metabolic assays of odorants with saliva/nasal mucus analyzed by gas chromatography mass spectrometry revealed that human saliva and nasal mucus exhibit the following 3 enzymatic activities: (i) methylation of 2-FT into furfuryl methylsulfide (FMS); (ii) reduction of hexanal into hexanol; and (iii) hydrolysis of benzyl acetate into benzyl alcohol. However, (iv) demethylation of methyl raspberry ketone was not observed. Real-time in vivo analysis using proton transfer reaction-mass spectrometry demonstrated that the application of 2-FT and hexanal through 3 different pathways via the nostril or through the mouth generated the metabolites FMS and hexanol within a few seconds. The concentration of FMS and hexanol in the exhaled air was above the perception threshold. A cross-adaptation study based on the activation pattern of human odorant receptors suggested that this metabolism affects odor perception. These results suggest that some odorants in food are metabolized in the human nasal mucus/saliva, and the resulting metabolites are perceived as part of the odor quality of the substrates. Our results help improve the understanding of the mechanism of food odor perception and may enable improved design and development of foods in relation to odor.

Published
2019
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20. Book Review Forum Murakami Yoichiro no kagaku-ron: Hihan to outou 村上陽一郎の科学論: 批判と応答 [Yoichiro Murakami’s Science Studies: Critiques and Response]

Author

Yuya Shimizu, Koichi Mikami, Akihisa Setoguchi, and Yuki Hagiwara

Subjects
General Social Sciences, Art history, Sociology, Discipline, History of science
Abstract

“For the half a century since he decided to pursue his career in the then young academic discipline of philosophy and history of science, Yoichiro Murakami has undoubtedly been one of the opinion l...

Published
2019
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21. Long-term sterile immunity induced by an adjuvant-containing live-attenuated AIDS virus

Author

Masamitsu N Asaka, Tomotaka Okamura, Yusuke Tsujimura, Takuya Yamamoto, Kazuhiro Matsuo, Yasuhiro Yasutomi, Tomohiro Kanuma, and Yuya Shimizu

Subjects
viruses, animal diseases, medicine.medical_treatment, T cell, virus diseases, Biology, Virology, Virus, Vaccination, Immune system, medicine.anatomical_structure, Antigen, Immunity, medicine, HIV vaccine, Adjuvant
Abstract

Antigen 85B (Ag85B) is one of the most dominant proteins secreted from most mycobacterial species, and it induces Th1-type immune responses as an adjuvant. We genetically constructed a live attenuated simian human immunodeficiency virus to express the adjuvant molecule Ag85B (SHIV-Ag85B). SHIV-Ag85B could not be detected 4 weeks after injection in cynomolgus macaques, and strong SHIV-specific T cell responses were induced in these macaques. When these macaques in which SHIV-Ag85B had become undetectable were challenged with pathogenic SHIV89.6P at 37 weeks after SHIV-Ag85B became undetectable, SHIV89.6P could not be detected after the challenge. Eradication of SHIV89.6P was confirmed by adoptive transfer experiments and CD8-depletion studies. The SHIV-Ag85B-inoculated macaques showed enhancement of Gag-specific monofunctional and polyfunctional CD8+T cells in the acute phase of pathogenic SHIV challenge. The results suggest that SHIV-Ag85B elicited strong sterile immune responses against pathogenic SHIV and that it may lead to the development of a vaccine for AIDS virus infection.ImportanceDevelopment of an effective HIV vaccine has been a major priority to control the worldwide AIDS epidemic. The moderately attenuated prototypic vaccine strain SIVmac239Δnef has been used in various studies; however, it does not provide sufficient effects to prevent infection. The use of adjuvant in vaccination is thought to be useful for enhancing the immune responses to various pathogens. In the present study, we constructed a live attenuated SHIV virus expressing adjuvant molecule Ag85B and assessed vaccine effects in cynomolgus macaques. The present study shows that live-attenuated SHIV expressing Ag85B elicits viral antigen-specific polyfunctional CD8+T cell responses against pathogenic SHIV and provide the possibility of eradicating a pathogenic lentivirus from infected animals.

Published
2020
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22. Constructing higher order discontinuity-capturing schemes with upwind-biased interpolations and boundary variation diminishing algorithm

Author

Feng Xiao, Yuya Shimizu, Bin Xie, Xi Deng, Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Department of Electrical and Electronic Engineering, Southern University of Science and Technology of China (SUSTech), Tokyo Institute of Technology [Tokyo] (TITECH), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), and Southern University of Science and Technology (SUSTech)

Subjects
Polynomial, Finite volume method, General Computer Science, Computer science, General Engineering, Boundary variation diminishing, Boundary (topology), Upwind scheme, Function (mathematics), Very high order schemes, Shock capturing, 01 natural sciences, 010305 fluids & plasmas, Hyperbola, [SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], 010101 applied mathematics, Discontinuity (linguistics), Rate of convergence, 0103 physical sciences, 0101 mathematics, Algorithm
Abstract

Based on the fifth-order scheme in our previous work (Deng et. al (2019) [28]), a new framework of constructing very high order discontinuity-capturing schemes is proposed for finite volume method. These schemes, so-called P n T m − BVD (polynomial of n-degree and THINC function of m-level reconstruction based on BVD algorithm), are designed by employing high-order upwind-biased interpolations and THINC (Tangent of Hyperbola for INterface Capturing) functions with adaptive steepness as the reconstruction candidates. The final reconstruction function in each cell is determined with a multi-stage BVD (Boundary Variation Diminishing) algorithm so as to effectively control numerical oscillation and dissipation. We devise the new schemes up to eleventh order in an efficient way by directly increasing the order of the underlying upwind scheme using high order polynomials. The analysis of the spectral property and accuracy tests show that the new reconstruction strategy well preserves the low-dissipation property of the underlying upwind schemes with high-order polynomials for smooth solution over all wave numbers and realizes n + 1 order convergence rate. The performance of new schemes is examined through widely used benchmark tests, which demonstrate that the proposed schemes are capable of simultaneously resolving small-scale flow features with high resolution and capturing discontinuities with low dissipation. With outperforming results and simplicity in algorithm, the new reconstruction strategy shows great potential as an alternative numerical framework for computing nonlinear hyperbolic conservation laws that have discontinuous and smooth solutions of different scales.

Published
2020
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23. Influence of the location of nasal polyps on olfactory airflow and olfaction

Author

Tatsuya Yamasoba, Hironobu Nishijima, Yuya Shimizu, Tsutomu Nomura, Shu Kikuta, Takahisa Yamamoto, Kenji Kondo, and Yu Mizushima

Subjects
Meatus, medicine.diagnostic_test, Chronic rhinosinusitis, business.industry, Airflow, Computed tomography, Olfaction, Anatomy, respiratory system, medicine.disease, digestive system diseases, 03 medical and health sciences, surgical procedures, operative, 0302 clinical medicine, Otorhinolaryngology, otorhinolaryngologic diseases, Immunology and Allergy, Medicine, Nasal polyps, 030223 otorhinolaryngology, business, Olfactory Region, neoplasms, 030217 neurology & neurosurgery
Abstract

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) analysis. We also compared olfactory airflow and olfaction between patients with nasal polyps at different locations using CFD analysis and an olfactory test. Methods Nasal computed tomography images were used to generate a normal model and 4 virtual nasal polyp models based on polyp locations, including the olfactory region (all-olfactory model), the region anterior to the olfactory region (preolfactory model), the middle meatus (middle-meatus model), and the superior meatus (superior-meatus model). Various airflow parameters were compared between these models and a normal model without polyps. We then performed a similar comparison between the 3-dimensional (3D) reconstruction models of patients with nasal polyps, and retrospectively investigated the correlation between olfaction and nasal polyp location in those patients. Results Virtual nasal polyp analysis revealed dispersion of olfactory airflow in the all-olfactory model. Olfactory airflow and odorant transport showed maximum decrease in the preolfactory model and a slight decrease in the superior-meatus model. Olfactory airflow by polyps was further decreased by blockade of the olfactory airflow inlet than of the outlet. The findings obtained by patients corresponded well to those of the virtual polyp analysis. Conclusion Olfactory airflow and olfaction are differentially affected by nasal polyp location. This finding is important for planning polyp-removal surgeries from the perspective of improving patient olfaction.

Published
2018
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24. Low CT Attenuation Values of Sinonasal Benign Tumours Relative to the Brainstem Identify Schwannomas

Author

Hironobu Nishijima, Tomoaki Nakada, Shu Kikuta, Yuya Shimizu, Tatsuya Yamasoba, Kenji Kondo, and Harushi Mori

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Juvenile nasopharyngeal angiofibroma, Inverted papilloma, Computed tomography, Ct attenuation, Schwannoma, Benign tumours, 030218 nuclear medicine & medical imaging, Diagnosis, Differential, Young Adult, 03 medical and health sciences, 0302 clinical medicine, otorhinolaryngologic diseases, Humans, Medicine, 030223 otorhinolaryngology, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Otorhinolaryngology, Female, Radiology, Brainstem, Tomography, X-Ray Computed, business, Neurilemmoma, Paranasal Sinus Neoplasms, Brain Stem
Abstract

Objectives: On computed tomography (CT), sinonasal schwannoma displays as a soft-tissue mass without any distinctive features. Our aim was to define the radiological criteria for distinguishing schwannoma from other sinonasal benign tumours. Methods: We retrospectively identified consecutive patients who were pathologically diagnosed with benign sinonasal tumours between 2007 and 2016. CT attenuation values were compared between benign tumours and the brainstem. The utilities of demographic factors, clinical factors, and CT parameters for predicting the CT attenuation values of the brainstem were analysed by univariate and multivariate regression. Results: Of the 111 identified cases of benign tumours, the CT attenuation values of tumours and the brainstem were analysed in 36 cases (schwannoma, 4 cases; inverted papilloma, 26; juvenile nasopharyngeal angiofibroma, 3; cavernous haemangioma, 3). The CT attenuation values of the schwannomas were significantly lower than in the brainstem, while those of the other tumours were significantly higher than in the brainstem. No factors affected the CT attenuation values of the brainstem. Conclusion: Low CT attenuation values of sinonasal benign tumours relative to the brainstem could distinguish schwannomas from other benign tumours.

Published
2018
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25. Performance of interference suppression system in environment where artificial noise is mixed into multiple desired signals

Author

Mitoshi Fujimoto and Yuya Shimizu

Subjects
business.industry, Computer science, Noise (signal processing), Noise reduction, Signal, Digital filter, Electromagnetic interference, Reduction (complexity), Interference (communication), Electronic engineering, Artificial noise, business, AM radio, Digital signal processing, Taped delay line
Abstract

Recently, electromagnetic interference in AMradio receivers associated with noise generated from the powercontrol unit (DC-DC converters) in hybrid vehicles (HVs) hasbecomes a serious problem. To address this problem, a noisesuppression method thorough digital signal processing in anAM radio is proposed in the past research. However, themethod is only applicable to single desired signal. In this paper,the reduction performance by the method for multiple desiredsignals is confirmed., 2020 International Symposium on Antennas and Propagation (ISAP) 25-28 Jan. 2021 Osaka, Japan

Published
2021

26. Intravenous olfactory test latency correlates with improvement in post-infectious olfactory dysfunction

Author

Kyohei Horikiri, Hironobu Nishijima, Kaori Kanaya, Yuya Shimizu, Shu Kikuta, Kenji Kondo, and Tatsuya Yamasoba

Subjects
Adult, Male, medicine.medical_specialty, Olfaction, Audiology, Infections, Cohort Studies, Olfaction Disorders, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Diabetes mellitus, Internal medicine, Reaction Time, Humans, Medicine, Latency (engineering), 030223 otorhinolaryngology, Retrospective Studies, business.industry, Retrospective cohort study, Recovery of Function, General Medicine, Middle Aged, Prognosis, medicine.disease, Otorhinolaryngology, 030220 oncology & carcinogenesis, Predictive value of tests, Female, Smoking status, business, Body mass index, Cohort study
Abstract

This cohort study showed that onset latency in the intravenous olfactory test (IVO) may help predict when olfaction in patients with post-infectious olfactory dysfunction (PIOD) improves.To identify factors that predict the olfactory improvement period in patients with PIOD.All consecutive patients presenting with PIOD in 1994-2014 who were followed up for 2 years were identified retrospectively. The ability of demographic/clinical factors (age, sex, body mass index, presence/absence of allergic rhinitis, treatment/non-treatment with herbal medicines, patient dependence on herbal medicine treatment, presence/absence of diabetes mellitus, and smoking status) and olfactory test factors (response/no response and onset latency and duration in the IVO test, and detection and recognition scores on the TT olfactory test) to predict the olfactory improvement period (defined respectively as the time from PIOD onset or olfactory testing to the first self-report of olfaction improvement) was analyzed by univariate and multivariate regression.Of the 187 PIOD patients, the prognostic ability of demographic/clinical factors was analyzed in 65. None predicted the olfactory improvement period. Of the 65 patients, 20 did not respond in the IVO test. In the remaining 45 patients, onset latency (but not the other olfactory test factors) was a significant prognosticator of olfactory improvement period (R

Published
2017
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28. Pulsatile tinnitus and carotid artery dissection

Author

Yuya Shimizu and Masato Yagi

Subjects
Adult, Male, medicine.medical_specialty, Cervical Artery, Lumen (anatomy), Carotid Artery, Internal, Dissection, 030218 nuclear medicine & medical imaging, Carotid artery dissection, Brain ischemia, Tinnitus, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, medicine, Humans, Antihypertensive Agents, business.industry, General Medicine, Amaurosis fugax, medicine.disease, Surgery, Stenosis, Otorhinolaryngology, Cardiology, medicine.symptom, Internal carotid artery, business, Carotid Artery, Internal, Magnetic Resonance Angiography, 030217 neurology & neurosurgery
Abstract

Carotid artery dissection is an uncommon entity associated with head and neck pain, partial Horner’s syndrome, amaurosis fugax, and brain ischemia, which may all occur in isolation or in combination. Herein, we report a rare case of cervical artery dissection in which pulsatile tinnitus was the only reported symptom. A 38-years-old man attended our hospital with a 4-days history of left side pulsatile tinnitus which began after stumbling. He had no other symptom. MRA showed luminal stenosis with pseudo lumen of the internal carotid artery. The patient was diagnosed with left internal carotid artery dissection and treated with antihypertensive therapy accordingly. After 2 months, the stenosis and tinnitus spontaneously resolved.

Published
2018
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29. Doubly robust‐type estimation of population moments and parameters in biased sampling

Author

Yuya Shimizu and Takahiro Hoshino

Subjects
Statistics and Probability, education.field_of_study, Population, Estimator, Missing data, Moment (mathematics), Consistency (statistics), Statistics, Consistent estimator, Covariate, Statistics, Probability and Uncertainty, education, Sampling bias, Mathematics
Abstract

We propose an estimation method of population moments or population parameters in "biased sampling data" in which for some units of data, not only the variable of interest but also the covariates, have missing observations and the proportion of "missingness" is unknown. We use auxiliary information such as the distribution of covariates or their moments in random sampling data in order to correct the bias. Moreover, with additional assumptions, we can correct the bias even if we have only the moment information of covariates. The main contribution of this paper is the development of a doubly robust-type estimator for biased sampling data. This method provides a consistent estimator if either the regression function or the assignment mechanism is correctly specified. We prove the consistency and semi-parametric efficiency of the doubly robust estimator. Both the simulation and empirical application results demonstrate that the proposed estimation method is more robust than existing methods.

Published
2019
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30. Limiter-free discontinuity-capturing scheme for compressible gas dynamics withreactive fronts

Author

Yuya Shimizu, Bin Xie, Raphaël Loubère, Feng Xiao, Xi Deng, Department of Electrical and Electronic Engineering, Southern University of Science and Technology of China (SUSTech), Institut de Mathématiques de Toulouse UMR5219 (IMT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Tokyo Institute of Technology [Tokyo] (TITECH), Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Los Alamos National Laboratory, Group T-7, Los Alamos National Laboratory ( LANL ), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Southern University of Science and Technology (SUSTech), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
General Computer Science, Discretization, Computer science, Detonation, Classification of discontinuities, 01 natural sciences, 010305 fluids & plasmas, symbols.namesake, boundary variation diminishing, stiff detonation waves, [ SPI.FLUID ] Engineering Sciences [physics]/Reactive fluid environment, THINC scheme, 0103 physical sciences, Applied mathematics, 0101 mathematics, [MATH]Mathematics [math], ComputingMilieux_MISCELLANEOUS, ComputingMethodologies_COMPUTERGRAPHICS, Finite volume method, [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, General Engineering, discontinuities, [ MATH.MATH-NA ] Mathematics [math]/Numerical Analysis [math.NA], Solver, Euler equations, Hyperbola, 010101 applied mathematics, Discontinuity (linguistics), symbols, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract

International audience; This work proposes a new spatial reconstruction scheme in finite volume frameworks. Different from long-lastingreconstruction processes which employ high order polynomials enforced with some carefully designed limiting pro-jections to seek stable solutions around discontinuities, the current discretized scheme employs THINC (Tangentof Hyperbola for INterface Capturing) functions with adaptive sharpness to solve both smooth and discontinuoussolutions. Due to the essentially monotone and bounded properties of THINC function, difficulties to solve sharpdiscontinuous solutions and complexities associated with designing limiting projections can be prevented. A newsimplified BVD (Boundary Variations Diminishing) algorithm, so-called adaptive THINC-BVD, is devised to reducenumerical dissipations through minimizing the total boundary variations for each cell. Verified through numericaltests, the present method is able to capture both smooth and discontinuous solutions in Euler equations for com-pressible gas dynamics with excellent solution quality competitive to other existing schemes. More profoundly, itprovides an accurate and reliable solver for a class of reactive compressible gas flows with stiff source terms, such asthe gaseous detonation waves, which are quite challenging to other high-resolution schemes. The stiff C-J detonationbenchmark test reveals that the adaptive THINC-BVD scheme can accurately capture the reacting front of the gaseousdetonation, while the WENO scheme with the same grid resolution generates unacceptable results. Owing also to itsalgorithmic simplicity, the proposed method can become as a practical and promising numerical solver for compress-ible gas dynamics, particularly for simulations involving strong discontinuities and reacting fronts with stiff sourceterm.

Published
2018
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31. Berezinskii-Kosterlitz-Thouless transition in lattice Schwinger model with one flavor of Wilson fermion

Author

Yuya Shimizu and Yoshinobu Kuramashi

Subjects
Physics, Condensed Matter::Quantum Gases, Quantum Physics, Strongly Correlated Electrons (cond-mat.str-el), 010308 nuclear & particles physics, Conformal field theory, High Energy Physics::Lattice, High Energy Physics - Lattice (hep-lat), FOS: Physical sciences, Expectation value, Fermion, Computer Science::Digital Libraries, 01 natural sciences, Renormalization, Condensed Matter - Strongly Correlated Electrons, Kosterlitz–Thouless transition, High Energy Physics - Lattice, 0103 physical sciences, Homogeneous space, Gauge theory, 010306 general physics, Central charge, Quantum Physics (quant-ph), Mathematical physics
Abstract

We have made a detailed study of the phase structure for lattice Schwinger model with one flavor of Wilson fermion on the $(m,g)$ plane. For numerical investigation, we develop a decorated tensor renormalization method for lattice gauge theories with fermions incorporating the Grassmann tensor renormalization. Our algorithm manifestly preserves rotation and reflection symmetries. We find not only a parity-broken phase but also a Berezinskii-Kosterlitz-Thouless (BKT) transition by evaluating the central charge and an expectation value of a projection operator into the parity-odd subspace. The BKT phase boundaries converge into the degenerated doubler pole $(m,g)=(-2,0)$, while the parity-breaking transition line ends at the physical pole $(m,g)=(0,0)$. In addition, our analysis of scaling dimensions indicates that a conformal field theory with $\mathrm{SU}(2)$ symmetry arises on the line of $m=-2$., Comment: 14 pages, 17 figures

Published
2017
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32. Contactless direct heart-motion sensor using femtofarad-level capacitance-variation detector with VHF-band LC-oscillator

Author

Takakuni Douseki, Kei Igarashi, Ami Tanaka, Kambara Yuta, Hisashi Nishikawa, and Yuya Shimizu

Subjects
Physics, Electronic oscillator, business.industry, Oscillation, Acoustics, Detector, Electrical engineering, Very high frequency, Dielectric, Capacitance, sense organs, Variation (astronomy), business, Sensitivity (electronics)
Abstract

As the heart expands and contracts, the distance between the walls of the heart and the surface of the body changes continuously. This structural change causes the dielectric constant of the body to vary. To detect that variation, a capacitance-variation detector with a high sensitivity on the order of 100 aF has been developed. It employs an LC-oscillator architecture with 98 MHz, and the change in capacitance is determined from the oscillation frequency shift. Experiments demonstrated that it detected the movement of the heart of an actual person from the frequency shift. The system detects not only heart-beat count but also the real movement of heart itself.

Published
2016
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33. Programmable multimode, multichannel universal wireless receiver with FFT-based multicarrier demodulator for batteryless wireless sensors

Author

Ryota Suematsu, Takeshi Nishihashi, Kei Igarashi, Ami Tanaka, Takakuni Douseki, Yuya Shimizu, and Hisashi Nishikawa

Subjects
Engineering, Discriminator, Frequency-shift keying, business.industry, 020208 electrical & electronic engineering, Transmitter, Fast Fourier transform, Electrical engineering, Data_CODINGANDINFORMATIONTHEORY, 02 engineering and technology, 020202 computer hardware & architecture, Amplitude modulation, 0202 electrical engineering, electronic engineering, information engineering, Electronic engineering, Demodulation, Antenna (radio), business, Communication channel
Abstract

A programmable multimode, multichannel receiver that has only one antenna and 16 integrated receivers was developed. The receivers are managed by an FPGA containing an FFT capability and programmable demodulators. When multiple transmitters operate on different channels and/or in different modes, such as FM on Channel A and ASK on Channel B, the universal receiver is programmed to assign an FM discriminator to Channel A for demodulation, while the FFT output is directly connected to a DAC for Channel B because the original AM modulation is already reproduced in the FFT output. Experiments to verify the capability of the universal receiver were carried out with a 314.5-MHz FM modulated batteryless transmitter for a wireless drum set and a 315-MHz OOK batteryless transmitter for a tachometer in a yo-yo. It was found that the universal receiver received the FM signal at a rate of 4 FFT cycles/ms and the ASK signal at 16 FFT cycles/ms.

Published
2016
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35. Analysis of antibody response by temperature-sensitive measles vaccine strain in the cotton rat model

Author

Tetsuro Katayama, Niho Murayama, Tetsuo Nakayama, Akio Shinohara, Tetsuo Morita, Akatsuki Saito, Hironori Miyata, Takeshi Haga, Yuya Shimizu, Kazuyuki Uchida, Yoshitaka Goto, Katsuhiro Komase, Takumi Sakamoto, Chihiro Koshimoto, Kiyoaki Katahira, and Hiroshi Sato

Subjects
Measles Vaccine, Immunology, Virus Replication, Microbiology, Virus, Cell Line, Measles virus, Immune system, Animals, Immunology and Allergy, Sigmodontinae, Cotton rat, Lung, Cells, Cultured, General Veterinary, biology, Temperature, Antibody titer, Cotton rat, Measles vaccine, Temperature sensitive, General Medicine, biology.organism_classification, Virology, Disease Models, Animal, Infectious Diseases, Antibody Formation, Humoral immunity, biology.protein, Female, Lymph Nodes, Measles vaccine, Antibody
Abstract

Measles virus (MeV) vaccine strain, AIK-C, is temperature sensitive (ts), which is thought to be associated with attenuation of virus pathogenicity. In this study, replication and antibody response were examined in cotton rats using viruses carrying different forms of the P gene, which is responsible for the ts phenotype of strain AIK-C and its parental Edmonston strain. When cotton rats were inoculated intranasally, ts viruses neither replicated in lungs, nor reproducibly generated an antibody response. When inoculated intramusculary (i.m.), however, ts strains raised an antibody titer in all animals. This response was not observed when ultraviolet-inactivated virus was used. ts virus, inoculated i.m., was recovered from cotton rat drainage lymph nodes. These results suggest that ts virus, inoculated i.m., could replicate in the cotton rat, presumably at the superficial lymph node, and induce an antibody response. Therefore, cotton rats can serve as a small-animal model for investigating immune responses to safer ts vaccine, as well as recombinant vaccine using AIK-C as a vector for protection against other infectious agents.

Published
2009
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36. Characterization of lectin isolated from Momordica charantia seed as a B cell activator

Author

Hidenori Tanaka, Hiroyuki Iwata, Jun Toyama, Yoshitaka Goto, Yuya Shimizu, Ryo Akashi, Akira Sawaguchi, Takeshi Haga, Li Huang, and Takumi Adachi

Subjects
Momordica charantia, T-Lymphocytes, Immunology, Naive B cell, B-Lymphocyte Subsets, Dose-Response Relationship, Immunologic, Immunoglobulins, Biology, Lymphocyte Activation, Mice, immune system diseases, hemic and lymphatic diseases, medicine, Splenocyte, Immunology and Allergy, Animals, Immunologic Factors, neoplasms, B cell, Cell Proliferation, chemistry.chemical_classification, B-Lymphocytes, Mice, Inbred BALB C, Momordica, Activator (genetics), Lectin, Galactose, Momordica charantia seed lectin, B cell activator, T cell independent, BALB/c mice, biology.organism_classification, Molecular biology, medicine.anatomical_structure, Biochemistry, chemistry, Seeds, biology.protein, B7-2 Antigen, Plant Lectins, Cell activation, Glycoprotein, Protein Binding
Abstract

Lectin isolated from the seeds of Momordica charantia (MCL) is a galactose-specific glycoprotein. To investigate the effects of MCL on cell activation, we analyzed the responses of BALB/c splenocytes, thymocytes, T cells and B cells on MCL stimulation. Proliferation assays showed that MCL selectively stimulates the B cell subset of splenocytes (p < 0.05) in a dose and time dependent manner and that this activation proceeds without the involvement of T cells. Flow cytometric analysis revealed that the fluorescein isothiocyanate (FITC)-labeled MCL binds to B cells, which was inhibited by specific sugars, including galactose. Mouse immunoglobulin (Ig) was able to inhibit MCL-induced proliferation of mouse B cells, suggesting MCL stimulates B cell activation via membrane Ig in the B cell surface. Moreover, after 96-h co-culture, MCL triggered splenocytes to produce a large amount of non-specific IgM in culture supernatants (p < 0.01). Additionally, MCL was shown to up-regulate the cell activation marker CD86, in a B cell subpopulation distinct from that affected by LPS. These data suggest that MCL is a T cell-independent B cell activator and a polyclonal Ig inducer, and provide further information on the immunomodulatory effect of MCL.

Published
2008

37. A genetically engineered live-attenuated simian–human immunodeficiency virus that co-expresses the RANTES gene improves the magnitude of cellular immunity in rhesus macaques

Author

Yuya Shimizu, Masashi Okoba, Takeshi Haga, Kentaro Ibuki, Katsuhisa Inaba, Tomoyuki Miura, Masanori Hayami, Ai Himeno, Kentaro Kaneyasu, and Yoshitaka Goto

Subjects
CD4-Positive T-Lymphocytes, Male, Chemokine, Cellular immunity, HIV Antigens, T cell, viruses, animal diseases, T-Cell Antigen Receptor Specificity, Virus, Interferon-gamma, RANTES, Adjuvants, Immunologic, stomatognathic system, Immunity, Virology, medicine, Animals, HIV vaccine, Chemokine CCL5, Adjuvant, Acquired Immunodeficiency Syndrome, biology, SHIV, HIV-1, SIV, RANTES, Adjuvant, Vaccine, Chemokine, ELISPOT, Vaccination, virus diseases, hemic and immune systems, Viral Load, Macaca mulatta, CD4 Lymphocyte Count, medicine.anatomical_structure, SHIV, SIV, Immunology, biology.protein, HIV-1, Simian Immunodeficiency Virus, Vaccine, Reassortant Viruses
Abstract

Regulated-on-activation-normal-T-cell-expressed-and-secreted (RANTES), a CC-chemokine, enhances antigen-specific T helper (Th) type-1 responses against HIV-1. To evaluate the adjuvant effects of RANTES against HIV vaccine candidate in SHIV-macaque models, we genetically engineered a live-attenuated SHIV to express the RANTES gene (SHIV-RANTES) and characterized the virus's properties in vivo. After the vaccination, the plasma viral loads were same in the SHIV-RANTES-inoculated monkeys and the parental nef-deleted SHIV (SHIV-NI)-inoculated monkeys. SHIV-RANTES provided some immunity in monkeys by remarkably increasing the antigen-specific CD4+ Th cell-proliferative response and by inducing an antigen-specific IFN-gamma ELISpot response. The magnitude of the immunity in SHIV-RANTES-immunized animals, however, failed to afford greater protection against a heterologous pathogenic SHIV (SHIV-C2/1) challenge compared to control SHIV-NI-immunized animals. SHIV-RANTES immunized monkeys, elicited robust cellular CD4+ Th responses and IFN-gamma ELISpot responses after SHIV-C2/1 challenge. These findings suggest that the chemokine RANTES can augment vaccine-elicited, HIV-specific CD4+ T cell responses.

Published
2007
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39. Poly-2-methoxyethylacrylate-coated cardiopulmonary bypass circuit can reduce transfusion of platelet products compared to heparin-coated circuit during aortic arch surgery

Author

Osamu Adachi, Kiichiro Kumagai, Katsuhiro Hosoyama, Shunsuke Kawamoto, Masatoshi Akiyama, Yumi Sugawara, Konosuke Sasaki, Yoshikatsu Saiki, Yuya Shimizu, Satoshi Kawatsu, Koki Ito, and Marina Suzuki

Subjects
Blood Platelets, Male, medicine.medical_specialty, Extracorporeal Circulation, Polymers, Biomedical Engineering, Medicine (miscellaneous), Aorta, Thoracic, 030204 cardiovascular system & hematology, law.invention, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Coated Materials, Biocompatible, law, Cardiopulmonary bypass, medicine, Humans, Platelet, Aged, Aged, 80 and over, Cardiopulmonary Bypass, business.industry, Heparin, Extracorporeal circulation, Albumin, Anticoagulants, Perioperative, Middle Aged, Blood proteins, Cardiac surgery, 030228 respiratory system, Acrylates, Anesthesia, Female, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Several coating techniques for extracorporeal circulation have been developed to reduce the systemic inflammatory response during cardiopulmonary bypass (CPB). We compared the clinical effectiveness and biocompatibility of poly-2-methoxyethylacrylate (PMEA)- and heparin-coated CPB circuits in total aortic arch replacement (TAR) with the prolonged use of the bypass technique. Twenty patients who underwent elective TAR were divided randomly into two equal groups: group P (n = 10) to use PMEA-coated circuits and group H (n = 10) to use heparin-coated circuits. Clinical outcomes, hematological variables, and acute phase inflammatory response were analyzed perioperatively. Demographic, CPB, and clinical outcome data were similar for both groups. Hemoglobin and platelet count showed similar time-course curves. However, the amount of platelet products transfused intraoperatively was significantly larger in group H (group P 26.0 ± 7.0 units; group H 33.0 ± 6.7 units, p = 0.04). Total protein, and albumin levels were significantly higher in group P during and after the operation (total protein, p = 0.04; albumin, p = 0.02). The use of PMEA-coated circuit is associated with retainment of perioperative plasma proteins levels and may help to reduce transfusion of platelet products in TAR in comparison with the heparin-coated circuit.

Published
2015

40. In Vitro and in Vivo Stability of Plasmids in Attenuated Salmonella enterica serovar typhimurium Used as a Carrier of DNA Vaccine is Associated with its Replication Origin

Author

Takeshi Haga, Yuya Shimizu, Ai Ikejiri, Tomoyuki Miura, Hironori Miyata, Hidenori Matsui, Shino Kumabe, Li Huang, and Yoshitaka Goto

Subjects
Salmonella typhimurium, Salmonella, Administration, Oral, Vaccines, Attenuated, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, DNA vaccination, Microbiology, Mice, Plasmid, In vivo, Vaccines, DNA, medicine, Animals, Mice, Inbred BALB C, General Veterinary, biology, General Medicine, beta-Galactosidase, biology.organism_classification, Virology, PBR322, In vitro, Titer, Salmonella enterica, Female, Animal Science and Zoology, Pharmaceutical Vehicles, Plasmids
Abstract

The ability of live attenuated Salmonella enterica serovar typhimurium (S. typhimurium) as a carrier of DNA vaccine was evaluated using model plasmid encoding beta-galactosidase (beta-Gal) and BALB/c mice. We constructed pBRCMVbeta, beta-Gal expression apparatus having a replication origin from low copy pBR322. Comparison of the plasmid stability showed that pBRCMVbeta remained stable in Salmonella even after oral administration, while pUC-based pCMVbeta tended to be lost quickly. However, titers for beta-Gal specific IgG in sera did not significantly increase in mice orally administered S. typhimurium harboring pBRCMVbeta. These data suggest that the stability of plasmid in S. typhimurium is associated with its replication origin. Further studies are required to scientifically establish this methodology.

Published
2006
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41. NMR and magnetic studies on 7 K anomaly in Tl3H(SO4)2

Author

Tomoaki Suzuki, Seiichiro Ikehata, Yasumitsu Matsuo, and Yuya Shimizu

Subjects
Magnetization, Condensed matter physics, Proton, Absorption spectroscopy, Chemistry, Relaxation (NMR), Materials Chemistry, Spin–lattice relaxation, Proton NMR, General Chemistry, Condensed Matter Physics, Magnetic susceptibility, Magnetic dipole
Abstract

Measurements of the spin-lattice relaxation time, NMR absorption line and magnetization have been carried out on the Tl3H(SO4)2 crystal below 50 K. The anomaly at around 7 K was: (1) the spin-lattice relaxation times of 1H and 205Tl nuclei increase steeply with decreasing temperature below 7 K, (2) the NMR absorption lines below 7 K shift to the high-magnetic field side in comparison with that above 7 K, and (3) the 1H NMR line width exhibits a drastic increase of the line width with decreasing temperature below 7 K. These results indicate that the magnetic dipole fluctuation of the proton changes at 7 K. On the other hand, there are no remarkable anomalies of magnetic susceptibility at around 7 K. From these results it is deduced that the anomaly at around 7 K is caused by the change in quantum mechanical process of the proton from proton tunneling to zero-point vibration of hydrogen in the hydrogen bond with the decrease of temperature.

Published
2004
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42. Characterization of vpr Vector Constructed from Chimeric Simian and Human Immunodeficiency Virus

Author

Nanase Yamazaki, Takeshi Haga, Masashi Okoba, Masanori Hayami, Tomoyuki Miura, Shino Kumabe, Iouri L. Kozyrev, Yuya Shimizu, Yoshitaka Goto, and Takeo Kuwata

Subjects
Genes, vpr, T-Lymphocytes, animal diseases, viruses, Genetic Vectors, Molecular Sequence Data, DNA, Recombinant, Human immunodeficiency virus (HIV), Gene Expression, Biology, Simian, Virus Replication, medicine.disease_cause, Insert (molecular biology), Cell Line, Pathogenesis, Open Reading Frames, stomatognathic system, SHIV, vector, vpr, medicine, Animals, Humans, Vector (molecular biology), Chemokine CCL5, Gene, Genetics, Base Sequence, General Veterinary, Interleukin-6, virus diseases, biology.organism_classification, Interleukin-12, Virology, Kinetics, Restriction enzyme, Viral replication, HIV-1, Interleukin-2, Simian Immunodeficiency Virus, Interleukin-5
Abstract

Chimeric simian and human immunodeficiency viruses (SHIVs) are useful tool for investigating AIDS pathogenesis and for development of vaccine. We constructed a SHIV-vpr vector (designated as SHIV-3sj) by replacing vpr region with restriction enzyme sites. SHIV-3sj was designed to express inserted gene along with its viral replication. Five cytokine genes were inserted into SHIV-3sj, and ability of viral replication and expression of the inserted genes were examined. The short insert including RANTES and IL-5 resulted in the successful expression from SHIV-3sj, while the construct having longer genes including IL-2, IL-6 and IL-12p35 failed to become replication competent. These results suggest that the length of the insert is an important factor for the replication ability of SHIV-3sj vector., SIV/HIVキメラウイルス(SHIV)のvpr領域を制限酵素サイトに置換し,SHIV-3sjベクターを作成した.5種のサイトカイン遺伝子をSHIV3sjに挿入した結果,RANTESやIL-5といった短い遺伝子は発現が確認されたが,IL-2,IL-6,IL-12p35といった長い遺伝子を挿入したものは複製能を欠いた.挿入遺伝子の長さがSHIV-3sjベクターの複製を規定している可能性が示唆された.

Published
2003

43. 1 H and 205 Tl Spin-Lattice Relaxation at Low Temperatures in Tl 3 H(SO 4 ) 2

Author

Shinya Kawachi, Yuya Shimizu, Seiichiro Ikehata, and Yasumitsu Matsuo

Subjects
Phase transition, Tunnel effect, Materials science, Proton, Condensed matter physics, Relaxation (NMR), Spin–lattice relaxation, Anomaly (physics), Condensed Matter Physics, Magnetic dipole, Ferroelectricity, Electronic, Optical and Magnetic Materials
Abstract

It was found from the temperature dependence of spin-lattice relaxation rates of 1 H and 205 Tl nuclei ( 1 H- T 1 m 1 and 205 Tl- T 1 m 1 ) that spin-lattice relaxations of 1 H and 205 Tl result from a magnetic dipole-dipole relaxation. It was also found from the analysis of T 1 's that the energy for the flip-flop motion of protons from O…H--O to O--H…O becomes 2.0 meV at low temperatures. These results suggest that Tl 3 H(SO 4 ) 2 shows the quantum mechanical process such as proton tunneling at low temperatures. The anomalous behavior of 1 H- T 1 m 1 at around 61 K indicates that proton dynamics is changed at around 61 K. Furthermore, it is suggested from the anomalies of 1 H- T 1 m 1 and 205 Tl- T 1 m 1 at around 7 K that Tl 3 H(SO 4 ) 2 shows a phase transition accompanied by the anomaly of the magnetic dipole-dipole fluctuation at around 7 K.

Published
2003
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44. Proton dynamics at low temperatures in Tl3H(SO4)2: possible quantum mechanical process of proton

Author

Shinya Kawachi, Yasumitsu Matsuo, Seiichiro Ikehata, and Yuya Shimizu

Subjects
Permittivity, Crystal, Phase transition, Proton, Condensed matter physics, Chemistry, Materials Chemistry, Spin–lattice relaxation, Rectangular potential barrier, General Chemistry, Dielectric, Anomaly (physics), Condensed Matter Physics
Abstract

Proton dynamics in the Tl 3 H(SO 4 ) 2 crystal has been examined from the measurement of the 1 H spin–lattice relaxation time T 1 below 120 K directly. It was found that T 1 shows the steep increase at around 61 K with increasing temperature and the minimum at 15 K. From the behavior of T 1 at around 15 K, the energy which is necessary for protons to move between two equilibrium positions in the hydrogen bond has been estimated to be 2.0 meV at low temperatures. This value is very low in comparison with the classical potential barrier height. Moreover, no dielectric anomalies are observed at around 15 K. These results indicate that quantum mechanical process of proton in the energy difference of 2.0 meV would exist at low temperatures in this crystal. In addition, the measured temperature dependence of T 1 deviates from the calculated one above 61 K. It was also found from dielectric measurement that the anomaly of dielectric constant is observed at around 61 K. This dielectric behavior is different from that (antiferroelectric-like behavior) observed in the same type M 3 D 1− x H x (XO 4 ) 2 (M=K, Rb; X=S, Se; x =0–1) crystals at low temperatures. These results indicate that the anomaly observed in the measurement of T 1 and dielectric constant at around 61 K could be caused by a new type of phase transition or a new type of dielectric anomaly in the M 3 H(XO 4 ) 2 crystals accompanied by the change of proton dynamics.

Published
2002
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46. Grassmann Tensor Renormalization Group Approach to One-Flavor Lattice Schwinger Model

Author

Yoshinobu Kuramashi and Yuya Shimizu

Subjects
Physics, High Energy Physics - Theory, Nuclear and High Energy Physics, Phase transition, Strongly Correlated Electrons (cond-mat.str-el), Critical phenomena, High Energy Physics::Lattice, High Energy Physics - Lattice (hep-lat), FOS: Physical sciences, Fermion, Renormalization group, Universality (dynamical systems), Condensed Matter - Strongly Correlated Electrons, High Energy Physics - Lattice, High Energy Physics - Theory (hep-th), Lattice (order), Lattice gauge theory, Quantum mechanics, Ising model, Mathematical physics
Abstract

We apply the Grassmann tensor renormalization group to the lattice regularized Schwinger model with one-flavor of the Wilson fermion. We study the phase diagram in the $(\beta,\kappa)$ plane performing a detailed analysis of the scaling behavior of the Lee-Yang zeros and the peak height of the chiral susceptibility. Our results strongly indicate that the whole range of the phase transition line starting from $(\beta,\kappa)=(0.0,0.380665(59))$ and ending at $(\infty,0.25)$ belongs to the two-dimensional Ising universality class similarly to the free fermion case., Comment: 9 pages, 11 figures

Published
2014
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48. ChemInform Abstract: Trithallium Hydrogen Bis(sulfate), Tl3H(SO4)2, in the Super-Ionic Phase by X-Ray Powder Diffraction

Author

Yasumitsu Matsuo, Shinya Kawachi, Yuya Shimizu, and Seiichiro Ikehata

Subjects
Crystal, Crystallography, Hydrogen, chemistry, Rietveld refinement, Phase (matter), X-ray, chemistry.chemical_element, Ionic bonding, General Medicine, Isostructural, Powder diffraction
Abstract

The structure of trithallium hydrogen bis­(sulfate), Tl3H(SO4)2, in the super-ionic phase has been analyzed by Rietveld analysis of the X-ray powder diffraction pattern. Atomic parameters based on the isotypic Rb3H(SeO4)2 crystal in space group R\overline 3m in the super-ionic phase were used as the starting model, because it has been shown from the comparison of thermal and electric properties in Tl3H(SO4)2 and M3H(SO4)2 type crystals (M = Rb, Cs or NH4) that the room-temperature Tl3H(SO4)2 phase is isostructural with the high-temperature R\overline 3m-symmetry M3H(SO4)2 crystals. The structure was determined in the trigonal space group R\overline 3m and the Rietveld refinement shows that an hydrogen-bond O—­H⋯O separation is slightly shortened compared with O—H⋯O separations in isotypic M3H(SeO4)2 crystals. In addition, it was found that the distortion of the SO4 tetrahedra in Tl3H(SO4)2 is less than that in isotypic crystals.

Published
2010
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49. [Innovation of vaccine adjuvants]

Author

Yuya, Shimizu, Katsuo, Karamatsu, Akihiro, Matsubara, and Yasuhiro, Yasutomi

Subjects
Squalene, Antigens, Bacterial, Cholera Toxin, Vaccines, Freund's Adjuvant, Water, Saponins, Th1 Cells, Mice, Adjuvants, Immunologic, Bacterial Proteins, Drug Design, Animals, Humans, Oils, Acyltransferases
Abstract

The enhancement of immune responses to vaccine antigen by adjuvants is critical for prevention of infectious disease. Here, we summarized the current status of adjuvant development and adjuvant categories like mineral salts, oil emulsion, and microorganism-derived adjuvants. Our resent study suggested that Ag85B of mycobacteria, which cross-reacts among mycobacteria species, elicits helper T-cell type 1 (Th1) immune responses as a novel adjuvant. These responses were enhanced in mice sensitized by BCG before vaccination. Since most humans have been sensitized by spontaneous infections or by vaccination with mycobacteria, these findings indicate that Ag85B is a promising adjuvant for enhancing Th1 immune responses of vaccine candidates. The study on the mechanisms of adjuvanticity will improve the development of novel vaccine adjuvants for human use.

Published
2008

50. [Development of oral vaccines]

Author

Akihiro, Matsubara, Yuya, Shimizu, Katsuo, Karamatsu, and Yasuhiro, Yasutomi

Subjects
Dosage Forms, Viral Hepatitis Vaccines, Vaccines, Mucous Membrane, Drug Design, Communicable Disease Control, Administration, Oral, Animals, Humans, Immunity, Mucosal, Hepatitis E
Abstract

In the increasing crisis of pandemic of infectious diseases all over the world in recent years, it is the most necessary to develop readily available vaccines even in developing countries. Since many pathogens establish their initial infections through the mucosal surface in our bodies, the induction of mucosal immune responses by vaccines are thought to be important for the prevention of infectious diseases through mucosal site. Oral administration of vaccines has abilities to elicit mucosal immune responses at mucosal tissues with various advantages such as easy skill for administration, less stressful for vaccine recipients and safer than systemic injection. Here, we show our novel strategies for inducing mucosal immune responses by oral vaccine administration.

Published
2008

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